Prior plastic deformation processing was utilized to tune the mechanical performance of Ti40Zr25Ni3Cu12Be20 bulk metallic glass. After shear pre-deformation, the variations in the mechanical properties and the free vo...
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Prior plastic deformation processing was utilized to tune the mechanical performance of Ti40Zr25Ni3Cu12Be20 bulk metallic glass. After shear pre-deformation, the variations in the mechanical properties and the free volume content were examined by recourse to differential scanning calorimetry (DSC). X-ray diffraction (XRD), Vickers hardness measurements and uniaxial compression tests. The plastic strain prior to failure of the pre-deformed samples first increases and then decreases with increasing prior plastic strain. The hardness values of the pre-deformed samples exhibit an opposite trend The variations in the mechanical performance for the pre-deformed samples were ascribed to the variation in free volume content associated with the competition between the annihilation process by diffusion atomic jumping and the stress-driven free volume creation (C) 2010 Elsevier Ltd. All rights reserved
We have prepared columnar self-assembled Cu2S hexagonal nanoplates induced by a Sn-X complex for the first time and demonstrated that the Sn-X complex can affect not only the morphology of the nanocrystals but also th...
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We have prepared columnar self-assembled Cu2S hexagonal nanoplates induced by a Sn-X complex for the first time and demonstrated that the Sn-X complex can affect not only the morphology of the nanocrystals but also the self-assembly ability of the nanocrystals.
Background: IL-24 (interleukin-24) is a promising multifunctional anticancer agent with the ability of selectively inducing tumor cell apoptosis while sparing normal cells. Besides, IL-24 can enhance immune response t...
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Background: IL-24 (interleukin-24) is a promising multifunctional anticancer agent with the ability of selectively inducing tumor cell apoptosis while sparing normal cells. Besides, IL-24 can enhance immune response to tumor and suppress tumor angiogenesis. In this study, we introduced IL-24 into the triple regulated oncolytic adenovirus, ***.E1A((Delta 24)).E1B((Delta 55)).IL-24, in which E1A was deleted 24 bp (from 923 bp to 946 bp) to target Rb (retinoblastoma) deficient or dysfunctional tumors and driven by survivin promoter (sp) to target almost all tumors, and the E1B was deleted its 55 KDa gene. Results: ***.E1A((Delta 24)).E1B((Delta 55)).IL-24 exhibited much better antitumor effect than E1 single regulated oncolytic adenovirus ONYX-015 in vitro experiments. Furthermore, ***.E1A((Delta 24)).E1B((Delta 55)).IL-24 could effectively inhibit the progression of the NCI-H460 xenograft lung carcinoma in nude mice. Methods: The antitumor effect of ***.E1A((Delta 24)).E1B((Delta 55)).IL-24 was assessed by MTT assay and crystal violet staining in a panel of tumor cells. Apoptotic cell staining and western blot analysis were performed to observe morpholgical changes of tumor cells and detect the changes of some proteins in caspase pathway. Moreover, the antitumor effect of ***.E1A((Delta 24)).E1B((Delta 55)).IL-24 in nude mice was assessed for big tumor size. Conclusion: This study firstly used the E1A and E1B triple regulated oncolytic adenovirus vector carrying IL-24 to treat large tumors and attained efficient antitumor effect both in vitro and in vivo, which provides an experimental foundation for clinical cancer therapy.
Using silica nanorattles filled with N-[3(trimethoxysilyl) propyl] ethylenediamine as nanoreactors, size-tunable gold cores are fabricated inside the silica nanorattles using a facile, efficient, and large-scale method.
Using silica nanorattles filled with N-[3(trimethoxysilyl) propyl] ethylenediamine as nanoreactors, size-tunable gold cores are fabricated inside the silica nanorattles using a facile, efficient, and large-scale method.
The purpose of this study was to evaluate the feasibility of using tissue-engineered nerve grafts for delayed repair of peripheral nerve defects. A 1-month delayed, 10-mm long sciatic nerve defect was created for rats...
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The purpose of this study was to evaluate the feasibility of using tissue-engineered nerve grafts for delayed repair of peripheral nerve defects. A 1-month delayed, 10-mm long sciatic nerve defect was created for rats, which were divided into three grafted groups and a non-grafted group. For bridging the nerve defects, the rats in three grafted groups were subjected to surgical repair with tissue-engineered nerve grafts made of a chitosan/polyglycolic acid (PGA) conduit filled with neural stem cells (NSCs), chitosan/PGA conduits, and autologous nerve grafts, respectively. At 3 months after nerve grafting, the data from electrophysiology, retrograde tracing and histological investigation revealed that the better outcomes in sciatic nerve regeneration and target muscle re-innervation were achieved in three grafted groups as compared to those in non-grafted group without major differences between three grafted groups. Our results suggest that grafting of chitosan/PGA conduits might be a promising technique for repairing peripheral nerve injuries after a 1-month delay, while introduction of NSCs seem to show no significant additional benefits to regenerative outcomes.
作者：
Tian, BingHua, YuejinZhejiang Univ
Key Lab Nucl Agr Sci Chinese Minist Agr & Zhejiang Prov Inst Nucl Agr Sci Hangzhou 310029 Zhejiang Peoples R China
Bacteria from the phylum Deinococcus-Thermus are known for their resistance to extreme stresses including radiation, oxidation, desiccation and high temperature. Cultured Deinococcus-Thermus bacteria are usually red o...
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Bacteria from the phylum Deinococcus-Thermus are known for their resistance to extreme stresses including radiation, oxidation, desiccation and high temperature. Cultured Deinococcus-Thermus bacteria are usually red or yellow pigmented because of their ability to synthesize carotenoids. Unique carotenoids found in these bacteria include deinoxanthin from Deinococcus radio-durans and thermozeaxanthins from Thermus thermophilus. Investigations of carotenogenesis will help to understand cellular stress resistance of Deinococcus-Thermus bacteria. Here, we discuss the recent progress toward identifying carotenoids, carotenoid biosynthetic enzymes and pathways in some species of Deinococcus-Thermus extremophiles. In addition, we also discuss the roles of carotenoids in these extreme bacteria.
In this paper a unified address data schema was proposed on the basis of analyzing the addresses frequently used in china. The model describes and stores all types of address elements, such as cities, towns and villag...
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ISBN:
(纸本)9781424495665
In this paper a unified address data schema was proposed on the basis of analyzing the addresses frequently used in china. The model describes and stores all types of address elements, such as cities, towns and villages, etc., and their relationships. Based on this schema, the rules and algorithms of the address matching mode were presented. Finally an address database and a prototype system are implemented based on the addressing schema and the address matching mode. The experiment shows the system has high address matching rate and fast address matching speed.
The presence of cracks in the rotor is one of the most dangerous and critical defects for rotating machinery. Defect of fatigue cracks may lead to long out-of-service periods, heavy damages of machines and severe econ...
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The presence of cracks in the rotor is one of the most dangerous and critical defects for rotating machinery. Defect of fatigue cracks may lead to long out-of-service periods, heavy damages of machines and severe economic consequences. With the method of finite element, vibration behavior of cracked rotors and crack detection was received considerable attention in the academic and engineering field. Various researchers studied the response of a cracked rotor and most of them are focused on the crack detection based on vibration behavior of cracked rotors. But it is often difficult to identify the crack parameters quantitatively. Second generation wavelets （SGW） finite element has good ability in modal analysis for singularity problems like a cracked rotor. Based on the fact that the feature of SGW could be designed depending on applications, a multiresolution finite element method is presented. The new model of SGW beam element is constructed. The first three natural frequencies of the rotor with different crack location and size were solved with SGW beam elements, and the database for crack diagnosis is obtained. The first three metrical natural frequencies are employed as inputs of the database and the intersection of the three frequencies contour lines predicted the normalized crack location and size. With the Bently RK4 rotor test rig, rotors with different crack location and size are tested and diagnosed. The experimental results denote the cracks quantitative identification method has higher identification precision. With SGW finite element method, a novel method is presented that has higher precision and faster computing speed to identify the crack location and size.
Unlike that of sintering of fine powders, chips are consolidated by hot deformation in the solid-state recycling. In this work, conventional extrusion (CE) and cyclic extrusion compression (CEC) are used to investigat...
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Unlike that of sintering of fine powders, chips are consolidated by hot deformation in the solid-state recycling. In this work, conventional extrusion (CE) and cyclic extrusion compression (CEC) are used to investigate single and multi-passes shear deformation on the consolidation of chips during solid-state recycling. The results show that utilization of Mg chips with smaller specific surface area (i.e. coarser powder) contributes to easier solid-state bonding because of the decrease in specific surface area which promotes suppression of oxide contamination in the recycled specimens. Enhanced consolidation of chips is not only ascribed to the physical mechanisms caused by plastic deformation, but also to atom diffusion between chips triggered by shear plastic deformation at elevated temperatures. Multi-passes shear deformation breaks the oxide films easier into small particles which are dispersed within the grains or at grain boundaries. It is postulated that the shear deformation of chips is responsible for the better consolidation of chips by high-temperature deformation. (C) 2010 Elsevier B.V. All rights reserved.
This paper has researched and analyzed on the fractal dimension calculating method and selected Peleg Carpet Covered algorithm which is fit for fractal physiognomy analysis to research. Aiming at the shortage of Peleg...
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ISBN:
(纸本)9780878492459
This paper has researched and analyzed on the fractal dimension calculating method and selected Peleg Carpet Covered algorithm which is fit for fractal physiognomy analysis to research. Aiming at the shortage of Peleg Carpet Covered algorithm, an improved Carpet Covered algorithm is proposed. By experiment, the performance of original algorithm and improved algorithm is compared and validated, and the results show that improved algorithm has improved the calculating accuracy and texture-differentiating ability. Applying this algorithm to fractal topography creating can make the fractal topography model be alike to genuine physiognomy.
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