Alternative mechanisms for prostate-specific antigen elevation:A prospective analysis of 222 transurethral resections of prostate patients

作     者：Koenraad van Renterghem JJMCH de la Rosette Herbert Thijs Erika Wisanto Ruth Achten Jean-Paul Ory Gommert van Koeveringe 

作者机构：Department of UrologyJessa Hospital3500 HasseltBelgium Department of UrologyAcademic Hospital Amsterdam1105 AZ AmsterdamThe Netherlands Interuniversity Institute for Biostatistics and Statistical BioinformaticsHasselt University3500 HasseltBelgium Interuniversity Institute for Biostatistics and Statistical BioinformaticsKULeuven3000 LeuvenBelgium Department of PathologyJessa Hospital3500 HasseltBelgium Department of AnesthesiologyJessa Hospital3500 HasseltBelgium Department of UrologyUniversity Hospital Maastricht6229 HX MaastrichtThe Netherlands 

出 版 物：《World Journal of Clinical Urology》 (世界临床泌尿杂志)

年 卷 期：2014年第3卷第2期

页      面：144-151页

学科分类：10[医学] 

基　　金：the ‘Kwaliteitsfonds Jessa ZH’ for the financial support 

主　　题：Transurethral resection of the prostate Prostate-specific antigen Bladder outlet obstruction Lower urinary tract symptoms Prostate inflammation 

摘      要：AIM: To investigate the relationship between prostatespecific antigen(PSA) levels and(1) bladder outlet obstruction(BOO) and(2) the severity of prostate ***: Two hundred and twenty-two consecutive patients undergoing transurethral resection of the prostate(TURP) were prospectively included. Patients with proven urinary tract infection and/or known prostate cancer were excluded. PSA levels, International Prostate Symptoms Score(IPSS), prostate weight, post residual volume and pressure flow parameters were determined. A histopathological assessment of the presence and severity of inflammation was also ***: Patients had a mean age of 69.1 ± 8.6 years(45-90 years), with mean preoperative PSA levels of 4.7 ± 5.4 ng/m L(0.2-32.5 ng/m L) and IPSS of 15.7 ± 6.9(0-32). Mean Pdet Q max was 96.3 ± 34.4 cm H2O(10-220 cm H2O). The mean resected prostate weight was 39.4 ± 27.3 g(3-189 g). Correlations were observed between PSA(logarithmic) and resected prostate weight(r = 0.54; P 0.001), PSA(logarithmic) and Pdet Q max(r = 0.17; P = 0.032), and resected prostate weight and Pdet Q max(r = 0.39; P 0.001). Furthermore, low correlations were observed between PSA(logarithmic) and active(r = 0.21; P 0.0001) and chronic(r = 0.19; P = 0.005) inflammation. CONCLUSION: In this study we showed a correlation between BOO(Pdet Q max) and PSA(logarithmic). Furthermore, we demonstrated a weak correlation between PSA(logarithmic) and active as well as chronic prostatic inflammation.