Clinical biomarkers of perioperative neurocognitive disorder:initiation and recommendation

作     者：Jianhui Liu Cheng Li Junyan Yao Lei Zhang Xuan Zhao Xin Lv Zhiqiang Liu Changhong Miao Yingwei Wang Hong Jiang Weifeng Yu Tianlong Wang Dongxin Wang E Wang Xiaoping Gu Hailong Dong Junli Cao Yuan Shen Weihong Song Shengdi Chen Yanjiang Wang Guanghui Liu Zhongcong Xie Lize Xiong Jialin C.Zheng 

作者机构：Department of Anesthesiology Shanghai Ninth People’s Hospital School of Medicine Shanghai Jiao Tong University Department of Anesthesiology Shanghai Renji Hospital Shanghai Jiao Tong University School of Medicine Department of Anesthesiology Xuanwu Hospital Capital Medical University Department of Anesthesiology and Critical Care Medicine Peking University First Hospital Department of Anesthesiology Xiangya Hospital of Central South University Department of Anesthesiology Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Department of Anesthesiology Xijing Hospital Fourth Military Medical University Jiangsu Province Key Laboratory of Anesthesiology Xuzhou Medical University Department of Anesthesiology The Affiliated Hospital of Xuzhou Medical University Shanghai Mental Health Center of Shanghai Jiao Tong University Department of Anesthesiology Tongji Hospital School of Medicine Tongji University Anesthesia and Brain Research Institute Tongji University Oujiang Laboratory Key Laboratory of Alzheimer’s Disease of Zhejiang Province Zhejiang Provincial Clinical Research Center for Mental Disorders Institute of Aging School of Mental Health Affiliated Kangning Hospital The Second Affiliated Hospital Yuying Children’s Hospital Wenzhou Medical University Department of Neurology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Department of Neurology Daping Hospital Third Military Medical University State Key Laboratory of Membrane Biology Institute of Zoology Chinese Academy of Sciences Geriatric Anesthesia Research Unit Department of Anesthesia Critical Care and Pain Medicine Massachusetts General Hospital Harvard Medical School Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation Clinical Research Center for Anesthesiology and Perioperative Medicine Translational Research Institute of Brain and Brain-Like Intelligence Shanghai Fourth People’s Hospital School of Medicine Tongji University Center for Translational Neurodegeneration and Regenerative Therapy Tongji Hospital Affiliated to Tongji University School of Medicine Shanghai China Translational Research Institute of Brain and Brain-Like Intelligence Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine Department of Anesthesiology and Perioperative Medicine Shanghai Fourth People's Hospital School of Medicine Tongji University Department of Anesthesiology Shanghai East Hospital School of Medicine Tongji University Department of Anesthesiology Shandong Provincial Key Medical and Health Laboratory of Anesthesia and Brain Function (The Affiliated Hospital of Qingdao University) The Affiliated Hospital of Qingdao University Department of Anesthesiology Shanghai Tenth People's Hospital School of Medicine Tongji University Department of Anesthesiology Shanghai Pulmonary Hospital School of Medicine Tongji University Department of Anesthesiology Obstetrics and Gynecology Hospital of Fudan University Department of Anesthesiology Zhongshan Hospital Fudan University Department of Anesthesiology Huashan Hospital Fudan University 

出 版 物：《Science China Life Sciences》 (中国科学:生命科学(英文版))

年 卷 期：2025年

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China (82171194, 82371204, 82171183, 82293642) the Shanghai Municipal Science and Technology Commission Biomedical Science and Technology Project (22S31902600) 

摘      要：Perioperative neurocognitive disorder(PND) is a significant neurological complication in aging perioperative patients that impacts postoperative cognition. PND is currently diagnosed through cognitive function testing, which is limited by its subjectivity and time requirements. Thus, the identification of biomarkers to assess PND onset is a priority to identify at-risk individuals and enable interventions and treatments to patient outcomes. This article synthesizes expert perspectives on brain aging and PND, presents the latest clinical evidence on PND biomarkers(imaging, electroencephalography, and molecular biomarkers), and delves into the relationship between PND and other age-related cognitive disorders. Thorough review of PND research identified several biomarkers with high sensitivity and specificity,offering a solid scientific foundation to predict and diagnose PND. These biomarkers not only enhance diagnostic accuracy for clinicians but also provide opportunities for earlier intervention and more effective treatment, potentially enhancing patient outcomes and quality of life.