Regulatory effects of lncRNAs and miRNAs on autophagy in malignant tumorigenesis

作     者：Yin, Qingqing Feng, Wei Shen, Xianjuan Ju, Shaoqing 

作者机构：Nantong Univ Affiliated Hosp Ctr Lab Med Nantong Peoples R China Nantong Univ Affiliated Hosp Surg Comprehens Lab Nantong Peoples R China 

出 版 物：《BIOSCIENCE REPORTS》 (生物科学报告)

年 卷 期：2018年第38卷第5期

页      面：BSR20180516-BSR20180516页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 07[理学] 

基　　金：National Nature Science Foundation of China Key Project of Jiangsu Province [ZDXKB2016011] 

主　　题：autophagy large intervening non-coding RNA microRNA oncogenesis gene therapy 

摘      要：Autophagy is an important process in endogenous substrate degradation by lysosomes within cells, with a degree of evolutionary conservation. Like apoptosis and cell senescence, cell autophagy is a very important biological phenomenon involving the development and growth of biological processes. Abnormal autophagy may lead to tumorigenesis. In recent years, increasing studies have demonstrated that long non-coding RNAs (lncRNAs) and miRNAs can regulate cell autophagy by modulating targetting gene expression. In this review, we will provide an overview of lncRNAs and miRNAs in autophagy modulation and new insights into the underlying mechanisms, as well as their potential utilization in disease diagnosis, prognosis, and therapy.