Transcription factors regulating crop uptake and translocation of the micronutrient Cu have not been *** isolated a novel R2R3-MYB transcription factor,OsMYB84,and showed that it was a positive regulator involved in u...
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Transcription factors regulating crop uptake and translocation of the micronutrient Cu have not been *** isolated a novel R2R3-MYB transcription factor,OsMYB84,and showed that it was a positive regulator involved in uptake and transport of Cu via activation of OsCOPT2 and OsHMA ***84 was highly expressed in roots and anthers and induced by *** of OsMYB84 promoted uptake and root-to-shoot translocation of Cu in rice,facilitated Cu distribution into grain and increased grain *** contrast,mutation of OsMYB84 reduced Cu concentration in xylem ***84 bound to the promoter region of OsCOPT2 and OsHMA5 and upregulated their ***2 mutants showed reduced uptake of Cu and OsHMA5 overexpression lines showed increased root-to-shoot translocation of Cu.
Oral delivery of protein and peptide drugs presents considerable challenges due to their susceptibility to digestive enzymes in gastrointestinal(Gl)tract and low efficiency of transepithelial ***,inspired by efficient...
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Oral delivery of protein and peptide drugs presents considerable challenges due to their susceptibility to digestive enzymes in gastrointestinal(Gl)tract and low efficiency of transepithelial ***,inspired by efficient absorption of protein-based nutrients,we constructed several kinds of oral drug delivery systems by mimicking natural amino acid and oligopeptide absorption *** kinds of amino acids and two kinds of oligopeptides were chosen as targeting ligands to mediate transportation of orally administered nanoparticles(NPs).Liraglutide(Lira),a kind of glucagon like peptide-1(GLP-1)receptor agonist,was used as model *** functionalized NPs could protect Lira from enzymatic degradation in Gl ***,compared with amino acid-modified NPs,oligopeptide-modified NPs exhibited greater transepithelial transport efficiency and were primarily absorbed in the proximal small intestine due to the high expression and transportation mediated by proton coupled oligopeptide transporter 1(PEPT1).These Lira-loaded NPs could effectively control the blood glucose level,reduce plasma lipid level,and repair tissue damage on type 2 diabetic mice and even showed comparable hypoglycemic effects of subcutaneous injection(s.c.)free *** study demonstrates the potential of mimicking natural oligopeptide absorption route to enhance oral delivery of protein and peptide drugs.
The green growth impact of global value chain embedding becomes more complex in the context of digital transformation. Based on partially linear functional-coefficient model, this paper used panel data for 16 Chinese ...
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The green growth impact of global value chain embedding becomes more complex in the context of digital transformation. Based on partially linear functional-coefficient model, this paper used panel data for 16 Chinese industrial sectors from 2007 to 2020 to assess the impact and underlying mechanisms of global value chain on green total factor productivity considering the moderating role of digitalization. The results revealed that global value chain position and backward participation caused green productivity to decrease, while forward participation had a non-significant effect. As the digitalization level rose, the impact of global value chain position on green productivity changed from negative to positive. Moreover, green productivity was increasingly inhibited by forward participation, but the adverse effects of backward participation gradually subsided. Actually, digitalization boosted green technological progress effects of global value chain position and backward participation, but impeded the technological progress of forward participation, thus affecting green productivity. Therefore, to achieve green growth, china's industrial sector must accelerate the synergistic development of digital transformation and global value chain, and focus on the different impacts of participation modes.
The direct bonding copper(DBC)substrates of insulated gate bipolar transistor(IGBT)modules degrade inevitably under cycling thermo‐mechanical stress,causing potential threat to the reliability of IGBT ***,little atte...
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The direct bonding copper(DBC)substrates of insulated gate bipolar transistor(IGBT)modules degrade inevitably under cycling thermo‐mechanical stress,causing potential threat to the reliability of IGBT ***,little attention has been paid to monitoring their *** paper proposes a DBC degradation monitoring method for IGBT modules,which combines boundary‐dependent thermal network and feedback control.A thermal network is employed to describe the internal material degradation of IGBT modules and can be extracted from a finite‐element method *** boundary conditions including power losses and DBC degradation are considered,enabling the thermal network suitable for various working conditions and different DBC degradation conditions of IGBT *** DBC degradation is characterised by its equivalent thermal conductivities measured in the thermal cycling ageing *** the basis of the boundary‐dependent thermal network,feedback control is applied to monitor DBC degradation by regulating boundary‐dependent thermal ***,the proposed model is verified from the effectiveness and accuracy of DBC degradation monitoring and junction temperature *** method casts new light on thermal network modelling and could provide a feasible method for the monitoring of DBC degradation.
Precision measurement of magnetic fields is a crucial issue in both fundamental scientific research and practical sensing *** sensitive detection of a vector magnetic field poses a significant challenge in quantum mag...
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Precision measurement of magnetic fields is a crucial issue in both fundamental scientific research and practical sensing *** sensitive detection of a vector magnetic field poses a significant challenge in quantum magnetometry,particularly in estimating a vector DC magnetic field with high ***,we propose a comprehensive protocol for quantum vector DC magnetometry,utilizing selective phase accumulation in both non-entangled and entangled quantum *** upon the principles of Ramsey interferometry,our protocol enables the selective accumulation of phase for a specific magnetic field component by incorporating a meticulously designed pulse *** the individual measurement scheme,we employ three individual quantum interferometries to independently estimate each of the three magnetic field ***,in the simultaneous measurement scheme,the application of a pulse sequence along different directions enables the simultaneous estimation of all three magnetic field components using only one quantum ***,by employing an entangled state(such as the Greenberger-Horne-Zeilinger state)as the input state,the measurement precisions of all three components may reach the Heisenberg *** study not only establishes a general protocol for measuring vector magnetic fields using quantum probes,but also presents a viable pathway for achieving entanglement-enhanced multi-parameter estimation.
Aqueous zinc ion batteries（AZIBs） have excellent development prospects due to their high theoretical capacity and low ***,the commercial separator represented by glass fiber（GF） in AZIBs usually exhibits uneven po...
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Aqueous zinc ion batteries（AZIBs） have excellent development prospects due to their high theoretical capacity and low ***,the commercial separator represented by glass fiber（GF） in AZIBs usually exhibits uneven porosity,poor zincophilicity,and insufficient functional groups,resulting in the emergence of the zinc anode dendrites and side *** a separator with specific interfacial ion transport behavior is essential to achieve a highly stable reversible zinc ***,an anionic metal-organic framework（MOF） functionalized separator（GF-Bio-MOF-100） was presented to accelerate the desolvation process and modulate Zn2+flux,thereby delivering the decreased nucleation overpotential and uniform Zn2+*** in-depth kinetics investigations combined with the in-situ Raman spectroscopy demonstrate that the carbonyl group within the Bio-MOF-100 is capable of capturing the H2O molecules of [Zn（H2O）6]2+via the H-bond interaction,which further accelerates the desolvation process and transport kinetics of Zn2+.Meanwhile,the anionic framework of the GFBio-MOF-100 separator acts as an interfacial ion channel to regulate the Zn2+flux and enables dendrite-free Zn2+deposition and ***,the Zn|GF-Bio-MOF-100|Zn symmetric cell exhibited a stable Zn2+plating/stripping behavior and it could cycle for 2000 h at 0.3 mA ***,the assembled Zn|GF-Bio-MOF-100|MnO2full cell delivers a capacity retention of 83.9%after 1000 cycles at 0.5 A *** work provides new insights into the design of functionalized separators for long-life AZIBs.
A substantial reduction in groundwater level,exacerbated by coal mining activities,is intensifying water scarcity in western china’s ecologically fragile coal mining ***’s national strategic goal of achieving a carb...
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A substantial reduction in groundwater level,exacerbated by coal mining activities,is intensifying water scarcity in western china’s ecologically fragile coal mining ***’s national strategic goal of achieving a carbon peak and carbon neutrality has made eco-friendly mining that prioritizes the protection and efficient use of water resources *** on the resource characteristics of mine water and heat hazards,an intensive coal-water-thermal collaborative co-mining paradigm for the duration of the mining process is *** integrated system for the production,supply,and storage of mining companion resources is achieved through technologies such as roof water inrush prevention and control,hydrothermal quality improvement,and deep-injection geological *** active preventive and control system achieved by adjusting the mining technology and a passive system centered on multiobjective drainage and grouting treatment are suggested,in accordance with the original geological characteristics and dynamic process of water *** implementing advanced multi-objective drainage,specifically designed to address the“skylight-type”water inrush mode in the Yulin mining area of Shaanxi Province,a substantial reduction of 50%in water drillings and inflow was achieved,leading to stabilized water conditions that effectively ensure subsequent safe coal *** integrated-energy complementary model that incorporates the clean production concept of heat utilization is also *** findings indicate a potential saving of 8419 t of standard coal by using water and air heat as an alternative heating source for the Xiaojihan coalmine,resulting in an impressive energy conservation of 50.2%and a notable 24.2%reduction in carbon *** ultra-deep sustained water injection of 100 m^(3)·h^(-1)in a single well would not rupture the formation or cause water leakage,and 7.87×10^(5)t of mine water could be effectively stored in the Liujiagou Formation,presenti
In this paper,a theoretical framework of Multiagent Simulation(MAS)is proposed for strategic bidding in electricity markets using reinforcement learning,which consists of two parts:one is a MAS system used to simulate...
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In this paper,a theoretical framework of Multiagent Simulation(MAS)is proposed for strategic bidding in electricity markets using reinforcement learning,which consists of two parts:one is a MAS system used to simulate the competitive bidding of the actual electricity market;the other is an adaptive learning strategy bidding system used to provide agents with more intelligent bidding *** ExperienceWeighted Attraction(EWA)reinforcement learning algorithm(RLA)is applied to the MAS model and a new MAS method is presented for strategic bidding in electricity markets using a new Improved EWA(IEWA).From both qualitative and quantitative perspectives,it is compared with three other MAS methods using the Roth-Erev(RE),Q-learning and *** results show that the performance of the MAS method using IEWA is proved to be better than the *** four MAS models using four RLAs are built for strategic bidding in electricity *** running the four MAS models,the rationality and correctness of the four MAS methods are verified for strategic bidding in electricity markets using reinforcement learning.
Flavonoids, such as homoeriodictyol derivatives, hold significant value in nutraceuticals, foods, and pharmaceuticals. Microbial synthesis of these products has emerged as a powerful approach due to its sustainability...
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Flavonoids, such as homoeriodictyol derivatives, hold significant value in nutraceuticals, foods, and pharmaceuticals. Microbial synthesis of these products has emerged as a powerful approach due to its sustainability and environmental friendliness. However, constructing microbial cell factories of homoeriodictyol derivatives is often challenged by the lack of a biosynthesis pathway and the poor performance of endogenous metabolic networks. Here, an efficient Saccharomyces cerevisiae cell factory was designed and metabolically engineered for the de novo biosynthesis of homoeriodictyol 7-O-glucoside. Relieving the feedback inhibition and overexpressing the key enzymes successfully achieved the biosynthesis of homoeriodictyol with a titer of 174.0 mg L-1. Enzyme screening strategies explored missing glycosyltransferases and unveiled the homoeriodictyol 7-O-glucoside synthesis pathway for the first time. Blocking the glycoside hydrolysis pathway improved the titer of homoeriodictyol 7-O-glucoside by a substantial 7.2-fold. Metabolically regulating NADPH regeneration reduced the intermediate accumulation by 91.3%, while strengthening uridine diphosphate-glucose and substrate supply further boosted the homoeriodictyol 7-O-glucoside production. Altogether, these advancements led to a record homoeriodictyol 7-O-glucoside titer of 600.2 mg L-1 and a yield of 12.2 mg g-1 glucose. Overall, the versatile S. cerevisiae cell factory shows the potential to synthesize homoeriodictyol 7-O-glucoside, contributing to the green and sustainable production of natural products.
Peroxy radicals(RO_(2)),which are formed during the oxidation of volatile organic compounds,play an important role in atmospheric oxidation ***,the measurement of RO_(2),especially distinct species of RO_(2)radicals,i...
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Peroxy radicals(RO_(2)),which are formed during the oxidation of volatile organic compounds,play an important role in atmospheric oxidation ***,the measurement of RO_(2),especially distinct species of RO_(2)radicals,is important and greatly helps the exploration of atmospheric chemistry *** the speciated detection of RO_(2)radicals remains challenging,various methods have been developed to study them in *** methods can be divided into spectroscopy and mass spectrometry *** spectroscopy methods contain laser-induced fluorescence(LIF),UV-absorption spectroscopy,cavity ring-down spectroscopy(CRDS)and matrix isolation and electron spin resonance(MIESR).The mass spectrometry methods contain chemical ionization atmospheric pressure interface time-of-flight mass spectrometry(CI-APi-TOF),chemical ionization mass spectrometry(CIMS),CI-Orbitrap-MS and the third-generation proton transfer reaction-time-of-flight mass spectrometer(PTR3).This article reviews technologies for the speciated detection of RO_(2)radicals and the applications of these *** addition,a comparison of these techniques and the reaction mechanisms of some key species are ***,possible gaps are proposed that could be filled by future research into speciated RO_(2)radicals.
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