检索结果-内蒙古大学图书馆

2021 OES China Ocean Acoustics, COA 2021

作者： zhao, Dexin Meng, luwen Li, Guangming Wang, Tao Academy of Military Sciences National Innovation Institute of Defense Technology Beijing China

ISBN: (纸本)9781728181905

In order to effectively separate multiple target signals and reduce noise interference to underwater target signals, the frequency-wavenumber(f-k) filtering method commonly used in the seismic data processing was applied to the separation of underwater multi-target signals and the denoising processing of underwater acoustic data. By analyzing the f-k spectrum of multi-target underwater acoustic data, the parameters of the sector-filter were designed, then f-k filtering of multi-target underwater acoustic data were carried out. The filtering processing results show that the f-k filtering method can separate the multi-target signals that are aliased in the time domain and the frequency domain. And the f-k filtering method also has a certain inhibitory effect on noise, which can effectively improve the signal-to-noise ratio. © 2021 IEEE.

关键词： Signal to noise ratio

来源：评论

学校读者我要写书评

暂无评论

The complex association of VRK2 with major depressive disorder in Han Chinese population

引用

JOURNAL OF AFFECTIVE DISORDERS 2025年 383卷 260-266页

作者： Luo, Binbin Huo, Jinhua zhao, Lijuan Guo, Xiaoge Zhang, luwen Yang, Yongfeng Li, Shiwu Zhong, Jingmei Lv, Luxian Li, Ming Guo, Yongbo Xiao, Xiao Li, Wenqiang Xinxiang Med Univ Affiliated Hosp 2 Henan Mental Hosp Xinxiang 453003 Henan Peoples R China Xinxiang Med Univ Henan Collaborat Innovat Ctr Prevent & Treatment M Henan Key Lab Biol Psychiat Xinxiang 453003 Henan Peoples R China Chinese Acad Sci Kunming Inst Zool Yunnan Key Lab Anim Models & Human Dis Mech Kunming 650201 Yunnan Peoples R China Univ Chinese Acad Sci Kunming Coll Life Sci Kunming 650201 Yunnan Peoples R China First Peoples Hosp Yunnan Prov Dept Psychiat Kunming 650201 Yunnan Peoples R China

Background: Major depressive disorder (MDD) is a polygenic condition with substantial heritability, with genome-wide association studies (GWAS) identifying several risk loci in European populations, including the VRK2 gene. However, the association between VRK2 and MDD in non-European populations, particularly in Han Chinese, remains underexplored. Methods: We genotyped four VRK2 SNPs (rs2678907, rs11682175, rs1568452, rs1518395) in a cohort of 1878 MDD cases and 1800 controls of Han Chinese descent. Genotyping was performed using SNaPShot, and linkage disequilibrium (LD) was assessed with SHEsis. Associations between the SNPs and MDD were evaluated via logistic regression in PLINK. VRK2 mRNA expression in the amygdala and peripheral blood was quantified by RTqPCR, with statistical significance determined by ANCOVA and t-tests. A meta-analysis incorporating an independent East Asian GWAS cohort was also conducted. Results: In our Han Chinese cohort, rs2678907 was significantly associated with MDD (P = 4.17 x 10-5, OR = 1.217). Meta-analysis with independent East Asian GWAS further confirmed the associations of rs2678907 with MDD. Haplotype analysis of VRK2 SNPs in Han Chinese revealed the haplotypes (T-G for rs11682175-rs2678907 and C-G for rs1568452-rs2678907) associated with an increased MDD risk and elevated VRK2 mRNA expression. Additionally, MDD patients showed significantly higher VRK2 mRNA levels in peripheral blood than controls (P = 1.85 x 10-7). Conclusions: These findings provide strong evidence for the role of VRK2 in MDD risk in Han Chinese individuals. Our results underscore the potential of VRK2 as a genetic and expression-based biomarker for MDD, highlighting the importance of accounting for population-specific genetic variations in psychiatric research. Further research is essential to explore the functional implications of VRK2 in MDD pathogenesis.

关键词： Biomarker Han Chinese MDD SNP VRK2

来源：评论

学校读者我要写书评

暂无评论

Experimental Investigation on Seabed Seismic Wave Induced by a Pulse Acoustic Source

Experimental Investigation on Seabed Seismic Wave Induced by...

引用

2021 OES China Ocean Acoustics, COA 2021

作者： Meng, luwen zhao, Dexin Wang, Tao Li, Guangming Academy of Military Sciences National Innovation Institute of Defense Technology Beijing China

ISBN: (纸本)9781728181905

To observe the separation phenomenon of the various components of the seabed seismic wave and obtain the propagation characteristics of each component in the time domain, a pulse acoustic source experiment was designed and carried out on the lake. The experimental results show that: different types of seabed seismic wave can be induced by air gun pulse sound sources in shallow water, and they can be received by vertical vibration sensors placed on the bottom of the water;the seabed seismic wave is dominated by Scholte wave, whose propagation speed is related to the parameters of the lake bottom medium and lower than the underwater acoustic velocity;the dominant frequency of the Scholte wave is below 25 Hz, which is not easily interfered by strong acoustic signals in the water. © 2021 IEEE.

关键词： Seismic waves

来源：评论

学校读者我要写书评

暂无评论

Combining immune checkpoint inhibitors and molecular-targeted agents with hepatic arterial infusion chemotherapy for hepatocellular carcinoma with inferior vena cava and/or right atrium tumor thrombus

引用

HEPATOLOGY INTERNATIONAL 2025年第3期19卷 560-575页

作者： Zhong, Suixing Yi, Junzhe Chen, Song Mo, Xiaoyan Chen, Qifeng Guo, Wenbo Jiang, Xiongying Mu, luwen Hu, Yue Wang, Jiongliang Song, Yujia Xu, Jie Tan, Genjun Shi, Ming Chen, Minshan Lyu, Ning zhao, Ming Sun Yat Sen Univ Canc Ctr Liver Canc Study & Serv Grp Dept Minimally Invas Intervent Therapy Guangzhou 510060 Peoples R China Sun Yat Sen Univ Dept Liver Surg Canc Ctr Guangzhou 510060 Peoples R China Sun Yat Sen Univ VIP Reg Canc Ctr Guangzhou 510060 Peoples R China Sun Yat Sen Univ Canc Ctr Guangdong Prov Clin Res Ctr Canc State Key Lab Oncol South China Guangzhou 510060 Peoples R China Collaborat Innovat Ctr Canc Med 651 Dongfeng East Rd Guangzhou 510060 Peoples R China Sun Yat Sen Univ Affiliated Hosp 1 Dept Intervent Radiol Guangzhou 510080 Peoples R China Sun Yat Sen Univ Sun Yat Sen Mem Hosp Intervent Radiol Div Guangzhou 510120 Peoples R China Sun Yat Sen Univ Affiliated Hosp 3 Dept Vasc Intervent Radiol Guangzhou 510630 Peoples R China

Background Hepatocellular carcinoma with inferior vena cava and/or right atrium tumor thrombus (HCC-IVC/RATT) has a poor prognosis and lacks evidence for standard first-line systemic therapy. This study aims to evaluate the effectiveness and safety of three therapeutic regimens in HCC-IVC/RATT: immune checkpoint inhibitors plus molecular-targeted agents (ICI-MTA), hepatic arterial infusion chemotherapy (HAIC), and their combination (ICI-MTA-HAIC). Methods This multicenter retrospective cohort study included consecutive HCC-IVC/RATT who received ICI-MTA-HAIC, ICI-MTA, or HAIC from June 2015 to December 2023. Propensity score matching (PSM) was used to balance baseline characteristics. Results A total of 355 patients were included: 209 received ICI-MTA-HAIC, 66 received ICI-MTA, and 80 received HAIC. After PSM, the ICI-MTA-HAIC group showed superior median overall survival (OS) to both the ICI-MTA (18.0 vs. 7.5 months, p < 0.001) and HAIC (18.5 vs. 7.1 months, p < 0.001) groups. The ICI-MTA-HAIC group demonstrated better median progression-free survival (PFS) and objective response rate (ORR) compared to the ICI-MTA (PFS: 9.5 vs. 4.4 months;ORR: 47.0% vs. 21.3%, all p < 0.001) and HAIC (PFS: 9.5 vs. 4.4 months;ORR: 48.8% vs. 21.6%, all p < 0.001) groups. There was no significant difference in OS, PFS, or ORR between the ICI-MTA and HAIC groups (all p > 0.05). Grade 3-4 adverse event rates were 49.8%, 33.3%, and 35.0% for the ICI-MTA-HAIC, ICI-MTA, and HAIC groups, respectively. No unexpected events or treatment-related deaths were observed. Conclusion ICI-MTA-HAIC was a safe and effective therapy that prolonged the survival of HCC-IVC/RATT compared to ICI-MTA or HAIC.

关键词： Hepatocellular carcinoma Tumor thrombus Immune checkpoint inhibitors Molecular-targeted agents Hepatic arterial infusion chemotherapy

来源：评论

学校读者我要写书评

暂无评论

Network prediction of surgical complication clusters:a prospective multicenter cohort study

引用

Science China(Life Sciences) 2023年第7期66卷 1636-1646页

作者： Xiaochu Yu Peng Wu Zixing Wang Wei Han Yuguang Huang Shijie Xin Qiang Zhang Shengxiu zhao Hong Sun Guanghua Lei Taiping Zhang luwen Zhang Yubing Shen Wentao Gu Hongwei Li Jingmei Jiang Peking Union Medical College Hospital Chinese Academy of Medical SciencesBeijing100730China Institute of Basic Medical Sciences Chinese Academy of Medical Sciences/School of Basic MedicinePeking Union Medical CollegeBeijing100005China The First Hospital of China Medical University Shenyang110001China Qinghai Provincial People’s Hospital Xining810007China Xiangya Hospital of Central South University Changsha410008China Research Department PaodingAIBeijing100083China

Complicated relationships exist in both occurrence and progression of surgical complications,which are difficult to account for using a separate quantitative method such as prediction or *** of 51,030 surgical inpatients were collected from four academic/teaching hospitals in a prospective cohort study in *** relationship between preoperative factors,22 common complications,and death was *** input from 54 senior clinicians and following a Bayesian network approach,a complication grading,cluster-visualization,and prediction(GCP)system was designed to model pathways between grades of complication and preoperative risk factor *** the GCP system,there were 11 nodes representing six grades of complication and five preoperative risk factor clusters,and 32 arcs representing a direct *** critical targets were pinpointed on the *** status was a fundamental cause widely associated(7/32 arcs)with other risk factor clusters and *** Society of Anesthesiologists(ASA)score≥3 was directly dependent on all other risk factor clusters and influenced all severe *** III complications(mainly pneumonia)were directly dependent on4/5 risk factor clusters and affected all other grades of *** of grade,complication occurrence was more likely to increase the risk of other grades of complication than risk factor clusters.

关键词： surgical complication network system complication grading complication prediction complication management

来源：评论

学校读者我要写书评

暂无评论

Form-stable phase-change materials supported by 1-octadecylamine-modified montmorillonite for latent heat storage

引用

INTERNATIONAL JOURNAL OF ENERGY RESEARCH 2021年第6期45卷 8871-8881页

作者： Fan, Dongli Meng, Yuan Shen, Danni Cao, Yufeng Chen, Kangli Qian, luwen Liu, Jie zhao, Qin Nantong Univ Sch Chem & Chem Engn Nantong Peoples R China

Form-stable phase-change materials (FSPCMs) are of great significance for relieving the contradiction of energy supply and demand. Unfortunately, the practical application of FSPCMs is severely compromised by their intrinsic drawbacks including lower latent heat storage (LHS) capacities, inferior interfacial compatibility, and cycling durability. Herein, we have provided a group of novel FSPCMs with higher LHS capacities, using paraffin as the LHS materials, which tightly intertwines with the 1-octadecylamine-modified montmorillonite (C18-MMT) under the capillary action as well as induced dipole force due to its n-alkyl chains compatibility. The obtained composite FSPCMs not only exhibit high melting enthalpies (137.56 J/g) but also demonstrate enhanced shape stability and thermal stability. In addition, the composites also render an impressive long-term thermal cycling capability and structure stability even after 100 thermal cycling durability tests, which are believed to have great potential for application in the thermal management of green energy-saving buildings.

关键词： 1-octadecylamine-modified montmorillonite form-stable phase-change materials high latent heat storage capacity paraffin

来源：评论

学校读者我要写书评

暂无评论

基于改进PRM的机械臂避障路径规划

引用

机械传动 2024年第12期48卷 87-93,148页

作者：游达章赵恒毅宋璐闻湖北工业大学机械工程学院湖北武汉430068 湖北省现代制造质量工程重点实验室湖北武汉430068 湖北三六一一应急装备有限公司湖北武汉430050

为解决传统概率路线图法(Probabilistic Roadmap Method,PRM)效率低、路线冗余、路径平滑度不够等问题,针对机械臂避障路径规划提出了一种改进PRM。使用Sobol序列采样方法提高概率路线图的连通性,提升方法成功率;采用冗余节点剪枝与基... 详细信息

为解决传统概率路线图法(Probabilistic Roadmap Method,PRM)效率低、路线冗余、路径平滑度不够等问题,针对机械臂避障路径规划提出了一种改进PRM。使用Sobol序列采样方法提高概率路线图的连通性,提升方法成功率;采用冗余节点剪枝与基于二分法插值的渐进路线修剪方法,使路径更加趋近最优解;最后,使用五次多项式插值方法对路径进行了平滑处理,使机械臂运动更加稳定平滑。仿真结果表明,改进的PRM提高了路径规划成功率,优化了路径,缩短了节点数与路径长度,且机械臂受力更加均匀平滑,证明该方法能有效合理地实现机械臂避障及路径规划。

关键词：运动规划概率路线图法 Sobol序列采样路径优化五次多项式插值

来源：评论

学校读者我要写书评

暂无评论

Targeting TRMT5 suppresses hepatocellular carcinoma progression via inhibiting the HIF-1αpathways

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第1期24卷 50-63页

作者： Qiong zhao luwen ZHANG Qiufen HE Hui CHANG Zhiqiang WANG Hongcui CAO Ying ZHOU Ruolang PAN Ye CHEN Department of Genetics and Department of Genetic and Metabolic DiseaseThe Children's HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Zhejiang Provincial Key Laboratory of Genetic and Developmental Disorders Institute of GeneticsZhejiang UniversityHangzhou 310058China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious Diseasesthe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Xiangshan Hospital of TCM Medical and Health Group Ningbo 315700China Zhejiang Provincial Key Laboratory of Cell-Based Drug and Applied Technology Development Hangzhou 311121China

Accumulating evidence has confirmed the links between transfer RNA(tRNA)modifications and tumor *** present study is the first to explore the role of tRNA methyltransferase 5(TRMT5),which catalyzes the m1G37 modification of mitochondrial tRNAs in hepatocellular carcinoma(HCC)***,based on bioinformatics and clinical analyses,we identified that TRMT5 expression was upregulated in HCC,which correlated with poor *** TRMT5 attenuated HCC proliferation and metastasis both in vivo and in vitro,which may be partially explained by declined extracellular acidification rate(ECAR)and oxygen consumption rate(OCR).Mechanistically,we discovered that knockdown of TRMT5 inactivated the hypoxia-inducible factor-1(HIF-1)signaling pathway by preventing HIF-1αstability through the enhancement of cellular oxygen ***,our data indicated that inhibition of TRMT5 sensitized HCC to doxorubicin by adjusting HIF-1α.In conclusion,our study revealed that targeting TRMT5 could inhibit HCC progression and increase the susceptibility of tumor cells to chemotherapy ***,TRMT5 might be a carcinogenesis candidate gene that could serve as a potential target for HCC therapy.

关键词： Transfer RNA(tRNA) tRNA methyltransferase 5(TRMT5) Hepatocellular carcinoma(HCC) Hypoxia-inducible factor-1α(HIF-1α)

来源：评论

学校读者我要写书评

暂无评论

Levels of neuronal pentraxin 2 in plasma is associated with cognitive function in patients with schizophrenia

引用

PSYCHOPHARMACOLOGY 2024年第4期241卷 865-874页

作者： Zhou, Jiahui Li, Xiaojing Wang, Xiujuan Yang, Yongfeng Nai, Aoyang Shi, Han zhao, Jingyuan Zhang, Jianhong Ding, Shuang Han, Yong Liu, Qing Zhang, luwen Chen, Tengfei Liu, Bing Yue, Weihua Lv, Luxian Li, Wenqiang Xinxiang Med Univ Henan Mental Hosp Affiliated Hosp 2 Xinxiang Peoples R China Xinxiang Med Univ Henan Key Lab Biol Psychiat Xinxiang Peoples R China Int Joint Res Lab Psychiat & Neurosci Henan Xinxiang Peoples R China Beijing Normal Univ State Key Lab Cognit Neurosci & Learning Beijing Peoples R China Chinese Inst Brain Res Beijing Peoples R China Peking Univ Inst Mental Hlth Beijing Peoples R China Minist Hlth Key Lab Mental Hlth Beijing Peoples R China

RationaleThe precise diagnosis and treatment of cognitive impairment remains a major challenge in the field of schizophrenia (SCZ) research. Synaptic dysfunction and loss are thought to be closely related to the occurrence and development of SCZ and may be involved in cognitive *** purpose of this study was to investigate whether neuronal pentraxins (NPTXs) plays a role in the etiology of SCZ and provide evidence of its possible therapeutic value a new target for drug *** recruited 275 participants, of whom 148 were SCZ from psychiatric hospital and 127 healthy control (HC) subjects from communities. Plasma concentrations of NPTXs were measured in HC and SCZ at baseline and after 8 weeks of antipsychotic treatment. The MATRICS Cognitive Consensus Battery was used to evaluate cognitive function. Furthermore, the brain is parcellated into 246 subregions using the Brainnetome atlas, and we extracted regional white matter volumes from magnetic resonance images of the SCZ *** NPTX2 levels were significantly lower in SCZ compared with HC subjects, but were significantly raised in SCZ after 8 weeks of antipsychotic treatment compared to baseline. In addition, baseline plasma NPTX2 levels were positively correlated with cognitive *** findings indicate that NPTX2 may reveal novel aspects of disease etiology and act as a promising target for new drug development.

关键词： Neuronal pentraxin 2 Schizophrenia Cognitive Synapse

来源：评论

学校读者我要写书评

暂无评论

Passive Broadband Acoustic Source Localization Based on Orthogonal Propagator Method

Passive Broadband Acoustic Source Localization Based on Orth...

引用

2021 OES China Ocean Acoustics, COA 2021

作者： Wang, Tao zhao, Dexin Meng, luwen Liu, Feng Chen, Liang Academy of Military Sciences National Innovation Institute of Defense Technology Beijing China

ISBN: (纸本)9781728181905

In the field of underwater acoustic signal processing, broadband array signal processing is an important research issue, which is more complex than that of narrowband. Broadband passive localization of underwater acoustic sources is investigated in this study. In order to improve the ability to locate multiple radiation sources which are emitted from ships, the orthogonal propagator method (OPM) is proposed to estimate direction of arrival (DOA) for the target. Based on the theory of spatial spectrum estimation, the linear decomposition of the covariance matrix is adopted to form the orthogonal propagator, and the spatial spectrum is constructed according to orthogonality of subspaces. Then, the directions of ship radiation noises are determined by searching the extreme points of the spatial spectrum. For broadband underwater acoustic signals, the non-coherent subspace method is used to average the effective frequency points in bandwidth to reduce noise interference, and OPM algorithm operating in broadband underwater acoustic signal, on arbitrary sonar array, is derived. In order to verify this method, numerical simulations are conducted to test its performance in localization accuracy, beam width and spatial resolution. During the simulations, a uniform linear array consisting of 96 elements is designed. Additionally, comparisons between the proposed method and conventional beamforming technique are conducted. Comparison results show that the OPM method performs better in spatial directivity and spatial resolution. © 2021 IEEE.

关键词： Covariance matrix

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：