Amino acid intake plays a crucial role in the Warburg effect of *** microbes can regulate intestinal amino acid ***,it is still unknown whether probiotic therapy can protect the host from intestinal tumor invasion by ...
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Amino acid intake plays a crucial role in the Warburg effect of *** microbes can regulate intestinal amino acid ***,it is still unknown whether probiotic therapy can protect the host from intestinal tumor invasion by reducing amino acid *** in vitro methods,three acid-tolerant strains from fermented pickles were screened *** azoxymethane/dextran sulfate sodium-induced colon cancer models,we evaluated the therapeutic effects of Lactobacillus brevis CLB3,Lactobacillus plantarum XLP,and Lactobacillus johnsonii CM on model *** functional mechanisms were further explained through anatomy section,quantitative reverse transcription polymerase chain reaction(qRT-PCR),Western blot,and immunohistochemical staining analyses as well as database mining and gut *** Lactobacillus brevis(***)CLB3 treatment significantly improved the clinical signs and symptoms of colon cancer,alleviated colon damage,and inhibited colon carcinogenesis in *** addition,this treatment significantly increased gut cultivable Lactobacillus abundance,inhibited the expression and translation levels of the tumor metabolism-related solute carrier(SLC)amino acid transporter including SLC7A5 and SLC7A11,lowered circulating interleukin-6(IL-6)and interleukin-17A(IL-17A)levels,and improved the accumulation of tumor-infiltrating lymphocytes and cancer proliferation *** findings suggest that *** CLB3 can reduce amino acid transport,inhibit mammalian target of rapamycin(mTOR)signaling and enhance intestinal anti-tumor immune responses,which provides a potential targeting amino acid transporter strategy for preventing colorectal cancer.
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