Tissue engineering for a long time has been recognized as a promising alternative to donor tissues which often demand exceeding *** acceptance is that biologic function lost in host tissues will be able to be restored...
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Tissue engineering for a long time has been recognized as a promising alternative to donor tissues which often demand exceeding *** acceptance is that biologic function lost in host tissues will be able to be restored and maintained by tissue *** various structures of engineered tissue scaffolds have been developed for tissue substitute,the goal of producing a clinically useful tissue scaffold is still far from being *** ideal tissue-engineered scaffold should be mechanically stable and
By a scaffold elongation strategy, a series of (Z)-3-(5-(3-benzyl-4-oxo-2-thioxothiazolidinylidene)methyl)-N-(3-carboxy-4-hydroxy)phenyl-2,5-dimethylpyrroles and related derivatives with a linear multi-aromatic-ring s...
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By a scaffold elongation strategy, a series of (Z)-3-(5-(3-benzyl-4-oxo-2-thioxothiazolidinylidene)methyl)-N-(3-carboxy-4-hydroxy)phenyl-2,5-dimethylpyrroles and related derivatives with a linear multi-aromatic-ring skeleton were designed, synthesized, and evaluated in HIV-1 gp41 and cellular assays. Among them, the most active compounds, 12e, 12g, and 12k with a one-carbon linker (n = 1) between the rhodanine (C) and phenyl (D) rings, exhibited very promising inhibitory potency with IC50 values of 1.8-2.6 mu M and EC50 values of 0.3-1.5 mu M against gp41 6-HB formation and HIV-1 replication in MT-2 cells, respectively. Additionally, they were almost equally effective against both T20-sensitive and resistant strains. The related SAR studies and molecular modeling results provided potential for further developing a new class of non-peptide small molecular fusion inhibitors targeting the HIV-1 gp41. (C) 2013 Elsevier Ltd. All rights reserved.
For the basic requirements of power system operation of security, high quality, economy, environmental protection, a multi-objective optimal power flow(MOPF) model is established to minimize three objective functions ...
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For the basic requirements of power system operation of security, high quality, economy, environmental protection, a multi-objective optimal power flow(MOPF) model is established to minimize three objective functions of load buses voltage deviations, network active power loss, pollution gas emissions and meanwhile to satisfy the security constraints of power transmission limits in lines. The normal boundary intersection method (NBI) is adopted to transform three-objective optimal power flow model into a series of single-objective optimization model, and then the interior point method is used to obtain the evenly distributed Pareto frontier in objective functions space. According to fuzzy membership and entropy weight of various targets, the comprehensive compromise optimal solution can be identified from the Pareto frontier surface, which is employed as the operation dispatching scheme of the system. By the multi-objective optimization calculation of the IEEE 9-buses system and the IEEE 39-buses system, the results validate the effectiveness of the proposed model and algorithm, and indicate that the comprehensive compromised optimal solution can be used as an optimal dispatching scheme of power system operation.
The shortages of the present method of data processing of flocculating sedimentation are pointed out and analyzed in this study. A new method of data processing is put forward and the advantages of this new method are...
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ISBN:
(纸本)9783037855386
The shortages of the present method of data processing of flocculating sedimentation are pointed out and analyzed in this study. A new method of data processing is put forward and the advantages of this new method are discussed. Compared to the conventional method, the isolines of partial removal efficiency need not to be drawn when the new method is employed and the new method is straightforward, practical and accurate and it is worth to be popularized.
Hybrid α-Fe2O3/MWCNT nanostructures were prepared via the hydrolysis of ferric nitrate in the presence of MWCNTs. The amount of deposited α-Fe2O3, which influences the nanoparticle size and coverage density, was tun...
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