Genetic and epigenetic contribution to astrocytic gliomas pathogenesis

作     者：Khani, Pouria Nasri, Farzad Chamani, Fateme Khani Saeidi, Farzane Nahand, Javid Sadri Tabibkhooei, Alireza Mirzaei, Hamed 

作者机构：IUMS Fac Med Dept Med Genet & Mol Biol Tehran Iran Iran Univ Med Sci Student Res Comm Tehran Iran IUMS Fac Med Dept Med Immunol Tehran Iran Shahid Beheshti Univ Med Sci Sch Med Dept Immunol Tehran Iran Tarbiat Modares Univ Sch Med Sci Dept Med Genet Tehran Iran Iran Univ Med Sci Fac Med Dept Virol Tehran Iran Iran Univ Med Sci Dept Neurosurg Tehran Iran Kashan Univ Med Sci Res Ctr Biochem & Nutr Metab Dis Kashan Iran 

出 版 物：《JOURNAL OF NEUROCHEMISTRY》 (神经化学杂志)

年 卷 期：2019年第148卷第2期

页      面：188-203页

核心收录：

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 071003[理学-生理学] 

基　　金：Research Council of Mashhad University of Medical Sciences School of Medicine of Mashhad University of Medical Sciences Research Council of Iran University of Medical Sciences School of Medicine of Iran University of Medical Sciences 

主　　题：astrocytic glioma molecular mechanism therapy 

摘      要：Astrocytic gliomas are the most common and lethal form of intracranial tumors. These tumors are characterized by a significant heterogeneity in terms of cytopathological, transcriptional, and (epi)genomic features. This heterogeneity has made these cancers one of the most challenging types of cancers to study and treat. To uncover these complexities and to have better understanding of the disease initiation and progression, identification, and characterization of underlying cellular and molecular pathways related to (epi)genetics of astrocytic gliomas is crucial. Here, we discuss and summarize molecular and (epi)genetic mechanisms that provide clues as to the pathogenesis of astrocytic gliomas.