检索结果-内蒙古大学图书馆

Green coffee bean extract improves obesity by decreasing body fat in high-fat diet-induced obese mice

Asian Pacific Journal of Tropical Medicine 2016年第7期9卷 616-624页

作者： Bong-Keun Choi Sung-Bum Park Dong-Ryung Lee Hae Jin Lee Ying-Yu Jin Seung Hwan Yang Joo-Won Suh Nutra Pharm Tech Giheung-gu Interdisciplinary Program of Biomodulation Myongji University Center for Nutraceutical and Pharmaceutical Materials Myongji University

Objective:To evaluate possible lipid catabolism and body fat regulation effects of 3-caffeoylquinic acid in Green coffee bean extract(GCBE) in high-fat diet(HFD)-induced obese ***:Obesity was induced in mice using a HFD for four ***,mice were fed only HFD or HFD with GCBE at 50,100,and 200 mg/*** acid synthesis mechanism regulation of body fat was investigated through real-time PCR and Western blot *** fat reduction was measured through dual-energy X-ray ***:In HFD-induced obese mice,GCBE treatment significantly decreased body weight gain,liver weight and white adipose tissue weights with regulation of adipose tissue lipolysis hormones,like adiponectin and *** treatment decreased mR NA expression levels of adipogenesis and adipocyte metabolism related genes in adipose tissues and the liver,and decreased the corresponding protein *** energy X-ray absorptiometry measurements were used to compare body fat between mice on high-fat and those treated with *** treated mice had a lower fat mass compared to HFD alone fed mice and relative body weight and fat mass were markedly ***:GCBE has a potential anti-obesity effect with lowering body fat accumulation by regulating adipogenesis and lipid metabolism-related genes and proteins in WAT and liver.

关键词： Green coffee bean extract High-fat diet induced obese mice Adipogenesis Body fat Dual energy X-ray absorptiometry

来源：评论

学校读者我要写书评

暂无评论

Monascus pilosus-fermented black soybean inhibits lipid accumulation in adipocytes and in high-fat diet-induced obese mice

引用

Asian Pacific Journal of Tropical Medicine 2015年第4期8卷 276-282页

作者： Young-Sil Lee Bong-Keun Choi Hae Jin Lee Dong-Ryung Lee Jinhua Cheng Won-Keun Lee Seung Hwan Yang Joo-Won Suh Center for Nutraceutical and Pharmaceutical Materials Myongji University Interdisciplinary Program of Biomodulation Myongji University Division of Bioscience and Bioinformatics College of Natural ScienceMyongji University

Objective:To explore the anti-obesity effects and the mechanism of action of Monascus pilosus(***)-fermented black soybean(MFBS)extracts(MFBSE)and MFBS powders(MFBSP)in adipocytes and high-fat diet(HFD)-induced obese mice,***:Black soybean was fermented with ***,and the main constituents in MFBS were analyzed by HPLC *** vitro,MFBSE were examined for anti-adipogenic effects using Oil-Red O *** vivo,mice were fed a normal-fat diet(NFD)control,HFD control or HFD containing 1 g/kg MFBSP for 12 weeks,and then body weight gain and tissues weight ***-time PCR and western blot assay were used to determine the mechanism of anti-adipogenic ***:MFBSE inhibited lipid accumulation in 3T3-L1 adipocytes without exerting cell *** treatment in HFD-fed mice significantly decreased the body weight gain compared with the HFD control *** and MFBSP treatment resulted in significantly lower mRNA levels of adipogenesis-related genes,such as peroxisome proliferator-activated receptorγ(PPARγ),fatty acid-binding protein 4(FABP4),and fatty acid synthase(FAS),in adipocytes and in white adipose tissue(WAT)of HFD-induced obese ***:These results suggest that the anti-obesity effects of MFBS are elicited by regulating the expression of adipogenesis-related genes in adipocytes and WAT of HFDinduced obese mice.

关键词： Monascus pilosus Black soybean Adipocytes High-fat diet-induced obese mice Anti-obesity Adipogenesis-related genes

来源：评论

学校读者我要写书评

暂无评论

Roots extracts of Adenophora triphylla *** improve obesity in 3T3-L1 adipocytes and high-fat diet-induced obese mice

引用

Asian Pacific Journal of Tropical Medicine 2015年第11期8卷 879-886页

作者： Dong-Ryung Lee Young-Sil Lee Bong-Keun Choi Hae Jin Lee Sung-Bum Park Tack-Man Kim Han Jin Oh Seung Hwan Yang Joo-Won Suh NutraPham Tech Center for Nutraceutical and Pharmaceutical Materials Myongji University Interdisciplinary Program of Biomodulation Myongji University DONG IL Pharmtec Department of Family Medicine.VIEVIS NAMUH Hospital

Objective:To investigate the anti-obesity activity and the action mechanism of the roots of Adenophora triphylla *** extract(ATE) in high-fat diet(HFD)-induced obese mice and 3T3-LI ***:The roots of Ademption triphylla were extracted with 70%*** demonstrate the compounds,linoleic acid was analyzed by using gas chromatography:and the anti-obesity effects and possible mechanisms of ATE were examined in 3T3-L1 adipocytes and HFD-induced obese ***:Treatment with ATE inhibited the lipid accumulation without cytotoxicity in 3T3-L1 ***,200 and 400 mg/kg ATE treatment significantly decreased the body weight gain,white adipose tissues(WATs) weight and plasma triglyceride level,while 100 and 200 mg/kg ATE treatment increased the plasma high-density lipoprotein cholesterol level in the HFD-induced obese mice,as compared with the HFD *** with 200 and 400 mg/kg ATE also lowered the size of adipocytes in adipose tissue and reduced the lipid accumulation in *** treatment showed significantly lower expression level of adipogenesis-relatcd proteins,such as peroxisome proliferator-activated receptor y,fatty acid binding protein(aP2),fatty acid synthase in 3T3-L1 adipocytes;and furthermore,decreased peroxisome proliferatoractivated receptor γ,aP2,fatty acid synthase,sterol regulatory element binding protein-1c,and lipoprotein lipase mRNA expression levels in WAT of the HFD-induced obese ***:These results suggested that the ATE has an anti-obesity effect,which may be elicited by regulating the expression of adipogenesis and lipogenesis-related genes and proteins in adipocytes and WAT of the HFD-induced obese mice.

关键词： Roots of Adenophora triphylla var. japonica extrac

来源：评论

学校读者我要写书评

暂无评论

Protective effects of a polymethoxy flavonoids-rich Citrus aurantium peel extract on liver fibrosis induced by bile duct ligation in mice

引用

Asian Pacific Journal of Tropical Medicine 2016年第12期9卷 1135-1141页

作者： Seol-Wa Lim Dong-Ryung Lee Bong-Keun Choi Hong-Suk Kim Seung Hwan Yang Joo-Won Suh Kyung Soo Kim Graduate School of Biomedicine & Health Sciences Catholic University Nutra Pharm Tech Interdisciplinary Program of Biomodulation Myongji University Department of Biotechnology Chonnam National University Center for Nutraceutical and Pharmaceutical Materials Myongji University

Objective: To evaluate the possible protective effect of Citrus aurantium peel extract(CAE) against apoptosis in cholestatic liver fibrosis induced by bile duct ligation in mice. Methods: Male ICR mice were divided to 5 groups: 1) Control group(Sham-operated mice), 2) Cholestatic liver injury group induced by bile duct ligation(BDL), 3) BDL mice treated with silymarin(200 mg/kg) for 4 weeks, 4) BDL mice treated with 50 mg/kg CAE for 4 weeks, 5) BDL mice treated with 200 mg/kg CAE for 4 weeks. Mice were sacrificed and liver fibrosis was evaluated by serum and hepatic tissue biochemistry tests and liver histopathological examination. Effects of CAE on inflammation and apoptosis gene regulation were investigated through real-time PCR. CAE effect on lipid metabolism related signaling was determined by western blot analysis. Results: In BDL mice, administration of CAE for 4 weeks markedly attenuated liver fibrosis based on histopathological alteration. Serum and hepatic tissue biochemistry results revealed that CAE(50 and 200 mg/kg) decreased the levels of alanine transaminase, aspartate transaminase, gamma glutamyl transferase, total bilirubin, nitric oxide, and thiobarbituric acid reactive substances. Real-time PCR and western blot analysis showed that CAE regulated inflammation, apoptosis, and lipid metabolism factors increased by BDL. Interleukin family, tumor necrosis factor α, and related apoptosis factors m RNA levels were increased by BDL treatment. However, these increases were suppressed by CAE administration. In addition, CAE effectively increased phosphorylation of AMPactivated protein kinase, nuclear factor E2-related factor 2, and related cytoprotective proteins. Conclusions: CAE can efficiently regulate BDL-induced liver injury with antioxidant, antiinflammatory, and antiapoptotic activities.

关键词： Liver injury Bile duct ligation Cholestasis Citrus aurantium peel extract Hepatic fibrosis

来源：评论

学校读者我要写书评

暂无评论

Single-cell based morphological analysis of bacteria using microwell-patterned hydrogel structure 21

Single-cell based morphological analysis of bacteria using m...

引用

21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

作者： Yoon, J. Kim, Y.K. Jung, Y.G. Park, W. Department of Electronic Engineering Kyung Hee University Korea Republic of Interdisciplinary Program of Biomodulation College of Natural Science Korea Republic of Center for Nutraceutical and Pharmaceutical Materials Myongji University Korea Republic of Myongji Bioefficiency Research Centre Korea Republic of

ISBN: (纸本)9780692941836

We present a convenient technique to shorten the required time for testing minimum antibiotic concentration at which bacteria stops growth and to monitor the bacteria that matures in any form through single-cell morphological analysis that can determine antimicrobial susceptibility by analyzing morphological changes in single bacterial cell automatically trapped in a narrow space. We trapped single bacterial cell in specific space and observed the growth of several types of bacteria with environment of antibiotics. Additionally, we could confirm that the minimum inhibitory concentrations obtained through the attempts matched in the Clinical Laboratory Standard Institute quality control range. © 17CBMS-0001.

关键词： Morphology

来源：评论

学校读者我要写书评

暂无评论

Immune enhancement effect of an herb complex extract through the activation of natural killer cells and the regulation of cytokine levels in a cyclophosphamide-induced immunosuppression rat model

引用

Asian Pacific Journal of Tropical Medicine 2018年第12期11卷 653-658页

作者： Sung Min Woo Woo Rin Choi Dooly Jang Chun Sik Yi Hae Lim Kim Kyung Hyeon Kim Jong Tae Kim Won Hee Choi Seung Hee Jang Min Jeung Kim Ji Hyang Wee Yeon Ki Kim Bao Le Interdisciplinary Program of Biomodulation Myongji UniversityYonginGyeonggi 17058Republic of Korea Center for Nutraceutical and Pharmaceutical Materials Myongji UniversityYonginGyeonggi 17058Republic of Korea Teazen Co. B-606 Acrotower230 Sinim-daeroDongan-guAnyang-siGyeonggi-do 14067Republic of Korea Department of Food Science&Biotechnology Shin Ansan UniversityAnsanGyeonggi 15435Republic of Korea' Division of Bioscience and Bioinformatics Myongji UniversityYonginGyeonggi 17058Republic of Korea Department of Biotechnology Chonnam National UniversityYeosuChonnam 59626Republic of Korea

Objective: To investigate the effects of a herb complex extract(HCE) prepared from Cornus officinalis Sieb. Et Zucc., Eriobotrya japonica Lindley, and olive leaves on immune response of mouse spleen NK cells in vitro and in vivo analysis. Methods: The activity of natural killer(NK) cells was measured in splenocytes and YAC-1 cells. Mice were immunosuppressed using cyclophosphamide(5 mg/kg body weight). Three different doses of HCE(200, 400, and 800 mg/kg body weight) and red ginseng extract(800 mg/kg body weight) which was used as standard immunomodulatory herb were administered orally for 4 weeks. The body weight, dietary, water intake, organs(liver, thymus, and spleen) weight, completed blood count, and cytokines(tumor necrosis factor alpha, interferon gamma, and interleukin-2) production was measured. Results: At the maximum concentration of HCE, the activity of NK cells was increased by 48.5%. HCE increased liver, spleen, and thymus weights without altering numbers of white blood cells, lymphocytes, and neutrophils in a cyclophosphamide-induced immunosuppression rat model. However, HCE recovered the inhibited cytokine expression; HCE(800 mg/kg) increased cytokines levels. The results indicate the immune enhancement potential of this HCE. Conclusion: The HCE enhances immunity by increasing NK cell activity, regulating cytokine levels, and maintaining spleen weight. Therefore, it may be used as a potential immunity enhancer.

关键词： Immune system enhancement Cyclophosphamide Cornus officinalis Sieb Et Zucc Eriobotrya japonica Lindley Olive leaves

来源：评论

学校读者我要写书评

暂无评论

Effect of fermentation with Monascus pilosus on the antioxidant activities and phenolic acid contents of adzuki bean(Vigna angularis)

引用

Journal of Coastal Life Medicine 2015年第4期 276-283页

作者： Jinhua Cheng Sung-Kwon Lee Sasikumar Arunachalam Palaniyandi Joo-Won Suh Seung Hwan Yang Center for Nutraceutical and Pharmaceutical Materials Myongji UniversityCheoin-guYonginGyeonggi-Do 449-728Korea Interdisciplinary Program of Biomodulation Myongji UniversityCheoin-guYonginGyeonggi-Do 449-728Korea Division of Bioscience and Bioinformatics College of Natural ScienceMyongji UniversityCheoin-guYonginGyeonggi-Do 449-728Korea

Objective:To enhance physiological activities of adzuki bean(Vigna angularis)via fermentation with Monascus pilosus(***).Methods:The adzuki bean fermentation conditions with *** were optimized,and the effect of Monascus-fermentation on the antioxidant capacity and phenolic acid contents of adzuki bean was ***:Optimal fermentation conditions were determined by the production of monacolin *** highest monacolin K production was observed in 5%inoculum sized on day 15 in *** and bound phenolic acids were isolated from native and fermented adzuki bean.A 1.9-fold decrease was observed in bound p-coumaric acid content,whereas the contents of bound ferulic and sinapic acids were increased by 28-and 1.7-fold,***,the contents of free phenolic acids such as p-coumaric,ferulic,and sinapic acids were increased by 2.6-,5.2-,and 7.2-fold,*** fermentation of adzuki bean by *** enhanced the activities of DPPH■radical scavenging,ferrous ion-chelating,nitric oxide scavenging,and ferric antioxidant reducing activities 2.2-,1.7-,1.2-,and 1.8-fold,***:Results from our study suggest that the contents of p-coumaric,ferulic,and sinapic acids in adzuki bean were highly increased by fermentation with ***,resulting in enhanced various antioxidant activities.

关键词： Adzuki bean Monascus pilosus Fermentation Monacolin K Phenolic acids Antioxidant activity

来源：评论

学校读者我要写书评

暂无评论

Precision cancer medicine in ovarian cancer

引用

Cancer Letters 2024年 581卷 216546-216546页

作者： Kim, Se Ik Jo, HyunA. Kim, Heeyeon Lee, Juwon Cho, Untack Kim, Soochi Kim, Boyun Seol, Aeran Lee, Maria Lee, Cheol Ahn, Taejin Song, Yong Sang Department of Obstetrics and Gynecology Seoul National University College of Medicine Seoul 03080 Republic of Korea Cancer Research Institute Seoul National University College of Medicine Seoul 03080 Republic of Korea WCU Biomodulation Department of Agricultural Biotechnology Seoul National University Seoul 08826 Republic of Korea Department of Neurology and Neurological Sciences Stanford University School of Medicine Stanford CA 94305 USA Paul F. Glenn Laboratories for the Biology of Aging Stanford University School of Medicine Stanford CA 94305 USA Department of SmartBio Kyungsung University College of Life and Health Science Busan 48434 Republic of Korea Department of Obstetrics and Gynecology Korea University Anam Hospital College of Medicine Korea University Seoul 02841 Republic of Korea Department of Pathology Seoul National University College of Medicine Seoul 03080 Republic of Korea Department of Life Science Handong Global University Pohang-si Gyeongbuk 37554 Republic of Korea Interdisciplinary Program in Cancer Biology Seoul National University College of Medicine Seoul 03080 Republic of Korea

来源：评论

学校读者我要写书评

暂无评论

Author Correction: Evaluating Tumor Evolution via Genomic Profiling of Individual Tumor Spheroids in a Malignant Ascites

引用

Scientific reports 2018年第1期8卷 17395页

作者： Sungsik Kim Soochi Kim Jinhyun Kim Boyun Kim Se Ik Kim Min A Kim Sunghoon Kwon Yong Sang Song Department of Electrical and Computer Engineering Seoul National University Seoul 08826 Republic of Korea. Interdisciplinary Program for Bioengineering Seoul National University Seoul 08826 Republic of Korea. Seoul National University Hospital Biomedical Research Institute Seoul National University Hospital Seoul 03080 Republic of Korea. Cancer Research Institute Seoul National University College of Medicine Seoul 03080 Republic of Korea. Department of Anesthesiology McGovern Medical School The University of Texas Health Science Center at Houston Houston TX USA. Department of Obstetrics and Gynecology Seoul National University College of Medicine Seoul 03080 Republic of Korea. Department of Pathology Seoul National University College of Medicine Seoul 03080 Republic of Korea. Department of Electrical and Computer Engineering Seoul National University Seoul 08826 Republic of Korea. skwon@snu.ac.kr. Institutes of Entrepreneurial BioConvergence Seoul National University Seoul 08826 Republic of Korea. skwon@snu.ac.kr. Seoul National University Hospital Biomedical Research Institute Seoul National University Hospital Seoul 03080 Republic of Korea. skwon@snu.ac.kr. Cancer Research Institute Seoul National University College of Medicine Seoul 03080 Republic of Korea. yssong@snu.ac.kr. Department of Obstetrics and Gynecology Seoul National University College of Medicine Seoul 03080 Republic of Korea. yssong@snu.ac.kr. Interdisciplinary Program in Cancer Biology Seoul National University College of Medicine Seoul 03080 Republic of Korea. yssong@snu.ac.kr. Biomodulation Department of Agricultural Biotechnology Seoul National University Seoul 03080 Republic of Korea. yssong@snu.ac.kr.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.

关键词：

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：