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Chronic exposure to tralopyril induced abnormal growth and calcium regulation of turbot (Scophthalmus maximus)

CheMOSPheRE 2022年 299卷 134405页

作者： Liu, Bin Li, Ping he, shuwen Xing, Shaoying Chen, Chengzhuang Liu, Ling Li, Zhi-Hua Shandong Univ Marine Coll Weihai 264209 Shandong Peoples R China

Tralopyril is an emerging marine antifouling agent with limited data on its effects on fish growth and calcium regulation. To determine the changes induced by long-term exposure to tralopyril, multi-levels (such as molecular, biochemical, and individual levels) responses were measured in turbot at different concentrations (1 mu g/ L, 20 mu g/L). The results showed that 1 mu g/L mainly affected the immune response, while 20 mu g/L affected the synthesis and metabolism of steroids and fat. However, different concentrations of tralopyril affected the syn-thesis, secretion and action of parathyroid hormone and growth hormone. The expression of GH/IGF axis gene and the level of growth hormone increased significantly, leading to abnormal growth. The energy tradeoff be-tween immunity and growth at 1 mu g/L tralopyril pressure may inhibit growth. The change of Ca2+ level was accompanied by the disturbance of PTH-related gene expression. The results of molecular docking showed that the disturbance of Ca2+ regulation might be attributed to the inhibition of vitamin D receptor by tralopyril, which affected the vitamin D signaling pathway. This study provides scientific data for the in-depth under-standing and risk assessment of the toxicological effects of tralopyril and reveals the potential threat of tralopyril to environmental health.

关键词： Tralopyril Marine fish RNA-Seq Physiological responses

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Novel sRNA and regulatory genes repressing the adhesion of Salmonella enteritidis exposed to meat-related environment

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FOOD CONTROL 2020年第0期110卷 107030-000页

作者： Hu, Haijing Jia, Kun Wang, Huhu Xu, Xinglian Zhou, Guanghong he, shuwen Nanjing Agr Univ Natl Ctr Meat Qual & Safety Control Nanjing 210095 Peoples R China Nanjing Agr Univ Jiangsu Collaborat Innovat Ctr Meat Prod & Proc Q Nanjing 210095 Peoples R China

Salmonella is the leading cause of infectious disease outbreaks associated with meat products, residual meat particles on food-contact surfaces can influence the biofilm formation of microorganisms. The transcriptional landscape and expression of novel small non-coding RNAs (sRNAs) were investigated during the biofilm formation of S. Enteritidis exposed to meat thawing loss broth (MTLB) in this study. The genes of csgB, adrA and funH were differentially expressed. Notably, a total of nineteen candidate sRNAs predicted to be involved in the regulation of biofilm formation were discovered in S. Enteritidis. Four specific deletion mutants were successfully established, and further investigation indicated that these mutants improved their functions in swimming, swarming, and auto-aggregation, as well as their surface hydrophobicity. Moreover, these novel sRNAs repressed adhesion and biofilm formation of S. Enteritidis on stainless steel and polystyrene surfaces. These findings are beneficial for illustrating the complex regulatory networks of biofilm formation of Salmonella.

关键词： Salmonella enteritidis sRNA Biofthn Inhibition Meat Stress

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Systematic toxicological analysis of the effect of salinity on the physiological stress induced by triphenyltin in Nile tilapia

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AQUATIC TOXICOLOGY 2023年第1期257卷 106441页

作者： Li, Zhi-Hua Xing, Shaoying Li, Ping he, shuwen Cao, Zhihan Wang, Xu Cao, Xuqian Liu, Bin You, Hong Shandong Univ Marine Coll Weihai 264209 Shandong Peoples R China Harbin Inst Technol State Key Lab Urban Water Resources & Environm Harbin 150001 Peoples R China

Triphenyltin (TPT), a synthetic chemical, is prevalent in complex salinity areas, including estuaries and coastal regions. However, current studies on the toxicological effects of TPT relevant to the environment at different salinities are limited. In the study, biochemical, histological, and transcriptional analyses of TPT and salinity alone, or in combination, was performed on the Nile tilapia (Oreochromis niloticus) liver. Nile tilapia exhibited weakened antioxidant defenses and liver damage. Transcriptomic analysis revealed that TPT exposure primarily affected lipid metabolism and immunity;salinity exposure alone particularly affected carbohydrate metabolism;combined exposure primarily immune-and metabolic-related signaling pathways. In addition, the single expo-sure to TPT or salinity induced inflammatory responses by up-regulating the expression of pro-inflammatory cytokines, whereas combined exposure suppressed inflammation by down-regulating pro-inflammatory cyto-kine levels. These findings are beneficial to understand the negative effects of TPT exposure in Nile tilapia in the broad salinity zones and its potential defense mechanisms.

关键词： Triphenyltin Salinity Nile tilapia Systematic toxicological analysis Transcriptome

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Effects of tralopyril on histological, biochemical and molecular impacts in Pacific oyster, Crassostrea gigas

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CheMOSPheRE 2022年 289卷 133157页

作者： Wang, Xu Li, Ping he, shuwen Xing, Shaoying Cao, Zhihan Cao, Xuqian Liu, Bin Li, Zhi-Hua Shandong Univ Marine Coll Weihai 264209 Shandong Peoples R China

Recently, the toxic effects of tralopyril, as a new antifouling biocide, on aquatic organisms have aroused widespread attention about the potential toxicity. However, the mechanism of tralopyril on marine mollusks has not been elaborated clearly. In this study, the histological, biochemical and molecular impacts of tralopyril on adult Crassostrea gigas were investigated. The results indicated that the 96 h LC50 of tralopyril to adult Crassostrea gigas was 911 mu g/L. After exposure to tralopyril (0, 40, 80 and 160 mu g/L) for 6 days, the mantle mucus secretion coverage ratio of Crassostrea gigas was increased with a dose-dependent pattern. Catalase (CAT) activity was significantly increased, amylase (AMS) activity, acid phosphatase (ACP) activity and calcium ion (Ca2+) concentration significantly decreased. Meanwhile, integrated biomarker responses (IBR) index suggested that higher concentrations of tralopyril caused severer damage to Crassostrea gigas. In addition, the mRNA expression levels of biomineralization related genes in the mantle were significantly upregulated. Collectively, this study firstly revealed the histological, biochemical and molecular impacts of tralopyril exposure on adult Crassostrea gigas, which provided new insights for understanding the toxicity of tralopyril in marine mollusks.

关键词： Handling Editor Willie Peijnenburg Tralopyril Marine mollusks IBR Molecular biomarkers

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一类带临界指数的Schr?dinger耦合系统的正基态解

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四川轻化工大学学报（自然科学版） 2021年第3期34卷 94-100页

作者：贺书文四川民族学院理工学院四川康定626001

非线性Schr9dinger耦合系统已成为研究热点,该类系统被广泛应用于数学物理问题中的量子力学、非线性光学等领域。基于Ekeland变分原理和一些分析技巧,研究了一类带临界指数的非线性Schr9dinger耦合系统正基态解的存在性,对定义在无界域... 详细信息

非线性Schr9dinger耦合系统已成为研究热点,该类系统被广泛应用于数学物理问题中的量子力学、非线性光学等领域。基于Ekeland变分原理和一些分析技巧,研究了一类带临界指数的非线性Schr9dinger耦合系统正基态解的存在性,对定义在无界域上与含有临界指数的耦合问题是其中比较困难的部分。首先,建立变分框架与定义Nehari流形和最低能量值,将求该类系统的解转化为求对应能量泛函的临界点。然后,当系统满足一定条件时,验证能量泛函满足山路几何结构,并估计能量值的取值范围。最后,利用集中紧性原理分两种情形得到该类系统非平凡基态解的存在性,同时获得的基态解可以是正基态解,推广了已有的研究结果。

关键词： Schr9dinger耦合系统临界指数 Ekeland变分原理正基态解

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GPR40 AGONISTS

GPR40 AGONISTS

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作者： Iyassu SEBHAT shuwen he Simon MATHIEU

标准号: US20230151037(A1)

This disclosure is directed, at least in part, to GPR40 agonists useful for the treatment of conditions or disorders involving the gut-brain axis. In some embodiments, the GPR40 agonists are gut-restricted compounds. In some embodiments, the GPR40 agonists are full agonists or partial agonists. In some embodiments, the condition or disorder is a metabolic disorder, such as diabetes, obesity, nonalcoholic steatohepatitis (NASH), or a nutritional disorder such as short bowel syndrome.

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Effects of ocean acidification and tralopyril on bivalve biomineralization and carbon cycling: A study of the Pacific Oyster (Crassostrea gigas)

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ENVIRONMENTAL POLLUTION 2022年 313卷 120161页

作者： Wang, Xu Li, Ping Cao, Xuqian Liu, Bin he, shuwen Cao, Zhihan Xing, Shaoying Liu, Ling Li, Zhi-Hua Shandong Univ Marine Coll Weihai 264209 Shandong Peoples R China

The combined effects of emerging pollutants and ocean acidification (OA) on marine organisms and marine ecosystems have attracted increasing attention. However, the combined effects of tralopyril and OA on marine organisms and marine ecosystems remain unclear. In this study, Crassostrea gigas (C. gigas) were exposed to tralopyril (1 mu g/L) and/or OA (PH = 7.7) for 21 days and a 14-day recovery acclimation. To investigate the stress response and potential molecular mechanisms of C. gigas to OA and tralopyril exposure alone or in combination, as well as the effects of OA and/or tralopyril on bivalve biomineralization and marine carbon cycling. The results showed that the combined toxicity was between that of acidification and tralopyril alone. Single or combined exposure activated the general stress defense responses of C. gigas mantle, affected energy metabolism and biomineralization of the organism and the carbon cycle of the marine ecosystem. Moreover, acidification -induced and tralopyril-induced toxicity showed potential recoverability at molecular and biochemical levels. This study provides a new perspective on the molecular mechanisms of tralopyril toxicity to bivalve shellfish and reveals the potential role of tralopyril and OA on marine carbon cycling.

关键词： Crassostrea gigas Tralopyril Ocean acidification Biomineralization Carbon cycle

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A new perspective on endocrine disrupting effects of triphenyltin on marine medaka: From brain transcriptome, gut content metabolome and behavior

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CheMOSPheRE 2022年第Part4期307卷 136190页

作者： he, shuwen Yu, Daode Li, Ping Zhang, Min Xing, Shaoying Liu, Bin Sun, Cuici Liu, Ling Li, Zhi-Hua Shandong Univ Marine Coll Weihai 264209 Shandong Peoples R China Marine Biol Inst Shandong Prov Qingdao 266104 Shandong Peoples R China Qingdao Agr Univ Marine Sci & Engn Coll Qingdao 266109 Shandong Peoples R China Chinese Acad Sci South China Sea Inst Oceanol State Key Lab Trop Oceanog Guangzhou 510301 Peoples R China Shandong Univ Marine Coll Weihai 264209 Peoples R China

Triphenyltin (TPT) is an endocrine contaminant that is often detected in the environment. However, the mechanism of the effects of TPT on biological systems is not fully understood. here we exposed marine medaka (Oryzias melastigma) to TPT for 21 days. Brain transcriptome, intestinal content metabolism group, and behavior analysis were carried out. Through the comprehensive analysis of multiomics for the in-depth understanding of the ways related to health improvement, we determined that the glycine-serine-threonine metabolic axis was most perturbed by TPT. Through behavioral analysis, it was found that there was behavioral hyperactivity in the exposed group;behavioral hyperactivity may be caused by the interference of TPT with the neuroendocrine system. In order to gain a full understanding of the impacts of TPT on human health, transcriptomic screening of differential genes and an impartial attitude based on bioinformatics were used. Gene-disease interaction analysis using the Comparative Toxicogenomics Database (CTD) revealed the possible effects of TPT on human health. Finally, based on these findings, the relevant adverse outcome pathway (AOP), which is the "epigenetic modi-fication of PPARG leading to adipogenesis," was identified from AOP Wiki. Further research is required to validate the potential AOP of TPT.

关键词： Triphenyltin Adverse outcome pathway (AOP) Transcriptomics Marine medaka

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Effects of short-term exposure to tralopyril on physiological indexes and endocrine function in turbot (Scophthalmus maximus)

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AQUATIC TOXICOLOGY 2022年 245卷 106118-106118页

作者： Liu, Bin Li, Ping he, shuwen Xing, Shaoying Cao, Zhihan Cao, Xuqian Wang, Xu Li, Zhi-Hua Shandong Univ Marine Coll Weihai 264209 Shandong Peoples R China

Tralopyril is an emerging marine antifouling agent with potential toxic effects on non-target aquatic organisms. To evaluate the toxicity of tralopyril, to turbot (Scophthalmus maximus), we assessed biomarkers, including oxidative stress, neumtoxicity, and osmotic homeostasis regulation enzymes, after a 7-day exposure to tralopyril (5 mu g/L, 15 mu g/L, 30 mu g/L). Superoxide dismutase activity was significantly decreased at 30 mu g/L, and Ca2+-Mg2+-ATPase activity in the gills was significantly increased at 15 mu g/L and 30 mu g/L. No statistically significant differences in the responses of acetylcholinesterase and nitric oxide were detected. In addition, 15 mu g/L and 30 mu g/L tralopyril induced hyperthyroidism, reflected by significantly increased of T3 levels. The expression levels of hypothalamus-pituitary-thyroid axis-related genes were also upregulated. The molecular docking results showed that the thyroid system disruption was not caused by competitive binding to the receptor. In addition, the integrated biomarker response index showed that 15 mu g/L tralopyril had the greatest effect on turbot. In general, tralopyril caused oxidative damage, affected energy metabolism, and interfered with the endocrine system. These findings could provide reference data for assessing the ecological risk of tralopyril in marine environments.

关键词： Tralopyril Marine fish Physiological stress Integrated biomarker responses Molecular docking

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AMPK ACTIVATORS

AMPK ACTIVATORS

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作者： Iyassu SEBHAT shuwen he

标准号: US20220340599(A1)

This disclosure is directed, at least in part, to AMPK activators useful for the treatment of conditions or disorders associated with AMPK. In some embodiments, the condition or disorder is associated with the gut-brain axis. In some embodiments, condition or disorder is associated with systemic infection and inflammation from having a leaky gut barrier. In some embodiments, the AMPK activators are gut-restricted compounds. In some embodiments, the AMPK activators are agonists, super agonists, full agonists, or partial agonists.

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