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Comparison of deep learning-assisted blinking analysis system and Lipiview interferometer in dry eye patients: a cross-sectional study

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EYE AND VISION 2024年第1期11卷 1页

作者： Ren, Yueping Wen, Han Bai, Furong Huang, Binge Wang, Zhenzhen Zhang, shuwen Pu, Yaojia Le, Zhenmin Gong, Xianhui Wang, Lei Chen, wei Zheng, Qinxiang Wenzhou Med Univ Eye Hosp Natl Clin Res Ctr Ocular Dis Wenzhou 325027 Zhejiang Peoples R China Wenzhou Med Univ Sch Ophthalmol & Optometry 270 Xueyuan West Rd Wenzhou 325027 Zhejiang Peoples R China

BackgroundAbnormal blinking pattern is associated with ocular surface diseases. However, blink is difficult to analyze due to the rapid movement of eyelids. Deep learning machine (DLM) has been proposed as an optional tool for blinking analysis, but its clinical practicability still needs to be proven. Therefore, the study aims to compare the DLM-assisted Keratograph 5M (K5M) as a novel method with the currently available Lipiview in the clinic and assess whether blinking parameters can be applied in the diagnosis of dry eye disease (DED).MethodsThirty-five DED participants and 35 normal subjects were recruited in this cross-sectional study. DED questionnaire and ocular surface signs were evaluated. Blinking parameters including number of blinks, number of incomplete blinking (IB), and IB rate were collected from the blinking videos recorded by the K5M and Lipiview. Blinking parameters were individually collected from the DLM analyzed K5M videos and Lipiview generated results. The agreement and consistency of blinking parameters were compared between the two devices. The association of blinking parameters to DED symptoms and signs were evaluated via *** total, 140 eyes of 70 participants were included in this study. Lipiview presented a higher number of IB and IB rate than those from DLM-assisted K5M (P <= 0.006). DLM-assisted K5M captured significant differences in number of blinks, number of IB and IB rate between DED and normal subjects (P <= 0.035). In all three parameters, DLM-assisted K5M also showed a better consistency in repeated measurements than Lipiview with higher intraclass correlation coefficients (number of blinks: 0.841 versus 0.665;number of IB: 0.750 versus 0.564;IB rate: 0.633 versus 0.589). More correlations between blinking parameters and DED symptoms and signs were found by DLM-assisted K5M. Moreover, the receiver operating characteristic analysis showed the number of IB from K5M exhibiting the highest area under curve of 0.773.C

关键词： Incomplete blinking Deep learning model Dry eye disease

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Association between serum sodium and 28-day mortality in sepsis patients: A secondary data analysis from three large critical illness cohorts

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THERAPEUTIC APHERESIS AND DIALYSIS 2024年第1期28卷 96-102页

作者： Li, wei Li, shuwen Yuan, Jia Chen, Xianjun Chen, Qimin Xiao, Chuan Li, Qing Li, Lu Liu, Ying He, Juan Chen, Lu Shen, Feng Guizhou Med Univ Affiliated Hosp Dept Crit Care Med Guiyang Peoples R China Guizhou Med Univ Affiliated Hosp Dept Res Guiyang Peoples R China Guizhou Med Univ Affiliated Hosp Dept Crit Care Med Guiyang 550001 Peoples R China

Objective: The present study was designed to explore the association between serum sodium and mortality in patients with sepsis by using a large sample, multicenter MIMIC-IV ***: We extracted the data of 34 925 sepsis patients from the retrospective cohort mimicIV database. After adjusting the confounders, we explored the independent effects of serum sodium on 28-day ***: A nonlinear relationship existed between serum sodium and 28-day mortality, of which a negative association was found between serum sodium and 28-day mortality (odds ratio: 0.95, 95% CI: 0.94, 0.96, p = 0.0001) when serum sodium was in 102 mmol/L to 138 mmol/L, but a positive correlation appeared when sodium climbed to the range of 140-179 mmol/L (odds ratio: 1.04, 95% CI: 1.03-1.06, p = 0.0001).Conclusions: Both lower and higher serum sodium levels are associated with an increased risk of death in sepsis patients.

关键词： 28-day mortality sepsis serum sodium

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IMAGE STEGANALYSIS WITH CONVOLUTIONAL VISION TRANSFORMER 47

IMAGE STEGANALYSIS WITH CONVOLUTIONAL VISION TRANSFORMER

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47th IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP)

作者： Luo, Ge wei, Ping Zhu, shuwen Zhang, Xinpeng Qian, Zhenxing Li, Sheng Fudan Univ Sch Comp Sci Shanghai Peoples R China

ISBN: (纸本)9781665405409

Recent research has shown that deep learning based methods offer more accurate detection for image steganalysis than the traditional detection paradigm based on rich media models. Existing network architectures based on deep learning, however, stack more and more convolutional layers to increase local receptive fields for image stegananlysis. Limited by hardware, the detector with several convolutional layers may not extract features of steganography images from a global perspective effectively. In this paper, we propose a Convolutional Vision Transformer for image stegananlysis, which can capture both local and global dependencies among noise features. In image processing phase, our network preserves CNN frame for its capacity of producing image noise residuals. Different from previous methods, we utilize the attention mechanism of vision transformer for feature extraction and classification. The proposed network is validated on two public image datasets (BOSSbase 1.01 and ALASKA #2). Experimental results demonstrate that our network performs well over fixed-size dataset and arbitrary-size dataset.

关键词： Stegananlysis deep leraning convolutional vision transformer

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Ion channel Piezo1 activation aggravates the endothelial dysfunction under a high glucose environment

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CARDIOVASCULAR DIABETOLOGY 2024年第1期23卷 150页

作者： Zhang, Xiaoyu Leng, Shaoqiu Liu, Xinyue Hu, Xiang Liu, Yan Li, Xin Feng, Qi Guo, wei Li, Nailin Sheng, Zi Wang, shuwen Peng, Jun Shandong Univ Qilu Hosp Cheeloo Coll Med Dept Hematol Jinan Peoples R China Chinese Acad Med Sci & Peking Union Med Coll Inst Hematol Natl Clin Res Ctr Blood Dis State Key Lab Expt Hematol Tianjin Peoples R China Chinese Acad Med Sci & Peking Union Med Coll Blood Dis Hosp Tianjin Peoples R China Shandong Univ Adv Med Res Inst Jinan Peoples R China Shandong Univ Qilu Hosp Cheeloo Coll Med Shandong Key Lab Immunochematol Jinan Peoples R China Shandong Univ Natl Key Lab Innovat & Transformat Luobing Theory Jinan Peoples R China Shandong Univ Key Lab Cardiovasc Remodeling & Funct Res Chinese Minist Educ Chinese Natl Hlth CommissQilu HospCheeloo Coll M Jinan Peoples R China Shandong Univ Qilu Hosp Chinese Acad Med Sci Cheeloo Coll Med Jinan Peoples R China Zhejiang Univ Affiliated Hosp 1 Inst Hematol Sch Med Hangzhou 310029 Peoples R China Karolinska Inst Dept Med Solna Cardiovasc Med Unit Stockholm Sweden

Background Vasculopathy is the most common complication of diabetes. Endothelial cells located in the innermost layer of blood vessels are constantly affected by blood flow or vascular components;thus, their mechanosensitivity plays an important role in mediating vascular regulation. Endothelial damage, one of the main causes of hyperglycemic vascular complications, has been extensively studied. However, the role of mechanosensitive signaling in hyperglycemic endothelial damage remains *** Vascular endothelial-specific Piezo1 knockout mice were generated to investigate the effects of Piezo1 on Streptozotocin-induced hyperglycemia and vascular endothelial injury. In vitro activation or knockdown of Piezo1 was performed to evaluate the effects on the proliferation, migration, and tubular function of human umbilical vein endothelial cells in high glucose. Reactive oxygen species production, mitochondrial membrane potential alternations, and oxidative stress-related products were used to assess the extent of oxidative stress damage caused by Piezo1 *** Our study found that in VECreERT2;Piezo1flox/flox mice with Piezo1 conditional knockout in vascular endothelial cells, Piezo1 deficiency alleviated streptozotocin-induced hyperglycemia with reduced apoptosis and abscission of thoracic aortic endothelial cells, and decreased the inflammatory response of aortic tissue caused by high glucose. Moreover, the knockout of Piezo1 showed a thinner thoracic aortic wall, reduced tunica media damage, and increased endothelial nitric oxide synthase expression in transgenic mice, indicating the relief of endothelial damage caused by hyperglycemia. We also showed that Piezo1 activation aggravated oxidative stress injury and resulted in severe dysfunction through the Ca2+-induced CaMKII-Nrf2 axis in human umbilical vein endothelial cells. In Piezo1 conditional knockout mice, Piezo1 deficiency partially restored superoxide dismutase activity and reduced malondia

关键词： Piezo1 Endothelial dysfunction Hyperglycemia Oxidative stress Nrf2

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Atomic Cluster Outperforms Single Atom in Hydrogen Evolution and Hydrazine Oxidation for Energy-Efficient Water Splitting

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ADVANCED FUNCTIONAL MATERIALS 2025年第19期35卷

作者： Liu, Chunhua Wu, shuwen Yang, Yang wei, Jinshan Chen, Shujing Sun, Xiao-Qing Luo, Shuiping Hussain, Muhammad Bilal Feng, Renfei Fu, Xian-Zhu Liu, Shao-Qing Luo, Jing-Li Shenzhen Univ Coll Mat Sci & Engn Guangdong Res Ctr Interfacial Engn Funct Mat Shenzhen Key Lab Energy Electrocatalyt Mat Shenzhen 518055 Guangdong Peoples R China Shenzhen Univ Coll Phys & Optoelect Engn Shenzhen 518060 Guangdong Peoples R China Univ Toronto Dept Mat Sci & Engn 184 Coll St Toronto ON M5S 3E4 Canada Canadian Light Source Inc 44 Innovat Blvd Saskatoon SK S7N 0X4 Canada

The hydrazine-assisted water splitting (HzAWS) is promising for energy-saving hydrogen production. However, developing efficient bifunctional catalysts that exert hydrogen evolution reaction (HER) and hydrazine oxidation reaction (HzOR) at industrial-grade current densities remains challenging. Here, RuC-NiCoP catalyst, ruthenium clusters (RuC) immobilized onto NiCoP, is developed to elucidate the superior performance of RuC in enhancing bifunctional electrocatalytic activity over ruthenium single atoms (RuSA). The RuC-NiCoP achieves current densities of 10 and 100 mA cm-2 for HER and HzOR with working potentials of -10 and -89 mV, respectively, outperforming RuSA-NiCoP (-16 and -65 mV). During HzAWS, a cell voltage reduction of 1.77 V at 300 mA cm-2 is observed compared to overall water splitting. Density functional theory calculations reveal that RuC improves the adsorption energy for H2O and N2H4, optimizes the H* intermediate desorption, and reduces the dehydrogenation barrier from *N2H3 to *N2H2. Additionally, the direct hydrazine fuel cell with a RuC-NiCoP anode delivers an impressive power density of 226 mW cm-2 and enables a self-powered hydrogen production system, achieving an unprecedented hydrogen production rate of 4.9 mmol cm-2 h-1. This work offers a new perspective on developing efficient sub-nanoscale bifunctional electrocatalysts and advancing practical energy-saving hydrogen production techniques.

关键词： direct hydrazine fuel cell hydrazine oxidation ruthenium cluster self-powered hydrogen production

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CPI-203 improves the efficacy of anti-PD-1 therapy by inhibiting the induced PD-L1 overexpression in liver cancer

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CANCER SCIENCE 2022年第1期113卷 28-40页

作者： Niu, Xiaoge Wang, wei Liang, Taizhen Li, Shasha Yang, Chan Xu, Xinfeng Li, Lin Liu, shuwen Southern Med Univ Sch Pharmaceut Sci Guangdong Prov Key Lab New Drug Screening Guangzhou 510515 Peoples R China Southern Med Univ Zhujiang Hosp Dept Special Med Serv Ctr Guangzhou Peoples R China Southern Med Univ Guangdong Prov Inst Nephrol State Key Lab Organ Failure Res Guangzhou Peoples R China

Hepatocellular carcinoma (HCC) is one of the commonest lethal malignancies worldwide, and often diagnosed at an advanced stage, without any curative therapy. Immune checkpoint blockers targeting the programmed death receptor 1 (PD-1) have shown impressive antitumor activity in patients with advanced-stage HCC, while the response rate is only 30%. Inducible PD-L1 overexpression may result in a lack of response to cancer immunotherapy, which is attributed to a mechanism of adaptive immune resistance. Our study investigated that the overexpression of PD-L1 promoted the invasion and migration of liver cancer cells in vitro, and the induced overexpression of PD-L1 in the tumor microenvironment could weaken the effects of anti-PD-1 immunotherapy in a BALB/c mouse model of liver cancer. CPI-203, a small-molecule bromodomain-containing protein 4 (BRD4) inhibitor, which can potently inhibit PD-L1 expression in vitro and in vivo, combined with PD-1 antibody improved the response to immunotherapy in a liver cancer model. Cell transfection and chromatin immunoprecipitation assay manifested that BRD4 plays a key role in PD-L1 expression;CPI-203 can inhibit PD-L1 expression by inhibiting the BRD4 occupation of the PD-L1 promoter region. This study indicates a potential clinical immunotherapy method to reduce the incidence of clinical resistance to immunotherapy in patients with HCC.

关键词： BRD4 inhibitor IFN-gamma immunotherapy liver cancer PD-L1

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Prognosis of colon cancer patients based on enhancer RNAs-related genes

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JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 2023年第13期149卷 12443-12457页

作者： Han, Xinhao Tian, wei Sun, Lin Wang, Hongying Li, Yan Jia, Huixun Gao, Guohong Mai, Liudan Yin, shuwen Zhang, Qiuju Liu, Yanlong Harbin Med Univ Sch Publ Hlth Dept Biostat 157 Baojian Rd Harbin 150081 Heilongjiang Peoples R China Shanghai Jiao Tong Univ Shanghai Peoples Hosp 1 Dept Ophthalmol Sch Med Shanghai Peoples R China Harbin Med Univ Dept Colorectal Surg Canc Hosp 150 Haping Rd Harbin 150081 Heilongjiang Peoples R China

PurposeColon cancer (CC) is a cancer of the large intestine with high prevalence and poor prognosis. enhancer RNAs. Therefore, valuable tools or biomarkers for predicting patient status, directing clinical practice, and reducing overtreatment are needed. Enhancer RNAs (eRNAs), a class of noncoding RNAs transcribed from enhancers, have been shown to function as regulators of oncogene or tumor suppressor gene expression. The aim of our study was to explore the potential roles of eRNAs and their target enhancer-related genes (ERGs) in the prognosis of *** CC cases (stage I-III) from The Cancer Genome Atlas database were used as a training set, and cases from the Gene Expression Omnibus were used as the validation set. ERGs associated with prognosis were screened through three steps: potential, candidate, and prognosis ERGs. Multivariate Cox proportional hazards analysis was used to identify independent prognostic factors, and a nomogram was created. Calibration curves were drawn by comparing predicted and observed survival probability. For validation, the calibration curves and ROC analysis were also applied to two external validation sets. The biological significance and clinical application of the genes obtained were *** on the multiple tiers of strict screening, 11 prognostic ERGs were obtained, which were combined to obtain a prognosis signature. A compound nomogram integrating age, TNM classification, and the prognostic signature was constructed. The model was reliable in distinguishing the risk of patients with stage I-III CC, with AUCs of 0.78 and 0.70 at 5 and 7 years, respectively. There was good reproducibility in calibration curves. The prognostic model also yielded good prediction capability in the validation *** this study, the usefulness and specificity of the ERGs in prognosis were described, which should be considered a key feature in the clinical guidance of CC patients with early stage. We concluded t

关键词： Enhancer RNA Super-enhancer RNA Enhancer-related genes CC Prognosis

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Molecular dynamics simulation on micro-explosion of water-in-oil droplets in presence of solid particles or electric field

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INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER 2022年 196卷

作者： wei, Mingrui Yang, shuwen Ju, Hongling Guo, Guanlun Wuhan Univ Technol Hubei Key Lab Adv Technol Automot Components Wuhan 430070 Peoples R China Wuhan Univ Technol Hubei Collaborat Innovat Ctr Automot Components Te Wuhan 430070 Peoples R China

The effects of solid particles or external electric field on the whole micro-explosions, especially bub-ble nucleation, were explored by molecular dynamics simulation. The corresponding reasons are also re-vealed. For this purpose, a water-in-oil droplet in nitrogen environment were constructed and the whole micro-explosion processes were simulated. Bubble nucleation time and nucleation temperature were es-timated and compared with the cases in presence of solid particles or an electric field. The energy, force and coordination number of the water sub-droplet were explored to clarify the effects of the solid parti-cles or an electric field. Results indicate that the presence of solid particles or an electric field can shorten the nucleation time and lower nucleation temperature, which are effective ways to control the micro -explosion process. Adding solid particles can weaken the potential restriction on water molecules, which much facilitates water molecules evaporations, and the effect is positive correlation with solid particle sizes. The effect of an external electric field on micro-explosion is essentially caused by the reduction of electrostatic potential. In the alternating electric field case, the reason for the faster temperature rise and the shorter nucleation time is that the sinusoidal change of the electrostatic force.(c) 2022 Elsevier Ltd. All rights reserved.

关键词： Micro-explosion Solid particles Electric field Molecular dynamics simulation

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钴酸锂智能电池管理系统的FPGA实现

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电测与仪表 2019年第4期56卷 43-47页

作者：魏淑稳杨玉华单彦虎焦新泉中北大学仪器科学与动态测试教育部重点实验室太原030051 中北大学电子测试技术国家重点实验室太原030051

针对飞行器地面控制设备锂离子电池组的智能管理系统实现复杂、可靠性差问题,研究了基于FPGA的结构简单、可靠性高的锂离子电池智能管理系统。该智能电池管理系统的被动平衡管理模块能自动处理电池过冲过放问题,提供精准的满电停充标志... 详细信息

针对飞行器地面控制设备锂离子电池组的智能管理系统实现复杂、可靠性差问题,研究了基于FPGA的结构简单、可靠性高的锂离子电池智能管理系统。该智能电池管理系统的被动平衡管理模块能自动处理电池过冲过放问题,提供精准的满电停充标志;采用改进的安时积分法进行SOC测量,充分考虑电池的老化情况。经试验测试,智能电池管理系统的SOC模块能够达到专业的电池管理芯片容量测算精度,平衡管理模块能够有效延长电池使用时间,有效抑制过冲。

关键词：锂离子电池组智能电池管理系统 FPGA 被动平衡安时积分法

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Suture Maps Based on Structural Enhanced Imaging Endoscope for Laparoscopic Robotic Surgery

Suture Maps Based on Structural Enhanced Imaging Endoscope f...

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Conference on Lasers and Electro-Optics (CLEO)

作者： Le, Hanh N. D. wei, shuwen Leonard, Simon Opfermann, Justin Krieger, Axel Kang, Jin U. Johns Hopkins Univ Dept Elect & Comp Engn 3400 North Charles St Baltimore MD 21218 USA Johns Hopkins Univ Dept Comp Sci 3400 North Charles St Baltimore MD 21218 USA Childrens Natl Hlth Syst Sheikh Zayed Inst Pediat Surg Innovat 111 Michigan Ave NW Washington DC 20010 USA Univ Maryland Dept Mech Engn College Pk MD 20742 USA

A detection method for cutting scheme in 3D is proposed to assist robotic surgical manipulation, leading to an automatic suturing suggestion mapping.

ISBN: (纸本)9781943580422

A detection method for cutting scheme in 3D is proposed to assist robotic surgical manipulation, leading to an automatic suturing suggestion mapping.

关键词： Camera calibration Edge detection LED sources Near infrared radiation Structured illumination microscopy Three dimensional reconstruction

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