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Doctor interaction behavior, patient participation in value co-creation and patient satisfaction: cross-sectional survey in a tertiary-level hospital from Guangzhou, China

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SCIENTIFIC REPORTS 2024年第1期14卷 1-11页

作者： Mai, Shumin Chang, Lu Xu, Richard Huan su, shuwen Wang, Dong Southern Med Univ Sch Hlth Management Guangzhou Peoples R China Hong Kong Polytech Univ Fac Hlth & Social Sci Dept Rehabil Sci Kowloon Hong Kong Peoples R China Foshan Univ Foshan Stomatol Hosp Sch Med Foshan Peoples R China

Value co-creation can be defined as the joint benefit that is created by patients and medical service providers through the integration of their respective resources. Participation and interaction between doctors and patients can generate an outcome that benefits both sides. Relevant studies of value co-creation in the healthcare field are limited. This study established hypotheses to explore the association between doctor interaction behavior, patient participation in value co-creation, and patient satisfaction. A cross-sectional survey was conducted with 637 patients (outpatients and inpatients) at a tertiary-level hospital in Guangzhou, China. The analysis result indicated that doctor interaction behavior could stimulate patient participation in value co-creation then increase patient satisfaction. The standardized total effect, direct effect, and indirect effect were 0.641 (95%CI: 0.055 similar to 0.067), 0.546 (95%CI: 0.044 similar to 0.059), and 0.095 (95%CI: 0.032 similar to 0.166), respectively. Patient participation in value co-creation mediated the relationship between doctor interaction behavior and patient satisfaction. Among the different dimensions of doctor interaction behavior, access, risk assessment and transparency dimensions were associated with positive patient participation in value co-creation. During the treatment process, doctor interaction and patient participation can get satisfying results.

关键词： Value co-creation Interaction behavior Patient satisfaction DART Patient perception

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Association between the C-reactive protein-albumin-lymphocyte index and metabolic syndrome: evidence from the 2003-2010 national health and nutrition examination survey

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DIABETOLOGY & METABOLIC SYNDROME 2025年第1期17卷 1-11页

作者： Wu, Lanlan Han, Dunzheng Xue, Yuting He, Shangfei Ma, Zhuang su, shuwen Li, Peixin Liu, Shenrong Zhou, Haobin Guangzhou Med Univ Affiliated Hosp 1 Dept Cardiol Guangzhou 510120 Guangdong Peoples R China

Background Metabolic syndrome (MetS) is a global public health problem that significantly impacts human health and quality of life. The relationship between MetS and the C-reactive protein-albumin-lymphocyte (CALLY) index is uncertain. Methods This study analyzed the data of 7,534 individuals from the National Health and Nutrition Examination survey cycles (2003-2010 cycles). Weighted logistic regression and weighted restricted cubic spline (RCS) curve analyses were used to identify the relationships between the CALLY index and MetS, as well as its components. Results Of the 7,534 participants, 2,086 were diagnosed with MetS. The estimated prevalence of MetS decreased with an increase in the CALLY index (P < 0.001). Multivariable logistic regression analysis showed that the odds ratio of MetS was 0.25 (95% confidence interval 0.20-0.32, P < 0.001) in the highest CALLY index quartile compared with the lowest quartile after adjusting for confounding variables. The RCS curve analysis revealed non-linear relationships between the CALLY index and MetS or its components. Conclusions This study revealed an inverse relationship between the CALLY index and MetS risk. The CALLY index might be valuable for identifying individuals who are at a high risk of MetS. Clinical trial numberNot applicable.

关键词： C-reactive protein-albumin-lymphocyte index Metabolic syndrome

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Associations of the C-reactive protein-albumin-lymphocyte index with all-cause and cardiovascular mortality among individuals with cardiovascular disease: evidence from the NHANES 2001-2010

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BMC CARDIOVASCULAR DISORDERS 2025年第1期25卷 1-11页

作者： Han, Dunzheng Wu, Lanlan Zhou, Haobin Xue, Yuting He, Shangfei Ma, Zhuang su, shuwen Li, Peixin Liu, Shenrong Huang, Zheng Guangzhou Med Univ Affiliated Hosp 1 Dept Cardiol 151 Yanjiang West Rd Guangzhou 510120 Guangdong Peoples R China

Background Evidence regarding the C-reactive protein-albumin-lymphocyte (CALLY) index and mortality risk in individuals with cardiovascular disease (CVD) is scarce. This study investigated the relationships of the CALLY index with all-cause and cardiovascular mortality risk in CVD patients among American adults. Methods This study enrolled 2183 CVD individuals from five NHANES cycles (2001-2010), and mortality outcomes were determined by linking the data to National Death Index (NDI) records up to December 31, 2019. Weighted multivariate Cox regression models and subgroup analyses were performed to assess the associations of the CALLY index with all-cause and cardiovascular mortality. A restricted cubic spline (RCS) was used to visualize the association of the CALLY index with mortality risk. Results During a median follow-up of 122 months (interquartile range, 71-157 months), 1208 (weighted percentage, 49.62%) of the 2183 CVD individuals died, including 398 (weighted percentage, 24.85%) with cardiovascular deaths and 810 (weighted percentage, 75.15%) with noncardiovascular deaths. Cox regression revealed an inverse correlation between the CALLY index and the risk of all-cause and cardiovascular mortality after adjusting for covariates. Compared with individuals with a lower CALLY index, those with a higher CALLY index had a significantly lower risk of both all-cause (HR 0.58, 95% CI: 0.48, 0.71, p < 0.001) and cardiovascular mortality (HR 0.54, 95% CI: 0.38, 0.76, p < 0.001). The RCS regression analysis revealed a nonlinear association between the CALLY index and all-cause and cardiovascular mortality (p < 0.05 for nonlinearity) in CVD patients. The associations were consistent in the subgroup analyses regardless of age, sex, income, education level, race, smoking status, diabetes, and hypertension (all p values for interactions > 0.05). Conclusion An increased CALLY index is independently associated with decreased all-cause and cardiovascular mortality in CVD pati

关键词： Cardiovascular disease Mortality C-reactive protein-albumin-lymphocyte index

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Neutrophil percentage-to-albumin ratio and the risk of all-cause and cardiovascular mortality: a 20-year follow-up cohort study of 36,428 US adults

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BMC PUBLIC HEALTH 2025年第1期25卷 1-11页

作者： Han, Dunzheng Wu, Lanlan Zhou, Haobin Li, Peixin Liu, Shenrong Xue, Yuting He, Shangfei Ma, Zhuang su, shuwen Huang, Zheng Guangzhou Med Univ Affiliated Hosp 1 Dept Cardiol Guangzhou 510120 Peoples R China

BackgroundThe neutrophil percentage-to-albumin ratio (NPAR) has been identified as a prognostic indicator of mortality in various diseases;however, its association with all-cause and cardiovascular mortality in the general population remains insufficiently *** retrospective cohort study analyzed data from 36,428 individuals who participated in the National Health and Nutrition Examination survey between 1999 and 2018. Participants were divided into tertiles based on NPAR levels, with follow-up data collected through December 31, 2019. Weighted multivariable Cox regression models were employed to assess the associations between NPAR and both all-cause and cardiovascular mortality. Kaplan-Meier survival analyses were used to compare survival rates across NPAR tertiles. Additionally, restricted cubic spline analyses and subgroup and sensitivity analyses were conducted to further investigate these *** the follow-up period of up to 20 years, 4,716 deaths occurred among the 36,428 participants, including 1,260 deaths attributed to cardiovascular disease. At baseline, the mean NPAR was 13.66 (SD 2.42), the average age was 45.75 years (SD 16.20), and 50.33% of participants were female. Multivariable analyses showed that individuals in the highest NPAR tertile had a significantly increased risk of both all-cause mortality (HR, 95% CI: 1.45, 1.33-1.57) and cardiovascular mortality (HR, 95% CI: 1.69, 1.39-2.06). Kaplan-Meier survival curves demonstrated significant differences in both all-cause and cardiovascular mortality across NPAR groups. A nonlinear association was observed between NPAR and the risk of both all-cause and cardiovascular mortality. Sensitivity analyses confirmed the robustness of these associations. Additionally, a significant interaction between NPAR and hypertension was identified in relation to all-cause mortality (relative excess risk due to interaction, 95% CI: 0.20, 0.07-0.34;multiplicative interaction, P = 0.04)

关键词： Mortality Neutrophil percentage-to-albumin ratio NHANES

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Trimethylamine N-oxide aggravates human aortic valve interstitial cell inflammation by regulating the macrophages polarization through a N6-methyladenosine-mediated pathway

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ATHEROSCLEROSIS 2025年 402卷 119109-119109页

作者： Wen, Liming Lin, Xiangjie Hu, Dongtu Li, Juncong Xie, Kaiji Li, Shunyi su, shuwen Duan, Xiaolin Zhong, Guoheng Lin, Yingwen Chen, Yangchao Xu, Tianyu Zeng, Qingchun Southern Med Univ Nanfang Hosp Dept Cardiol State Key Lab Organ Failure Res Guangzhou 510515 Peoples R China Southern Med Univ Guangdong Prov Key Lab Cardiac Funct & Microcircul Guangzhou 510515 Peoples R China Guangzhou Regenerat Med & Hlth Guangdong Lab Bioland Lab Guangzhou 510005 Peoples R China Chinese Univ Hong Kong Fac Med Sch Biomed Sci Shatin Hong Kong Peoples R China Sun Yat Sen Univ Dept Cardiol NHC Key Lab Assisted Circulat Affiliated Hosp 1 Guangzhou 510080 Peoples R China

Background: Trimethylamine N-oxide (TMAO) is a gut microbial metabolite that promotes calcified aortic valve disease (CAVD), but the underlying mechanism remains obscure. Herein, we aim to test the hypothesis that TMAO regulated the inflammatory process in aortic valves via N6-methyladenosine (m6A) RNA methylationmediated macrophage polarization. Methods: In vitro, we stimulated macrophages (Phorbol-12-Myristate-13-Acetate-induced THP-1) with TMAO and assessed the expression of methyltransferase-like 3 (Mettl3), IL-1 receptor associated kinase M (IRAK-M) and polarization markers. The interaction between YTH domain family protein 2 (YTHDF2) and IRAK-M mRNA was explored by RNA-IP and RNA decay assay. Functionally, the effects of macrophages on human aortic valve interstitial cells (AVICs) were measured via macrophage adhesion assay and co-culture system. In vivo, the influence of IRAK-M on CAVD development was verified using Irak-m- /- mice. Result: Mettl3 was highly expressed while IRAK-M was decreased in human calcified aortic valves. In vitro, TMAO upregulated the expression of Mettl3, while the expression of IRAK-M, an important negative regulator of the NF kappa B pathway, was remarkably decreased in macrophages. TMAO also induced classical macrophage activation (M1 polarization). Mechanistically, IRAK-M was identified as a target of Mettl3-mediated m6A modification, indicating the involvement of m6A methylation in the regulation of NF-kappa B activation. Moreover, RIP assay revealed the direct interaction between YTHDF2 and IRAK-M mRNA and this process was dependent on Mettl3. TMAO-treated macrophage conditioned medium induced inflammatory responses in human aortic valve interstitial cells (AVICs). In vivo experiments showed that the deletion of IRAK-M significantly accelerated the progression of aortic valve lesion in mice administrated with high-fat and choline diet (HFCD). Conclusion: TMAO induces the expression of Mettl3 in macrophages. Mettl3 promotes M1 po

关键词： Calcified aortic valve disease Trimethylamine N -Oxide Macrophage polarization N6-methyladenosine IRAK-M

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4-Octyl itaconate suppresses the osteogenic response in aortic valvular interstitial cells via the Nrf2 pathway and alleviates aortic stenosis in mice with direct wire injury

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FREE RADICAL BIOLOGY AND MEDICINE 2022年第0期188卷 404-418页

作者： Peng, Xin su, shuwen Zeng, Jingxin Xie, Kaiji Yang, Xi Xian, Gaopeng Xiao, Zezhou Zhu, Peng Zheng, Shaoyi Xu, Dingli Zeng, Qingchun Southern Med Univ Nanfang Hosp Dept Cardiol State Key Lab Organ Failure Res Guangzhou 510515 Peoples R China Southern Med Univ Guangdong Prov Key Lab Shock & Microcirculat Guangzhou 510515 Peoples R China Guangzhou Regenerat Med & Hlth Guangdong Lab Bioland Lab Guangzhou 510515 Peoples R China Southern Med Univ Nanfang Hosp Dept Cardiovasc Surg Guangzhou 510515 Peoples R China

Calcific aortic valve disease (CAVD) is the most prevalent valvular heart disease in older individuals, but there is a lack of drug treatment. The cellular biological mechanisms of CAVD are still unclear. Oxidative stress and endoplasmic reticulum stress (ER stress) have been suggested to be involved in the progression of CAVD. Many studies have demonstrated that 4-octyl itaconate (OI) plays beneficial roles in limiting inflammation and oxidative injury. However, the potential role of OI in CAVD has not been thoroughly explored. Thus, we investigated OI-mediated modulation of ROS generation and endoplasmic reticulum stress to inhibit osteogenic differentiation in aortic valve interstitial cells (VICs). In our study, calcified aortic valves showed increased levels of ER stress and superoxide anion, as well as abnormal expression of Hmox1 and NQO1. In VICs, OI activated the Nrf2 signaling cascade and contributed to Nrf2 stabilization and nuclear translocation, thus augmenting the expression of genes downstream of Nrf2 (Hmox1 and NQO1). Moreover, OI ameliorated osteogenic medium (OM)-induced ROS production, mitochondrial ROS levels and the loss of mitochondrial membrane potential in VICs. Furthermore, OI attenuated the OM-induced upregulation of ER stress markers, osteogenic markers and calcium deposition, which were blocked by the Nrf2-specific inhibitor ML385. Interestingly, we found that OM -induced ER stress and osteogenic differentiation were ROS-dependent and that Hmox1 silencing triggered ROS production, ER stress and elevated osteogenic activity, which were inhibited by NAC. Overexpression of NQO1 mediated by adenovirus vectors significantly suppressed OM-induced ER stress and osteogenic markers. Collectively, these results showed the anti-osteogenic effects of OI on AVICs by regulating the generation of ROS and ER stress by activating the Nrf2 signaling pathway. Furthermore, OI alleviated aortic stenosis in a mouse model with direct wire injury. Due to its ant

关键词： 4-Octyl itaconate Calcified aortic valve diseases Oxidative stress Endoplasmic reticulum stress

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GPS-RTK测量技术在水利工程测量中的应用

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中国高新科技 2023年第15期 136-138页

作者：苏述文甘肃省疏勒河流域水资源利用中心双塔灌区管理处甘肃酒泉736100

GPS-RTK测量技术是一种高精度的测量技术,在水利工程测量中应用广泛。文章通过对GPS-RTK测量技术的原理和特点进行分析,阐述了其在水利工程测量中的应用和优势,可应用于河道水位监测、堤防变形监测、水文测量和工程量测量4个方面,并结... 详细信息

GPS-RTK测量技术是一种高精度的测量技术,在水利工程测量中应用广泛。文章通过对GPS-RTK测量技术的原理和特点进行分析,阐述了其在水利工程测量中的应用和优势,可应用于河道水位监测、堤防变形监测、水文测量和工程量测量4个方面,并结合实际案例进行了详细阐述和说明。研究结果表明,GPS-RTK测量技术应用在水利工程测量中具有高精度、高效率、高可靠性、覆盖范围广、操作简便等优势,能够为水利工程的建设和管理提供重要支撑和保障。

关键词： GPS-RTK测量技术水利工程测量应用优势

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Targeted inhibition of PTPN22 is a novel approach to alleviate osteogenic responses in aortic valve interstitial cells and aortic valve lesions in mice

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BMC MEDICINE 2023年第1期21卷 252-252页

作者： Li, Shunyi Luo, Zichao su, shuwen Wen, Liming Xian, Gaopeng Zhao, Jing Xu, Xingbo Xu, Dingli Zeng, Qingchun Southern Med Univ Nanfang Hosp Dept Cardiol State Key Lab Organ Failure Res Guangzhou 510515 Peoples R China Southern Med Univ Guangdong Prov Key Lab Cardiac Funct & Microcircul Guangzhou 510515 Peoples R China Univ Macau Inst Chinese Med Sci State Key Lab Qual Res Chinese Med Macau Peoples R China Georg August Univ Univ Med Ctr Gottingen Dept Cardiol & Pneumol Gottingen Germany

Background Calcific aortic valve disease (CAVD) is the most prevalent valvular disease and has high morbidity and mortality. CAVD is characterized by complex pathophysiological processes, including inflammation-induced osteoblastic differentiation in aortic valve interstitial cells (AVICs). Novel anti-CAVD agents are urgently needed. Protein tyrosine phosphatase nonreceptor type 22 (PTPN22), an intracellular nonreceptor-like protein tyrosine phosphatase, is involved in several chronic inflammatory diseases, including rheumatoid arthritis and diabetes. However, it is unclear whether PTPN22 is involved in the pathogenesis of CAVD. Methods We obtained the aortic valve tissue from human and cultured AVICs from aortic valve. We established CAVD mice model by wire injury. Transcriptome sequencing, western bolt, qPCR, and immunofluorescence were performed to elucidate the molecular mechanisms. Results Here, we determined that PTPN22 expression was upregulated in calcific aortic valve tissue, AVICs treated with osteogenic medium, and a mouse model of CAVD. In vitro, overexpression of PTPN22 induced osteogenic responses, whereas siRNA-mediated PTPN22 knockdown abolished osteogenic responses and mitochondrial stress in the presence of osteogenic medium. In vivo, PTPN22 ablation ameliorated aortic valve lesions in a wire injury-induced CAVD mouse model, validating the pathogenic role of PTPN22 in CAVD. Additionally, we discovered a novel compound, 13-hydroxypiericidin A 10-O-alpha-D-glucose (1 -> 6)-beta-D-glucoside (S18), in a marine-derived Streptomyces strain that bound to PTPN22 with high affinity and acted as a novel inhibitor. Incubation with S18 suppressed osteogenic responses and mitochondrial stress in human AVICs induced by osteogenic medium. In mice with aortic valve injury, S18 administration markedly alleviated aortic valve lesions. Conclusion PTPN22 plays an essential role in the progression of CAVD, and inhibition of PTPN22 with S18 is a novel option for the fur

关键词： Calcific aortic valve disease PTPN22 Natural product Osteogenic responses Mitochondrial stress

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利用导管损伤制备钙化性主动脉瓣疾病小鼠模型的最优时间选择

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南方医科大学学报 2022年第10期42卷 1532-1538页

作者：曾婧欣苏舒文冼高鹏曾庆春许顶立南方医科大学南方医院心内科器官衰竭防治国家重点实验室广东广州510515

目的探讨利用导管损伤制备钙化性主动脉瓣疾病小鼠模型的最优时间。方法通过向8周龄小鼠右颈总动脉插入导管,在超声引导下将导管送至主动脉瓣口处损伤主动脉瓣膜,对导管损伤主动脉瓣膜后不同时间段的C57BL6小鼠主动脉瓣膜进行比较,将... 详细信息

目的探讨利用导管损伤制备钙化性主动脉瓣疾病小鼠模型的最优时间。方法通过向8周龄小鼠右颈总动脉插入导管,在超声引导下将导管送至主动脉瓣口处损伤主动脉瓣膜,对导管损伤主动脉瓣膜后不同时间段的C57BL6小鼠主动脉瓣膜进行比较,将小鼠分为对照组、造模后4周、造模后8周与造模后16周组,从适应性喂养至造模结束取材均给予普通饲料饮食。使用超声检测小鼠心脏短轴缩短率、主动脉瓣膜峰值流速及主动脉瓣口面积,使用苏木素-伊红染色观察小鼠主动脉瓣膜厚度变化及瓣膜组织结构变化,利用茜素红染色检测小鼠主动脉瓣膜钙盐沉积情况,使用免疫荧光方法检测瓣膜成骨相关蛋白碱性磷酸酶表达。结果小鼠从造模8周后开始出现心脏短轴缩短率明显下降。导管损伤4周、8周、16周后小鼠主动脉瓣膜明显增厚(P=0.002),4周、8周和16周比较无统计学差异;导管损伤4周、8周、16周后钙盐沉积明显增多(P<0.0001),4周、8周和16周比较无统计学差异;4周、8周、16周后成骨相关蛋白ALP指标表达量明显升高(P=0.0016)。导管损伤4周、8周和16周ALP表达量相比无统计学差异。结论在保证小鼠生存率的情况下,导管损伤主动脉瓣膜4周后的小鼠模型即可模拟钙化性主动脉瓣膜疾病病理生理改变。

关键词：钙化性主动脉瓣膜疾病动物模型导管损伤

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IMAS: An intelligent medical analysis system based on concept graph

IMAS: An intelligent medical analysis system based on concep...

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2020 ER Forum, Demo and Posters, ER Forum 2020, co-located with 39th International Conference on Conceptual Modeling, ER 2020

作者： Wang, Xiaoli Xie, Yixiang Xie, Siqi Bao, Zhifeng su, shuwen School of Informatics Xiamen University China RMIT University Australia

We develop an intelligent medical analysis system, denoted by IMAS, to support medical practice based on concept graph. The system provides an eficient medical archives processing tool and supports effective medical data searching and analysis. We first collect clinical data and sensor data from several hospitals. Historical medical archives are processed to provide valuable prior knowledge for patients. Second, we employ a novel data modeling technique based on evolving graphs to effectively support medical practice. Graph indexing and searching algorithms are implemented to support efficient medical case searching. With our system, users can easily pinpoint valuable historical medical information they are interested in, retrieve closely relevant medical cases for further diagnosis, and navigate to our interactive Q&A platform for treatment information. To our best knowledge, this is the first fulledged system to examine every phase in the smart healthcare system pipeline based on concept graph. We have implemented the system and the source codes are available at https://***/emmali808/ADDS. Copyright © 2020 for this paper by its authors.

关键词： Diagnosis

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