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Inflammatory resolution and vascular barrier restoration after retinal ischemia reperfusion injury

JOURNAL OF NEUROINFLAMMATION 2021年第1期18卷 186-186页

作者： Abcouwer, Steven F. Shanmugam, Sumathi Muthusamy, Arivalagan Lin, Cheng-mao Kong, Dejuan Hager, Heather liu, xuwen Antonetti, David A. Univ Michigan Kellogg Eye Ctr Dept Ophthalmol & Visual Sci Michigan Med Ann Arbor MI 48105 USA Esperovax Inc Plymouth MI 48170 USA Dept Mol & Integrat Physiol Ann Arbor MI 48109 USA

Background: Several retinal pathologies exhibit both inflammation and breakdown of the inner blood-retinal barrier (iBRB) resulting in vascular permeability, suggesting that treatments that trigger resolution of inflammation may also promote iBRB restoration. Methods: Using the mouse retinal ischemia-reperfusion (IR) injury model, we followed the time course of neurodegeneration, inflammation, and iBRB disruption and repair to examine the relationship between resolution of inflammation and iBRB restoration and to determine if minocycline, a tetracycline derivative shown to reverse microglial activation, can hasten these processes. Results: A 90-min ischemic insult followed by reperfusion in the retina induced cell apoptosis and inner retina thinning that progressed for approximately 2 weeks. IR increased vascular permeability within hours, which resolved between 3 and 4 weeks after injury. Increased vascular permeability coincided with alteration and loss of endothelial cell tight junction (TJ) protein content and disorganization of TJ protein complexes. Shunting of blood flow away from leaky vessels and dropout of leaky capillaries were eliminated as possible mechanisms for restoring the iBRB. Repletion of TJ protein contents occurred within 2 days after injury, long before restoration of the iBRB. In contrast, the eventual re-organization of TJ complexes at the cell border coincided with restoration of the barrier. A robust inflammatory response was evident a 1 day after IR and progressed to resolution over the 4-week time course. The inflammatory response included a rapid and transient infiltration of granulocytes and Ly6C(+) classical inflammatory monocytes, a slow accumulation of Ly6C(neg) monocyte/macrophages, and activation, proliferation, and mobilization of resident microglia. Extravasation of the majority of CD45(+) leukocytes occurred from the superficial plexus. The presence of monocyte/macrophages and increased numbers of microglia were sustained until

关键词： Ischemia-reperfusion injury Retinal vasculature Blood-retina barrier Tight junctions Resolution of inflammation Microglia Leukocytes Granulocytes Monocytes Myeloid-derived macrophages Minocycline TNF-alpha IL-1 beta Cox-2 Serpina3n

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Employing supercritical n-butanol to remove the EVA film for the delamination of photovoltaic laminated module

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JOURNAL OF SUPERCRITICAL FLUIDS 2025年 219卷

作者： Wang, xuwen liu, Zhifeng Ruan, Haoda Li, Xinyu Zhang, Lei Hefei Univ Technol Sch Mech Engn Hefei 230009 Peoples R China Anhui Prov Key Lab Low Carbon Recycling Technol & Hefei 230009 Peoples R China State Key Lab Environm Adaptabil lndustrial Prod Guangzhou 510300 Peoples R China

The rapid advancement of the photovoltaic (PV) industry has elevated the recycling and reuse of decommissioned PV modules to critical challenges, essential for tackling environmental concerns and achieving resource reutilization. To facilitate the efficient layering of PV modules and recovery of valuable materials, this study proposes a PV module degradation and recycling process utilizing supercritical n-butanol. A systematic evaluation was conducted to assess the effects of various factors on the dissolution ratio of PV modules, with an appropriate range of process parameters selected for optimization. A second-order regression model was developed to predict the dissolution ratio of the EVA film. Comparison of actual dissolution ratio with model predictions confirmed the high accuracy of the fitted model. Finally, characterization and elemental analysis of cells recovered from the supercritical process demonstrated the effectiveness of this recycling method, achieving more thorough degradation on the cell surfaces.

关键词： Photovoltaic Supercritical n-butanol Degradation Recycling Characterization

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Synthesis and structure-activity relationships of thieno[2,3-d]pyrimidines as atypical protein kinase C inhibitors to control retinal vascular permeability and cytokine-induced edema

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BIOORGANIC & MEDICINAL CHEMISTRY 2020年第11期28卷 115480-115480页

作者： liu, xuwen Wilson, Michael W. liu, Kun Lee, Pil Yeomans, Larisa Hagen, Susan E. Lin, Cheng-Mao Wen, Bo Sun, Duxin White, Andrew D. Showalter, Hollis D. Antonetti, David A. Univ Michigan Dept Ophthalmol & Visual Sci Ann Arbor MI 48105 USA Univ Michigan Dept Med Chem Ann Arbor MI 48105 USA Univ Michigan Vahlteich Med Chem Core Ann Arbor MI 48109 USA Univ Michigan Dept Pharmaceut Sci Ann Arbor MI 48109 USA Univ Michigan Dept Mol & Integrat Physiol Ann Arbor MI 48109 USA

Studies demonstrate that small molecule targeting of atypical protein kinase C (aPKC) may provide an effective means to control vascular permeability, prevent edema, and reduce inflammation providing novel and important alternatives to anti-VEGF therapies for certain blinding eye diseases. Based on a literature tricyclic thieno[2,3-d] pyrimidine lead (1), an ATP-competitive inhibitor of the aPKC iota (iota) and aPKC zeta (zeta) isoforms, we have synthesized a small series of compounds in 1-2 steps from a readily available chloro intermediate. A single pyridine congener was also made using 2D NMR to assign regiochemistry. Within the parent pyrimidine series, a range of potencies was observed against aPKC zeta whereas the pyridine congener was inactive. Selected compounds were also tested for their effect toward VEGF-induced permeability in BREC cells. The most potent of these (7l) was further assayed against the aPKC iota isoform and showed a favorable selectivity profile against a panel of 31 kinases, including kinases from the AGC superfamily, with a focus on PKC isoforms and kinases previously shown to affect permeability. Further testing of 7l in a luciferase assay in HEK293 cells showed an ability to prevent TNF-alpha induced NF kappa B activation while not having any effect on cell survival. Intravitreal administration of 7l to the eye yielded a complete reduction in permeability in a test to determine whether the compound could block VEGF- and TNF alpha-induced permeability across the retinal vasculature in a rat model. The compound in mice displayed good microsomal stability and in plasma moderate exposure (AUC and C-max), low clearance, a long half-life and high oral bioavailability. With IV dosing, higher levels were observed in the brain and eye relative to plasma, with highest levels in the eye by either IV or PO dosing. With a slow oral absorption profile, 7l accumulates in the eye to maintain a high concentration after dosing with higher levels than in

关键词： Blinding eye diseases atypical protein kinaseC (aPKC) Vascular permeability Vascular endothelial growth factor (VEGF) Tumor necrosis factor-alpha (TNF alpha) Homology model Thieno[2,3-d]pyrimidine inhibitors SAR

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人工智能视域下的分工与人的全面发展——对马克思分工理论的思考

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社会主义研究 2019年第4期 25-31页

作者：刘旭雯华东理工大学马克思主义学院

马克思分工理论主要探讨了分工与人的发展的内在逻辑,指出分工的历史是一部人类社会发展史,社会分工程度与生产力发展水平以及人的解放程度有着密切联系,并明确了只有共产主义才能“消灭分工”。马克思关于分工与人的发展理论对人工智... 详细信息

马克思分工理论主要探讨了分工与人的发展的内在逻辑,指出分工的历史是一部人类社会发展史,社会分工程度与生产力发展水平以及人的解放程度有着密切联系,并明确了只有共产主义才能“消灭分工”。马克思关于分工与人的发展理论对人工智能的发展有着重要启示,人工智能的发展在推动生产力、人类解放和世界历史的发展中都具有重要影响。未来人工智能的发展将向着造就全社会高度发达的生产力、为人的自由全面发展提供发展空间、推动资本主义世界历史向共产主义世界历史转变的方向迈进。

关键词：人工智能分工人的全面发展共产主义

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Prediction and optimization method for welding quality of components in ship construction

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SCIENTIFIC REPORTS 2024年第1期14卷 1-18页

作者： liu, Jinfeng Cheng, Yifa Jing, xuwen liu, Xiaojun Chen, Yu Jiangsu Univ Sci & Technol Zhenjiang 212100 Jiangsu Peoples R China Southeast Univ Nanjing 211189 Peoples R China

Welding process, as one of the crucial industrial technologies in ship construction, accounts for approximately 70% of the workload and costs account for approximately 40% of the total cost. The existing welding quality prediction methods have hypothetical premises and subjective factors, which cannot meet the dynamic control requirements of intelligent welding for processing quality. Aiming at the low efficiency of quality prediction problems poor timeliness and unpredictability of quality control in ship assembly-welding process, a data and model driven welding quality prediction method is proposed. Firstly, the influence factors of welding quality are analyzed and the correlation mechanism between process parameters and quality is determined. According to the analysis results, a stable and reliable data collection architecture is established. The elements of welding process monitoring are also determined based on the feature dimensionality reduction method. To improve the accuracy of welding quality prediction, the prediction model is constructed by fusing the adaptive simulated annealing, the particle swarm optimization, and the back propagation neural network algorithms. Finally, the effectiveness of the prediction method is verified through 74 sets of plate welding experiments, the prediction accuracy reaches over 90%.

关键词： Quality prediction Components welding Welding quality Process parameter optimization

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腰椎间盘突出患者腰椎CT三维重建影像的解剖学测量及其在单边双通道内镜手术中的临床意义

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中华解剖与临床杂志 2022年第9期27卷 608-613页

作者：刘续文朱斌王其飞钟华璋陈磊霍星荆珏华田大胜安徽医科大学第二附属医院骨科合肥230601 合肥工业大学数学学院信息与计算科学系合肥230601

目的探讨腰椎间盘突出症患者腰椎CT三维重建影像解剖学特点及其在单边双通道内镜手术中的意义。方法横断面调查研究。纳入安徽医科大学第二附属医院骨科2019年1月—2020年6月收治的腰椎间盘突出症的患者50例,其中男32例、女18例,年龄23~... 详细信息

目的探讨腰椎间盘突出症患者腰椎CT三维重建影像解剖学特点及其在单边双通道内镜手术中的意义。方法横断面调查研究。纳入安徽医科大学第二附属医院骨科2019年1月—2020年6月收治的腰椎间盘突出症的患者50例,其中男32例、女18例,年龄23~69(64.1±13.4)岁。病变节段:L2/31例,L_(4/5)18例,L_(5)/S_(1)23例,L_(3/4)合并L_(4/5)1例,L_(4/5)合并L_(5)/S_(1)6例。均采用单边双通道内镜辅助下腰椎间盘突出髓核摘除术治疗。术前患者均行腰椎CT扫描及三维容积重建,观察患者腰椎整体形态结构,使用放射工作站软件测量两侧椎板夹角、椎板宽度、关节突关节矢状化程度以及椎板下移程度,并进行腰椎节段间及侧别间比较。结果(1)棘突与两侧椎板呈“人”字形平滑连接,两侧椎板向两侧弧形展开。两侧椎板夹角自L_(3)至L_(5)逐渐增大,分别为70°±11°、78°±12°和92°±13°,差异有统计学意义(F=42.25,P<0.001)。(2)椎板下缘向两侧延伸,椎板宽度自L_(3)至L_(5)逐渐增宽,左侧分别为(14.0±2.4)、(15.7±2.6)和(18.7±2.8)mm,右侧分别为(14.4±2.4)、(16.4±2.3)和(19.2±2.8)mm,各节段椎板宽度右侧均大于左侧,差异均有统计学意义(t=2.13、4.00、2.78,P值均<0.05)。(3)椎板末端逐渐增宽膨大成关节面,关节面L_(3/4)~L_(5)/S_(1)逐渐由矢状化转变为冠状化,左侧分别为60°±10°、50°±9°和42°±11°,右侧分别为58°±11°、48°±10°和40°±13°。同一节段左右两侧对比,在L_(3/4)差异有统计学意义(t=2.92,P=0.005),在L_(4/5)及L_(5)/S_(1)差异均无统计学意义(t=1.29、1.79,P值均>0.05)。(4)椎板下移程度自L_(3)至L_(5)逐渐减小,分别为(6.8±2.1)、(5.1±2.3)和(2.4±2.3)mm,差异有统计学意义(F=50.39,P<0.001)。结论腰椎间盘突出症患者从L_(3)到L_(5),两侧椎板夹角逐渐增大、椎板宽度逐渐增大、关节突关节逐渐由矢状化转变为冠状化、椎板下移程度逐渐减小。了解腰椎解剖的节段性变化有助于单边双通道内镜手术的顺利进行、椎板去除范围的确定、对关节突关节的保护以及椎间盘位置的确定。

关键词：椎间盘移位腰椎三维成像内镜单边双通道内镜技术体层摄影术,X线计算机

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日本电力现货市场运行现状及对中国的启示

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全球能源互联网 2021年第5期4卷 497-505页

作者：杨素肖汉雄王阳蒋宇丁羽刘胥雯孙燕一国网能源研究院有限公司北京市昌平区102209 国网江苏省电力有限公司江苏省南京市210008

日本新一轮电力体制改革启动以后,现货市场的交易量大幅提升,市场结构也逐渐完善,对中国电力现货市场建设有较大的借鉴意义。深入分析日本电力现货市场的结构和运行规律,包括日前市场、日内市场和平衡机制。对改革后市场主体、市场价格... 详细信息

日本新一轮电力体制改革启动以后,现货市场的交易量大幅提升,市场结构也逐渐完善,对中国电力现货市场建设有较大的借鉴意义。深入分析日本电力现货市场的结构和运行规律,包括日前市场、日内市场和平衡机制。对改革后市场主体、市场价格、交易量等进行逐年变化趋势分析。总结改革过程中出现的问题和日本的解决方式,最后提出对中国电力市场建设的启示和建议。

关键词：日本电力市场现货市场日前市场日内市场平衡机制

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Temporal assembly patterns of microbial communities in three parallel bioreactors treating low-concentration coking wastewater with differing carbon source concentrations

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Journal of Environmental Sciences 2024年第3期137卷 455-468页

作者： Weijia Li Yu Xia Na Li Jie Chang Jing liu Pei Wang xuwen He School of Chemical and Environmental Engineering China University of Mining and Technology-BeijingBeijing 100083China

Carbon source is an important factor of biological treatment systems, the effects of which on their temporal community assembly patterns are not sufficiently understood *** this study, the temporal dynamics and driving mechanisms of the communities in three parallel bioreactors for low-concentration coking wastewater(CWW) treatment with differing carbon source concentrations(S0 with no glucose addition, S1 with 200 mg/L glucose addition and S2 with 400 mg/L glucose addition) were comprehensively studied. Highthroughput sequencing and bioinformatics analyses including network analysis and Infer Community Assembly Mechanisms by Phylogenetic bin-based null model(iCAMP) were used. The communities of three systems showed turnover rates of 0.0029~0.0034 every 15days. Network analysis results showed that the S0 network showed higher positive correlation proportion(71.43%) and clustering coefficient(0.33), suggesting that carbon source shortage in S0 promoted interactions and cooperation of microbes. The neutral community model analysis showed that the immigration rate increased from 0.5247 in S0 to 0.6478in S2. The iCAMP analysis results showed that drift(45.89%) and homogeneous selection(31.68%) dominated in driving the assembly of all the investigated microbial *** contribution of homogeneous selection increased with the increase of carbon source concentrations, from 27.92% in S0 to 36.08% in S2. The OTUs participating in aerobic respiration and tricarboxylic acid(TCA) cycle were abundant among the bins mainly affected by deterministic processes, while those related to the metabolism of refractory organic pollutants in CWW such as alkanes, benzenes and phenols were abundant in the bins dominated by stochastic processes.

关键词： Coking wastewater treatment Temporal dynamics Network analysis Deterministic processes Stochastic processes

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Stable self-crosslinking phase change composites with vertically aligned boron nitride for high thermal conductivity thermal interface materials

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CERAMICS INTERNATIONAL 2024年第11期50卷 19829-19837页

作者： liu, Chunlei Duan, Xiaoyuan Zhang, Wei Huo, Qianqiang Sui, xuwen liu, Yaqing Liang, Chaobo North Univ China Coll Mat Sci & Engn Key Lab Funct Nanocomposites Shanxi Prov Taiyuan 030051 Peoples R China Northwestern Polytech Univ Sch Chem & Chem Engn Shaanxi Key Lab Macromol Sci & Technol Xian 710072 Peoples R China

Thermal interface materials (TIMs) must have a high through-plane thermal conductivity in order to efficiently transfer the heat generated by electronic components to heat sinks. Nevertheless, the achievement of high through-plane thermal conductivity is still a great challenge due to the inadequate thermal conductivity network as well as the lack of thermal response from the polymer matrix. Herein, we have developed a solid-solid phase change polymer matrix achieved through self-crosslinking polyethylene glycol (SCPEG). Subsequently, highperformance TIMs based on the SCPEG matrix and vertically aligned boron nitride (BN) nanosheets are obtained by bidirectional freezing, hot pressing, and longitudinal slicing. The prepared BN/SCPEG composites (BN content of 80 vol%) with a vertically oriented network achieved a through-plane thermal conductivity of 23.03 W m-1 K-1. More importantly, the vertically aligned BN nanosheets improve the thermal conductivity of composites, while the SCPEG matrix can reduce the hardness of composites by absorbing the heat, thus decreasing the contact thermal resistance.

关键词： Thermal interface materials Solid-solid phase change polymer matrix Self-crosslinking polyethylene glycol Vertically aligned boron nitride nanosheets

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Iodine-catalyzed intermolecular 1,2-thio (seleno)amination of alkenes with 1,2,3-triazoles and disulfides (diselenides) in air

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ORGANIC CHEMISTRY FRONTIERS 2024年第11期11卷 3066-3071页

作者： Ji, Jian Chen, xuwen Hu, Zongjing Guan, Cong liu, Jinhua Deng, Yaqi liu, Shunying East China Normal Univ Shanghai Engn Res Ctr Mol Therapeut & New Drug De Sch Chem & Mol Engn Shanghai 200062 Peoples R China

An iodine-catalyzed direct radical coupling method for 1,2-thio (seleno)amination of alkenes with 1,2,3-triazoles and disulfides (diselenides) in air was developed. Products were constructed in one pot with high chemoselectivity and regioselectivity as well as a wide range of substrate scopes (including terminal and internal alkenes). Preliminary mechanistic studies indicated that formation of the C-N bond proceeded via a desulfonation-associated tandem radical cross-coupling process. Iodine-catalyzed 1,2-thio (seleno)amination of alkenes via direct N- and C-centered radical cross-coupling was established to elicit highly regioselective beta-triazolized thioalkyl compounds.

关键词： Olefins

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