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27th International Symposium on Design & Diagnostics of Electronic Circuits & Systems (DDECS)

作者： Pan, Jie Li, Fanyang Yuan, Yidong Zhao, Tianting Shen, Hongwei Wen, Liguo Hu, Yi Jin, Jiazhen wu, shuwen Beijing Smart Chip Microelect Technol Co Ltd Beijing Peoples R China Fuzhou Univ Coll Phys & Informat Engn Fuzhou Peoples R China

ISBN: (纸本)9798350359343

This paper proposes a low-noise high-voltage rail-to-rail operational amplifier based on BCD process. For the protection of low-voltage devices in input stage, this paper proposes a common-mode voltage following circuit which not only realizes the stable performance of low-voltage input devices but also improves the gain under full supply voltage. In order to improve the response speed of large signals, this paper proposes a dynamic slew-rate enhancement technology to achieve the characteristics of low quiescent current and large slew-rate. Besides, this paper optimized the low-frequency noise of the proposed architecture. The circuit uses 180nmBCD process, and the simulation results show that after applying the above technology, the supply voltage range is 3.5-36 V, the quiescent current is about 0.99 mA, the equivalent input noise is 0.82 uVp-p, the slew-rate is 15.2 V/us, the setting time is 0.66 us and the open loop gain is 135 dB in full supply voltage range.

关键词： operational amplifier input stage protection slew-rate enhancement

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Single Cu-N4 sites enable atomic Fe clusters with high-performance oxygen reduction reactions

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ENERGY & ENVIRONMENTAL SCIENCE 2023年第8期16卷 3576-3586页

作者： wu, shuwen Jiang, Shang Liu, Shao-Qing Tan, Xuehai Chen, Ning Luo, Jing-Li Mushrif, Samir H. Cadien, Ken Li, Zhi Univ Alberta Dept Chem & Mat Engn Edmonton AB T6G 2V4 Canada Canadian Light Source Hard Xray Microanal BL 44 Innovat Blvd Saskatoon SK S7N 2V3 Canada

Atomically dispersed Fe-N-4 catalysts have proven to be promising alternatives to commercial Pt/C for the oxygen reduction reaction. Most reported Fe-N-4 catalysts suffer from inferior O-O bond-breaking capabilities due to superoxo-like O-2 adsorption, though the isolated dual-atomic metal site strategy is extensively adopted. Atomic Fe clusters show greater promise for promoting O-O bond cleavage by undergoing peroxo-like O-2 adsorption. However, the excessively strong binding strength between Fe clusters and oxygenated intermediates sacrifices the activity. Here, we first report a Fe-x/Cu-N@CF catalyst with atomic Fe clusters functionalized by adjacent single Cu-N-4 sites anchored on a porous carbon nanofiber membrane. Theoretical calculation indicates that the single Cu-N-4 sites can modulate the electronic configuration of Fe clusters to reduce the O-2* protonation reaction free energy which ultimately enhances the electrocatalytic performance. In particular, the Cu-N-4 sites can increase the overlap between the d orbitals of Fe and p orbitals of O to accelerate O-O cleavage in OOH*. As a result, this unique atomic catalyst exhibits a half potential (E-1/2) of 0.944 V in alkaline medium, exceeding that of commercial Pt/C, whereas its acidic performance E-1/2 = 0.815 V is comparable to that of Pt/C. This work shows the great potential of single atoms for improvements in atomic cluster catalysts.

关键词： Electrolytic reduction

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A coupled electrocatalytic system with reduced energy input for CO2 reduction and biomass valorization

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ENERGY & ENVIRONMENTAL SCIENCE 2023年第11期16卷 5305-5314页

作者： Liu, Shao-Qing Gao, Min-Rui wu, shuwen Feng, Renfei Wang, Yicheng Cui, Linfang Guo, Ying Fu, Xian-Zhu Luo, Jing-Li Shenzhen Univ Coll Mat Sci & Engn Guangdong Res Ctr Interfacial Engn Funct Mat Shenzhen Key Lab Energy Electrocatalyt MatShenzhe Shenzhen 518060 Peoples R China Univ Alberta Dept Chem & Mat Engn Edmonton AB T6G 1H9 Canada Canadian Light Source Inc Saskatoon SK S7N 0X4 Canada

Coupling the cathodic electrochemical CO2 reduction (eCO(2)RR) with the anodic electrochemical 5-hydroxymethylfurfural oxidation reaction (HMFOR) is an appealing approach to co-produce value-added chemicals and simultaneously lower the energy input, while the main challenge is to develop effective electrocatalysts for eCO(2)RR and HMFOR. Inspired by the techno-economic analysis, we herein report a coupling system for economical formate generation and biomass valorization by concurrent cathodic eCO(2)RR and anodic HMFOR. Single Cu atom doped Bi (Cu1Bi) and NiCo layer doubled hydroxides (NiCo LDHs) are used as the cathodic and anodic catalysts, respectively. Due to the accelerated water dissociation, the Cu1Bi cathode catalyst demonstrated remarkably high activity (j(formate) > 1 A cm(-2)) for formate conversion as well as robust stability (200 mA cm(-2) for 45 h). Meanwhile, the NiCo LDH anode displays high activity for HMF electrooxidation to 2,5-furandicarboxylic acid with a faradaic efficiency of over 95% at low potential. Consequently, the paired eCO(2)RR-HMFOR system reduces the electricity input for the eCO(2)RR-to-formate conversion to similar to 3493 kW h per tonne of formate, corresponding to 22.9% in energy saving compared to the conventional eCO(2)RR (similar to 4528 kW h per tonne of formate). This study offers an appealing route for CO2 reduction and biomass valorization with low energy consumption.

关键词： Binary alloys

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CD226 knockout reduces the development of CD8+T by impairing the TCR sensitivity of double-positive thymocytes

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IMMUNOLOGY 2023年第1期169卷 83-95页

作者： Ma, Jingchang Liu, Yitian Duan, Chujun wu, shuwen Xie, Yang Yang, Lu Li, Xuemei Wang, Yuling Zhang, Yuan Zhuang, Ran Fourth Mil Med Univ Dept Immunol 169 West Changle Rd Xian 710032 Shaanxi Peoples R China Northwestern Polytech Univ Inst Med Res 127 West Youyi Rd Xian 710072 Shaanxi Peoples R China

The costimulation molecule CD226 is widely involved in T cell differentiation, activation and immune functional regulation in peripheral immune tissues. CD226-deficient mice have impaired immune response capacity. The function of CD226 in regulating T cell development in the thymus, a central immune organ, is not yet fully understood. We investigated the development of thymocytes using CD226 knockout mice and single-cell sequencing techniques. CD226 began to be expressed in the second half of thymocyte development, with a gradual increase from the double-positive (DP) to single-positive (SP) phase and higher levels of CD226 on CD8+ T cells than on CD4+ T cells from the SP phase to mature T cells. In the thymus of CD226KO mice, the proportion of DPT at the quiescent phase (DPT-Q) increased, of which the Gzma+ cluster that tends to be CD8+ T cells and CD5+ cluster that is undergoing positive selection decreased dramatically. Afterward, the proportion of mature CD8+ T cells reduced dramatically. Depletion of CD226 impaired TCR activation signalling and diminished AKT/ERK/NF-kappa B/p38 phosphorylation levels. The diminished TCR responsiveness of DPT cells impeded their positive selection process and influenced the maturation of CD8+ T cells. In mechanism, CD226 knockout enhanced DPT cell apoptosis via impairing AKT phosphorylation. These results suggest that CD226 plays a significant role in T cell thymic development via modulation of TCR signalling, affecting CD8+ T cell maturation.

关键词： CD226 CD8+T cell positive selection single-cell sequencing thymocytes

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Atomic Cluster Outperforms Single Atom in Hydrogen Evolution and Hydrazine Oxidation for Energy-Efficient Water Splitting

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ADVANCED FUNCTIONAL MATERIALS 2025年第19期35卷

作者： Liu, Chunhua wu, shuwen Yang, Yang Wei, Jinshan Chen, Shujing Sun, Xiao-Qing Luo, Shuiping Hussain, Muhammad Bilal Feng, Renfei Fu, Xian-Zhu Liu, Shao-Qing Luo, Jing-Li Shenzhen Univ Coll Mat Sci & Engn Guangdong Res Ctr Interfacial Engn Funct Mat Shenzhen Key Lab Energy Electrocatalyt Mat Shenzhen 518055 Guangdong Peoples R China Shenzhen Univ Coll Phys & Optoelect Engn Shenzhen 518060 Guangdong Peoples R China Univ Toronto Dept Mat Sci & Engn 184 Coll St Toronto ON M5S 3E4 Canada Canadian Light Source Inc 44 Innovat Blvd Saskatoon SK S7N 0X4 Canada

The hydrazine-assisted water splitting (HzAWS) is promising for energy-saving hydrogen production. However, developing efficient bifunctional catalysts that exert hydrogen evolution reaction (HER) and hydrazine oxidation reaction (HzOR) at industrial-grade current densities remains challenging. Here, RuC-NiCoP catalyst, ruthenium clusters (RuC) immobilized onto NiCoP, is developed to elucidate the superior performance of RuC in enhancing bifunctional electrocatalytic activity over ruthenium single atoms (RuSA). The RuC-NiCoP achieves current densities of 10 and 100 mA cm-2 for HER and HzOR with working potentials of -10 and -89 mV, respectively, outperforming RuSA-NiCoP (-16 and -65 mV). During HzAWS, a cell voltage reduction of 1.77 V at 300 mA cm-2 is observed compared to overall water splitting. Density functional theory calculations reveal that RuC improves the adsorption energy for H2O and N2H4, optimizes the H* intermediate desorption, and reduces the dehydrogenation barrier from *N2H3 to *N2H2. Additionally, the direct hydrazine fuel cell with a RuC-NiCoP anode delivers an impressive power density of 226 mW cm-2 and enables a self-powered hydrogen production system, achieving an unprecedented hydrogen production rate of 4.9 mmol cm-2 h-1. This work offers a new perspective on developing efficient sub-nanoscale bifunctional electrocatalysts and advancing practical energy-saving hydrogen production techniques.

关键词： direct hydrazine fuel cell hydrazine oxidation ruthenium cluster self-powered hydrogen production

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Spirometra mansoni sparganosis identified by metagenomic next-generation sequencing: a case report

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INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES 2023年 128卷 128-131页

作者： Hu, Diefei Jin, Wenxiang Ding, Huarong Pang, Yu Ma, Shasha Yang, Min wu, shuwen Jiang, Muliang Pang, Lingling Luo, Shuming Ning, Qiuyue Guangxi Med Univ Dept Infect Dis Affiliated Hosp 1 Nanning Peoples R China KingMed Diagnost Guangzhou Peoples R China Guangxi Med Univ Dept burns & plast Surg Affiliated Hosp 1 Nanning Peoples R China Guangxi Med Univ Dept Radiol Affiliated Hosp 1 Nanning Peoples R China Guangxi Med Univ Dept Pathol Affiliated Hosp 1 Nanning Peoples R China Infect Dis Sect Second Nanning Peoples Hosp Nanning Peoples R China

A 30-year-old male patient had a cyst on the left hip and progressive enlargement for more than 2 months. Combined blood tests, magnetic resonance imaging, and pathology findings, cysticercosis infec-tion was suspected. However, the treatment for cysticercosis was ineffective. We conducted a metage-nomic next-generation sequencing (mNGS) analysis on the formalin-fixed, paraffin-embedded specimen of the patient's surgically excised tissue, and the results suggested Spirometra mansoni, mNGS was fur-ther confirmed by polymerase chain reaction and phylogenetic analysis of cytochrome c oxidase subunit 1 (cox1) gene. Based on these results, we found that mNGS provided a better method of diagnosing par-asitic infections.(c) 2022 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license ( http://***/licenses/by-nc-nd/4.0/ )

关键词： Metagenomic next-generation sequencing Spirometra mansoni Infection

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Novel Acyl Thiourea-Based Hydrophobic Tagging Degraders Exert Potent Anti-Influenza Activity through Two Distinct Endonuclease Polymerase Acidic-Targeted Degradation Pathways

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JOURNAL OF MEDICINAL CHEMISTRY 2024年第11期67卷 8791-8816页

作者： Ma, Xiaoyu Wang, Xueyun Chen, Feifei Zou, Wenting Ren, Junrui Xin, Lilan He, Pei Liang, Jinsen Xu, Zhichao Dong, Chune Lan, Ke wu, shuwen Zhou, Hai-Bing Wuhan Univ Zhongnan Hosp Sch Pharmaceut Sci Dept Hematol Wuhan 430071 Peoples R China Wuhan Univ Coll Life Sci State Key Lab Virol Wuhan 430072 Peoples R China Wuhan Univ Frontier Sci Ctr Immunol & Metab Technol Res Ctr Fluorinated Pharmaceut State Key Lab VirolProv Key Lab Dev Originated Di Wuhan 430071 Peoples R China Wuhan Univ Hubei Prov Engn & Technol Res Ctr Fluorinated Phar Wuhan 430071 Peoples R China

The spread of the influenza virus has caused devastating pandemics and huge economic losses worldwide. Antiviral drugs with diverse action modes are urgently required to overcome the challenges of viral mutation and drug resistance, and targeted protein degradation strategies constitute excellent candidates for this purpose. Herein, the first degradation of the influenza virus polymerase acidic (PA) protein using small-molecule degraders developed by hydrophobic tagging (HyT) technology to effectively combat the influenza virus was reported. The SAR results revealed that compound 19b with Boc(2)-(L)-Lys demonstrated excellent inhibitory activity against A/WSN/33/H1N1 (EC50 = 0.015 mu M) and amantadine-resistant strain (A/PR/8/H1N1), low cytotoxicity, high selectivity, substantial degradation ability, and good drug-like properties. Mechanistic studies demonstrated that the proteasome system and autophagic lysosome pathway were the potential drivers of these HyT degraders. Thus, this study provides a powerful tool for investigating the targeted degradation of influenza virus proteins and for antiviral drug development.

关键词： Antimicrobial agents Degradation Hydrophobicity Peptides and proteins Viruses

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Naloxone acceptance by outpatient veterans: A risk-prioritized telephone outreach event

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RESEARCH IN SOCIAL & ADMINISTRATIVE PHARMACY 2021年第5期17卷 1017-1020页

作者： wu, shuwen Frey, Theresa Wenthur, Cody J. William S Middleton Mem Vet Adm Med Ctr 2500 Overlook Terrace Madison WI 53705 USA Univ Wisconsin Madison 1033-5109 Rennebohm Hall777 Highland Ave Madison WI 53705 USA

Background: Opioid overdose is a major public health concern in the United States. Naloxone education and distribution can decrease the risk of overdose deaths. A previous study showed that a longitudinal, multi-attempt telephone intervention by a single pharmacy resident was effective for distributing naloxone to a high-risk veteran population. Objectives: The purpose of this project was to investigate whether a team-based, single-attempt telephone outreach event is effective for distributing naloxone to at-risk outpatient veterans. Methods: The Risk Index for Overdose or Serious Opioid-Induced Respiratory Depression (RIOSORD) tool was used to identify patients with risk class 4. Pharmacy trainees contacted 164 patients and offered naloxone. The primary outcome was the proportion of patients with RIOSORD risk class >4 who had naloxone before versus after the intervention. Results: The proportion of patients with RIOSORD class >4 who had a naloxone kit before and after the event was 0.28 and 0.63, respectively (difference = 0.35, p < 1 ? 10-6). Per-protocol analysis showed that of 164 patients contacted, 67% were reached (n = 109) and 80 patients accepted naloxone, corresponding to a 73% acceptance rate for those reached. Conclusions: A team-based telephone outreach event is an effective method for distributing naloxone to at-risk outpatient veterans.

关键词： Veteran Naloxone Telephone Outpatient

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Assessment of toxic metal pollution in Yueqing Bay and the extent of metal-induced oxidative stress in Tegillarca granosa raised in this water

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MARINE POLLUTION BULLETIN 2023年第PartB期194卷 115444页

作者： Yang, Yuqing Wang, Mengci Yu, Xinyu Wei, Jinyan wu, shuwen wu, Chenghui Chang, Alan Kueichieh Ying, Xueping Wenzhou Univ Coll Life & Environm Sci Wenzhou 325035 Zhejiang Peoples R China Wenzhou Univ Natl & Local Joint Engn Res Ctr Ecol Treatment Tec Wenzhou 325035 Peoples R China

Yueqing Bay is an important economic shellfish culture zone in Zhejiang Province, China. However, increased pollution in the water caused by toxic metals has led to the bioaccumulation of toxic metals in cockles such as Tegillarca granosa, and the consequence of toxic metal-associated toxicity in these animals. This study aimed to assess the concentration of toxic metals in the water and sediment in four different sites (Baisha, Qingjiang, Nanyue, and Wengyang) within Yueqing Bay and to evaluate the extent of metal bioaccumulation in T. granosa raised in the aquaculture farms located within the four sites, as well as the changes in biomarkers in T. granosa in response to the metals. The assessment was carried out at two different times of the year, January and July. The water and sediment samples taken from the aquaculture farms in Baisha (S1), Qingjiang (S2) and Nanyue (S3) were found to have a comprehensive toxic metal pollution index (Pc) <1, indicating that these farms were not polluted. However, the water and sediment samples taken from the aquaculture farm in Wengyang (S4) had a Pc between 1 and 2, indicating mild toxic metal pollution. The edible risk assessments (HQ) of T. granosa in all four farms were <1, and therefore, these cockles could be considered safe for human consumption. The toxic metal enrichment in T. granosa exhibited a strong correlation with the toxic metal content in the sediment. In all four farms, CAT and SOD activity levels in the visceral mass of T. granosa were higher than those found in the foot, and a significantly higher level of CAT activity was detected in July compared with January. Similarly, MDA and H2O2 contents in the visceral mass were also higher in July than in January. Tegillarca granosa individuals taken from S4 and S3 farms exhibited significantly higher levels of metallothionein (MT) mRNA and MDA compared with individuals from S1 and S2 farms. Furthermore, the levels of MDA and MT mRNA showed significant positive corre

关键词： Aquaculture farm Toxic metals Tegillarca granosa Biomarkers Toxicity assessment

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An Improved HMFCW Algorithm for Ranging in RFID System 15th

An Improved HMFCW Algorithm for Ranging in RFID System

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15th EAI International Conference on Communications and Networking, ChinaCom 2020

作者： Tian, Zengshan wu, shuwen Xie, Liangbo Liu, Xixi School of Communication and Information Engineering Chongqing University of Posts and Telecommunications Chongqing China

ISBN: (纸本)9783030677190

Since the measured phase is usually a wrapped phase during ranging, the phase-based ranging method needs to solve the ambiguity so as to obtain the true phase. HMFCW (heuristic multi-frequency continuous wave) algorithm provides the same tolerance of error for the observed phase of different frequencies. When the error of phase is within the tolerance and the range of ranging is less than the period, the phase error tolerance method can get the correct cycle number, and achieve a ranging accuracy of centimeter. However, when phase errors of some frequencies are large, HMFCW algorithm may have difficulty in solving the integer ambiguity, which leads to the decrease of ranging accuracy. In this paper, an improved HMFCW algorithm based on HMFCW algorithm is proposed. The improved HMFCW algorithm calculates the average value of the clustering phase results to eliminate the phases with large errors, and performs the cycle calculation to obtain the ranging value. Simulation results show that improved HMFCW algorithm can solve the problem of error in the cycle ambiguity solution caused by the point with large phase error effectively, and improve the ranging accuracy. © 2021, ICST Institute for Computer Sciences, Social Informatics and Telecommunications Engineering.

关键词： Errors

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