A saturated map of common genetic variants associated with human height

作     者：Yengo, Loic Vedantam, Sailaja Marouli, Eirini Sidorenko, Julia Bartell, Eric Sakaue, Saori Graff, Marielisa Eliasen, Anders U. Jiang, Yunxuan Raghavan, Sridharan Miao, Jenkai Arias, Joshua D. Graham, Sarah E. Mukamel, Ronen E. Spracklen, Cassandra N. Yin, Xianyong Chen, Shyh-Huei Ferreira, Teresa Highland, Heather H. Ji, Yingjie Karaderi, Tugce Lin, Kuang Lull, Kreete Malden, Deborah E. Medina-Gomez, Carolina Machado, Moara Moore, Amy Rueger, Sina Sim, Xueling Vrieze, Scott Ahluwalia, Tarunveer S. Akiyama, Masato Allison, Matthew A. Alvarez, Marcus Andersen, Mette K. Ani, Alireza Appadurai, Vivek Arbeeva, Liubov Bhaskar, Seema Bielak, Lawrence F. Bollepalli, Sailalitha Bonnycastle, Lori L. Bork-Jensen, Jette Bradfield, Jonathan P. Bradford, Yuki Braund, Peter S. Brody, Jennifer A. Burgdorf, Kristoffer S. Cade, Brian E. Cai, Hui Cai, Qiuyin Campbell, Archie Canadas-Garre, Marisa Catamo, Eulalia Chai, Jin-Fang Chai, Xiaoran Chang, Li-Ching Chang, Yi-Cheng Chen, Chien-Hsiun Chesi, Alessandra Choi, Seung Hoan Chung, Ren-Hua Cocca, Massimiliano Concas, Maria Pina Couture, Christian Cuellar-Partida, Gabriel Danning, Rebecca Daw, E. Warwick Degenhard, Frauke Delgado, Graciela E. Delitala, Alessandro Demirkan, Ayse Deng, Xuan Devineni, Poornima Dietl, Alexander Dimitriou, Maria Dimitrov, Latchezar Dorajoo, Rajkumar Ekici, Arif B. Engmann, Jorgen E. Fairhurst-Hunter, Zammy Farmaki, Aliki-Eleni Faul, Jessica D. Fernandez-Lopez, Juan-Carlos Forer, Lukas Francescatto, Margherita Freitag-Wolf, Sandra Fuchsberger, Christian Galesloot, Tessel E. Gao, Yan Gao, Zishan Geller, Frank Giannakopoulou, Olga Giulianini, Franco Gjesing, Anette P. Goel, Anuj Gordon, Scott D. Gorski, Mathias Grove, Jakob Guo, Xiuqing Gustafsson, Stefan Haessler, Jeffrey Hansen, Thomas F. Havulinna, Aki S. Haworth, Simon J. He, Jing Heard-Costa, Nancy Hebbar, Prashantha Hindy, George Ho, Yuk-Lam A. Hofer, Edith Holliday, Elizabeth Horn, Katrin Hornsby, Whitney E. Hottenga, Jouke-Jan Huang, Hongyan Huang, Jie Huerta-Chagoya, Alicia Huffman, Jennifer E. Hung, Yi-Jen Huo, Shaofeng Hwang, Mi Yeong Iha, Hiroyuki Ikeda, Daisuke D. Isono, Masato Jackson, Anne U. Jager, Susanne Jansen, Iris E. Johansson, Ingegerd Jonas, Jost B. Jonsson, Anna Jorgensen, Torben Kalafati, Ioanna-Panagiota Kanai, Masahiro Kanoni, Stavroula Karhus, Line L. Kasturiratne, Anuradhani Katsuya, Tomohiro Kawaguchi, Takahisa Kember, Rachel L. Kentistou, Katherine A. Kim, Han-Na Kim, Young Jin Kleber, Marcus E. Knol, Maria J. Kurbasic, Azra Lauzon, Marie Le, Phuong Lea, Rodney Lee, Jong-Young Leonard, Hampton L. Li, Shengchao A. Li, Xiaohui Li, Xiaoyin Liang, Jingjing Lin, Honghuang Lin, Shih-Yi Liu, Jun Liu, Xueping Lo, Ken Sin Long, Jirong Lores-Motta, Laura Luan, Jian'an Lyssenko, Valeriya Lyytikainen, Leo-Pekka Mahajan, Anubha Mamakou, Vasiliki Mangino, Massimo Manichaikul, Ani Marten, Jonathan Mattheisen, Manuel Mavarani, Laven McDaid, Aaron F. Meidtner, Karina Melendez, Tori L. Mercader, Josep M. Milaneschi, Yuri Miller, Jason E. Millwood, Iona Y. Mishra, Pashupati P. Mitchell, Ruth E. Mollehave, Line T. Morgan, Anna Mucha, Soeren Munz, Matthias Nakatochi, Masahiro Nelson, Christopher P. Nethander, Maria Nho, Chu Won Nielsen, Aneta A. Nolte, Ilja M. Nongmaithem, Suraj S. Noordam, Raymond Ntalla, Ioanna Nutile, Teresa Pandit, Anita Christofidou, Paraskevi Parna, Katri Pauper, Marc Petersen, Eva R. B. Petersen, Liselotte, V Pitkanen, Niina Polasek, Ozren Poveda, Alaitz Preuss, Michael H. Pyarajan, Saiju Raffield, Laura M. Rakugi, Hiromi Ramirez, Julia Rasheed, Asif Raven, Dennis Rayner, Nigel W. Riveros, Carlos Rohde, Rebecca Ruggiero, Daniela Ruotsalainen, Sanni E. Ryan, Kathleen A. Sabater-Lleal, Maria Saxena, Richa Scholz, Markus Sendamarai, Anoop Shen, Botong Shi, Jingchunzi Shin, Jae Hun Sidore, Carlo Sitlani, Colleen M. Slieker, Roderic K. C. Smit, Roelof A. J. Smith, Albert, V Smith, Jennifer A. Smyth, Laura J. Southam, Lorrain E. Steinthorsdottir, Valgerdur Sun, Liang Takeuchi, Fumihiko Tallapragada, Divyasripriyanka Taylor, Kent D. Tayo, Bamidele O. Tcheandjieu, Catherine Terzikhan, Natalie Tesolin, Paola Teumer, Alexander Theusch, Elizabeth Thompson, Deborah J. Thorleifsson, Gudmar Timmers, Paul R. H. J. Trompet, Stella Turman, Constance Vaccargiu, Simona van der Laan, Sander W. van der Most, Peter J. van Klinken, Jan B. van Setten, Jessica Verma, Shefali S. Verweij, Niek Veturi, Yogasudha Wang, Carol A. Wang, Chaolong Wang, Lihua Wang, Zhe Warren, Helen R. Wei, Wen Bin Wickremasinghe, Ananda R. Wielscher, Matthias Wiggins, Kerri L. Winsvold, Bendik S. Wong, Andrew Wu, Yang Wuttke, Matthias Xia, Rui Xie, Tian Yamamoto, Ken Yang, Jingyun Yao, Jie Young, Hannah Yousri, Noha A. Yu, Lei Zeng, Lingyao Zhang, Weihua Zhang, Xinyuan Zhao, Jing-Hua Zhao, Wei Zhou, Wei Zimmermann, Martina E. Zoledziewska, Magdalena Adair, Linda S. Adams, Hieab H. H. Aguilar-Salinas, Carlos A. Al-Mulla, Fahd Arnett, Donna K. Asselbergs, Folkert W. Asvold, Bjorn Olav Attia, John Banas, Bernhard Bandinelli, Stefania Bennett, David A. Bergler, Tobias Bharadwaj, Dwaipayan Biino, Ginevra Bisgaard, Hans Boerwinkle, Eric Boger, Carsten A. Bonnelykke, Klaus Boomsma, Dorret, I Borglum, Anders D. Borja, Judith B. Bouchard, Claude Bowden, Donald W. Brandslund, Ivan Brumpton, Ben Buring, Julie E. Caulfield, Mark J. Chambers, John C. Chandak, Giriraj R. Chanock, Stephen J. Chaturvedi, Nish Chen, Yii-Der Ida Chen, Zhengming Cheng, Ching-Yu Christophersen, Ingrid E. Ciullo, Marina Cole, John W. Collins, Francis S. Cooper, Richard S. Cruz, Miguel Cucca, Francesco Cupples, L. Adrienne Cutler, Michael J. Damrauer, Scott M. Dantoft, Thomas M. de Borst, Gert J. de Groot, Lisette C. P. G. M. De Jager, Philip L. de Kleijn, Dominique P., V de Silva, H. Janaka Dedoussis, George, V den Hollander, Anneke, I Du, Shufa Easton, Douglas F. Elders, Petra J. M. Eliassen, A. Heather Ellinor, Patrick T. Elmstahl, Solve Erdmann, Jeanette Evans, Michele K. Fatkin, Diane Feenstra, Bjarke Feitosa, Mary F. Ferrucci, Luigi Ford, Ian Fornage, Myriam Franke, Andre Franks, Paul W. Freedman, Barry, I Gasparini, Paolo Gieger, Christian Girotto, Giorgia Goddard, Michael E. Golightly, Yvonne M. Gonzalez-Villalpando, Clicerio Gordon-Larsen, Penny Grallert, Harald Grant, Struan F. A. Grarup, Niels Griffiths, Lyn Gudnason, Vilmundur Haiman, Christopher Hakonarson, Hakon Hansen, Torben Hartman, Catharina A. Hattersley, Andrew T. Hayward, Caroline Heckbert, Susan R. Heng, Chew-Kiat Hengstenberg, Christian Hewitt, Alex W. Hishigaki, Haretsugu Hoyng, Carel B. Huang, Paul L. Huang, Wei Hunt, Steven C. Hveem, Kristian Hypponen, Elina Iacono, William G. Ichihara, Sahoko Ikram, M. Arfan Isasi, Carmen R. Jackson, Rebecca D. Jarvelin, Marjo-Riitta Jin, Zi-Bing Jockel, Karl-Heinz Joshi, Peter K. Jousilahti, Pekka Jukema, J. Wouter Kahonen, Mika Kamatani, Yoichiro Kang, Kui Dong Kaprio, Jaakko Kardia, Sharon L. R. Karpe, Fredrik Kato, Norihiro Kee, Frank Kessler, Thorsten Khera, Amit, V Khor, Chiea Chuen Kiemeney, Lambertus A. L. M. Kim, Bong-Jo Kim, Eung Kweon Kim, Hyung-Lae Kirchhof, Paulus Kivimaki, Mika Koh, Woon-Puay Koistinen, Heikki A. Kolovou, Genovefa D. Kooner, Jaspal S. Kooperberg, Charles Kottgen, Anna Kovacs, Peter Kraaijeveld, Adriaan Kraft, Peter Krauss, Ronald M. Kumari, Meena Kutalik, Zoltan Laakso, Markku Lange, Leslie A. Langenberg, Claudia Launer, Lenore J. Le Marchand, Loic Lee, Hyejin Lee, Nanette R. Lehtimaki, Terho Li, Huaixing Li, Liming Lieb, Wolfgang Lin, Xu Lind, Lars Linneberg, Allan Liu, Ching-Ti Liu, Jianjun Loeffler, Markus London, Barry Lubitz, Steven A. Lye, Stephen J. Mackey, David A. Magi, Reedik Magnusson, Patrik K. E. Marcus, Gregory M. Vidal, Pedro Marques Martin, Nicholas G. Marz, Winfried Matsuda, Fumihiko McGarrah, Robert W. McGue, Matt McKnight, Amy Jayne Medland, Sarah E. Mellstrom, Dan Metspalu, Andres Mitchell, Braxton D. Mitchell, Paul Mook-Kanamori, Dennis O. Morris, Andrew D. Mucci, Lorelei A. Munroe, Patricia B. Nalls, Mike A. Nazarian, Saman Nelson, Amanda E. Neville, Matt J. Newton-Cheh, Christopher Nielsen, Christopher S. Nothen, Markus M. Ohlsson, Claes Oldehinkel, Albertine J. Orozco, Lorena Pahkala, Katja Pajukanta, Paivi Palmer, Colin N. A. Parra, Esteban J. Pattaro, Cristian Pedersen, Oluf Pennell, Craig E. Penninx, Brenda W. J. H. Perusse, Louis Peters, Annette Peyser, Patricia A. Porteous, David J. Posthuma, Danielle Power, Chris Pramstaller, Peter P. Province, Michael A. Qi, Qibin Qu, Jia Rader, Daniel J. Raitakari, Olli T. Ralhan, Sarju Rallidis, Loukianos S. Rao, Dabeeru C. Redline, Susan Reilly, Dermot F. Reiner, Alexander P. Rhee, Sang Youl Ridker, Paul M. Rienstra, Michiel Ripatti, Samuli Ritchie, Marylyn D. Roden, Dan M. Rosendaal, Frits R. Rotter, Jerome, I Rudan, Igor Rutters, Femke Sabanayagam, Charumathi Saleheen, Danish Salomaa, Veikko Samani, Nilesh J. Sanghera, Dharambir K. Sattar, Naveed Schmidt, Borge Schmidt, Helena Schmidt, Reinhold Schulze, Matthias B. Schunkert, Heribert Scott, Laura J. Scott, Rodney J. Sever, Peter Shiroma, Eric J. Shoemaker, M. Benjamin Shu, Xiao-Ou Simonsick, Eleanor M. Sims, Mario Singh, Jai Rup Singleton, Andrew B. Sinner, Moritz F. Smith, J. Gustav Snieder, Harold Spector, Tim D. Stampfer, Meir J. Stark, Klaus J. Strachan, David P. t' Hart, Leen M. Tabara, Yasuharu Tang, Hua Tardif, Jean-Claude Thanaraj, Thangavel A. Timpson, Nicholas J. Tonjes, Anke Tremblay, Angelo Tuomi, Tiinamaija Tuomilehto, Jaakko Tusie-Luna, Maria-Teresa Uitterlinden, Andre G. van Dam, Rob M. van der Harst, Pim Van der Velde, Nathalie van Duijn, Cornelia M. van Schoor, Natasja M. Vitart, Veronique Volker, Uwe Vollenweider, Peter Volzke, Henry Wacher-Rodarte, Niels H. Walker, Mark Wang, Ya Xing Wareham, Nicholas J. Watanabe, Richard M. Watkins, Hugh Weir, David R. Werge, Thomas M. Widen, Elisabeth Wilkens, Lynne R. Willemsen, Gonneke Willett, Walter C. Wilson, James F. Wong, Tien-Yin Woo, Jeong-Taek Wright, Alan F. Wu, Jer-Yuarn Xu, Huichun Yajnik, Chittaranjan S. Yokota, Mitsuhiro Yuan, Jian-Min Zeggini, Eleftheria Zemel, Babette S. Zheng, Wei Zhu, Xiaofeng Zmuda, Joseph M. Zonderman, Alan B. Zwart, John-Anker Chasman, Daniel, I Cho, Yoon Shin Heid, Iris M. McCarthy, Mark, I Ng, Maggie C. Y. O'Donnell, Christopher J. Rivadeneira, Fernando Thorsteinsdottir, Unnur Sun, Yan, V Tai, E. Shyong Boehnke, Michael Deloukas, Panos Justice, Anne E. Lindgren, Cecilia M. Loos, Ruth J. F. Mohlke, Karen L. North, Kari E. Stefansson, Kari Walters, Robin G. Winkler, Thomas W. Young, Kristin L. Loh, Po-Ru Yang, Jian Esko, Tonu Assimes, Themistocles L. Auton, Adam Abecasis, Goncalo R. Willer, Cristen J. Locke, Adam E. Berndt, Sonja, I Lettre, Guillaume Frayling, Timothy M. Okada, Yukinori Wood, Andrew R. Visscher, Peter M. Hirschhorn, Joel N. 

作者机构：Univ Queensland Inst Mol Biosci Brisbane Qld Australia Boston Childrens Hosp Div Endocrinol Boston MA 02115 USA Broad Inst MIT & Harvard Program Med & Populat Genet Cambridge MA 02142 USA Queen Mary Univ London Barts & London Sch Med & Dent William Harvey Res Inst London England Harvard Med Sch Boston MA 02115 USA RIKEN Ctr Integrat Med Sci Lab Stat Anal Yokohama Kanagawa Japan Osaka Univ Dept Stat Genet Grad Sch Med Osaka Japan Brigham & Womens Hosp Div Genet 75 Francis St Boston MA 02115 USA Brigham & Womens Hosp Div Rheumatol 75 Francis St Boston MA 02115 USA Harvard Med Sch Dept Med Boston MA 02115 USA Univ North Carolina Chapel Hill Dept Epidemiol Gillings Sch Global Publ Hlth Chapel Hill NC USA Univ Copenhagen Herlev & Gentofte Hosp Copenhagen Prospect Studies Asthma Childhood COPSAC Copenhagen Denmark Tech Univ Denmark Dept Hlth Technol Sect Bioinformat Copenhagen Denmark 23AndMe Sunnyvale CA USA Eastern Colorado Healthcare Syst Dept Vet Affairs Aurora CO USA Univ Colorado Div Biomed Informat & Personalized Med Anschutz Med Campus Aurora CO USA NCI Div Canc Epidemiol & Genet Rockville MD USA Univ Michigan Dept Internal Med Div Cardiol Ann Arbor MI 48109 USA Brigham & Womens Hosp Dept Med Div Genet 75 Francis St Boston MA 02115 USA Univ North Carolina Chapel Hill Dept Genet Chapel Hill NC USA Univ Massachusetts Dept Biostat & Epidemiol Sch Publ Hlth & Hlth Sci Amherst MA USA Univ Michigan Sch Publ Hlth Dept Biostat Ann Arbor MI 48109 USA Univ Michigan Sch Publ Hlth Ctr Stat Genet Ann Arbor MI 48109 USA Wake Forest Sch Med Dept Biostat & Data Sci Winston Salem NC 27101 USA Univ Oxford Li Ka Shing Ctr Hlth Informat & Discovery Big Data Inst Oxford England Univ Exeter Coll Med & Hlth Genet Complex Traits Exeter Devon England Univ Copenhagen Fac Hlth & Med Sci Ctr Hlth Data Sci Copenhagen Denmark Univ Oxford Wellcome Ctr Human Genet Nuffield Dept Med Oxford England Univ Oxford Nuffield Dept Populat Hlth Oxford England Univ Tartu Estonian Genome Ctr Inst Genom 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Med Ragama Sri Lanka Osaka Univ Dept Geriatr & Gen Med Grad Sch Med Suita Osaka Japan Kyoto Univ Ctr Genom Med Grad Sch Med Kyoto Japan Univ Penn Dept Psychiat Philadelphia PA 19104 USA Univ Edinburgh Ctr Global Hlth Usher Inst Edinburgh Midlothian Scotland Univ Edinburgh Ctr Cardiovasc Sci Queens Med Res Inst Edinburgh Midlothian Scotland Sungkyunkwan Univ Kangbuk Samsung Hosp Med Res Inst Sch Med Seoul South Korea Sungkyunkwan Univ Dept Clin Res Design & Evaluat SAIHST Seoul South Korea SYNLAB MVZ Humangenet Mannheim Mannheim Germany Lund Univ Dept Clin Sci Genet & Mol Epidemiol Unit Malmo Sweden Univ Toronto Dept Comp Sci Toronto ON Canada Univ Toronto Mississauga Dept Anthropol Mississauga ON Canada Queensland Univ Technol Genom Res Ctr Ctr Genom & Personalised Hlth Sch Biomed Sci Kelvin Grove Qld Australia Oneomics Soonchunhyang Mirai Med Ctr Bucheon Si South Korea NIA Lab Neurogenet NIH Bethesda MD 20892 USA NIH Ctr Alzheimers & Related Dementias Bldg 10 Bethesda MD 20892 USA Data Tecn Int Glen Echo MD USA Leidos Biomed Res Canc Genom Res Lab Rockville MD USA Case Western Reserve Univ Dept Populat & Quantitat Hlth Sci Cleveland OH 44106 USA Univ Massachusetts Chan Med Sch Dept Med Worcester MA USA Taichung Vet Gen Hosp Ctr Geriatr & Gerontol Taichung Taiwan Montreal Heart Inst Montreal PQ Canada Radboud Univ Nijmegen Dept Ophthalmol Med Ctr Nijmegen Netherlands Radboud Univ Nijmegen Med Ctr Dept Human Genet Nijmegen Netherlands Univ Cambridge MRC Epidemiol Unit Sch Clin Med Cambridge England Univ Bergen Ctr Diabet Res Dept Clin Sci Bergen Norway Lund Univ Dept Clin Sci Diabet Ctr Malmo Sweden Fimlab Labs Dept Clin Chem Tampere Finland Tampere Univ Fac Med & Hlth Technol Finnish Cardiovasc Res Ctr Tampere Dept Clin Chem Tampere Finland Tampere Univ Hosp Heart Ctr Dept Cardiol Tampere Finland Natl & Kapodistrian Univ Athens Dromokaiteio Psychiat Hosp Athens Greece Kings Coll London Dept Twin Res & Genet Epidemiol London England Guys & St Thomas Fdn Trust NIHR Biomed Res Ctr London England Univ Virginia Sch Med Ctr Publ Hlth Genom Charlottesville VA 22908 USA Univ Edinburgh Western Gen Hosp Inst Genet & Canc MRC Human Genet Unit Edinburgh Midlothian Scotland Dalhousie Univ Dept Psychiat Halifax NS Canada Dalhousie Univ Dept Community Hearth & Epidemiol Halifax NS Canada Ludwig Maximilians Univ Munchen Inst Psychiat Phen & Genom IPPG Univ Hosp Munich Germany Univ Hosp Essen Inst Med Informat Biometry & Epidemiol Essen Germany Massachusetts Gen Hosp Diabet Unit Boston MA 02114 USA Massachusetts Gen Hosp Ctr Genom Med Boston MA 02114 USA Amsterdam UMC Dept Psychiat Amsterdam Publ Hlth Amsterdam Netherlands Vrije Univ Amsterdam Netherlands Geisinger Biomed & Translat Informat Inst Danville PA USA Univ Penn Perelman Sch Med Inst Biomed Informat Dept Genet Philadelphia PA USA Univ Oxford Nuffield Dept Populat Hlth MRC Populat Hlth Res Unit Oxford England Univ Bristol Bristol Med Sch Populat Hlth Sci Bristol Avon England Univ Lubeck Inst Cardiogenet DZHK German Res Ctr Cardiovasc Res Partner Site Hamburg Lubeck Kiel Lubeck Germany Univ Heart Ctr Lubeck Lubeck Germany Nagoya Univ Dept Integrated Hlth Sci Publ Hlth Informat Unit Grad Sch Med Nagoya Aichi Japan Univ Gothenburg Sahlgrenska Acad Ctr Bone & Arthrit Res Inst Med Gothenburg Sweden Univ Gothenburg Sahlgrenska Acad Bioinformat Core Facil Gothenburg Sweden Korea Inst Sci & Technol Gangneung Inst Nat Prod Kangnung South Korea Lillebaelt Hosp Dept Clin Biochem Kolding Denmark Wellcome Sanger Inst Dept Human Genet Hinxton England Leiden Univ Med Ctr Dept Internal Med Sect Gerontol & Geriatr Leiden Netherlands CNR Inst Genet & Biophys A Buzzati Traverso Naples Italy Hosp Southern Jutland Dept Clin Biochem & Immunol Aabenraa Denmark Univ Aarhus Natl Ctr Register Based Res Aarhus Denmark Univ Turku Ctr Populat Hlth Res Turku Finland Turku Univ Hosp Turku Finland Univ Turku Res Ctr Appl & Prevent Cardiovasc Med Turku Finland Univ Split Med Sch Split Croatia Algebra Univ Coll Zagreb Croatia Icahn Sch Med Mt Sinai Charles Bronfman Inst Personalized Med New York NY 10029 USA Icahn Sch Med Mt Sinai Dept Environm Med & Publ Hlth New York NY 10029 USA Univ Zaragoza Aragon Inst Engn Res Zaragoza Spain Ctr Invest Biomed Red Bioingn Biomat & Nanomed CI Madrid Spain Ctr Noncommunicable Dis Karachi Pakistan Univ Groningen Univ Med Ctr Groningen Interdisciplinary Ctr Psychopathol & Emot Regulat Dept Psychiat Groningen Netherlands Helmholtz Zentrum Munchen Inst Translat Genom German Res Ctr Environm Hlth Neuherberg Germany Univ Oxford Churchill Hosp Oxford Ctr Diabet Endocrinol & Metab Radcliffe Dept Med Oxford England Hunter Med Res Inst New Lambton Hts NSW Australia Univ Newcastle Coll Hlth Sch Med & Publ Hlth New Lambton Hts NSW Australia IRCCS Neuromed Pozzilli Italy Univ Maryland Sch Med Dept Med Div Endocrinol Diabet & Nutr Baltimore MD 21201 USA Univ Maryland Sch Med Program Personalized & Genom Med Baltimore MD 21201 USA St Pau Biomed Res Inst IIB St Pau Unit Genom Complex Dis Barcelona Spain Karolinska Inst Ctr Mol Med Dept Med Cardiovasc Med Unit Stockholm Sweden NIA Lab Epidemiol & Populat Sci NIH Baltimore MD 21224 USA Hallym Univ Dept Biomed Sci Chunchon South Korea Consiglio Nazl Ric CNR Ist Ric Genet & Biomed Cagliari Italy Leiden Univ Med Ctr Dept Cell & Chem Biol Leiden Netherlands Locat Vrije Univ Amsterdam Amsterdam UMC Epidemiol & Data Sci Amsterdam Netherlands Amsterdam Cardiovasc Sci Amsterdam Netherlands Leiden Univ Med Ctr Dept Clin Epidemiol Leiden Netherlands Iceland Heart Assoc Kopavogur Iceland Wellcome Sanger Inst Hinxton England deCODE Genet Amgen Reykjavik Iceland Univ Bergen Dept Clin Sci Mohn Nutr Res Lab Bergen Norway Loyola Univ Chicago Parkinson Sch Hlth Sci & Publ Hlth Dept Publ Hlth Sci Maywood IL USA VA Palo Alto Hlth Care Syst Palo Alto CA USA Stanford Univ Dept Med Sch Med Stanford CA USA Univ Med Greifswald Inst Community Med Greifswald Germany DZHK German Ctr Cardiovasc Res Partner Site Greifswald Greifswald Germany Univ Calif Oakland Dept Pediat Cardiol Div Oakland CA USA Univ Cambridge Ctr Canc Genet Epidemiol Cambridge England Univ Cambridge Dept Publ Hlth & Primary Care Cambridge England Leiden Univ Med Ctr Dept Cardiol Leiden Netherlands Univ Utrecht Univ Med Ctr Utrecht Div Labs Cent Diagnost Lab Utrecht Netherlands Leiden Univ Med Ctr Dept Human Genet Leiden Netherlands Univ Amsterdam Dept Clin Chem Lab Genet Metab Dis Amsterdam UMC Amsterdam Netherlands Univ Amsterdam Amsterdam UMC Core Facil Metabol Amsterdam Netherlands Univ Utrecht Univ Med Ctr Utrecht Dept Cardiol Div Heart & Lungs Utrecht Netherlands Univ Groningen Univ Med Ctr Groningen Dept Cardiol Groningen Netherlands Huazhong Univ Sci & Technol Tongji Med Coll Sch Publ Hlth Dept Epidemiol & Biostat Wuhan Peoples R China Queen Mary Univ London NIHR Barts Cardiovasc Biomed Res Ctr Barts & London Sch Med & Dent London England Capital Med Univ Beijing Tongren Hosp Dept Ophthalmol Beijing Peoples R China Imperial Coll London MRC PHE Ctr Environm & Hlth Sch Publ Hlth Dept Epidemiol & Biostat London England Med Univ Vienna Dept Dermatol Vienna Austria Oslo Univ Hosp Dept Res & Innovat Div Clin Neurosci Oslo Norway Oslo Univ Hosp Dept Neurol Oslo Norway UCL Inst Cardiovasc Sci MRC Unit Lifelong Hlth & Ageing UCL London England Univ Freiburg Fac Med Inst Genet Epidemiol Freiburg Germany Univ Freiburg Med Ctr Freiburg Germany Univ Freiburg Fac Med Dept Med Nephrol & Primary Care 4 Freiburg Germany Univ Texas Hlth Sci Ctr Houston McGovern Med Sch Inst Mol Med Houston TX 77030 USA Kurume Univ Dept Med Biochem Sch Med Kurume Fukuoka Japan Rush Univ Med Ctr Rush Alzheimers Dis Ctr Chicago IL USA Rush Univ Med Ctr Dept Neurol Sci Chicago IL USA Weill Cornell Med Qatar Dept Genet Med Doha Qatar Alexandria Univ Dept Comp & Syst Engn Alexandria Egypt Tech Univ Munich German Heart Ctr Munich Dept Cardiol Munich Germany London North West Univ Healthcare NHS Trust Ealing Hosp Dept Cardiol London England Imperial Coll London Dept Epidemiol & Biostat London England Univ Cambridge Dept Publ Hlth & Primary Care Cardiovasc Epidemiol Unit Strangeways Res Lab Cambridge England Univ Michigan Dept Computat Med & Bioinformat Ann Arbor MI 48109 USA Massachusetts Gen Hosp Analyt & Translat Genet Unit Boston MA 02114 USA Broad Inst MIT & Harvard Stanley Ctr Psychiat Res Cambridge MA 02142 USA Univ North Carolina Chapel Hill Dept Nutr Gillings Sch Global Publ Hlth Chapel Hill NC USA Univ North Carolina Chapel Hill Carolina Populat Ctr Chapel Hill NC USA Erasmus MC Dept Clin Genet Rotterdam Netherlands Erasmus MC Dept Radiol & Nucl Med Rotterdam Netherlands Univ Adolfo Ibanez Latin Amer Brain Hlth BrainLat Santiago Chile Inst Nacl Ciencias Med & Nutr Salvador Zubiran Unidad Invest Enfermedades Metab & Direct Nutr Mexico City DF Mexico Tecnol Monterrey Escuela Med & Ciencias Salud Monterrey Mexico Univ Kentucky Coll Publ Hlth Dept Epidemiol Lexington KY USA Univ Kentucky Coll Publ Hlth Deans Off Lexington KY USA UCL Fac Populat Hlth Sci Inst Cardiovasc Sci London England UCL Hlth Data Res UK London England UCL Inst Hlth Informat London England Norwegian Univ Sci & Technol Fac Med & Hlth Sci KG Jebsen Ctr Genet Epidemiol Dept Publ Hlth & Nursing Trondheim Norway Norwegian Univ Sci & Technol Hunt Res Ctr Dept Publ Hlth & Nursing Levanger Norway Trondheim Reg & Univ Hosp St Olavs Hosp Clin Med Dept Endocrinol Trondheim Norway Univ Hosp Regensburg Dept Nephrol Regensburg Germany Azienda Toscana Ctr Geriatr Unit Florence Italy Jawaharlal Nehru Univ JNU Sch Biotechnol Syst Genom Lab New Delhi India Natl Res Council Italy Inst Mol Genet Pavia Italy Univ Texas Hlth Sci Ctr Houston Human Genet Ctr Houston TX 77030 USA Univ Texas Hlth Sci Ctr Houston Dept Epidemiol Houston TX 77030 USA Kliniken Sudostbayern Dept Nephrol & Rheumatol Regensburg Germany KfH Kidney Ctr Traunstein Traunstein Germany Aarhus Univ Ctr Genom & Personalized Med CGPM Aarhus Denmark Aarhus Univ Bioinformat Res Ctr Aarhus Denmark Univ San Carlos USC Off Populat Studies Fdn Cebu Philippines Univ San Carlos Dept Nutr & Dietet Cebu Philippines Pennington Biomed Res Ctr Human Genom Lab Baton Rouge LA USA Wake Forest Sch Med Dept Biochem Med Ctr Blvd Winston Salem NC USA Lillebaelt Hosp Dept Clin Biochem Vejle Denmark Univ Southern Denmark Inst Reg Hlth Res Odense Denmark Trondheim Reg & Univ Hosp St Olavs Hosp Clin Med Trondheim Norway Nanyang Technol Univ Lee Kong Chian Sch Med Singapore Singapore Imperial Coll Healthcare NHS Trust Imperial Coll London London England JSS Deemed Be Univ JSS Univ Acad Higher Educ & Res JSSAHER Adjunct Fac Mysuru India Duke NUS Med Sch Ophthalmol & Visual Sci Acad Clin Program Eye ACP Singapore Singapore Oslo Univ Hosp Dept Med Genet Oslo Norway Vestre Viken Hosp Trust Dept Med Res Gjettum Norway Univ Maryland Sch Med Dept Neurol Div Vasc Neurol Baltimore MD 21201 USA Baltimore Vet Affairs Med Ctr Dept Neurol Baltimore MD USA Hosp Especialidades Ctr Med La Raza Ctr Med Nacl Siglo 21 Inst Mexicano Seguro Social Unidad Invest Med Bioquim Mexico City DF Mexico Univ Sassari Dipartimento Sci Biomed Sassari Italy Intermt Med Ctr Intermt Heart Inst Murray UT USA Univ Penn Dept Surg Philadelphia PA 19104 USA Corporal Michael J Crescenz VA Med Ctr Philadelphia PA USA Univ Utrecht Univ Med Ctr Utrecht Dept Vasc Surg Utrecht Netherlands Wageningen Univ Dept Human Nutr Wageningen Netherlands Columbia Univ Ctr Translat & Computat Neuroimmunol Dept Neurol Med Ctr New York NY USA Univ Cambridge Dept Oncol Cambridge England Amsterdam UMC Dept Gen Practice Locat VUmc Amsterdam Publ Hlth Inst Amsterdam Netherlands Harvard TH Chan Sch Publ Hlth Dept Nutr Boston MA USA Massachusetts Gen Hosp Cardiac Arrhythmia Serv Boston MA 02114 USA Massachusetts Gen Hosp Cardiovasc Res Ctr Boston MA 02114 USA Lund Univ Dept Clin Sci Malmo Div Geriatr Med Malmo Sweden Victor Chang Cardiac Res Inst Mol Cardiol Div Darlinghurst NSW Australia St Vincents Hosp Cardiol Dept Darlinghurst NSW Australia UNSW Sydney Fac Med Kensington NSW Australia NIA Translat Gerontol Branch NIH Baltimore MD 21224 USA Univ Glasgow Robertson Ctr Biostat Glasgow Lanark Scotland Univ Texas Hlth Sci Ctr Houston Human Genet Ctr Sch Publ Hlth Houston TX 77030 USA Umea Univ Dept Publ Hlth & Clin Med Umea Sweden Wake Forest Sch Med Dept Internal Med Med Ctr Blvd Winston Salem NC USA Univ Melbourne Fac Vet & Agr Sci Parkville Vic Australia Agr Victoria Res Dept Jobs Precincts & Reg Bundoora Vic Australia Univ North Carolina Chapel Hill Injury Prevent Res Ctr Chapel Hill NC USA Univ North Carolina Chapel Hill Div Phys Therapy Chapel Hill NC USA Inst Nacl Salud Publ Ctr Invest Salud Poblac Cuernavaca Morelos Mexico Ctr Estudios Diabet Cuernavaca Morelos Mexico Childrens Hosp Philadelphia Div Human Genet Philadelphia PA 19104 USA Univ Penn Dept Pediat Perelman Sch Med Philadelphia PA 19104 USA Univ Penn Dept Genet Perelman Sch Med Philadelphia PA 19104 USA Childrens Hosp Philadelphia Div Endocrinol & Diabet Philadelphia PA 19104 USA Univ Iceland Fac Med Reykjavik Iceland USC Dept Prevent Med Keck Sch Med Los Angeles CA USA Childrens Hosp Philadelphia Div Pulm Med Philadelphia PA 19104 USA Univ Exeter Inst Biomed & Clin Sci Med Sch Exeter Devon England Univ Washington Dept Epidemiol Cardiovasc Hlth Res Unit Seattle WA 98195 USA Natl Univ Singapore Yong Loo Lin Sch Med Dept Paediat Singapore Singapore Natl Univ Hlth Syst Khoo Teck Puat Natl Univ Childrens Med Inst Singapore Singapore Med Univ Vienna Dept Internal Med 2 Div Cardiol Vienna Austria Univ Tasmania Menzies Res Inst Tasmania Hobart Tas Australia Univ Melbourne Royal Victorian Eye & Ear Hosp Ctr Eye Res Australia Melbourne Vic Australia Univ Western Australia Ctr Ophthalmol & Vis Sci Lions Eye Inst Perth WA Australia Massachusetts Gen Hosp Cardiol Div Boston MA 02114 USA Chinese Natl Human Genome Ctr Dept Genet Shanghai MOST Key Lab Heath & Dis Genom Shanghai Peoples R China Shanghai Ind Technol Inst Shanghai Peoples R China Univ Utah Dept Internal Med Salt Lake City UT 84112 USA Univ South Australia Australian Ctr Precis Hlth Clin & Hlth Sci Adelaide SA Australia South Australian Hlth & Med Res Inst Adelaide SA Australia Jichi Med Univ Dept Environm & Prevent Med Sch Med Shimotsuke Tochigi Japan Albert Einstein Coll Med Dept Epidemiol & Populat Hlth Bronx NY 10467 USA Ohio State Univ Sch Med Div Endocrinol Diabet & Metab Columbus OH 43210 USA Univ Oulu Fac Med Ctr Life Course Hlth Res Oulu Finland Oulu Univ Hosp Unit Primary Hlth Care Oulu Finland Brunel Univ London Coll Hlth & Life Sci Dept Life Sci Uxbridge Middx England Wenzhou Med Univ Eye Hosp Sch Ophthalmol & Optometry Wenzhou Peoples R China LUMC Einthoven Lab Expt Vasc Med Leiden Netherlands Netherlands Heart Inst Utrecht Netherlands Tampere Univ Hosp Dept Clin Physiol Tampere Finland Tampere Univ Fac Med & Hlth Technol Finnish Cardiovasc Res Ctr Tampere Dept Clin Physiol Tampere Finland Univ Tokyo Grad Sch Frontier Sci Dept Computat Biol & Med Sci Lab Complex Trait Genom Tokyo Japan Catholic Univ Korea Dept Ophthalmol Incheon St Marys Hosp Incheon South Korea Churchill Hosp NIHR Oxford Biomed Res Ctr Oxford England German Ctr Cardiovasc Res DZHK Partner Site Munich Heart Alliance Munich Germany Radboud Univ Nijmegen Med Ctr Radboud Inst Hlth Sci Dept Urol Nijmegen Netherlands Yonsei Univ Corneal Dystrophy Res Inst Coll Med Seoul South Korea Saevit Eye Hosp Goyang South Korea Ewha Womans Univ Coll Med Dept Biochem Seoul South Korea Univ Heart & Vasc Ctr UKE Hamburg Dept Cardiol Hamburg Germany Univ Birmingham Coll Med & Dent Sci Inst Cardiovasc Sci Birmingham W Midlands England German Ctr Cardiovasc Res Partner Site Hamburg Kiel Lubeck Hamburg Germany Atrial Fibrillat NETwork Munster Germany UCL UCL Inst Epidemiol & Hlth Care Dept Epidemiol & Publ Hlth London England Natl Univ Singapore Yong Loo Lin Sch Med Hlth Longev Translat Res Programme Singapore Singapore Univ Helsinki Helsinki Finland Helsinki Univ Hosp Dept Med Helsinki Finland Minerva Fdn Helsinki Finland Metropolitan Hosp Dept Prevent Cardiol Lipoprot Apheresis Unit Athens Greece Metropolitan Hosp Lipid Disorders Clin Athens Greece Imperial Coll London MRC PHE Ctr Environm & Hlth London England Imperial Coll London Natl Heart & Lung Inst London England Univ Leipzig Med Ctr Med Dept Endocrinol Nephrol Rheumatol 3 Leipzig Germany Univ Essex Inst Social & Econ Res Colchester Essex England Univ Eastern Finland Inst Clin Med Internal Med Kuopio Finland Kuopio Univ Hosp Kuopio Finland Univ Colorado Denver Dept Med Aurora CO USA Charite Univ Med Berlin Berlin Inst Hlth Berlin Germany Univ Hawaii Canc Ctr Epidemiol Program Honolulu HI USA Ewha Womans Univ Dept Internal Med Sch Med Seoul South Korea Peking Univ Dept Epidemiol & Biostat Hlth Sci Ctr Beijing Peoples R China Peking Univ Ctr Publ Hlth & Epidem Preparedness & Response Beijing Peoples R China Univ Kiel Inst Epidemiol Kiel Germany Univ Kiel Biobank Popgen Kiel Germany Chinese Acad Sci Univ Chinese Acad Sci Hangzhou Inst Adv Study Key Lab Syst Hlth Sci Zhejiang Prov Hangzhou Peoples R China Univ Copenhagen Fac Hlth & Med Sci Dept Clin Med Copenhagen Denmark Univ Iowa Hosp & Clin Div Cardiovasc Med Iowa City IA 52242 USA Univ Iowa Hosp & Clin Abboud Cardiovasc Res Ctr Iowa City IA 52242 USA Sinai Hlth Syst Alliance Human Dev Lunenfeld Tanenbaum Res Inst Toronto ON Canada Karolinska Inst Dept Med Epidemiol & Biostat Stockholm Sweden Univ Calif San Francisco Div Cardiol San Francisco CA 94143 USA Lausanne Univ Hosp Dept Med Internal Med Lausanne Switzerland Univ Lausanne Lausanne Switzerland SYNLAB Holding Deutschland SYNLAB Acad Mannheim Germany Med Univ Graz Clin Inst Med & Chem Lab Diagnost Graz Austria Duke Univ Sch Med Dept Med Div Cardiol Durham NC 27706 USA Duke Univ Sch Med Duke Mol Physiol Inst Durham NC USA QIMR Berghofer Med Res Inst Psychiat Genet Brisbane Qld Australia Univ Gothenburg Sahlgrenska Acad Inst Med Geriatr Med Gothenburg Sweden Baltimore Vet Adm Med Ctr Geriatr Res & Educ Clin Ctr Baltimore MD USA Univ Sydney Ctr Vis Res Westmead Millennium Inst Med Res Sydney NSW Australia Univ Sydney Westmead Millennium Inst Med Res Dept Ophthalmol Sydney NSW Australia Leiden Univ Med Ctr Dept Publ Hlth & Primary Care Leiden Netherlands Univ Edinburgh Usher Inst Populat Hlth Sci & Informat Edinburgh Midlothian Scotland Univ Penn Perelman Sch Med Div Cardiovasc Med Electrophysiol Sect Philadelphia PA USA Univ North Carolina Chapel Hill Dept Med Chapel Hill NC USA Norwegian Inst Publ Hlth Dept Chron Dis Oslo Norway Oslo Univ Hosp Dept Pain Management & Res Oslo Norway Sch Med Inst Human Genet Bonn Germany Univ Hosp Bonn Bonn Germany Sahlgrens Univ Hosp Dept Drug Treatment Gothenburg Sweden Inst Nacl Med Genom Lab Inmunogen & Enfermedades Metab Mexico City DF Mexico Univ Turku Paavo Nurmi Ctr Dept Phys Act & Hlth Sports & Exercise Med Unit Turku Finland 

出 版 物：《NATURE》 (自然)

年 卷 期：2022年第610卷第7933期

页      面：704-+页

核心收录：

学科分类：07[理学] 08[工学] 

基　　金：US National Institutes of Health (NIH) [75N92021D00001, 75N92021D00002, 75N92021D00003, 75N92021D00004, 75N92021D00005, AA07535, AA10248, AA014041, AA13320, AA13321, AA13326, DA12854, U01 DK062418, HHSN268201800005I, HHSN268201800007I, HHSN268201800003I] National Institute on Aging Intramural Research Program [R-35-HL135824, AA-12502, AA-00145, AA-09203, AA15416, K02AA018755, UM1 CA186107, U01 CA176726, CA141298, P01CA055075, HL54471, HL54472, HL54473, HL54495, HL54496, HL54509, U24 MH068457-06, R01D0042157-01A1, RO1 MH58799-03, MH081802, 1RC2MH089951-01, 1RC2 MH089995, R01 DK092127-04, R01DK110113, R01DK075787, R01DK107786, R01HL142302, R01HG010297, R01DK124097, R01HL151152, R01-HL046380, KL2-RR024990, R35-HL135818, R01-HL113338, R35HL135818, HL 046389, HL113338, K01 HL135405, R03 HL154284, R01HL086718, HG011052, N01-HC-25195, HHSN268201500001I, N02-HL-6-4278, R01-DK122503, U01AG023746, U01AG023712, U01AG023749, U01AG023755, U01AG023744, U19AG063893, R01-DK-089256, R01HL117078, R01 HL091357, R01 HL104135, R37-HL045508, R01-HL053353, R01-DK075787, U01-HL054512, R01-HL074166, R01-HL086718, R01-HG003054, U01HG004423, U01HG004446, U01HG004438, DK078150, TW005596, HL085144, RR020649, ES010126, DK056350, R01DK072193, R01 HD30880, R01 AG065357, R01DK104371, R01HL108427] Fogarty grant [U01 DK062418, R01DK075787, D43 TW009077, 263 MD 9164, N.1-AG-1-2111, HHSN268201800013I, HHSN268201800014I, HHSN268201800015I, HHSN268201800010I, HHSN268201800011I, HHSN268201800012I, KL2TR002490, T32HL129982, R01AG056477, R01AG034454, R01 HD056465, U01 HL054457, U01 HL054464, U01 HL054481, R01 HL119443, R01 HL087660, U01AG009740, RC2 AG036495, RC4 AG039029, 75N92020D00001, HHSN268201500003I, N01-HC-95159, 75N92020D00005, N01-HC-95160, 75N92020D00002, N01-HC-95161, 75N92020D00003, N01-HC-95162, 75N92020D00006, N01-HC-95163, 75N92020D00004, N01-HC-95164, 75N92020D00007, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169, UL1-TR-000040, UL1-TR-001079, UL1-TR-001420, N02-HL-64278, UL1TR001881, DK063491, R01-HL088457, R01-HL-60030, R01-HL067974, R01-HL-55005, R01-HL 067974, R01HL111249, R01HL11124904S1, U01HL54527, U01HL54498, EY014684, EY014684-03S1, EY014684-04S1, S10OD017985, S10RR025141, UL1TR002243, UL1TR000445, UL1RR024975, U01HG004798, R01NS032830, RC2GM092618, P50GM115305, U01HG006378, U19HL065962, R01HD074711, 5K08HL135275, R01 HL77398, NR013520, DK125187, HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700004I, HHSN268201700005I, R01HL087641, R01HL086694, U01HG004402, HHSN268200625226C, UL1RR025005, U01HG007416, R01DK101855, 15GRNT25880008, N01-HC65233, N01-HC65234, N01-HC65235, N01-HC65236, N01-HC65237, U01HG007376, HHSN268201100046C, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C, HHSN271201100004C, N01-AG-6-2101, N01-AG-6-2103, N01-AG-6-2106, R01-AG028050, R01-NR012459, P30AG10161, P30AG72975, R01AG17917, R01AG30146, U01AG46152, U01AG61256, AG000513, R01 HD58886, R01 HD100406, N01-HD-1-3228, N01-HD-1-3329, N01-HD-1-3330, N01-HD-1-3331, N01-HD-1-3332, N01-HD-1-3333, UL1 TR000077, R01 HG010067, R01CA64277, R01CA15847, UM1CA182910, R01CA148677, R01CA144034, UM1 CA182876, ZIA CP010152-20, U19 CA 148537-01, X01HG007492, HHSN268201200008I, Z01CP010119, R01-CA080122, R01-CA056678, R01-CA082664, R01-CA092579, K05-CA175147, P30-CA015704, CA063464, CA054281, CA098758, CA164973, R01CA128813, K25 HL150334, U19 CA148065, CA128978, 1U19 CA148065, 1U19 CA148112, U01-DK105535, DK093757, HL129982, T32 HL007055] Wellcome Trust [076113/B/04/Z, 079895, 090532/Z/09/Z, 203141/Z/16/Z, 201543/B/16/Z, 084723/Z/08/Z, 090532, 098381, 217065/Z/19/Z, WT088806, WT092830/Z/10/Z, 202802/Z/16/Z, 216767/Z/19/Z, 104036/Z/14/Z, 098051, WT098051, 212946/Z/18/Z, 202922/Z/16/Z, 104085/Z/14/Z, 088158/Z/09/Z, 221854/Z/20/Z, 212904/Z/18/Z, WT095219MA, 068545/Z/02, 076113, 106130, 203141, 212259, 072960/Z/03/Z, 084726/Z/08/Z, 084727/Z/08/Z, 085475/Z/08/Z, 085475/B/08/Z, 212945/Z/18/Z] UK Medical Research Council [G0000934, MR/N013166/1, U. MC_UU_00007/10, G0601966, G0700931] MRC Integrative Epidemiology Unit [MC_UU_00011/1, MC_UU_00019/1, G9521010D, MC_UU_12015/1, MC_PC_13046, MC_ PC_13049, MC-PC-14135, MC_UU_00017/1, MC_UU_12026/2, MC_U137686851, K013351, R024227, MC_UU_00007/10, MR/M016560/1, G1001799, MC_PC_20026] Cancer Research UK: CRUK Integrative Cancer Epidemiology Programme [C18281/A29019, C16077/A29186, C500/A16896, C5047/A7357, C1287/A10118, C1287/A16563, C5047/A3354, C5047/A10692, C16913/A6135, C5047/A1232, C490/A10124, C1287/A10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C8197/A16565] Australian Research Council [DP0770096, DP1093502, DE200100425, FL180100072] Australian National Health and Medical Research Council [241944, 389875, 389891, 389892, 389938, 442915, 442981, 496739, 496688, 552485, 613672, 613601, 1011506, 1172917, 572613, 403981, 1059711, 1027449, 1044840, 1021858, 974159, 211069, 457349, 512423, 302010, 571013, 1154518, 1103329, 1186500, 209057, 396414, 1074383, 390130, 1009458, 1113400] UK National Institute for Health Research Centres: Barts Biomedical Research Centre Comprehensive Biomedical Research Centre Imperial College Healthcare NHS Trust [RP-PG-0407-10371, 16/136/68] University of Bristol NIHR Biomedical Research Centre [BRC-1215-2001] Academic Clinical Fellowship Leicester Cardiovascular Biomedical Research Centre [BRC-1215-20010] Barts Biomedical Research Centre King's College London Biomedical Research Centre at the University of Cambridge, Oxford Biomedical Research Centre European Union [018996, LSHG-CT-2006-018947, HEALTH-F2-2013-601456, 01KL1802, 305739, 727565, 310644 MACULA, LSHM-CT-2007-037273, SOC 95201408 05F02, SOC 98200769 05F02, LSHM-CT-2006-037593, 279143, 643774, 223004, 786833, 810645, FP7-HEALTH-F4-2007, 201413, 9602768, QLG1-CT-2001-01252, LSHG-CT-2006-01894, 733100, HEALTH-F2-2009-223175, LSHG-CT-2006-01947, HEALTH-F4-2007-201413, QLG2-CT-2002-01254, 602633, 634935, 633784] IMI-SUMMIT program [755320, 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主　　题：Genetic markers Genome-wide association studies Quantitative trait 

摘      要：Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes(1). Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel(2)) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10-20% (14-24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries. A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.