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Computerized analysis of acceleration parameter for the non-stress test normal and potentially abnormal fetuses

Computer Assisted Surgery 2016年第sup1期21卷 1-5页

作者： li, Guangfei Zhang, Song Yang, lin li, Shufang Wang, Yan Hao, Dongmei Yang, Yimin li, xuwen Zhang, Lei Xu, Mingzhou Beijing Univ Technol Coll Life Sci & Bioengn Beijing Peoples R China Peking Univ Hosp 3 Obstet & Gynecol Beijing Peoples R China Beijing Yes Med Devices Co Ltd Beijing Peoples R China Beijing Aerosp Changfeng Co Ltd Beijing Peoples R China

Non-stress testing (NST) is the primary method of determining fetal condition during the perinatal period, and as such, has high specificity. However, short-term monitoring and visual inspection of the cardiotocogram demonstrates several limitations in understanding fetal status which can be mistaken as predictors of neonatal asphyxia. Fetal electrocardiography (FECG) is a novel, long-term monitoring method which can reflect more objective and accurate fetal information. This article presents experimental results of four fetal heart rate (FHR) acceleration features of 44 fetuses extracted from FECG. The novelty of this approach lies in its combined use of parameters which can express both duration and amplitude of heart rate acceleration. Results demonstrate that most parameters significantly differ between normal fetuses and fetuses with suspected abnormalities. Results are promising for the identification of a set or parameters which may be used as classifiers to improve the success rate when distinguishing between normal and abnormal fetuses.

关键词： Fetal heart rate acceleration FECG gestational age

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Click-Nucleic-Acid-Containing Codelivery System Inducing Collapse of Cellular Homeostasis for Tumor Therapy through Bidirectional Regulation of Autophagy and Glycolysis

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ACS APPliED MATERIALS & INTERFACES 2020年第52期12卷 57757-57767页

作者： Guo, Qin Chen, Qinjun Zhang, Yujie Zhou, Wenxi li, xuwen li, Chao Zhang, Yiwen Chen, Hongyi liu, Peixin Chu, Yongchao Sun, Tao Jiang, Chen Fudan Univ State Key Lab Med Neurobiol Key Lab Smart Drug Delivery Minist Educ Shanghai 201203 Peoples R China Fudan Univ MOE Frontiers Ctr Brain Sci Sch Pharm Dept Pharmaceut Shanghai 201203 Peoples R China

As a rapid proliferating tissue, tumor cells have to optimize nutrient utilization to withstand harsh conditions. Several approaches have been explored to inhibit the growth and metastasis of tumor by disrupting the reprogrammed tumor metabolism. However, nutrient limitations within solid tumors may induce the metabolic flexibility of malignant cells to sustain growth and survival using one nutrient to fill metabolite pools normally supplied by the other. To overcome this predicament, a promising click-nucleic-acid-containing platform for codelivery of rapamycin, anti-PFKFB4 siRNA, and targeting ligand aptamer AS1411 was applied. PFKFB4 could act as a promising target for tumor therapy for being a molecular fulcrum that could couple glycolysis to autophagy by promoting aggressive metastatic tumors. The downregulation of PFKFB4 can help inhibit the SRC3/Akt/mTOR pathway, leading autophagy to the direction of promoting apoptosis of tumor cells, which is induced by the collapse of tumor cellular homeostasis, while low dosages of rapamycin could decrease surgery-induced immune dysfunction. Enhanced tumor autophagy, favorable in vivo antitumor efficacy, and effective systematic immune activation are observed after treatment, suggesting that autophagy and glycolysis can serve as an integrated target for tumor treatment.

关键词： tumor metabolism codelivery click nucleic acid immune activation tumor therapy

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Nanomaterials with dual immunomodulatory functions for synergistic therapy of breast cancer brain metastases

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Bioactive Materials 2023年第9期27卷 474-487页

作者： Zhenhao Zhao Chufeng li Yiwen Zhang Chao li Yongchao Chu xuwen li Peixin liu Hongyi Chen Yu Wang Boyu Su Qinjun Chen Tao Sun Chen Jiang Department of Pharmaceutics School of PharmacyFudan UniversityKey Laboratory of Smart Drug DeliveryMinistry of EducationState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceShanghai201203China

A long-standing paucity of effective therapies results in the poor outcomes of triple-negative breast cancer brain *** has made progress in the treatment of tumors,but limited by the non-immunogenicity of tumors and strong immunosuppressive environment,patients with TNBC brain metastases have not yet benefited from *** immunoregulatory strategies with enhanced immune activation and reversal of the immunosuppressive microenvironment provide new therapeutic options for ***,we propose a cocktail-like therapeutic strategy of microenvironment regulation-chemotherapy-immune synergistic sensitization and construct reduction-sensitive immune microenvironment regulation nanomaterials(SIL@T).SIL@T modified with targeting peptide penetrates the BBB and is subsequently internalized into metastatic breast cancer cells,releasing silybin and oxaliplatin responsively in the ***@T preferentially accumulates at the metastatic site and can significantly prolong the survival period of model *** studies have shown that SIL@T can effectively induce immunogenic cell death of metastatic cells,activate immune responses and increase infiltration of CD8+T ***,the activation of STAT3 in the metastatic foci is attenuated and the immunosuppressive microenvironment is *** study demonstrates that SIL@T with dual immunomodulatory functions provides a promising immune synergistic therapy strategy for breast cancer brain metastases.

关键词： Breast cancer brain metastases Drug delivery Immunogenic cell death Microenvironmental regulation STAT3

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Facile synthesis of 3D N-doped porous carbon nanosheets as highly active electrocatalysts toward the reduction of hydrogen peroxide

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NANOSCALE 2018年第31期10卷 14923-14930页

作者： Lu, Nannan Zhang, Tingting Yan, Xiaoyi Gu, Yue liu, He Xu, Zhiqian Xu, Haixin li, xuwen Zhang, Zhiquan Yang, Ming Jilin Univ Coll Chem Changchun 130012 Jilin Peoples R China Jilin Univ Hosp 1 Dept Breast Surg Changchun 130012 Jilin Peoples R China

Constructing three-dimensional (3D) conductive frameworks with high specific surface areas and porous structures is indispensable for their applications as electrocatalysts. In this work, we illustrate for the first time that 3D N-doped porous carbon nanosheets (3D-NS), which are synthesized via a facile one-pot pyrolysis reaction using glucose and melamine as raw materials, can serve as high performance and green electrocatalysts for the reduction of H2O2. Moreover, a series of 3D-NS samples with a controllable content of nitrogen were obtained by adjusting the calcination temperature. From our research, the 3D-NS obtained at 900 degrees C possessed high specific surface areas, porous structures, proper dosages of N atoms, suitable degrees of graphitization and defects. Furthermore, we also illustrate their application in H2O2 electrochemical sensing in physiological environments. Under optimum conditions, the 3D-NS-based sensor displays a wide linear scope in the range of 0.5-14 000 mu M and a low detection limit of 0.18 mu M (S/N = 3). Therefore, with desirable selectivity, stability and anti-interference performance, the proposed sensor can be feasibly applied to detect H2O2 in human serum samples.

关键词： Electrocatalysts

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Analysis of ginsenosides in Panax ginseng in high pressure microwave-assisted extraction

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FOOD CHEMISTRY 2008年第1期110卷 161-167页

作者： Wang, Yutang You, Jingyan Yu, Yong Qu, Chenfing Zhang, Huarong Ding, Lan Zhang, Hanqi li, xuwen Jilin Univ Coll Chem Changchun 130012 Peoples R China

High pressure microwave assisted extraction (HPMAE) was applied to extract the ginsenosides from Panax ginseng root. The influences of extraction solvent, extraction pressure and extraction time were individually investigated. HPMAE has been compared with other extraction methods, including Soxhlet extraction, ultrasound-assisted extraction and heat reflux extraction. The determination of ginsenosides was performed by HPLC-ESI-MS. The results indicated that the HPMAE not only took a shorter time but also afforded higher extraction yields of ginsenosides, especially ginsenoside Rb-1, Rc, Rb-2 and Rd. Furthermore, the neutral ginsenosides and malonyl ginsenosides in Panax ginseng root extracts by HPMAE were investigated. The malonyl ginsenoside m-Rb-1, m-Rc, m-Rb-2 and m-Rd degraded in HPMAE at 400 kPa (109-112 degrees C) in 70% (v/v) ethanol-water and at 600 kPa (112-115 degrees C) in methanol, and transformed into corresponding neutral ginsenoside Rb-1, Rc, Rb-2 and Rd. Using water as extraction solution, tile neutral ginsenosides degraded under HPMAE at 400 kPa (135-140 degrees C), and transformed into less polarity rare ginsenosides. (c) 2008 Elsevier Ltd. All rights reserved.

关键词： microwave assisted extraction Panax ginseng ginsenoside HPLC/MS degradation

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Steroidal saponins from the roots of Polygonatum odoratum and their inhibitory effects against pancreatic lipase

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PHYTOCHEMISTRY LETTERS 2023年 53卷 202-210页

作者： Zhao, Dexin Yan, Jianghong Shi, Xiaolei Sun, Zhiheng Xie, Huili Wang, Bingzi Jin, Yongri li, xuwen Jilin Univ Coll Chem Changchun 130012 Peoples R China Jilin Prov Acad Tradit Chinese Med Clin Hosp 1 Changchun 130021 Peoples R China Jilin Univ Coll Food Sci & Engn Changchun 130062 Peoples R China

Twenty steroidal saponins were isolated from the water extract of fresh fibrous roots of Polygonatum odoratum (Mill.) Druce, of which seven were new compounds (1-7) along with thirteen known compounds (8-20). Their chemical structures were elucidated by extensive spectroscopic and chemical techniques. All isolated compounds were evaluated for porcine pancreatic lipase inhibitory activity. Compounds 9 and 10 showed inhibitory effects with IC50 values of 201.90 +/- 0.036 mu M and 151.20 +/- 0.058 mu M (positive control orlistat;2.82 +/- 0.060 mu M).

关键词： Polygonatum odoratum (Mill ) Druce Steroidal saponins Pancreatic lipase inhibitors

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A study of a fetal heart rate calculation system based on R-R interval

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TECHNOLOGY AND HEALTH CARE 2020年第S1期28卷 S187-S195页

作者： Zhang, Yisong Zhang, Song Yang, lin Yang, Yimin li, xuwen Hao, Dongmei Xu, Mingzhou Shao, Jing Beijing Univ Technol Coll Life Sci & Bioengn Intelligent Physiol Measurement & Clin Translat Beijing Int Base Sci & Technol Cooperat Beijing 100024 Peoples R China Beijing Aerosp ChangFeng Co Ltd Beijing 100071 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

BACKGROUND: Fetal electrocardiogram (FECG) can be obtained in a non-invasive manner to monitor fetal growth status. OBJECTIVE: In this study, a fetal heart rate (FHR) calculation system was proposed, which consists of the FECG recorder (MF-HOLTER) and the FECG monitoring software (FECG-MS). The abdomen electrocardiogram (AECG) of pregnant woman is acquired through the MF-HOLTER. The FECG-MS packs the AECG data and calls the FECG separation algorithm to obtain the separated FECG and the fetal QRS (FQRS) position. The FHR is further obtained by calculating the R-R interval value. At the same time, this study proposed a FQRS position correction algorithm to calculate the correct FHR values. METHOD: In order to verify the accuracy of the FHR calculation, the ECG signal of FLUKE's PS320 FETAL SIMULATOR and clinical data were simultaneously tested. RESULTS: The accuracy rate is over 98% in processing the simulator's data. In processing clinical data, the FHR values obtained by both the system proposed in this study and Monica AN24 are very close, and the difference is less than 1 bpm. CONCLUSION: The results show that the FHR calculation system is accurate and stable, and has a positive application value and prospect.

关键词： Fetal ECG fetal heart rate R-R interval fetal QRS position correction

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Design of Wide-Range High-Precision Cesium Oven Temperature Control System for Time-Keeping Cesium Beam Frequency Standards

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APPliED SCIENCES-BASEL 2025年第3期15卷 1128-1128页

作者： liu, Jie li, Xiaofeng li, Chao Hu, xuwen li, Qingyue Sun, Fuyu Zhang, Shougang Chinese Acad Sci Natl Time Serv Ctr 3 East Shuyuan Rd Xian 710600 Peoples R China Nanchang Univ Sch Phys & Mat Sci Nanchang 330031 Peoples R China Chinese Acad Sci Key Lab Time Reference & Applicat 3 East Shuyuan Rd Xian 710600 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China

The temperature fluctuation of a cesium oven has a significant impact on the performance of time-keeping cesium beam frequency standards. We have designed a circuit system for the precise temperature control of the cesium oven used in it. The use of a 24-bit analog-to-digital converter ensures a temperature measurement resolution more than 0.5 mK within the working range. The digital PID algorithm guarantees the accuracy of error signal computation, and a 16-bit digital-to-analog converter improves the resolution of the control current adjustment. Ultimately, we achieved the goal of keeping the temperature fluctuation of the cesium oven to less than 4 mK within a working range of 120 degrees C. The results indicate that the circuit system effectively ensures the performance of the cesium beam frequency standard.

关键词： time-keeping cesium beam frequency standards cesium oven temperature control digital PID

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Interaction and sorption mechanisms of phthalate plasticizers and Cd²⁺ on biochar

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ENVIRONMENTAL POLLUTION 2025年 373卷 126176页

作者： li, Wenjie Wang, Jian Chen, xuwen Mosa, Ahmed ling, Wanting Gao, Yanzheng Nanjing Agr Univ Inst Organ Contaminant Control & Soil Remediat Coll Resources & Environm Sci Nanjing 210095 Peoples R China Mansoura Univ Fac Agr Soils Dept Mansoura 35516 Egypt

Biochar exhibits significant potential for the remediation of soil contaminated with organic pollutants and heavy metals. A comprehensive understanding of the interfacial interactions and sorption mechanisms of lowhydrophobicity phthalate plasticizers, such as dimethyl phthalate (DMP) and diethyl phthalate (DEP), along with Cd2+ on biochar, is essential for the effective remediation of polluted soil environments. This study systematically examines the interaction and sorption mechanisms of PAEs-Cd2+ on biochar at both macro and micro levels using sorption batch experiments and molecular dynamics simulations. The sorption of contaminants by biochar occurred through a combination of physical and chemical mechanisms. The presence of coexisting pollutants reduced the sorption capacity of biochar to PAEs but had a minimal effect on Cd2+ adsorption. In the co-sorption system, PAEs and Cd2+ demonstrated distinct interaction behaviors. Due to its smaller molecular size and higher diffusion coefficient, Cd2+ readily bonded to surface sorption sites on biochar and infiltrated its pores. Although PAE-ion complexes enhanced the sorption of pollutants by biochar, PAE molecules, and cluster structures primarily accumulated on the biochar surface, interacting with heavy metals through electrostatic forces. This interaction reduced the contribution of pore filling to pollutant sorption and weakened the desorption hysteresis capacity of biochar. The intraparticle diffusion model had similar results. Thus, a larger specific surface area and an abundant pore structure are crucial factors in improving the co-sorption capacity of biochar. This study offers novel insights into the sorption behavior of PAEs and Cd2+ on biochar within organicinorganic composite pollution.

关键词： Composite pollution Biochar Phthalate esters Cd2+ Molecular dynamics

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Microenvironment-tailored micelles restrain carcinoma-astrocyte crosstalk for brain metastasis

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JOURNAL OF CONTROLLED RELEASE 2022年 349卷 520-532页

作者： Zhao, Zhenhao Zhang, Yujie li, Chao li, xuwen Chu, Yongchao Guo, Qin Zhang, Yiwen Xia, Weiyi liu, Peixin Chen, Hongyi Wang, Yu li, Chufeng Sun, Tao Jiang, Chen Fudan Univ Sch Pharm Dept Pharmaceut Key Lab Smart Drug Delivery Shanghai 201203 Peoples R China Fudan Univ MOE Frontiers Ctr Brain Sci Shanghai 201203 Peoples R China

Breast-to-brain metastatic cells can interact with the surrounding cells, including astrocytes and microglia, to generate a pro-tumorigenic niche. Breast-to-brain metastasis can be treated using a dual strategy of eliminating metastatic tumor cells and normalizing their localized microenvironment. The effective accumulation of drugs at the action site of metastasis is crucial to realizing the above strategy, especially when dealing with the bloodbrain barrier (BBB)-penetrating and tumor-targeting tactics. Here, we establish an in-situ microenvironmenttailored micelle (T-M/siRNA) to co-deliver therapeutic siRNA and paclitaxel (PTX) into the breast-to-brain metastasis. Anchored with a D-type cyclic peptide, T-M/siRNA can penetrate the BBB and subsequently target the brain metastases. Upon internalization by metastatic tumor cells, T-M/siRNA can release PTX in the highlevel glutathione (GSH), resulting in killing cancer cells. Meanwhile, the micellar structure is dissociated, resulting in lowering the charge density to release the loaded siRNA that can targeted downregulate the expression of protocadherin 7 (PCDH7). Treatment of model mice revealed that T-M/siRNA can inhibit the abnormal activation of astrocytes and immunosuppressive activation of microglia, resulting in significantly enhanced synergistic anti-tumor efficacy. This study indicates that the micelle system can serve as a hopeful strategy to treat breast-to-brain metastasis.

关键词： Breast -to -brain metastasis Micelle Microenvironment Protocadherin 7 Paclitaxel

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