BACKGROUND: The risk factors of hypertensive disorders in pregnancy (HDP) could be summarized into three categories: clinical epidemiological factors, hemodynamic factors and biochemical factors. OBJECTIVE: To establi...
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BACKGROUND: The risk factors of hypertensive disorders in pregnancy (HDP) could be summarized into three categories: clinical epidemiological factors, hemodynamic factors and biochemical factors. OBJECTIVE: To establish models for early prediction and intervention of HDP. METHODS: This study used the three types of risk factors and support vector machine (SVM) to establish prediction models of HDP at different gestational weeks. RESULTS: The average accuracy of the model was gradually increased when the pregnancy progressed, especially in the late pregnancy 28-34 weeks and >= 35 weeks, it reached more than 92%. CONCLUSION: Multi-risk factors combined with dynamic gestational weeks' prediction of HDP based on machine learning was superior to static and single-class conventional prediction methods. Multiple continuous tests could be performed from early pregnancy to late pregnancy.
In this work, the content of flavonoid glycosides and astragalosides in a Chinese medicine injection was determined by using the magnetic dispersive solid phase extraction method coupled with high performance liquid c...
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In this work, the content of flavonoid glycosides and astragalosides in a Chinese medicine injection was determined by using the magnetic dispersive solid phase extraction method coupled with high performance liquid chromatography with an evaporative light-scattering detector (HPLC/ELSD). Multi-walled carbon nanotubes (MWCNTs) modified by Fe3O4 nanoparticles obtained in a one-step synthetic procedure, were used as a sorbent to conveniently remove the analytes from water. Single factor experiments were performed to investigate the factors that affected the extraction efficiency, such as the hydroxyl content of the modified MWCNTs, the amount of sorbent, the type of elution solvent, the volume of elution solvent, sample pH and salting-out effect. Under the appropriate optimal conditions, the limits of detection (LODs) and limits of quantification (LOQs) for the three glycosides ranged from 0.16 mu g/mL to 0.60 mu g/mL and 0.58 mu g/mL to 1.24 mu g/mL, respectively. Moreover, the intra- and interday precision ranged from 1.9% to 2.9% and 2.4% to 4.5%, respectively. Meanwhile, the recoveries of spiked samples were measured, which ranged from 91.1% to 96.2% with relative standard deviations (RSDs) ranging from 2.8% to 3.8%. Accordingly, the application of the proposed method for the analysis of Chinese medicine injection samples offered several advantages: an acceptable precision, low LODs and good recoveries. This work might provide a research basis for the quality control of Chinese medicine injections and the further study of the Kang'ai injection.
The antioxidant capacity of 22 kinds of fruits was measured by the developed electron spin resonance (ESR) method based on Cu2+ sensor. Cu2+ is reduced to Cu+ by the antioxidants in the fruits, and the remaining Cu2+ ...
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The antioxidant capacity of 22 kinds of fruits was measured by the developed electron spin resonance (ESR) method based on Cu2+ sensor. Cu2+ is reduced to Cu+ by the antioxidants in the fruits, and the remaining Cu2+ was determined by ESR and UV-Vis spectroscopy. Cu2+ can give an ESR signal whereas Cu+ cannot, and the loss of the ESR signal was used to quantify the antioxidant capacity of various fruits. The results were shown as vitamin C equivalent antioxidant capacity (VCEAC). The VCEAC values obtained by ESR and UV-Vis methods ranged from 24.23 to 688.61 mg/100 g and from 24.12 to 677.79 mg/100 g, respectively. Cupric ion reducing antioxidant capacity (CUPRAC) and 1,1-diphenyl-2-picryl-hydrazyl (DPPH) methods were employed for comparison. Based on Pearson's correlation test, the results obtained by CUPRAC and DPPH methods were both significantly correlated with these obtained by the present method, which indicated that the novel method was reliable. Total phenolic content for all kinds of fruits was measured with the Folin-Ciocalteu reagent, and VCEAC values obtained by the ESR method were significantly correlated with total phenolic contents.
Marine sponges of the genus Stelletta are well known as rich sources of diverse and complex biologically relevant natural products, including alkaloids, terpenoids, peptides, lipids, and steroids. Some of these metabo...
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Marine sponges of the genus Stelletta are well known as rich sources of diverse and complex biologically relevant natural products, including alkaloids, terpenoids, peptides, lipids, and steroids. Some of these metabolites, with novel structures and promising biological activities, have attracted a lot of attention from chemists seeking to perform their total synthesis in parallel to intensive biological studies towards new drug leads. In this review, we summarized the distribution of the chemically investigated Stelletta sponges, the isolation, synthesis and biological activities of their secondary metabolites, covering the literature from 1982 to early 2018.
Amorphous materials have recently received much attention as catalysts for electrochemical reactions. However, there are relatively few reports focused on the structure change of amorphous catalysts during the catalys...
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Amorphous materials have recently received much attention as catalysts for electrochemical reactions. However, there are relatively few reports focused on the structure change of amorphous catalysts during the catalysis process, although this is quite important to the identification of active species and in revealing the reaction mechanism. Herein, amorphous Co-Ni sulfide in the form of a nanoplate and nanowire hybrid on the surface of nickel foam is prepared as the electrode for the hydrogen evolution reaction (HER). During the hydrogen evolution process, the amorphous Co-Ni sulfide is in-situ transformed into crystalline Ni, S-co-doped CoO which is actually responsible for the catalysis of HER The transformation process is studied in detail by high-resolution transmission electron microscopy (HRTEM), X-ray photoelectron spectroscopy (XPS), and theoretical calculations. The in-situ formed electrode presents a high activity and durability toward HER in alkaline media. The Ni and S dopants, sulfurization temperature, and electrode substrate are revealed to be important factors that affect the activity. The present work will not only give more insights in the structure evolution of the electrocatalyst during HER but also provides a new strategy to the fabrication of new electrocatalysts.
Transition metal sulfide is considered as a kind of promising noble metal-free material for hydrogen evolution reaction (HER). However, most of conventional sulfurization methods require high temperature and/or long r...
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Transition metal sulfide is considered as a kind of promising noble metal-free material for hydrogen evolution reaction (HER). However, most of conventional sulfurization methods require high temperature and/or long reaction time. Herein, a sulfurization strategy at room temperature (25 degrees C) by using Na2S in aqueous solution is applied to sulfurize nickel foam-supported nickel-cobalt carbonate hydroxide nanowire array, during which amorphous sulfide gradually forms on the surface of nanowire and finally replaces the nanowire completely. It is found that the electrode sulfurized for 5 min in which only a thin sulfide layer is formed presents nearly identical catalytic performance for HER with the electrode that is sufficiently sulfurized for 120 min. The electrode sulfurized at 25 degrees C for 5 min only needs an overpotential of 100 mV to achieve hydrogen evolution current at 10 mA cm(-2) in 1 M KOH, and negligible loss of activity is observed after working at a current density of 20 mA cm(-2) for 25 h. The interface between carbonate hydroxide and sulfide is considered to play an important role in the catalysis of HER. The observation in this work can provide new insights into the sulfurization process and the role of sulfide in the process of HER. (C) 2019 Elsevier Ltd. All rights reserved.
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