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NSUN3 Aggravates Sepsis-Associated Acute Kidney Injury by Stabilising TIFA mRNA Through m5C

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 2025年第4期52卷 e70026页

作者： zhang, Chenran Shen, Wenming Zheng, xuwen Zhu, Ming Xu, Kaiqi Huang, Hai Yin, Jinnan Wujin Peoples Hosp Dept Emergency Changzhou Jiangsu Peoples R China

BackgroundAcute kidney injury (AKI) is a common complication of sepsis and also a risk factor for progression of chronic kidney disease. NOP2/Sun RNA methyltransferase 3 (NSUN3) is involved in the regulation of sepsis progression. However, the mechanism by which NSUN3 regulates sepsis-associated AKI (SA-AKI) remains unclear. MethodsSA-AKI mouse model and lipopolysaccharide (LPS)-induced injury model in HK-2 cells were constructed. Haematoxylin-eosin staining, quantitative polymerase chain reaction (qPCR), western blotting, cell counting kit 8, flow cytometry, 2 ',7 '-dichlorofluorescein diacetate, enzyme-linked immunosorbent assay, methylation RNA immunoprecipitation-qPCR, actinomycin D and TdT-mediated dUTP Nick-End Labelling staining assays were utilised to explore the expression and related mechanism of NSUN3 in the SA-AKI models. ResultsThe expression of NSUN3 and tumour necrosis factor receptor-associated factor (TRAF)-interacting protein with forkhead-associated domain (TIFA) was upregulated in mice with SA-AKI and LPS-induced HK-2 cells. Knockdown of NSUN3 inhibited LPS-induced injury in HK-2 cells. Mechanically, NSUN3 increased TIFA mRNA stability and upregulated its expression through m5C modification. Moreover, knockdown of NSUN3 was found to alleviate LPS-induced HK-2 cell injury and SA-AKI in mice by reducing TIFA expression. ConclusionNSUN3 aggravates SA-AKI by stabilising TIFA mRNA through m5C, indicating that NSUN3 may be a biomarker for SA-AKI.

关键词： acute kidney injury m5C NSUN3 sepsis TIFA

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The s-d interaction induced hydrogen trapping effect in α-U (130)/ twin boundary region

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SURFACES AND INTERFACES 2025年 61卷

作者： Jin, Jingyuan zhang, Yujuan Lv, Wenting Zhao, xuwen Miao, Chengzhen Ji, Hefei Yang, Yu Univ Sci & Technol Beijing Sch Mat Sci & Engn Beijing 100083 Peoples R China Inst Appl Phys & Computat Math LCP Beijing 100088 Peoples R China China Acad Engn Phys Inst Mat Res Mianyang 621900 Peoples R China

Hydrogen embrittlement is a serious obstacle to the safe storage and practical application of metal uranium. In this work, the hydrogen solution characteristics in the (130)/[001] twin grain boundary region in alpha-U metal are studied by first-principles theoretical and electron backscatter diffraction experimental methods. Our results show that the solution energy of hydrogen atom is the lowest at the (130)/[001] twin boundary plane, and increases as the distance from the twin boundary expands. Hydrogen atoms need to overcome energy barriers to diffuse both along and vertical to the twin boundary plane, i.e., the H atoms are trapped at the interstitial sites in the twin boundary region. It is also found that the s-d interaction between H and U atoms has induced the hydrogen trapping effect. Furthermore, the existence of Nb atom notably lowers the hydrogen solution energy and deepens the hydrogen trap in the region of (130)/[001] twin boundary, which is attributed to the intensified s-d interaction between H and U/Nb atoms. These findings are expected to reveal the underlying mechanism of the microstructural evolution of H atoms in U and provide a theoretical guidance for enlightenment to mitigate or inhibit hydriding corrosion in U metal.

关键词： Hydrogen corrosion Uranium Grain boundary First-principles Electron backscatter diffraction

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Physical information-enhanced graph neural network for predicting phase separation

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Chinese Physics B 2024年第7期33卷 278-283页

作者：张亚强王煦文王雅楠郑文 Institute of Public-Safety and Big Data College of Computer Science and Technology(College of Data Science)Taiyuan University of TechnologyJinzhong 030600China Shanxi Engineering Research Centre for Intelligent Data Assisted Treatment Changzhi Medical CollegeChangzhi 046000China Innovation Academy for Microsatellites of Chinese Academy of Sciences Shanghai 200050China

Although phase separation is a ubiquitous phenomenon, the interactions between multiple components make it difficult to accurately model and predict. In recent years, machine learning has been widely used in physics simulations. Here,we present a physical information-enhanced graph neural network(PIENet) to simulate and predict the evolution of phase separation. The accuracy of our model in predicting particle positions is improved by 40.3% and 51.77% compared with CNN and SVM respectively. Moreover, we design an order parameter based on local density to measure the evolution of phase separation and analyze the systematic changes with different repulsion coefficients and different Schmidt *** results demonstrate that our model can achieve long-term accurate predictions of order parameters without requiring complex handcrafted features. These results prove that graph neural networks can become new tools and methods for predicting the structure and properties of complex physical systems.

关键词： graph neural network phase separation machine learning dissipative particle dynamics

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Rosellosides A and B, two phenyloxazole glycosides from Glycyrrhiza inflata-derived fungus Rosellinia sp. Glinf021

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NATURAL PRODUCT RESEARCH 2025年第7期39卷 2036-2040页

作者： Gu, Gan Hou, xuwen zhang, Jiayin Pan, Xiaoqian Xu, Dan Lai, Daowan Zhou, Ligang China Agr Univ Coll Plant Protect Dept Plant Pathol Beijing Peoples R China

Two new chlorinated phenyloxazole glycosides, named rosellosides A (1) and B (2), were isolated from the endophytic fungus Rosellinia sp. Glinf021, which was derived from the medicinal plant Glycyrrhiza inflata (Leguminosae). Both compounds were rare chlorinated polyketide glycosides bearing an oxazole moiety. Their structures were elucidated by analysis of the NMR and HRESIMS data, and their absolute configurations were determined by quantum chemical ECD calculations and X-ray crystallography.

关键词： Endophytic fungus Rosellinia sp. Glinf021 Glycyrrhiza inflata rosellosides A and B chlorinated phenyloxazole glycosides

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Carbon sequestration in overlying methane hydrate layers via hydrate technology: Feasibility and synergistic benefits

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ENVIRONMENTAL TECHNOLOGY & INNOVATION 2025年 37卷

作者： zhang, Zhaobin Li, Yuxuan Li, Shouding He, Jianming Xie, Zhuoran Li, Xiao Lu, Cheng Qin, xuwen Chinese Acad Sci Inst Geol & Geophys Key Lab Deep Petr Intelligent Explorat & Dev Beijing 100029 Peoples R China Chinese Acad Sci Innovat Acad Earth Sci Beijing 100029 Peoples R China Univ Chinese Acad Sci Coll Earth & Planetary Sci Beijing 100049 Peoples R China China Geol Survey Minist Nat Resources Oil & Gas Resources Survey Beijing 100083 Peoples R China China Geol Survey Minist Nat Resources Beijing 100037 Peoples R China

Excessive carbon dioxide emissions pose a global environmental issue, and carbon sequestration technology offers a solution. This study based on independently developed simulator proposes a novel approach for carbon dioxide sequestration in the overlying layers of methane hydrate reservoirs using carbon dioxide hydrate technology. The feasibility and risks of this method are evaluated over a time scale of 100,000 years. Results show that carbon dioxide migrates upwards after injection, forming highly saturated hydrate shells at the migration front. Within these carbon dioxide hydrate shells, a portion of the carbon dioxide is sequestered in liquid and dissolved forms;however, over tens of thousands of years, 20% of the COQ will dissolve, while less than 1% will escape. The study highlights the synergy between methane hydrate extraction and carbon sequestration, as the cold seawater down draw effect from extraction enhances sequestration efficiency and safety. Given the widespread distribution of methane hydrate reservoirs globally, this research provides new insights into carbon sequestration technology.

关键词： Carbon dioxide sequestration Hydrate Carbon dioxide hydrate shells Carbon dioxide escapes Methane hydrate extraction

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A low-temperature process for lithium extraction from lithium-bearing mineral: Conversion behavior and mechanisms

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SEPARATION AND PURIFICATION TECHNOLOGY 2025年 357卷

作者： Luo, Shaojun Zheng, Xiaohong Liu, Haichao zhang, Qing He, Mingming Wang, Yuehai He, xuwen Sun, Zhi China Univ Min & Technol Beijing Sch Chem & Environm Engn Beijing 100083 Peoples R China Chinese Acad Sci Inst Proc Engn Natl Engn Res Ctr Green Recycling Strateg Met Res Beijing 100190 Peoples R China China Univ Geosci Beijing Sch Mat Sci & Technol Beijing Key Lab Mat Utilizat Nonmet Minerals & Sol Natl Lab Mineral Mat Beijing 100083 Peoples R China Shanghai Polytech Univ 2360 Jinhai Rd Shanghai 201209 Peoples R China

Lithium extraction from lithium-bearing clay mineral (LiBC) has received significant attention due to the increasing demand of lithium for the advanced renewable energy industry. However, the low contents of valuable elements and stable physiochemical properties of LiBC result in high energy consumption and low efficiency in extracting lithium from LiBC. This study demonstrates a low-temperature strategy using (NH4)2SO4 as an additive to effectively extract lithium from LiBC. In details, the thermodynamic analysis verifies that Li, Al, and Fe can be converted to sulfates at 250-450 degrees C during thermal treatment, indicating the possibility for extraction of Li under low-temperature conditions. Subsequently, the leaching behavior of lithium under different roasting temperatures and water leaching conditions was investigated. The results show that 83.43 % of Li can be extracted under optimized conditions. The mechanism study was carried out through a number of characterization techniques including 3D microscope, TG-DSC, XRD, FTIR, and SEM. It reveals that formation of liquidus phase of molten salt is the key to achieve low-temperature roasting and transfer and reactions at the interface of molten salt and LiBC can be significantly enhanced that can easily breakdown the interlayer structures. Consequently, it offers distinct advantages, since the roasting temperature can be significantly decreased with minor impurity ions being leached into the solutions. This research therefore provides an efficient and environmentally friendly method for lithium extraction from minerals.

关键词： Lithium-bearing mineral Molten salt roasting Solid-liquid reaction Lithium Extraction Ammonium sulfate

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Synergistic optimization strategies for the development of multienzymatic cascade system-based electrochemical biosensors with enhanced performance

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BIOSENSORS & BIOELECTRONICS 2025年 274卷 117222页

作者： Zhu, Yuzhuo Cheng, Zhaoming Wang, Xueqi zhang, Chuanjun Li, xuwen Wei, Yanxue Wang, Jiajia Fang, Yuxin Wang, Yi zhang, Di Tianjin Univ Tradit Chinese Med Coll Pharmaceut Engn Tradit Chinese Med Tianjin 301617 Peoples R China Tianjin Univ Tradit Chinese Med Inst Tradit Chinese Med Tianjin 301617 Peoples R China Tianjin Key Lab Intelligent & Green Pharmaceut Tra Tianjin 301617 Peoples R China State Key Lab Chinese Med Modernizat Tianjin 301617 Peoples R China Tianjin Univ Tradit Chinese Med Coll Acumox & Tuina Res Ctr Expt Acupuncture Sci Tianjin 301617 Peoples R China Natl Clin Res Ctr Chinese Med Acupuncture & Moxibu Tianjin 301617 Peoples R China

Multienzymatic cascade system (MCS) strategies have been a topic of growing interest in the electrochemical biosensor research field owing to their many advantages. By combining two or more enzymes in an appropriate manner, MCS approaches can extend the range of detection for particular analytes while improving the overall efficiency of biocatalytic cascade reactions. Compared with mono-enzyme biosensors, the integration of MCS and electrochemical biosensor platforms is inherently more challenging owing to the increased complexity of the resultant system. In recent years, substantial progress in the development of MCS-based electrochemical biosensors with enhanced analytical performance has been made. This review provides an overview of the types of MCS strategies and their biosensor applications, together with a summary of synergistic optimization approaches that can help improve key parameters including sensitivity, selectivity, and stability when designing MCS-based electrochemical biosensors. These discussions include examples of published biosensor platforms (2016-2024) while also surveying key advances in associated research areas including redox mediators/enzyme coimmobilization, enzyme engineering, multienzyme spatial regulation, enzyme-nanozyme integration and others. Lastly, a brief overview of current challenges and future perspectives pertaining to MCS-based electrochemical biosensor design is provided.

关键词： Multienzymatic system Electrochemical biosensor Cascade reaction Synergistic strategy Enzymatic biosensor

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Cocrystals of axially N-embedded quasi-carbon nanohoops via modulating the electron affinity of guest acceptors

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SCIENCE CHINA-CHEMISTRY 2025年 1-8页

作者： zhang, Li Qiu, Shuhai Hu, Shunlong Xu, Hanren Sun, xuwen Jiang, Wei Qu, Da-Hui Wang, Zhaohui East China Univ Sci & Technol Feringa Nobel Prize Scientist Joint Res Ctr Key Lab Adv Mat & Joint Int Res Lab Precis Chem & Sch Chem & Mol EngnInst Fine ChemFrontiers Sci C Shanghai 200237 Peoples R China Tsinghua Univ Dept Chem Key Lab Organ Optoelect & Mol Engn Beijing 100084 Peoples R China

Organic donor-acceptor cocrystals of pi-conjugated molecues have shown diverse applications in materials science. However, most cocrystals exist in neutral forms dominated by pi-pi interactions, while the ionic congeners and corresponding properties are rarely studied due to difficulties in harnessing the degree of charge transfer. Herein, we report cocrystals of axially N-embedded quasi-carbon nanohoops (DPP-D and DPP-T) with electron deficient guests. By modulating the electron affinity of the acceptor guests, the electronic structures of the complexes can be tuned from neutral to ionic states. Specifically, DPP-D interacts with TCNB molecules to form neutral superstructures via intermolecular pi-pi interactions, giving rise to a deep-red emission in the solid state. In contrast, an ionic complex showing near-infrared region absorptions and paramagnetic character on account of strong charge-transfer interactions is generated when DDQ molecules are involved. Their unique properties can be explained by different degrees of charge transfer and assembly modes, which have clearly been manifested by crystal structures and theoretical calculations. Our studies provide rare examples of pi-conjugated macrocycle-based donor-acceptor cocrystals in both neutral and ionic forms, and give insight to the design of multicomponent carbon nanomaterials.

关键词： n-doped carbon nanohoop donor-acceptor cocrystal charge transfer interaction ionic state

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Comprehensive feasibility analysis of carbon dioxide hydrate sequestration: A numerical study based on horizontal well networks

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ENVIRONMENTAL TECHNOLOGY & INNOVATION 2025年 37卷

作者： Li, Yuxuan zhang, Zhaobin Li, Shouding He, Jianming Xie, Zhuoran Li, Xiao Lu, Cheng Qin, xuwen Chinese Acad Sci Inst Geol & Geophys State Key Lab Deep Petr Intelligent Explorat & Dev Beijing 100029 Peoples R China Univ Chinese Acad Sci Coll Earth & Planetary Sci Beijing 100049 Peoples R China Minist Nat Resources China Geol Survey Beijing 100037 Peoples R China

Carbon dioxide sequestration is a crucial strategy for achieving carbon neutrality. This study explores a novel approach to carbon dioxide storage in marine environments in the form of hydrate, addressing the stringent site requirements of traditional geological storage methods. Using a custom-developed simulator, a conceptual model for carbon dioxide sequestration in subsea reservoirs under a horizontal well network configuration was constructed. Key factors, including seawater depth, injection depth, and well spacing, were analyzed through simulations to quantify carbon dioxide storage capacity and assess associated risks under various sequestration scenarios. The results indicate that increasing seawater depth boosts both COQ storage capacity and safety, while deeper injection enhances safety but reduces hydrate storage capacity and raises leakage potential. Closer well spacing improves early-stage safety but increases long-term risks. The study outlines distinct sequestration stages and provides detailed analyses of COQ migration and phase transformations over time, contributing insights for advancing COQ sequestration strategies.

关键词： Carbon dioxide sequestration Hydrate Horizontal well network Seawater depth Injection depth Well spacing

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Varicella vaccine effectiveness evaluation in Wuxi, China: A retrospective cohort study

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EPIDEMIOLOGY & INFECTION 2024年 152卷 e105-e105页

作者： Xiu, Shixin Xu, Zhuping Wang, xuwen zhang, Li Wang, Qiang Yang, Min Shen, Yuan Nanjing Med Univ Affiliated Wuxi Ctr Dis Control & Prevent Wuxi Ctr Dis Control & Prevent Dept Immunizat Wuxi Peoples R China Nanjing Med Univ Affiliated Wuxi Ctr Dis Control & Prevent Wuxi Ctr Dis Control & Prevent Dept Chron Communicable Dis Wuxi Peoples R China Jiangyin Cty Ctr Dis Control & Prevent Publ Hlth Dept Wuxi Peoples R China Fudan Univ Sch Publ Hlth Dept Epidemiol Shanghai Peoples R China Nanjing Med Univ Affiliated Wuxi Ctr Dis Control & Prevent Wuxi Ctr Dis Control & Prevent Wuxi Peoples R China

Varicella is a vaccine-preventable infectious disease. Since 1 December 2018, the varicella vaccine has been included in the local Expanded Programme on Immunization (EPI) in Wuxi, China, and children born after 1 December 2014 are eligible for free vaccination. To evaluate the effect of varicella vaccination in Wuxi city, we selected 382 397 children born from 2012 to 2016 as subjects. Their disease data were obtained from the Chinese Disease Prevention and Control Information System, and their vaccination data were obtained from the Jiangsu Province Vaccination Integrated Service Management Information System. The incidence of breakthrough varicella cases increased in the first 4 years and reached the peak in the fifth year. With the increase of vaccination rate, the incidence of varicella decreased significantly. The vaccine effectiveness (VE) was found to be 88.17%-95.78% for one dose and 98.65%-99.93% for two doses. Although the VE per dose decreased from 99.57% in the first year to 93.04% in the eighth year, it remained high. These findings confirmed the effectiveness of varicella vaccination in children, supported the use of a two-dose varicella vaccination strategy to achieve better protection, and provided important insights into the optimal vaccination strategy for varicella prevention in children.

关键词： screening method vaccine effectiveness varicella vaccine number of varicella cases vaccination rates

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