Unraveling the therapeutic potential of the LncRNA-dependent noncanonical Hedgehog pathway in cancer

作     者：Xing, Zhen Lin, Chunru Yang, Liuqing 

作者机构：Univ Texas MD Anderson Canc Ctr Dept Mol & Cellular Oncol Houston TX 77030 USA Univ Texas Houston Cancer Biol Program Houston TX 77004 USA Univ Texas MD Anderson Canc Ctr Ctr RNA Interference & Non Coding RNAs Houston TX 77030 USA 

出 版 物：《MOLECULAR & CELLULAR ONCOLOGY》 (Mol. Cell. Oncol.)

年 卷 期：2015年第2卷第4期

页      面：Article: e998900页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Long non-coding RNA BCAR4 signaling pathway Hedgehog Gli2 breast cancer lung metastasis cancer treatment locked nucleic acid 

摘      要：Acquired resistance to Hedgehog pathway inhibitors has been reported in the clinical setting and upregulation of noncanonical Hedgehog signaling is one of the major underlying mechanisms behind this resistance. As demonstrated in our recent study, greater clinical efficacy might be achieved by focusing on downstream targets of the chemokine activated noncanonical Hedgehog signaling pathway such as BCAR4 and phospho-GLI2 (Ser149).