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Steroidal saponins from the roots of Polygonatum odoratum and their inhibitory effects against pancreatic lipase

PHYTOCHEMISTRY LETTERS 2023年 53卷 202-210页

作者： Zhao, Dexin Yan, Jianghong Shi, Xiaolei Sun, Zhiheng Xie, Huili Wang, Bingzi Jin, Yongri li, xuwen Jilin Univ Coll Chem Changchun 130012 Peoples R China Jilin Prov Acad Tradit Chinese Med Clin Hosp 1 Changchun 130021 Peoples R China Jilin Univ Coll Food Sci & Engn Changchun 130062 Peoples R China

Twenty steroidal saponins were isolated from the water extract of fresh fibrous roots of Polygonatum odoratum (Mill.) Druce, of which seven were new compounds (1-7) along with thirteen known compounds (8-20). Their chemical structures were elucidated by extensive spectroscopic and chemical techniques. All isolated compounds were evaluated for porcine pancreatic lipase inhibitory activity. Compounds 9 and 10 showed inhibitory effects with IC50 values of 201.90 +/- 0.036 mu M and 151.20 +/- 0.058 mu M (positive control orlistat;2.82 +/- 0.060 mu M).

关键词： Polygonatum odoratum (Mill ) Druce Steroidal saponins Pancreatic lipase inhibitors

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A Methionine Allocation Nanoregulator for the Suppression of Cancer Stem Cells and Support to the Immune Cells by Epigenetic Regulation

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ADVANCED SCIENCE 2025年第15期12卷 e2415207页

作者： Su, Boyu Chen, Qinjun li, xuwen Fang, Mingzhu Wang, Yu Song, Haolin You, Haoyu Zhou, Zheng Wu, Yuxing Zhao, Zhenhao Chen, Yun Fan, Hongrui li, Chufeng Jiang, Chen Sun, Tao Fudan Univ State Key Lab Med Neurobiol Sch Pharm Dept PharmaceutKey Lab Smart Drug DeliveryMinist Shanghai 201203 Peoples R China MOE Frontiers Ctr Brain Sci Shanghai 201203 Peoples R China Fujian Med Univ Affiliated Hosp 1 Natl Reg Med Ctr Dept Digest Dis Binhai Campus Fuzhou 350212 Peoples R China Quzhou Fudan Inst Quzhou 324003 Peoples R China

Epigenetic dysregulation is prevalent in human cancers, affecting gene expression and metabolic patterns to meet the demands of malignant evolution and abnormal epigenetic processes, and resulting in a protumor immune microenvironment. Tumors require a steady supply of methionine for maintaining epigenetic flexibility, which is the only exogenous precursor of methyl donor S-adenosylmethionine for methylation, crucial for their resistance to therapies and survival in a nutrient-deficient microenvironment. Thus, tumor cells upregulate the Lat4 transporter to compete and deprive methionine in the microenvironment, sustaining their malignant phenotypes and also impairing immune cell functions. Addressing this methionine addiction is the key to overcoming drug resistance and improving immune response. Despite the challenge of lacking specific Lat4 inhibitors, an oxaliplatin prodrug crosslinked fluorinated polycation/anti-Lat4 small interfering RNA complex nanoregulator (AS-F-NP) has been designed and developed here. This nanoregulator restricted the greedy methionine uptake of tumor cells by knocking down Lat4, which in turn inhibited the malignant evolution of the tumor while restoring the viability and function of tumor-infiltrating immune cells.

关键词： cancer therapy epigenetic immune methionine oxaliplatin siRNA

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Oral Intervention of Narirutin Ameliorates the Allergic Response of Ovalbumin Allergy

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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2022年第41期70卷 13313-13326页

作者： Shi, Xiaolei Zhao, lina Niu, liyan Yan, Yixuan Chen, Qiushi Jin, Yongri li, xuwen Jilin Univ Coll Food Sci & Engn Changchun 130012 Peoples R China Jilin Univ Coll Chem Changchun 130012 Peoples R China

A new intervention was investigated for the induction of oral tolerance (OT) of OVA using narirutin by in vivo and in vitro experiments combined with network pharmacology and structural analysis of molecular docking. Narirutin (and its metabolism naringenin) has effects on OT by affecting B cell function, DCs, and T cell response by prediction. It was verified that narirutin could affect B cell function of secreting antibodies, thereby reducing the ability of DCs to absorb antigens by affecting GATA3, CCR7, STAT5, and MHCII expression and regulating T cell response by suppressing Th2 and improving Treg cells in vivo. Molecular docking showed that steric hindrance effects may be the reason for weaker binding energy with targets of narirutin. However, this does not mean that it has no bioactivity, for it can inhibit mast cell degranulation. This finding is interesting because it offers the possibility of using natural compounds to promote oral tolerance.

关键词： oral tolerance narirutin food allergy OVA intervention network pharmacology

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An efficient strategy based on two-stage chromatography and in vitro evaluation for rapid screening and isolation of acetylcholinesterase inhibitors from Scutellaria baicalensis Georgi

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JOURNAL OF SEPARATION SCIENCE 2022年第6期45卷 1170-1184页

作者： Hou, Wanchao liu, Chunming li, Sainan Zhang, Yuchi Jin, Yongri li, xuwen liu, Zhen Niu, Huazhou Xia, Jianli Jilin Univ Coll Chem Changchun Jilin Peoples R China Changchun Normal Univ Cent Lab Changchun Jilin Peoples R China

The extraction of Scutellaria baicalensis Georgi was investigated using the response surface methodology-genetic algorithm mathematical regression model, and the extraction variables were optimized to maximize the flavonoid yield. Furthermore, a simple and efficient ultrafiltration-liquid chromatography-mass spectrometry and molecular docking methods were developed for the rapid screening and identification of acetylcholinesterase inhibitors present in Scutellaria baicalensis Georgi. Subsequently, four major chemical constituents, namely baicalein, norwogonin, wogonin, and oroxylin A, were identified as potent acetylcholinesterase inhibitors. This novel approach, involving the use of ultrafiltration-liquid chromatography-mass spectrometry and molecular docking methods combined with stepwise flow rate counter-current chromatography and semi-preparative high-performance liquid chromatography, could potentially provide a powerful tool for the screening and extraction of acetylcholinesterase inhibitors from complex matrices and be a useful platform for the production of bioactive and nutraceutical ingredients.

关键词： acetylcholinesterase inhibitors countercurrent chromatography mathematical model purification Scutellaria baicalensis Georgi

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Study of Pulse Wave Changes in Patients with End-stage Renal Disease Receiving Hemodialysis Treatment Pulse Wave changes in Hemodialysis 4

Study of Pulse Wave Changes in Patients with End-stage Renal...

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4th International Symposium on Artificial Intelligence for Medicine Science (ISAIMS)

作者： li, Ziwei Wang, Chong Yang, lin Yang, Jie li, Ying lian, Cuiting Hao, Dongmei li, Guangfei Yang, Yimin li, xuwen Beijing Univ Technol Fac Environm & Life Sci Beijing Peoples R China Capital Med Univ Beijing Jishuitan Hosp Beijing Peoples R China

ISBN: (纸本)9798400708138

This study presents a novel experimental approach to investigate the changes in pulse wave patterns and pulse wave characteristic parameters in patients before, during, and after hemodialysis by analyzing radial artery pulse waves collected at time intervals from end-stage renal disease patients receiving hemodialysis. The results show that the morphology of the pulse wave is characterized by diversity between patients due to different vascular elasticity, but five categories can be classified according to the shape. When individuals of the same waveform Type-Are studied, we found that there were significant differences in some of the characteristic parameters of the pulse wave at different times of the day as the hemodialysis process progressed, a finding that also verifies the existence of hemodynamic changes during hemodialysis.

关键词： Hemodialysis Hemodynamics Pulse wave

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Facile approach for surfactant-free synthesis of Au@ginsenoside Rh2 nanoparticles and researches on anticancer activity

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CANCER NANOTECHNOLOGY 2022年第1期13卷 1-18页

作者： Yao, Hua Mu, Xupeng Wei, Zhenhong li, Xiuying Wu, liya Jin, Yongri li, xuwen li, Jing Jiang, Jinlan Jilin Univ Sci Res Ctr China Japan Union Hosp Changchun 130033 Peoples R China Jilin Univ Coll Chem Changchun 130021 Peoples R China

Background Inorganic nanocomposites especially Au nanostructures have exhibited outstanding physicochemical properties in biomedical fields. For further clinical applications on theranostics, especially drug delivery, numerous explorations of green and facile synthesis methods combining with pharmacoactive natural components have been investigated to construct safe and multifunctional bioactive Au nanoparticles (NPs). Ginsenoside Rh-2 is protopanaxadiol type compound isolated from plants of genus Panax, with excellent anticancer effect and antioxidant activity. In this research, we prepared the novel Au nanoparticles using ginsenoside Rh-2 as both reducing and stabilizing agents. Results The synthesized Au@ginsenoside Rh-2 NPs were proved to exhibit desirable inhibitory effect on different cancer cell lines, which benefited from the inherent anticancer effect of the ginsenoside Rh-2. Investigations in vitro indicated that Au@ginsenoside Rh-2 NPs inhibited cell proliferation, cell migration and invasion, induced cell cycle arrest, enhanced the reactive oxygen species (ROS) generation, and regulated the protein expressions of caspase-3, 8, 9 to trigger cell apoptosis as well. Conclusions Because of the absence of toxic chemical surfactants, the eco-friendly synthesis method of Au NPs modified by natural phytochemicals avoided tedious separation and modification processes. On the other hand, Au@ginsenoside Rh-2 NPs also improved water solubility and bioavailability of the hydrophobic drug ginsenoside Rh-2. It broadened minds for preparation and application of traditional Chinese medicines (TCMs) modified metal nanoparticles and deserved further study.

关键词： Ginsenoside Rh-2 Au nanoparticles Drug-modified nanocomposite Facile synthesis Anticancer activity

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Effect of Fe–N–C single atom/cluster catalyst on ORR of PEMFC

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International Journal of Hydrogen Energy 2025年 139卷 718-729页

作者： li, Ruina li, xuwen liu, Qingcheng Yue, Hua Meng, Yang Tian, Yuanyuan School of Automotive and Traffic Engineering Jiangsu University Jiangsu Zhenjiang212013 China Research Center of Fluid Machinery Engineering and Technology Jiangsu University Jiangsu Zhenjiang212013 China Zhejiang Shaoxing312000 China Key Laboratory of Chemical Additives for China National Light Industry College of Chemistry and Chemical Engineering Shaanxi University of Science and Technology Shaanxi Xi'an710021 China

With the continuous advancement of fuel cell technology, the exploration and development of highly efficient non - precious - metal catalysts for the oxygen reduction reaction (ORR) have emerged as a focal point of research. Fe–N–C catalysts have attracted much attention due to their excellent performance and low cost, and coupling single-atom catalysts (SACs) with atomic clusters (ACs) is an effective method to improve catalyst activity. This study used the pyrolysis method to synthesize iron atom catalysts (Fe–N–C SACs) and iron cluster coupled catalysts (Fe–N–C SACs/ACs) on ZIF-8 carbon support. It evaluated the catalyst performance through electrochemical testing. The experimental results showed that the introduction of Fe clusters improved the half-wave potential of the catalyst to 0.399 V, which represented an 8.2 % enhancement compared to the SAC catalyst and reached 87.1 % of that of the commercial Pt–C catalyst, and reduced the Tafel slope to 61.47 mV dec−1, effectively improving the ORR activity of the catalyst. We constructed FeN4 single atom catalyst models and FeN4/Fe4N6 single atom cluster catalyst models using density functional theory (DFT), analyzed their electronic structures and reaction mechanisms, and revealed the mechanism of action of iron clusters. DFT calculations showed that iron clusters altered the charge distribution of FeN4 sites, reducing the rate determining step (RDS) (OH desorption) energy to 0.5 eV, which promoted the desorption of products and the re-adsorption of reactants. As a result, the superior electrocatalytic performance of Fe–N–C SAC/AC is attributed to the synergistic effect between iron clusters and single atoms, which is influenced by the coordination environment and provides new ideas for designing efficient ORR catalysts. © 2025 Hydrogen Energy Publications LLC

关键词： Electrolytic reduction

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Design of Signal Source Board Based on PXIe Standard 22

Design of Signal Source Board Based on PXIe Standard

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8th International Conference on Computing and Artificial Intelligence, ICCAI 2022

作者： Tang, Changjiang Wu, Qiang li, xuwen liu, Jie Faculty of Information Technology Beijing University of Technology China

ISBN: (纸本)9781450396110

This paper designs a Signal Source Board based on PXIe standard. The Signal Source Board adopts XCKU060-2FFVA1157I of Xilinx company as the main control chip of the FPGA, AD9144 of ADI company as the DAC, the Host Computer sends the analog signal waveform code table to be generated to the Signal Source Board through the PCIe Bus, and then the FPGA of the Source Board based sends the analog signal waveform code table to two pieces of AD9144 through the JESD204B interface. Finally, the generated analog signal is filtered through the low-pass filter HMC1023, and completes the output of 8-channel analog signal. It achieves the high-quality generation of any modulated signal from baseband to mid-frequency, and meets the synchronous output requirements of 8-channel analog signal. © 2022 ACM.

关键词： Field programmable gate arrays (FPGA)

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Design and Implementation of Automatic Testing Software Based on Labview and TestStand 22

Design and Implementation of Automatic Testing Software Base...

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8th International Conference on Computing and Artificial Intelligence, ICCAI 2022

作者： Zhang, Youquan li, xuwen Wu, Qiang liu, Jie Beijing University of Technology China

ISBN: (纸本)9781450396110

With the increasing complexity of circuit board function, both the performance index of circuit board and the number of circuit test points are increasing day by day. It is far from satisfying the test demand of large-scale board production manually. In order to realize automatic test of electrical signal on board, automatic configuration of test sequence and automatic generation of test report, this paper designed an automatic test software management platform based on Labview and TestStand, and proposed a solution of automatic generation of test report according to template. And this paper provides a method of parameter configuration and management of instrument and result threshold of automatic test sequence, which further improves the test efficiency of automatic test and realizes unified management of test parameters, compared with gradually configuring instrument parameters in each test step of test sequence. © 2022 ACM.

关键词： Software testing

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Steroidal saponins from Allium chinense and their inhibitory effects on pancreatic lipase

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PHYTOCHEMISTRY LETTERS 2023年第1期55卷 22-29页

作者： Xie, Huili Shi, Xiaolei Wang, Bingzi Zhao, Dexin Sun, Zhiheng Chen, Yifu Feng, Yuezhu Jin, Yongri li, xuwen Jilin Univ Coll Chem Changchun 130012 Peoples R China Jilin Univ Coll Food Sci & Engn Changchun 130062 Peoples R China

Allium chinense *** is an important medicinal and edible homologous plant and indigenous to China and grown in other countries. Phytochemical studies have shown that it is rich in biologically active natural products. Herein, five new and twelve known steroidal saponins were isolated from the bulbs of Allium chinense ***. These compounds were structurally determined by analysis of their NMR, IR and HR-ESI-MS data. All isolates were evaluated for inhibition of porcine pancreatic lipase activity. Compounds 4, 7 and 10 exhibited potent inhibition of porcine pancreatic lipase. The relationship between structure and activity of these compounds is also investigated in this paper.

关键词： Allium chinense Steroidal saponins Extraction and isolation Structure identification lipase inhibitory activity

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