Green revolution gene drives adaptation of Arabidopsis to the extremely high altitude

作     者：Xing-Hui Hou Yong-Chao Xu Tianshu Sun Yan-Bo Gong Xin-Tong Li Guang-Teng Jin Yu-Tao Bian Yi-Ni Liu Juan Jiang Xiao-Min Niu Hongya Gu Ya-Long Guo 

作者机构：State Key Laboratory of Systematic and Evolutionary BotanyInstitute of BotanyChinese Academy of SciencesBeijing 100093China China National Botanical GardenBeijing 100093China State Key Laboratory for Protein and Plant Gene ResearchSchool of Life SciencesPeking UniversityBeijing 100871China College of Life SciencesUniversity of Chinese Academy of SciencesBeijing 100049China 

出 版 物：《Science China(Life Sciences)》 (中国科学(生命科学英文版))

年 卷 期：2025年第68卷第3期

页      面：859-870页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

基　　金：supported by the National Natural Science Foundation of China(31925004 and 32430008 to Y.-L.G.,and 32100175 to Y.-C.X.) CAS Project for Young Scientists in Basic Research(YSBR-078 to Y.-C.X.) 

主　　题：adaptation adaptive trait Arabidopsis thaliana high altitude molecular mechanism natural variation parallel evolution 

摘      要：To elucidate the process of adaptation,particularly the traits subject to natural selection and the molecular mechanisms underlying their natural variation,is one of the primary objectives of evolutionary *** uplifted landscape offers an excellent framework for understanding how organisms adapt to dramatic climatic *** investigate the genetic basis of plant adaptation to the extremely high altitude,we first compared the genomic and phenotypic variations of two closely related Arabidopsis thaliana accessions from high altitude(Xizang,also known as“Tibet)and low altitude(Yunnan),*** Xizang population represents a relict group characterized by a small effective population ***,the Xizang genome has more transposable elements(TEs)and more gene loss-offunction(LoF)*** expressed genes were enriched in biological processes of cellular response to oxygen-containing compound,regulation of defense response,and response to light ***,the phenotypic selection analysis revealed that silique density was under natural ***,we genetically mapped and validated that the LoF mutation of GA20ox1,the homologous gene of green revolution in rice,resulted in a higher silique density in Xizang *** that GA20ox1 is linked to Arabidopsis adaptation to the Alps Mountains,its parallel evolution plays an important role in the adaptation to Alpine ***,our results highlight that identifying adaptive traits and elucidating the molecular mechanisms underlying natural variation of these traits is crucial for unraveling the mystery of adaptive evolution and has significant implications for crop breeding.