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Flower-like gap-enhanced Raman tags wrapped with polydopamine-functionalized MoS2 nanosheets for phototheranostic nanoplatform

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JOURNAL OF MATERIALS SCIENCE 2025年第4期60卷 1873-1890页

作者： Chen, Ming Zhao, Xing Wang, Bin Li, Da Xu, Xiaoxuan Liu, Hongliang Ai, Siwen Sun, Lu Nankai Univ Inst Modern Opt Eye Inst Tianjin 300350 Peoples R China Nankai Univ Coll Artificial Intelligence Tianjin 300350 Peoples R China Tianjin Key Lab Microscale Opt Informat Sci & Tech Tianjin 300350 Peoples R China Chongqing Technol & Business Univ Sch Artificial Intelligence Chongqing 400067 Peoples R China

Phototheranostic nanoplatforms that perform simultaneous optical imaging and phototherapy through light activation are considered a promising approach for early diagnosis, surgical guidance, and precision treatment of cancer. In this work, we develop a novel flower-like gap-enhanced Raman tags (for brief, PMF-GERTs) wrapped with polydopamine (PDA)-functionalized molybdenum disulfide (MoS2) nanosheets. In PMF-GERTs, 4,4 '-biphenyldithiol (BPDT) Raman reporter molecules are embedded in the nanogap between the gold core and the flower-like shell, and PDA-functionalized MoS2 nanosheets (PDA/MoS2) were wrapped on the surface of the flower-shaped shell. Photothermal and photodynamic experiments show that PDA/MoS2 nanosheets significantly improve the photothermal performance and photodynamic response ability of Raman tags in the NIR-II region. Under the irradiation of 1064 nm laser (1 W/cm2), the PMF-GERTs solution can heat up to 66 degrees C within 300 s, and the photothermal conversion efficiency reaches 43.6%. Moreover, PMF-GERT also has excellent photothermal stability and photodynamic properties and can perform effective phototherapy on 4T1 tumor cells. In Raman spectra and mapping imaging experiments, PMF-GERTs have strong enhanced Raman signals, lower detection thresholds and long-time physiological environment stability (72 h). In addition, PMF-GETRs also have excellent performance in simulating biological tissues and biological Raman mapping imaging. This novel Raman tag is expected to be used to develop phototheranostic nanoplatform that integrates Raman imaging diagnosis and photothermal and photodynamic therapy.

关键词： Nanosheets

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Local and global self-attention enhanced graph convolutional network for skeleton-based action recognition

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PATTERN RECOGNITION 2025年 159卷

作者： Wu, Zhize Ding, Yue Wan, Long Li, Teng Nian, Fudong Hefei Univ Sch Artificial Intelligence & Big Data Hefei 230601 Peoples R China Anhui Univ Sch Artificial Intelligence Hefei 230601 Peoples R China

The current successful paradigm for skeleton-based action recognition is the combination of Graph Convolutional Networks (GCNs) modeling spatial correlations, and Temporal Convolution Networks (TCNs), extracting motion features. Such GCN-TCN-based approaches usually rely on local graph convolution operations, which limits their ability to capture complicated correlations among distant joints, as well as represent long-range dependencies. Although the self-attention originated from Transformers shows great potential in correlation modeling of global joints, the Transformer-based methods are usually computationally expensive and ignore the physical connectivity structure of the human skeleton. To address these issues, we propose a novel Local Global Self-Attention Enhanced Graph Convolutional Network (LG-SGNet) to simultaneously learn both local and global representations in the spatial-temporal dimension. Our approach consists of three components: The Local-Global Graph Convolutional Network (LG-GCN) module extracts local and global spatial feature representations by parallel channel-specific global and local spatial modeling. The Local-Global Temporal Convolutional Network (LG-TCN) module performs a joint-wise global temporal modeling using multi-head self attention in parallel with local temporal modeling. This constitutes anew multi-branch temporal convolution structure that effectively captures both long-range dependencies and subtle temporal structures. Finally, the Dynamic Frame Weighting Module (DFWM) adjusts the weights of skeleton action sequence frames, allowing the model to adaptively focus on the features of representative frames for more efficient action recognition. Extensive experiments demonstrate that our LG-SGNet performs very competitively compared the state-of-the-art methods. Our project website is available at https://***/DingYyue/LG-SGNet.

关键词： Graph convolutional networks Self-attention Skeleton-based action recognition

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Detection of organic dyes using Ag NPAs/SMP SERS substrate produced via sandpaper template-assisted lithography and liquid-liquid interface self-assembly

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ANALYTICAL AND BIOANALYTICAL CHEMISTRY 2024年第4期416卷 1047-1056页

作者： Tan, Yuanhang Zhou, Ziyu Xu, Yiting Xie, Atian Wu, Shangquan Xue, Changguo Anhui Univ Sci & Technol Sch Mat Sci & Engn Huainan 232001 Anhui Peoples R China Univ Sci & Technol China CAS Key Lab Mech Behav & Design Mat Hefei 230026 Peoples R China

Surface-enhanced Raman spectroscopy (SERS) is a highly sensitive and reliable fingerprinting technique. However, its analytical capability is closely related to the quality of a SERS substrate used for the analysis. In particular, conventional colloidal substrates possess disadvantages in terms of controllability, stability, and reproducibility, which limit their application. In order to address these issues, a simple, cost-effective, and efficient SERS substrate based on silver nanoparticle arrays (Ag NPAs) and sandpaper-molded polydimethylsiloxane (SMP) was proposed in this work. Successfully prepared via template lithography and liquid-liquid interface self-assembly (LLISA), the substrate can be applied to the specific detection of organic dyes in the environment. The substrate exhibited good SERS performance, and the limit of detection (LOD) of rhodamine 6G (R6G) was shown to be 10-7 M under the optimal conditions (1000 grit sandpaper) with a relative standard deviation (RSD) of 7.76%. Moreover, the SERS signal intensity was maintained at 60% of the initial intensity after the substrate was stored for 30 days. In addition, the Ag NPAs/SMP SERS substrate was also employed to detect crystal violet (CV) and methylene blue (MB) with the LODs of 10-6 M and 10-7 M, respectively. In summary, the Ag NPAs/SMP SERS substrate prepared in this study has great potential for the detection of organic dyes in ecological environments.

关键词： Surface-enhanced Raman spectroscopy Liquid-liquid interface self-assembly Sandpaper Silver nanoparticle arrays Polydimethylsiloxane Organic dyes

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Transcriptomic mechanism revealed IbGST4 and IbGST2 genes response to low-temperature stress in sweet potatoes

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POSTHARVEST BIOLOGY AND TECHNOLOGY 2024年 212卷

作者： Zhao, Wei-Sheng Yan, Long-Fei Hu, Kang-Di Zhou, Zhi-Lin Wang, Si-Qi Yan, Le-Ying Hu, Fan Zhang, Hua Yao, Gai-Fang Hefei Univ Technol Sch Food & Biol Engn Hefei 230009 Peoples R China Xuzhou Inst Agr Sci Xuhuai Dist Jiangsu Prov Xuzhou 221131 Peoples R China

Sweet potato ( Ipomoea batatas L.) is a crop native to the tropics that is weakly resistant to cold. Low temperatures are important factors limiting its storage. By analyzing the phenotypic and tuberous root color differences between Xushu 32 and Yanshu 25 under low -temperature treatment, we found that Xushu 32 showed less lowtemperature damage. Transcriptome analysis was performed on the tuberous roots of the two sweet potatoes at different storage times to further investigate the molecular mechanism. There were 7039 differentially coexpressed genes in Xushu 32 and 11033 differentially co -expressed genes in Yanshu 25 after 4 and 8 days of low -temperature treatment. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses showed that the percentage of differentially expressed genes in the glutathione metabolism pathway in Xushu 32 was significantly higher than that in Yanshu 25. Weighted correlation network analysis (WGCNA) analysis indicated that the expression modules of MElightcyan1 and MEmegenta3 were up -regulated under lowtemperature stress and that glutathione S-transferases (GSTs) were hub genes with high connectivity. The candidate genes IbGST2 and IbGST4 were highly similar to a rice glutathione S-transferase (GST) (Os10g0528900) by heatmap analysis and evolutionary tree analysis and may play a role in low -temperature stress. Subsequently, gene -silenced plants of the homologous genes SlBI-GST and SlGST-T4 in tomatoes were constructed using virus -induced gene silencing (VIGS) technology, and the contents of reactive oxygen species (ROS) metabolites and expression of BI-GST , GST-T4 , and the C -repeat binding transcription factors (CBFs) were determined. This suggested that BI- GST and GST- T4 genes could scavenge ROS and improve the cold tolerance of tomatoes. These results provide important insights into the roles of IbGST2 and IbGST4 in the storage characteristics of sweet potatoes under low -temperature stress.

关键词： Sweet potato ( Ipomoea batatas L.) Transcriptome sequencing Gene silencing ROS metabolites Low -temperature stress

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Na0.5Bi0.5TiO3:Y³⁺@PAN Nanofibers for Photocatalysis Using Synergetic Piezoelectric Effects

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ACS APPLIED NANO MATERIALS 2024年第11期7卷 12490-12498页

作者： Yuan, Wenfeng Liu, Yongqiang Liu, Weifeng Sun, Xianke Zhoukou Normal Univ Sch Phys & Telecommun Engn Zhoukou 466001 Peoples R China

A series of Na0.5Bi0.5TiO3-based catalysts were synthesized by using the solvothermal route. The successful synthesis of catalysts was confirmed by various measurements. The influence of Y3+ doping on the band gap was revealed by the UV-visible absorbance spectra. Their photocatalytic, piezocatalytic, and piezo-photocatalytic activities were investigated by degrading methylene blue. The results show that the Y3+ doping can enhance the catalytic activity of Na0.5Bi0.5TiO3 due to the more efficient harvesting of light, and the catalytic activity can be further enhanced by the support of polyacrylonitrile nanofibers on account of the existence of more active sites. The reaction constants of Na0.5Bi0.485Y0.015TiO3 and Na0.5Bi0.485Y0.015TiO3@PAN in photocatalysis processes are 0.0075 and 0.0112 min(-1), which is 1.23 and 1.84 times as many as that of Na0.5Bi0.5TiO3. In addition, the catalysts show higher catalytic activities when the catalysis is carried out at the operating condition including both simulated sunlight irradiation and ultrasonic vibration. The reaction constant of Na0.5Bi0.485Y0.015TiO3@PAN in piezo-photocatalysis is 0.0381 min(-1), which is 3.09 and 6.77 times of photocatalysis and piezocatalysis. The enhanced activity results from suppression of charge carrier recombination. The radicals of O-center dot(2)- and h(+) play actual roles in the catalytic processes.

关键词： Na0.5Bi0.5TiO3 piezo-photocatalysis Y3+ doping PAN supporting nanofiber

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Enhanced decision framework for two-player zero-sum Markov games with diverse opponent policies

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APPLIED INTELLIGENCE 2025年第6期55卷 1-21页

作者： Zhu, Jin Wang, Xuan Dullerud, Geir E. Univ Sci & Technol China Dept Automat Hefei 230027 Anhui Peoples R China Univ Illinois Dept Comp Sci Urbana IL 61801 USA

This paper takes into account a general two-player zero-sum Markov game scenario in which our agent faces multi-type opponents with multiple policies. To enhance our agent's return against opponent's diverse policies, a novel Decision-making Framework based on Opponent Distinguishing and Policy Judgment (DF-ODPJ) is proposed. On the basis of the pre-trained Nash equilibrium strategies, DF-ODPJ can distinguish the opponent's type by sampling from the interaction trajectory. Then a fast criterion is proposed to judge the opponent's policy which is proven to minimize the misjudgment probability with optimal threshold calculated. According to the identification results, appropriate policies are generated to enhance the return. The proposed DF-ODPJ is more flexible since it is orthogonal to existing Nash equilibrium algorithms and single-agent reinforcement learning algorithms. The experimental results on grid world, video games, and UAV aerial combat environments illustrate the effectiveness of DF-ODPJ. The code is available at https://***/ChenXJ295/DF-ODPJ.

关键词： Two-player zero-sum Markov games Opponents with diverse policies Opponent distinguishing and policy judgment Reward enhancement

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Design of Single-Cavity Dual-Band Filter Based on Stepped Impedance Resonators

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IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-EXPRESS BRIEFS 2024年第2期71卷 587-591页

作者： Chen, Lu Ding, Dawei Zhang, Xiu Yin Anhui Univ Sch Elect & Informat Engn Hefei 230601 Peoples R China Anhui Univ Sch Elect & Informat Engn & Informat Mat Intelligent Sensing Lab Anhui Prov Hefei 230601 Peoples R China South China Univ Technol Sch Elect & Informat Engn Guangzhou 510641 Peoples R China

This brief presents a single-cavity dual-band filter based on stepped impedance resonators (SIRs). This filter consists of a dielectric cylinder, four SIRs and an inductive cross-coupling structure (ICCS) placed inside a rectangular metal cavity. Through eigenmode analysis, the proposed filter could generate four resonant modes in two working bands. The ICCS is employed to obtain transmission zeros. After optimization, a compact single-cavity dual-band filter with low insertion loss, high selectivity, wide working bandwidth and wide out-of-band suppression is designed at 2470-2700 MHz and 3340-3750 MHz. Measured results show that the proposed filter could provide a promising candidate for both LTE (Long Term Evolution) and 5G (the Fifth Generation) mobile communication systems.

关键词： Resonator filters Band-pass filters Microwave filters Filtering theory Resonators Loss measurement Information filters Bandpass filter cavity filter dual-band filter stepped impedance resonator

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A genome-wide association study identified candidate genes associated with egg quality traits in Muscovy duck

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BMC GENOMICS 2025年第1期26卷 1-14页

作者： Yang, Wanli Yu, Shiqi Song, Danyu Lin, Weihuang Xu, Hanqi Lang, Xuqiao Zhang, Cheng Guo, Liping Chen, Xingyong Anhui Agr Univ Coll Anim Sci & Technol 130 Changjiang West Rd Hefei 230036 Peoples R China Anhui Agr Univ Anhui Prov Key Lab Local Livestock & Poultry Genet 130 Changjiang West Rd Hefei 230036 Peoples R China

Background Egg quality directly determines embryo development in meat-type poultry. However, it is difficult to directly select the egg quality of Muscovy duck. The genes and SNPs associated with egg quality screened by GWAS can be used for molecular breeding and accelerate the progress of selection in Muscovy duck. Result 295 Muscovy ducks were used for whole genome sequencing, and a total of 6,131,623 SNPs were obtained for further analysis. The heritability of egg quality ranged from 0.01 to 0.41, in which egg weight (EW) was 0.19, albumen weight (AW) was 0.16 and the yolk weight (YW) was 0.27. The genetic correlation of EW and AW, EW and YW, and eggshell thickness (EST) and eggshell strength (ESS) were 0.65, 0.51, and 0.74, respectively. Phenotypic correlations between egg quality ranged from - 0.13 to 0.17. A total of 68 SNPs significantly associated with EW were located within the genes PSMG4, SLC22A23, DNAH5, FABP6, ADAMST17, IGF1R, NTRK3, and SCAI. The linkage disequilibrium (LD) analysis identified 2_75684453_C > G, 2_76305509_A > G, 2_76350118_T > A, 11_3834664_C > T, 11_4339778_C > T, and 11_8079686_C > T as tagSNPs to represent the significant SNPs. Fifty SNPs significantly associated with YW were located within the genes XKR6, DNAJC24, SNCB, UNC5A, MAD1L1, NOTCH1, and WDR7. The SNPs 14_9186714_C > T, 14_9199818_A > G, 15_5452098_C > T, and 18_9038052_C > T were selected as tagSNPs. Fifty-four SNPs significantly associated with albumen height were located within the genes LIN9 and NID1. The SNP 3_17718980_A > G was selected as the tagSNP. The significant SNPs associated with eggshell strength were located within the genes CLPX, EPHA5, ZBTB44, NOL6, and UBAP1. The SNPs 25_1996726_A > C and 25_2078328_A > G were selected as tagSNPs. Genes associated with egg quality were significantly enriched in the positive regulation of the BMP signaling pathway in the GO enrichment analysis of biological processes. The KEGG enrichment analysis suggested that the SNPs l

关键词： Muscovy duck Egg quality GWAS Molecular breeding

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Armored polymyxin B: a nanosystem for combating multidrug-resistant Gram-negative bacilli

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RSC ADVANCES 2024年第53期14卷 39700-39707页

作者： Huang, Jianling Hong, Xiuwen Lv, Yunxiang Wang, Yueyue Han, Kexing Zhu, Chenghua Xie, Lixu Bengbu Med Univ Mol Diag Ctr Dept Pulm & Crit Care Med Anhui Clin & Preclin Key Lab Resp DisAffiliated H Bengbu 233000 Anhui Peoples R China Nanjing Med Univ Affiliated Hosp 2 Dept Pulm & Crit Care Med Nanjing 210011 Jiangsu Peoples R China China Pharmaceut Univ Nanjing Pukou Hosp TCM Pukou Hosp Chinese Med Nanjing 210000 Peoples R China Shandong Univ Dept Pulm & Crit Care Med Qilu Hosp Wenhua Xi Rd 107 Jinan 250012 Peoples R China

Bacterial infections cause high morbidity and mortality worldwide, and the emergence of drug-resistant bacteria further complicates the treatment of infections. Therefore, it is necessary to continuously develop new treatment methods. Polymyxin B (PMB), as the last line of defense, can combat most aerobic Gram-negative bacilli including common drug-resistant bacteria in clinical practice. However, the suboptimal lung tissue concentration of PMB and dose-dependent nephrotoxicity and neurotoxicity limit its clinical application. The nanodrug delivery system offers several key advantages, including high drug loading capacity, excellent biocompatibility, controlled release mechanisms, and targeted delivery. These features enhance the bioavailability of drugs while simultaneously reducing their toxicity and minimizing side effects. In this study, we designed a targeted nanodrug delivery system (PMB@HMnO2@NM) consisting of hollow mesoporous manganese dioxide (HMnO2) coated with neutrophil membrane (NM). In a mouse model of acute pneumonia induced by multidrug-resistant Pseudomonas aeruginosa, treatment with PMB@HMnO2@NM demonstrated the ability to target bacterial aggregation and specifically deliver the drug to the infected lung tissue. This targeted approach resulted in improved survival rates and reduced inflammatory damage without causing adverse effects. The findings of this study suggest the potential for developing a new class of multifunctional nanodrugs, providing new therapeutic strategies for multidrug-resistant (MDR) bacterial infections. Furthermore, these results provide a solid foundation for the design of biomimetic nanosized antibacterial drugs.

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Reinforcement-Learning-Based Composite Optimal Control for Looper Hydraulic Servo Systems in Hot Strip Rolling

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IEEE-ASME TRANSACTIONS ON MECHATRONICS 2023年第5期28卷 2495-2504页

作者： Wang, Yudong Shen, Hao Wu, Jiacheng Yan, Huaicheng Xu, Shengyuan Anhui Univ Technol Anhui Prov Key Lab Special Heavy Load Robot Maanshan 243002 Peoples R China Anhui Univ Technol Sch Met Engn Maanshan 243002 Peoples R China Anhui Univ Technol Sch Elect & Informat Engn Maanshan 243002 Peoples R China East China Univ Sci & Technol Key Lab Smart Mfg Energy Chem Proc Minist Educ Shanghai 200237 Peoples R China East China Univ Sci & Technol Sch Informat Sci & Engn Shanghai 200237 Peoples R China Nanjing Univ Sci & Technol Sch Automat Nanjing 210094 Peoples R China

The control scheme of the looper angle plays an essential role in hot rolling, which is directly related to the tension maintenance of the strip. The conventional scheme uses a proportion-integration-differentiation (PID) controller to control the servo valve to drive the hydraulic actuator. For different steel types and production temperature changes, the PID control mainly relies on empirical parameter adjustment, which may bring inaccuracy or inefficiency. The objective of this article is to propose a reinforcement-learning-based looper hydraulic servo optimization control scheme to automatically tune the control gain to optimum. First, the modeling error caused by variable parameters and the influence of external disturbance are considered, and the corresponding control model of the looper system is given. Subsequently, a feedforward controller with a radial basis neural-network-based disturbance observer is used to deal with modeling errors and disturbances. A feedback controller with off-policy reinforcement learning is applied in the meantime. The proposed control scheme can realize uniformly ultimately bounded of the system with Lyapunov theory. Simulation results verify the effectiveness of the proposed method.

关键词： Strips Servomotors Valves Optimal control Hydraulic systems Pistons Production Composite control looper hydraulic servo systems (HSSs) Index Terms nonlinear disturbance observer (NDO) reinforcement learning (RL)

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