A linear model for estimating propofol individualized dosage

作     者：Conceição Rocha Teresa Mendonça Mendes de Oliveira M. Eduarda Silva 

作者机构：Faculdade de Ciěncias da Universidade do Porto Rua do Campo Alegre 4169-007 Porto Portugal Faculdade de Economia da Universidade do Porto Rua Dr. Roberto Frias 4200-464 Porto Portugal Center for Research & Development in Mathematics and Applications (CIDMA) Universidade de Aveiro Portugal 

出 版 物：《IFAC Proceedings Volumes》 

年 卷 期：2012年第45卷第18期

页      面：337-342页

主　　题：Model approximation estimation parameters regression analysis error analysis linear prediction medical applications 

摘      要：In the last decades propofol became established as an intravenous agent for the induction and maintenance of both sedation and general anesthesia procedures. In order to achieve the desired clinical effects appropriate infusion rate strategies must be designed. Moreover, it is important to avoid or minimize side effects which may be associated with adverse cardiorespiratory effects and delayed recovery. Nowadays, to attain these purposes the continuous propofol delivery is usually performed through target-controlled infusion (TCI) systems whose algorithms rely on pharmacokinetic and pharmacodynamic models (Schraag, 2001). This work presents statistical models to estimate both the infusion rate and the bolus administration. The modeling strategy relies on multivariate linear models for panel data (Wooldridge, 2002), based on patient characteristics such as age, height, weight and gender along with the desired target concentration. A clinical database collected with a RugLoopII device on 84 patients undergoing ultrasonographic endoscopy under sedation-analgesia with propofol and remifentanil , (Gambús et al., 2011), is used to estimate the models (training set with 74 cases) and assess their performance (test set with 10 cases). The results obtained in the test set comprising a broad range of characteristics are satisfactory since the models are able to predict bolus and infusion rates comparable to those of TCI.