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13th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems (IEEE-NEMS)

作者： Shi, Jianhao Li, Hongfang Sun, Bin Zhao, Xiaolin Ding, Guifu Yang, Zhuoqing Shanghai Jiao Tong Univ Natl Key Lab Sci & Technol Micro Nano Fabricat 800 Dongchuan Rd Shanghai 200240 Peoples R China Chinese Acad Sci Shenzhen Inst Adv Technol Inst Biomed & Hlth Engn Shenzhen 518055 Peoples R China

ISBN: (纸本)9781538652732

This paper reports a flexible pressure sensor based on electroplated-Ni film induced mechanical cracking that realizes the resistance change once undergoing pressure. A lot of cracks will be induced at the tip of triangle patterns due to the stress concentration when the sensor is pressed, which results in the resistance change with pressure. The test results show that the gauge factor of the fabricated pressure sensor reaches a maximum gauge factor of 24.2482 kPa(-1) at 30.84 kPa. The fabricated pressure sensor has a response time of 18 ms and can even be applied in the wearable devices application, such as pulse detection.

关键词： flexible pressure sensor cracking wearable devices application

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Evaluation of spatial heterogeneity in the sensitivity of on-street parking occupancy to price change

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TRANSPORTATION research PART C-EMERGING techNOLOGIES 2017年第Apr.期77卷 67-79页

作者： Pu, Ziyuan Li, Zhibin Ash, John Zhu, Wenbo Wang, Yinhai Univ Washington Dept Civil & Environm Engn Seattle WA 98195 USA Southeast Univ Sch Transportat Si Pai Lou 2 Nanjing 210096 Jiangsu Peoples R China

Adjustment of parking price has long been considered an effective way to control parking demand and demand has often been shown to be affected by spatial factors. The primary objective of this study is to investigate the spatial heterogeneity in the sensitivity of parking occupancy to price change using data obtained in downtown San Francisco between 2011 and 2014. The performance-based pricing implemented in the study area allows parking rate to increase, decrease or remain unchanged in neighborhoods with parking occupancy levels higher than, lower than, or within a desired range. As such, the relationship between change in occupancy and change in parking rate is explored. The geographically weighted regression (GWR) method was used to capture the spatial heterogeneity in sensitivity in different blocks and modeling results showed that there is a significant negative correlation between occupancy change and parking rate change. Thus, sensitivity of on-street parking occupancy to price change has an obvious trend of spatial variation. By capturing the spatial heterogeneity in the dataset, the GWR model achieved higher prediction accuracy than a global model. Variables including time of day, block-level features, and socio-demographic characteristics were also found to be correlated with occupancy change. Based on the GWR outputs, a generalized linear model was estimated to further identify how various factors affect sensitivity in different block areas. Findings of this study can be used to help parking authorities with tasks such as identifying which blocks are suitable for balancing parking demand and supply by adjusting price and designing optimal parking rate schemes to achieve desired on-stteet parking occupancy levels. (C) 2017 Elsevier Ltd. All rights reserved.

关键词： Parking demand Spatial heterogeneity Geographically weighted regression

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Silver Inlaid with Gold Nanoparticle/Chitosan Wound Dressing Enhances Antibacterial Activity and Porosity, and Promotes Wound Healing

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BIOMACROMOLECULES 2017年第11期18卷 3766-3775页

作者： Li, Qing Lu, Fei Zhou, Guofang Yu, Kun Lu, Bitao Xiao, Yang Dai, Fangying Wu, Dayang Lan, Guangqian Southwest Univ Coll Text & Garments Chongqing 400715 Peoples R China Chongqing Engn Res Ctr Biomat Fiber & Modern Text Chongqing 400715 Peoples R China Guangdong Acad Agr Sci Sericulture & Agrifood Res Inst Guangzhou 510610 Guangdong Peoples R China

Silver inlaid with gold nanoparticles (Au-Ag NPs) prepared by using egg white with an average sized of 10 nm and homogeneous dispersion were tested and presented red fluorescence. Au-Ag NPs were loaded into chitosan as wound dressing (CS-Au-Ag). CS-Au-Ag released silver ions faster, in higher amount, and in a more durable manner than chitosan dressing loaded with silver nanoparticles with the same silver content (CS-Ag), consequently, showing enhanced antibacterial activity. Cytotoxicity tests indicated that CS-Au-Ag showed low cytotoxicity to L929 cells similar to CS-Ag. These data suggest that cytotoxicity, which restricts further application of silver NPs, can be eliminated by decreasing the silver content. CS-Au-Ag presented rich and well-distributed pores, good mechanical properties, and enhanced swelling and retention properties, contributing to keeping the wound moist in the presence of residual egg white. Altogether, our results suggest that CS-Au-Ag greatly promoted wound healing compared to CS-Ag in vivo, demonstrating that CS-Au-Ag presents great potential for wound dressing, promoting wound healing.

关键词： GOLD nanoparticles GOLD ChiTOSAN SILVER ions WOUND healing

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Comparison of higher-order multiphoton signal generation and collection at the 1700-nm window based on transmittance measurement of objective lenses

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JOURNAL OF BIOPHotONICS 2018年第1期11卷 2018 Jan;11(1)页

作者： Wen, Wenhui Wang, Yuxin Liu, Hongji Wang, Kai Qiu, Ping Wang, Ke Shenzhen Univ Coll Optoelect Engn Key Lab Optoelect Devices & Syst Minist Educ & Guangdong Prov Shenzhen Peoples R China Shenzhen Univ Coll Phys & Energy Shenzhen Peoples R China

One benefit of excitation at the 1700-nm window is the more accessible modalities of multiphoton signal generation. It is demonstrated here that the transmittance performance of the objective lens is of vital importance for efficient higher-order multiphoton signal generation and collection excited at the 1700-nm window. Two commonly used objective lenses for multiphoton microscopy (MPM) are characterized and compared, one with regular coating and the other with customized coating for high transmittance at the 1700-nm window. Our results show that, fourth harmonic generation imaging of mouse tail tendon and 5-photon fluorescence of carbon quantum dots using the regular objective lens shows an order of magnitude signal higher than those using the customized objective lens. Besides, the regular objective lens also enables a 3-photon fluorescence imaging depth of >1600 mu m in mouse brain in vivo. Our results will provide guidelines for objective lens selection for MPM at the 1700-nm window.

关键词： 5-photon fluorescence deep tissue fourth harmonic generation multiphoton microscopy

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Isoindoline nitroxide-labeled porphyrins as potential fluorescence-suppressed spin probes

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ORGANIC & BIOMOLECULAR CHEMISTRY 2017年第5期15卷 1245-1253页

作者： Liu, F. Zou, T. J. Tan, Z. L. Chen, S. Wu, Z. H. Yan, G. P. Zhang, Q. Liang, S. C. Yang, J. Wuhan Inst Technol Sch Mat Sci & Engn Wuhan 430074 Peoples R China Wuhan Univ Sch Pharm Wuhan 430072 Peoples R China

A series of isoindoline nitroxide-labeled porphyrins were synthesized by the reaction of 5-phenyldipyrromethane and 5-(4'-carboethoxy-methyleneoxyphenyl)dipyrromethane with 5-formyl-1,1,3,3-tetra-methylisoindolin-2-yloxyl (FTMIO) using the Lindsey method. The corresponding water-soluble spin-labeled porphyrins were also prepared. Subsequently, these compounds were characterized and their in vitro properties were evaluated. The electrochemical assay demonstrated that these isoindoline nitroxide-labeled porphyrins had similar electrochemical and redox properties to 5-carboxy-1,1,3,3-tetra-methylisoindolin-2-yloxyl (CTMIO). The electron paramagnetic resonance test showed that these porphyrins exhibited hyperfine splittings and characteristic spectra of CTMIO with typical nitroxide g-values and nitrogen isotropic hyperfine coupling constants. The in vitro cytotoxicity assay indicated that these porphyrins possessed low cytotoxicity to human renal tubular epithelial 293T cells (normal cells) and human hepatoma HepG2 cells (tumor cells). Fluorescence spectroscopy revealed that free base isoindoline nitroxide-labeled porphyrins exhibited fluorescence suppression characteristic of nitroxide-fluorophore systems. In vitro fluorescene imaging demonstrated that the reduced isoindoline nitroxide-labeled porphyrins eliminated fluorescence suppression and displayed strong red fluorescence imaging in HepG2 cells. Thus these isoindoline nitroxide-labeled porphyrins may be considered potentially as biological spin probes for fluorescence imaging and EPR spectroscopy.

关键词： Fluorescence Hep G2 Cells CYTotOXICITY TESTING characteristic spectrum Fluorescence Imaging electron paramagnetic resonance spectroscopy porphyrins Redox properties Resonance testing

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Rapid de novo generation of antigen specific human B cells with expression of Blimp-1 and AID by in vitro immunization

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EXPERIMENTAL CELL research 2017年第1期352卷 53-62页

作者： Fang, Xu Tong, Yue Tian, Hong Ning, Hongyu Gao, Xiangdong Yao, Wenbing China Pharmaceut Univ Sch Life Sci & Technol Jiangsu Key Lab Druggabil Biopharmaceut Nanjing 210009 Jiangsu Peoples R China

In vitro immunization with antigens and cytokines triggers specific human B-cell response in short periods and is therefore superior to conventional in vivo immunization for antibody development. However, this new technology is limited by low efficiency, poor reproducibility, and requirement of pre-immunized lymphocytes. In this study, we demonstrate a novel method for de novo inducing antigen-specific human B cells in vitro. Unlike previous in vitro immunization of unfractionated PBMCs, we firstly optimized the conditions for inducing monocyte-derived dendritic cells (DCs) to efficiently capture, process, and present antigens. Instead of using the conventional method to activate Th2 cells for in vitro immunization, we succeeded to differentiate naive CD4(+) T cells into T follicular helper (Tfh) cells using antigen-sensitized DCs and cytokine cocktail. We discovered the differentiated T cells expressed ICOS, PD-1, BCL-6, and IL-21 at high levels. After 12 days of T-B co-culture, we observed induced T cells efficiently promoted na ve B cells to differentiate into plasmablasts secreting antigen specific antibodies, with expression of Blimp-1 and AID related to affinity maturation and class switching. Thus, we established a new co-culture system with naive lymphocyte populations for de novo acquisition of specifically in vitro immunized B cells potentially for development of therapeutic antibodies, which also provides novel insights into understanding the complex interactions among immune cells in lymph nodes.

关键词： In vitro immunization Full human monoclonal antibodies Monocyte-derived DCs Tfh cells Naive B cells

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vScope: A Fine-Grained Approach to Schedule vCPUs in NUMA Systems 19

vScope: A Fine-Grained Approach to Schedule vCPUs in NUMA Sy...

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19th IEEE International Conference on high Performance Computing and Communications (HPCC) / 15th IEEE International Conference on Smart City (SmartCity) / 3rd IEEE International Conference on Data Science and Systems (DSS)

作者： Gan, Qingtian Wu, Song Jin, Hai Wang, Kun Huazhong Univ Sci & Technol Sch Comp Sci & Technol Cluster & Grid Comp Lab Serv Comp Technol & Syst Lab Wuhan 430074 Hubei Peoples R China

ISBN: (纸本)9781538625880

Non-Uniform Memory Access (NUMA) architecture has become the dominant architecture and is widely used in virtualization platforms. In NUMA-based cloud computing platform, arbitrary topology of vCPUs and memory may cause significant performance degradation for VMs, which introduces great challenges for virtual machine monitors (VMMs) to efficiently manage the vCPUs and memory. Previous studies mainly sample the characteristics of the vCPUs to indicate the optimizing strategies to reduce the NUMA overheads in virtualization platforms. But the typical periodical sampling methods have some deviations with the real vCPU characteristics. This leads to the inaccurate sampling and scheduling decisions for the optimizing strategies. Motivated by the inaccuracy in sampling methods and scheduling decisions, we propose a fine-grained scheduler, named vScope, which makes accurate scheduling decisions according to the guest OS processes in the vCPUs, to improve the performance of memory-intensive workloads in cloud platforms. In vScope, the VMM identifies the guest OS processes in the vCPUs and calculates the NUMA affinity of each process from the PMU data. At the end of vCPU's scheduling cycle, the scheduler appropriately schedules the vCPUs to their local NUMA node to alleviate the unnecessary NUMA overhead. We implement vScope in Xen-4.5.1 VMM and evaluate its effectiveness with some memory-intensive benchmarks. The experimental results shows that vScope can achieve up to 11.5% performance improvement for these workloads when compared with the Credit scheduler in Xen. Moreover, vScope only introduces limited overhead into the system.

关键词： Virtualization NUMA vCPU Scheduler Semantic-Gap

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Greedy Flipping for Constrained Word Deletion 31

Greedy Flipping for Constrained Word Deletion

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31st AAAI Conference on Artificial Intelligence

作者： Yao, Jin-ge Wan, Xiaojun Peking Univ Inst Comp Sci & Technol MOE Key Lab Computat Linguist Beijing 100871 Peoples R China

In this paper we propose a simple yet efficient method for constrained word deletion to compress sentences, based on top-down greedy local flipping from multiple random initializations. The algorithm naturally integrates various grammatical constraints in the compression process, without using time-consuming integer linear programming solvers. Our formulation suits for any objective function involving arbitrary local score definition. Experimental results show that the proposed method achieves nearly identical performance with explicit ILP formulation while being much more efficient.

关键词： Integer programming

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Temperature dependence simulation and characterization for InP/InGaAs avalanche photodiodes

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Frontiers of Optoelectronics 2018年第4期11卷 400-406页

作者： Yanli ZHAO Junjie TU Jingjing XIANG Ke WEN Jing XU Yang TIAN Qiang LI Yuchong TIAN Runqi WANG Wenyang LI Mingwei GUO Zhifeng LIU Qi TANG Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China Wuhan Aroptics-Tech Co. LTDWuhan 430074China Sichuan Branch China Unicom Network Communications Co.LtdChengdu 610041China

Based on the newly proposed temperature dependent dead space model, the breakdown voltage and bandwidth of InP/InGaAs avalanche photodiode (APD) have been investigated in the temperature range from -50°C to 100°C. It was demonstrated that our proposed model is consistent with the experimental results. Our work may provide a guidance to the design of APDs with controllably low temperature coefficient.

关键词： optical communication separate absorption grading charge and multiplication avalanche photodiode (SAGCM APD) dead space effect temperature coefficient

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Heat-induced inactivation mechanism of soybean Bowman-Birk inhibitors

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FOOD CHEMISTRY 2017年 232卷 712-720页

作者： He, Hui Li, Xingfei Kong, Xiangzhen Hua, Yufei Chen, Yeming Jiangnan Univ Sch Food Sci & Technol State Key Lab Food Sci & Technol 1800 Lihu Ave Wuxi 214122 Jiangsu Peoples R China

Due to the complications of the soymilk system, the heat-induced Bowman-Birk inhibitor (BBI) inactivation mechanism is not well known. In this study, two BBI samples with low and high purities were prepared from soymilk. It was confirmed that three groups (A, C, and D) of BBI, which are contained in soybean seeds, were transferred into soymilk during processing. On heating, it was found that 1) the two subdomains of BBI were not equally heat stable, 2) the conformation of BBI gradually changed, 3) some amino acid residues (namely, cystine, serine and lysine) in BBI were degraded, 4) BBI did not tend to form intermolecular cross-links with another BBI, but did slightly with non-BBI proteins. Based on some previous studies, the conformational change of BBI was attributed to beta-elimination reactions on the amino acid residues of BBI and the subsequent intramolecular reactions induced by the products yielded by the beta-elimination reactions. (C) 2017 Elsevier Ltd. All rights reserved.

关键词： Bowman-Birk inhibitors beta-Elimination reaction Disulfide bond Cystine-rich peptides

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