The chemical composition and biological activity of Sanghuangporus vaninii solid culture treated by static magnetic field were *** compounds were isolated and purified using ultrasonic extraction and semi-preparative ...
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The chemical composition and biological activity of Sanghuangporus vaninii solid culture treated by static magnetic field were *** compounds were isolated and purified using ultrasonic extraction and semi-preparative liquid *** structures were identified through spectral data,and the inhibitory activities againstα-amylase,α-glucosidase and pancreatic lipase were *** compounds,5,7-dihydroxy-3,4'-dimethoxyflavone(1),D-(+)-Trehalose(2),pinolenic acid(3),were extracted from the petroleum ether *** of peak heights indicated a significantly higher content of compounds subjected to a 4 mT static magnetic field compared to those *** tests revealed that compounds 1 and 2 exhibited strong anti-α-amylase and anti-α-glucosidase ***,compound 1 had inhibition rates of(65.37±0.05)%and(73.81±0.12)%after 4 mT treatment,compared to(57.26±0.11)%and(65.33±0.14)%*** 2 showed inhibition rates of(68.61±0.12)%and(65.38±0.09)%with the magnetic field,versus(60.71±0.06)%and(56.18±0.02)%*** 3 displayed a notable inhibitory effect on pancreatic lipase,with rates of(60.83±0.03)%after 4 mT treatment and(53.77±0.09)%*** study demonstrates that the static magnetic field enhances the chemical content and bioactivity of Sanghuangporus vaninii solid culture,providing a basis for its further development and application.
The fecal components of Blaptica dubia and Blatta lateralis were analyzed and characterized using solid-phase microextraction-gas chromatography-mass spectrometry(SPME-GC-MS)to explore can-didate compounds mediating t...
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The fecal components of Blaptica dubia and Blatta lateralis were analyzed and characterized using solid-phase microextraction-gas chromatography-mass spectrometry(SPME-GC-MS)to explore can-didate compounds mediating their aggregation *** results revealed that hydrocarbons and alde-hydes accounted for the majority of the 85 components detected in the fecula of ***,with hexadecane(6.721%)and tetradecanal(6.555%)as the most *** the fecula of ***,esters and hy-drocarbons accounted for the majority of the 93 identified components,with 3-phenylpropionic acid methyl ester(10.020%)and 2,7-dioxa-tricyclo[4.4.0.0(3,8)]deca-4,9-diene(3.604%)hexadecane(2.504%)*** fecal compositions of the two cockroach species exhibited similarities,with seven common substances identified out of a total of *** relative percentages of these common components in the fecula were 68.516%for *** and 53.541%for ***.
China's electricity market is now still in the mode of 'Unified market and two-tier operation' including provincial and inter-provincial market. The inter-provincial market is divided into the medium and l...
China's electricity market is now still in the mode of 'Unified market and two-tier operation' including provincial and inter-provincial market. The inter-provincial market is divided into the medium and long-term market and spot market. This study takes the inter provincial spot market as the research object, and proposes a unified optimization clearing algorithm for inter provincial spot market considering path constraints. The proposed method is able to handle AC-DC hybrid electricity network, and sort and determine the trading pairs using power flow tracing algorithm. The power market software PLEXOS and practical market data are used to simulate the proposed model, and the results show the accuracy and effectiveness.
Abstract Abstract 4926 CD30 is a member of the tumor necrosis factor (TNF) receptor family that is normally found on the cell surface of a small subset of activated lymphocytes but is overexpressed on the surface of a...
Abstract Abstract 4926 CD30 is a member of the tumor necrosis factor (TNF) receptor family that is normally found on the cell surface of a small subset of activated lymphocytes but is overexpressed on the surface of anaplastic large cell lymphoma (ALCL) and Hodgkins lymphoma (HL) cells. Although many drugs exist that treat lymphomas by triggering the intrinsic cell death pathway, current chemotherapeutic regimens are limited by unwanted side effects, including secondary malignancies that limit event-free survival. The tumor-restricted overexpression of CD30 makes it an attractive target for therapeutic intervention. Depending on the cellular context, CD30 stimulation has been linked to cell death, cell cycle arrest, or paradoxically, proliferation. In ALCL tumor cell lines, CD30 stimulation activates both the canonical and noncanonical NF-kB pathways while in HL tumor cell lines, CD30 stimulation only slightly enhances NF-kB activity above constitutive levels, implying a role for NF-kB in determining the sensitivity or resistance of lymphoma cells to CD30-induced apoptosis. In addition, IAP antagonists, small synthetic compounds that mimic the structure of the second mitochondrial activator of caspase (Smac) and target IAP molecules that affect the activation of the non-canonical NF-kB pathway, induce apoptosis and/or sensitize cells to death via secondary signals such as TNF. This suggests that the modulation of IAP levels, and consequently regulation of the non-canonical NF-kB pathways, may also have a role in determining tumor cell death. Using representative ALCL and HL tumor cell lines, we have found that CD30 stimulation via its physiologically ligand in combination with standard chemotherapeutic agents results in increased efficacy in tumor cell death in the majority of ALCL cell lines but not HL cell lines. Similarly, IAP antagonists in combination with standard chemotherapeutic agents also resulted in enhanced tumor cell death in most ALCL but not HL cell l
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