Roots extracts of Adenophora triphylla *** improve obesity in 3T3-L1 adipocytes and high-fat diet-induced obese mice

作     者：Dong-Ryung Lee Young-Sil Lee Bong-Keun Choi Hae Jin Lee Sung-Bum Park Tack-Man Kim Han Jin Oh Seung Hwan Yang Joo-Won Suh 

作者机构：NutraPham Tech Center for Nutraceutical and Pharmaceutical MaterialsMyongji University Interdisciplinary Program of BiomodulationMyongji University DONG IL Pharmtec Department of Family Medicine.VIEVIS NAMUH Hospital 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2015年第8卷第11期

页      面：879-886页

核心收录：

学科分类：100506[医学-中医内科学] 1006[医学-中西医结合] 1005[医学-中医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：carried out with the support of Cooperative Reycarch Program for Agriculture Science&Technology Development(Project No.P1134801)Rural Development Administration.Republic of Kores 

主　　题：Roots of Adenophora triphylla var. japonica extrac 

摘      要：Objective:To investigate the anti-obesity activity and the action mechanism of the roots of Adenophora triphylla *** extract(ATE) in high-fat diet(HFD)-induced obese mice and 3T3-LI ***:The roots of Ademption triphylla were extracted with 70%*** demonstrate the compounds,linoleic acid was analyzed by using gas chromatography:and the anti-obesity effects and possible mechanisms of ATE were examined in 3T3-L1 adipocytes and HFD-induced obese ***:Treatment with ATE inhibited the lipid accumulation without cytotoxicity in 3T3-L1 ***,200 and 400 mg/kg ATE treatment significantly decreased the body weight gain,white adipose tissues(WATs) weight and plasma triglyceride level,while 100 and 200 mg/kg ATE treatment increased the plasma high-density lipoprotein cholesterol level in the HFD-induced obese mice,as compared with the HFD *** with 200 and 400 mg/kg ATE also lowered the size of adipocytes in adipose tissue and reduced the lipid accumulation in *** treatment showed significantly lower expression level of adipogenesis-relatcd proteins,such as peroxisome proliferator-activated receptor y,fatty acid binding protein(aP2),fatty acid synthase in 3T3-L1 adipocytes;and furthermore,decreased peroxisome proliferatoractivated receptor γ,aP2,fatty acid synthase,sterol regulatory element binding protein-1c,and lipoprotein lipase mRNA expression levels in WAT of the HFD-induced obese ***:These results suggested that the ATE has an anti-obesity effect,which may be elicited by regulating the expression of adipogenesis and lipogenesis-related genes and proteins in adipocytes and WAT of the HFD-induced obese mice.