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IEEE 25th International Conference on Intelligent Transportation Systems (ITSC)

作者： yan, Han Wang, Di yang, xuwen Beijing Jiaotong Univ State Key Lab Traff Control & Safety Beijing Peoples R China Traff Control Technol Co Ltd Beijing Peoples R China

ISBN: (数字)9781665468800

ISBN: (纸本)9781665468800

Virtual coupling (vc) technology can highly increase the capacity of existing infrastructure. It includes formation coupling, cruise operation and formation decoupling. However, there are few research on vc cruise control considering actual train operation scenarios. In this paper, a leader-following vc trains cruise control model is focused on. Trains exchange their state information by bidirectional leader communication topology. Considering existing train operating scenarios, the method takes speed constraint, collision avoidance and input saturation into consideration. RBF neural network is used to deal with the nonlinearity caused by the unknown basic resistance of train and external resistance of train. By designing the appropriate sliding manifold, the stability of virtually coupled train set (VCTS) can be guaranteed. Finally, some simulations demonstrate the effectiveness of the control method. The final results show that all the state information can be limited to the required range by designing the appropriate parameters.

关键词： Virtual Coupling Sliding Manifold Neural Networks Adaptive Cruise Control

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Pharmaco-toxicological effects of the synthetic cannabinoids 4F-ABUTINACA, SDB-005, and JWH-018 in mice. In vitro and in vivo studies

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EUROPEAN JOURNAL OF PHARMACOLOGY 2025年 996卷 177586页

作者： Luo, xuwen Kuai, Lixin Shi, Xuesong Qiao, yanling Li, Kaixi Xu, Deli Di, Bin yan, Fang Xu, Peng China Pharmaceut Univ Sch Pharm Nanjing 210009 Peoples R China China Pharmaceut Univ Joint Lab Key Technol Narcot Control Off China Natl Narcot Control Commiss Beijing 100193 Peoples R China Minist Publ Secur Drug Intelligence & Forens Ctr Key Lab Drug Monitoring & Control Beijing 100193 Peoples R China

Background: Synthetic cannabinoids (SCs) are currently one of the most severely abused new psychoactive substances in the world. However, there remains a notable lack of pharmacological data on the newly emerged synthetic cannabinoids. In the present study, the in vitro and in vivo pharmacological effects of the fourth-generation synthetic cannabinoids 4F-ABUTINACA and SDB-005 are determined and compared to those of the first-generation synthetic cannabinoid JWH-018. Methods: In this study, the affinities of three SCs for CB1 receptors were evaluated using surface plasmon resonance (SPR) experiments. The acute toxicity of these three SCs was assessed through the up-and-down procedure, while their cannabinoid-specific pharmacological effects were determined through tetrad assays, which examined parameters such as temperature regulation, analgesia, locomotor activity, and catalepsy. Additionally, conditioned place preference (CPP) experiments and a precipitated withdrawal tests were conducted to assess the psychoactive effects and physical dependence of the SCs. Results: SPR experiments and acute toxicity tests demonstrated that in vitro KD values were positively correlated with in vivo ED50 potency estimates. All SCs were found to induce the classical "tetrad effects" in a dose-dependent manner. Notably, all SCs displayed significant biphasic effects in CPP experiments. Following the administration of the CB1 receptor antagonist rimonabant, a significant increase in head twitches and paw tremors was observed, indicating that the physical dependence manifested after the ingestion of SCs is mediated by the CB1 receptor. Conclusions: These findings suggest that these SCs have cannabinoid-specific pharmacological effects and abuse potential, providing robust experimental data to support future regulatory efforts.

关键词： 4F-ABUTINACA SDB-005 JWH-018 Tetrad CPP Precipitated withdrawal

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High-quality chromosome-level genome assembly of the whitespotted conger (Conger myriaster)

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SCIENTIFIC DATA 2025年第1期12卷 1-9页

作者： Han, Shenglei Li, Chen Li, Shuo Chen, yan Wang, Chenggang Liu, Kaiqiang Liu, Yuyan Wang, Hong-yan Wang, Qian Cao, xuwen Shi, Bao Shao, Changwei Jiangsu Ocean Univ Jiangsu Key Lab Marine Bioresources & Environm Lianyungang 222005 Peoples R China Chinese Acad Fishery Sci Yellow Sea Fisheries Res Inst State Key Lab Mariculture Biobreeding & Sustainabl Qingdao 266071 Shandong Peoples R China Qingdao Marine Sci & Technol Ctr Lab Marine Fisheries Sci & Food Prod Proc Qingdao 266237 Shandong Peoples R China Haiyang Yellow Sea Fisheries Co Ltd Yantai 265100 Peoples R China Chinese Acad Fishery Sci Hebei Key Lab Bohai Sea Fish Germplasm Resources C Beidaihe Cent Expt Stn Qinhuangdao 066100 Peoples R China

The whitespotted conger (Conger myriaster) is an ecologically and economically significant benthic marine species widely distributed across East Asia's coastal waters. Despite this importance, the genomic resources for this species remain limited, hindering evolutionary and aquaculture research. Here, we present the first high-quality chromosome-level genome assembly of C. myriaster using PacBio CLR, WGS, 10X Genomics and Hi-C data. The resulting 1.09 Gb genome assembly exhibits excellent contiguity, with 97.49% of sequences anchored onto 19 chromosomes. The assembled genome achieved a BUSCO completeness stands at 98.00%, containing 34.80% repetitive sequences and 24,063 predicted protein-coding genes. This foundational genomic resource overcomes a major limitation, providing the essential framework for future investigations into the evolutionary adaptations and for the genetic improvement of C. myriaster in aquaculture.

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水利工程造价管理中问题的解决对策

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长江技术经济 2019年第S01期3卷 38-40,60页

作者：晏绪文中国水电基础局有限公司天津301700

现阶段,水利工程在推动我国国民经济增长、解决水资源不足、满足不断增长的电力资源等方面发挥着重要的作用。水利工程的建设周期较长,需要投入大量的资金来保障各个阶段工作的顺利运转。因此,加强对水利工程的全过程造价管理至关重要... 详细信息

现阶段,水利工程在推动我国国民经济增长、解决水资源不足、满足不断增长的电力资源等方面发挥着重要的作用。水利工程的建设周期较长,需要投入大量的资金来保障各个阶段工作的顺利运转。因此,加强对水利工程的全过程造价管理至关重要。其不仅能够保障水利工程项目建设的科学性和合理性,还能够为水利工程单位减少各个环节产生的不必要支出。基于此,本文主要从投资决策阶段、设计阶段、施工阶段和竣工阶段四个方面造价管理对中国水电基础局有限公司存在的问题提出了具体的解决对策。以期能够对水利工程项目的全过程造价进行管理,从而全面提高水利工程建设的质量,促进水利工程企业的稳定、长久发展。

关键词：水利工程造价管理工程质量

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High expression of aryl hydrocarbon receptor (AhR) plays an important role in the formation of fibrous epulis

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ORAL DISEASES 2022年第8期28卷 2258-2266页

作者： Zeng, xuwen Xia, Siying yan, Xiangzhen Hu, Congjiao An, Kangkang Luo, Lijun Tongji Univ Shanghai Engn Res Ctr Tooth Restorat & Regenerat Dept Periodont Sch Stomatol Shanghai Peoples R China

Objectives Epulis is considered to be a massive reactive lesion rather than a true neoplasia. AhR is thought to be associated with inflammation and development of neoplasms. Here, we aimed to observe the expression of AhR in fibrous epulis and explore its role and possible mechanism in the pathogenesis of epulis. Materials and Methods Epulis and normal gingival tissues were collected, and AhR expression was detected at the mRNA and protein levels by quantitative polymerase chain reaction (qPCR) and immunohistochemistry, respectively. The expression levels of proinflammatory cytokines and apoptosis-related factor genes in human periodontal ligament cells (hPDLCs) and human gingival fibroblasts (hGFs) transfected with AhR short interfering RNA (siRNA) or negative control siRNA, upon stimulation with lipopolysaccharide of Porphyromonas gingivalis (Pg-LPS), were then examined. Finally, the expression levels of the proinflammatory cytokines and apoptosis-related factor genes in the epulis tissues were observed by qPCR. Results AhR expression in fibrous epulis was significantly increased at both the mRNA and protein levels. The expression of proinflammatory cytokines and apoptosis-related factor genes in hPDLCs transfected with AhR siRNA was significantly decreased when stimulated with Pg-LPS. The same trends were observed for hGFs. The opposite trend was detected in the epulis tissues. Conclusion AhR may be a key factor in fibrous epulis pathogenesis that acts by regulating the expression of BCL2 family genes and inflammatory factor-related genes.

关键词： apoptosis aryl hydrocarbon receptor fibrous epulis P gingivalis

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"Twisted" small molecule donors with enhanced intermolecular interactions in the condensed phase towards efficient and thick-film all-small-molecule organic solar cells

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JOURNAL OF MATERIALS CHEMISTRY A 2023年第26期11卷 13984-13993页

作者： Cheng, Xiafei Liang, Ziqi Liang, Shifeng Zhang, xuwen Xu, Jie Xu, yan Ni, Wang Li, Miaomiao Geng, yanhou Tianjin Univ Sch Mat Sci & Engn Tianjin Key Lab Mol Optoelect Sci Tianjin 300072 Peoples R China Tianjin Inst Power Sources Sci & Technol Power Sources Lab Tianjin 300384 Peoples R China Sinopec Beijing Res Inst Chem Ind Co Ltd Beijing 100013 Peoples R China Joint Sch Natl Univ Singapore & Tianjin Univ Int Campus Tianjin Univ Fuzhou 350207 Peoples R China

How to achieve high crystallinity and suitable phase scale simultaneously from the perspective of molecular engineering remains a long-standing challenge for all-small-molecule organic solar cells (ASM-OSCs). Herein, two small molecule donors, named DRTT-2Se (with two alkylselenophenyl chains) and DRTT-6Se (with six alkylselenophenyl chains), were designed and synthesized by introducing "twisted" backbones and building units with strong intermolecular interactions. The "twisted" skeletons of the molecules can suppress the molecular crystallization and avoid excessive aggregation during the film forming process, while the strong intermolecular interactions of the building units can encourage the formation of ordered molecular packing and nanoscale phase separation via post-treatments. Owing to the enhanced intermolecular interactions induced by alkylselenophenyl side chains, DRTT-2Se and DRTT-6Se with a "twisted" structure displayed more ordered pi-pi packing, and retained the similar nanoscale microstructures in the blend films in comparison to the "twisted" molecule with alkylthiophenyl side chains (DRTT-T), yielding improved hole transport and reduced charge recombination in OSCs. In addition, the alkylselenophenyl substituted molecules showed higher HOMO energy levels, which caused the larger HOMO offset to drive exciton dissociation, but did not increase the energy loss. As a result, the ASM-OSCs based on the selenophene-containing donors exhibited higher FF and J(sc), and similar V-oc, yielding superior PCEs (14.79% and 15.03%) compared to the DRTT-T based device (13.37%). More importantly, the appropriate film morphology made the device efficiency of DRTT-2Se and DRTT-6Se less sensitive to the thickness of active layers. This study provides some implications in designing small molecule donors with suitable crystallization behavior towards high-performance ASM-OSCs.

关键词： Molecules

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Steroidal saponins from the roots of Polygonatum odoratum and their inhibitory effects against pancreatic lipase

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PHYTOCHEMISTRY LETTERS 2023年 53卷 202-210页

作者： Zhao, Dexin yan, Jianghong Shi, Xiaolei Sun, Zhiheng Xie, Huili Wang, Bingzi Jin, Yongri Li, xuwen Jilin Univ Coll Chem Changchun 130012 Peoples R China Jilin Prov Acad Tradit Chinese Med Clin Hosp 1 Changchun 130021 Peoples R China Jilin Univ Coll Food Sci & Engn Changchun 130062 Peoples R China

Twenty steroidal saponins were isolated from the water extract of fresh fibrous roots of Polygonatum odoratum (Mill.) Druce, of which seven were new compounds (1-7) along with thirteen known compounds (8-20). Their chemical structures were elucidated by extensive spectroscopic and chemical techniques. All isolated compounds were evaluated for porcine pancreatic lipase inhibitory activity. Compounds 9 and 10 showed inhibitory effects with IC50 values of 201.90 +/- 0.036 mu M and 151.20 +/- 0.058 mu M (positive control orlistat;2.82 +/- 0.060 mu M).

关键词： Polygonatum odoratum (Mill ) Druce Steroidal saponins Pancreatic lipase inhibitors

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2D-Material-Based Volatile and Nonvolatile Memristive Devices for Neuromorphic Computing

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ACS MATERIALS LETTERS 2023年第4期5卷 1109-1135页

作者： Xia, xuwen Huang, Wen Hang, Pengjie Guo, Tao yan, Yong yang, Jianping yang, Deren Yu, Xuegong Li, Xing'ao Nanjing Univ Posts & Telecommun NJUPT New Energy Technol Engn Lab Jiangsu Prov Nanjing 210023 Peoples R China Nanjing Univ Posts & Telecommun NJUPT Sch Sci Nanjing 210023 Peoples R China Zhejiang Univ State Key Lab Silicon Mat Hangzhou 310027 Zhejiang Peoples R China Zhejiang Univ Sch Mat Sci & Engn Hangzhou 310027 Zhejiang Peoples R China Univ Waterloo Waterloo Inst Nanotechnol Ctr Adv Mat Joining Dept Mech & Mechatron Engn Waterloo ON N2L 3G1 Canada Henan Normal Univ Sch Phys Henan Key Lab Photovolta Mat Xinxiang 453007 Peoples R China Zhejiang Univ Sci & Technol Sch Sci Hangzhou 310027 Peoples R China

Neuromorphic computing can process large amounts of information in parallel and provides a powerful tool to solve the von Neumann bottleneck. Constructing an artificial neural network (ANN) is a common means to realize neuromorphic computing, which has exhibited potential applications in pattern recognition, complex sensing, and other areas. Reservoir computing (RC), which is another approach to realize neuromorphic computing, has shown some progress and attracted researchers' attention. Neuromorphic computing can be generally implemented by fabricating memristive array systems. 2D-material-based memristive systems and their applications in ANN and RC have been investigated substantially in recent years due to the unique properties of these systems, such as atomic-level thickness and high carrier mobility. In this Review, we first discuss the volatility and nonvolatility properties of memristive devices and their applications in ANN and RC. Second, 2D materials that can be used to fabricate these devices are introduced, and their classification, physical properties, and preparation methods are presented. Third, we discuss the working mechanisms of 2D-material-based synaptic devices, the mimicked synaptic functions, and the applications of these devices in neuromorphic computing through ANN and RC. Lastly, the performance, progress, and future development directions of 2D-material-based synaptic devices are analyzed. This work systematically investigates the status of 2D-material-based synaptic devices and promotes their utilization in neuromorphic computing.

关键词： Electrical conductivity Layers Memristors Polarization Two dimensional materials

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Oral Intervention of Narirutin Ameliorates the Allergic Response of Ovalbumin Allergy

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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2022年第41期70卷 13313-13326页

作者： Shi, Xiaolei Zhao, Lina Niu, Liyan yan, Yixuan Chen, Qiushi Jin, Yongri Li, xuwen Jilin Univ Coll Food Sci & Engn Changchun 130012 Peoples R China Jilin Univ Coll Chem Changchun 130012 Peoples R China

A new intervention was investigated for the induction of oral tolerance (OT) of OVA using narirutin by in vivo and in vitro experiments combined with network pharmacology and structural analysis of molecular docking. Narirutin (and its metabolism naringenin) has effects on OT by affecting B cell function, DCs, and T cell response by prediction. It was verified that narirutin could affect B cell function of secreting antibodies, thereby reducing the ability of DCs to absorb antigens by affecting GATA3, CCR7, STAT5, and MHCII expression and regulating T cell response by suppressing Th2 and improving Treg cells in vivo. Molecular docking showed that steric hindrance effects may be the reason for weaker binding energy with targets of narirutin. However, this does not mean that it has no bioactivity, for it can inhibit mast cell degranulation. This finding is interesting because it offers the possibility of using natural compounds to promote oral tolerance.

关键词： oral tolerance narirutin food allergy OVA intervention network pharmacology

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“营改增”与企业创新——基于企业税负的视角

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财政研究 2019年第3期35卷 63-78页

作者：张璇张计宝闫续文李春涛中南财经政法大学统计与数学学院中南财经政法大学金融学院

"营改增"政策通过有效控制企业税负的增加以促进其创新活动。本文利用2008—2015年中国A股上市公司数据,运用专利申请数度量创新产出,将中国2012年开始实施的"营改增"试点视为一个准自然实验,运用多时点双重差分模... 详细信息

"营改增"政策通过有效控制企业税负的增加以促进其创新活动。本文利用2008—2015年中国A股上市公司数据,运用专利申请数度量创新产出,将中国2012年开始实施的"营改增"试点视为一个准自然实验,运用多时点双重差分模型和倾向得分匹配方法考察"营改增"政策对企业创新行为的影响及其机制。结果发现,"营改增"的实施显著降低了企业平均的税负增幅,促进了企业创新,并且税负增幅下降越多的企业,其创新产出就越多。进一步研究发现,"营改增"通过税负变化促进企业创新的作用在民营、中小企业和法制环境较好地区的企业更为凸显。因此,深化结构性减税政策,切实减轻企业税负,才能更好地为企业创新输入源源不断的政策红利。

关键词： “营改增” 企业创新双重差分倾向得分匹配

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