Flow-mediated dilatation test using optoacoustic imaging: a proof-of-concept

作     者：Karlas, Angelos Reber, Josefine Diot, Gael Bozhko, Dmitry Anastasopoulou, Maria Ibrahim, Tareq Schwaiger, Markus Hyafil, Fabien Ntziachristos, Vasilis 

作者机构：HelmholtzZentrum Munchen Inst Biol & Med Imaging D-85764 Neuherberg Germany TUM Munich Sch Bioengn D-81675 Munich Germany Klinikum Rechts Der Isar Dept Cardiol Ismaningerstr 22 D-81675 Munich Germany Klinikum Rechts Der Isar Dept Nucl Med Ismaningerstr 22 D-81675 Munich Germany Univ Diderot Bichat Univ Hosp Dept Nucl Med Inserm 1148 Paris France 

出 版 物：《BIOMEDICAL OPTICS EXPRESS》 (生物医学光学快报)

年 卷 期：2017年第8卷第7期

页      面：3395-3403页

核心收录：

学科分类：0710[理学-生物学] 070207[理学-光学] 07[理学] 08[工学] 0803[工学-光学工程] 1009[医学-特种医学] 0702[理学-物理学] 

基　　金：Deutsche Forschungsgemeinschaft (DFG) of Germany [CRC 1123 (Z1), NT 3/10-1] Research Council (ERC) under European Union European Research Council (ERC) Funding Source: European Research Council (ERC) 

主　　题：Cardiovascular applications Computation methods Detector arrays Image quality Temporal resolution Tomographic image reconstruction 

摘      要：Label-free multispectral optoacoustic tomography (MSOT) has recently shown superior performance in visualizing the morphology of human vasculature, especially of smaller vessels, compared to ultrasonography. Herein, we extend these observations towards MSOT interrogation of macrovascular endothelial function. We employed a real-time handheld MSOT scanner to assess flow-mediated dilatation (FMD), a technique used to characterize endothelial function. A data processing scheme was developed to quantify the dimensions and diameter changes of arteries in humans and determine wall distensibility parameters. By enabling high-resolution delineation of the blood-vessel wall in a crosssectional fashion, the findings suggest MSOT as a capable alternative to ultrasonography for clinical FMD measurements. (C) 2017 Optical Society of America