作者:
Wang, KaiyueZhong, danniYang, LingxiaoZeng, ChengHu, QitaoZhou, MinTang, ZheZhejiang Univ
Affiliated Hosp 4 Int Inst Med Ctr Canc MedSch MedDept Surg Yiwu 322000 Peoples R China Zhejiang Univ
Int Inst Med Int Sch Med Yiwu 322000 Peoples R China Zhejiang Univ
Univ Edinburgh Inst Sch Med ZJU UoE Inst Haining 314400 Peoples R China Zhejiang Univ
Minist Educ Key Lab Canc Prevent & Intervent Hangzhou 310009 Peoples R China Zhejiang Univ
Affiliated Hosp 4 Sch Med Int Sch MedDept Resp & Crit Care Med Yiwu 322000 Peoples R China Zhejiang Univ
Ordos City Etuoke Banner Joint Res Ctr Haining 314400 Peoples R China Zhejiang Univ
Natl Key Lab Biobased Transportat Fuel Technol Hangzhou 310027 Peoples R China Zhejiang Univ
Sch Med Affiliated Hosp 2 Dept Surg Hangzhou Peoples R China
Transarterial chemoembolization (TACE) serves as a locoregional therapy for hepatocellular carcinoma (HCC) patients. Nevertheless, the rapiddissociation of conventional TACE (cTACE) preparations, attributed to the in...
详细信息
Transarterial chemoembolization (TACE) serves as a locoregional therapy for hepatocellular carcinoma (HCC) patients. Nevertheless, the rapiddissociation of conventional TACE (cTACE) preparations, attributed to the instability of the emulsion, often leads to inadequate concentrations of chemotherapeutic agents within the tumor site. Consequently, there exists a pressing demand for an embolic agent that possesses facile injectability and the capacity to provide continuous delivery of chemotherapy drugs. Herein, we leveraged the inherent drug-loading capabilities anddistinctive structural attributes of Spirulina platensis (SP) to formulate a novel microalgae embolic agent, doxorubicin loaded-Spirulina platensis (dOX-SP). The dOX-SP formulation exhibited a notable capacity fordrug loading anddemonstrated the ability to sustain drug release in response to acidic tumor microenvironments (TME). The spiral structure and micron-scale size of SP contributed to effective vascular embolization and continuous localizedrelease of dOX. Furthermore, the biodegradability of SP as a natural biomaterial ensured good biosafety, with its degradation products potentially enhancing the pH of TME. In a rat model of in-situ hepatocellular carcinoma, dOX-SP effectively suppressed tumor growth and significantly reduced tumor size following intra-arterial injection, while exhibiting minimal adverse effects. Taken together, the high drug loading capacity, effective vascular embolization, pH sensitivity, TME pH modulation, and biodegradability of dOX-SP made it a promising embolic agent for hepatocellular carcinoma treatment.
In the actual array antenna assembly process, changes in the assembly process parameters strongly impact the solder joints. Thus, it is always necessary to pay attention to the stress-strain situation of solder joints...
详细信息
In the actual array antenna assembly process, changes in the assembly process parameters strongly impact the solder joints. Thus, it is always necessary to pay attention to the stress-strain situation of solder joints to avoid their failure and affecting the overall performance of the resulting antenna products. In this paper, based on digital twin and cloud-edge collaboration technology, an online prediction method for array antenna assembly performance based on digital twinning and cloud-edge collaboration technology is proposed. First, key assembly process parameters such as the tightening torque, tightening sequence and part flatness of the array antenna are used as simulation inputs to carry out the finite element simulation. The mapping relationships between the assembly process parameters and assembly performance are determined, and simulation data samples are constructed. Then, a prediction method that combines ensemble learning and a BP neural network is proposed for assembly performance prediction of array antennas, and an assembly performance prediction model is constructed to realize the online prediction of assembly performance. The results show that the prediction is as expected. Finally, a digital twin-cloud-edge collaborative antenna assembly process performance prediction system is constructed, andreal-time monitoring of antenna assembly performance is performed when applied to an array antenna assembly process. The instance validation showed that the developed online prediction model has an average accuracy of 94.35%. This real-time monitoring method can ensure critical solder joint performance and improve the success rate of antenna assembly.
Chaos-based cryptosystems are regarded as highly secure techniques for image encryption. However, despite the considerable enhancement of encryption robustness provided by chaotic systems, security vulnerabilities may...
详细信息
Chaos-based cryptosystems are regarded as highly secure techniques for image encryption. However, despite the considerable enhancement of encryption robustness provided by chaotic systems, security vulnerabilities may still arise, potentially leading to drastic damage in contexts involving sensitive data such as medical or military images. Identifying these vulnerabilities anddeveloping corresponding countermeasures are essential to prevent security breaches and achieve higher protection. From this perspective, this research thoroughly examines the security of an image encryption scheme based on the 1d sine-powered chaotic map. This analysis identifies vulnerabilities within the scheme that can reduce it to a permutation-only scheme. Exploiting the found vulnerabilities, three distinct cryptanalysis attacks are proposed in this work. These attacks enable unauthorized individuals to replicate the encryption anddecryption processes without possessing the secret key, posing significant security risks. Under ciphertext-only attack, chosen-plaintext attack, and chosenciphertext attack conditions, the proposed attacks demonstrate their effectiveness through simulation and experimentation. Notably, the results indicate that these attacks can be executed within seconds and using only a few special plaintext or ciphertext images. An improved version of the analyzed scheme is introduced to address the identified vulnerabilities and enhance its security and speed.
As a widely producedrenewable, low-cost biomass resource, corn straw's physicochemical properties and utilization potential have been extensively studied in order to utilize it with high value and efficiency. How...
详细信息
As a widely producedrenewable, low-cost biomass resource, corn straw's physicochemical properties and utilization potential have been extensively studied in order to utilize it with high value and efficiency. However, the impact of the differences in physicochemical properties between different parts of corn straw on its utilization potential has been ignored before. In this study, the composition, chemical properties, and morphology of different parts of corn straw (root, stem, leaf, bract, and corncob) were characterized, and 18 key components were used as evaluation indexes to construct a comprehensive evaluation index system for straw combustion utilization, anaerobic digestion utilization, feed utilization, and fertilizer utilization. Furthermore, the weight of each index was determined using principal component analysis, and the comprehensive evaluation scores of different parts of corn straw were calculated. The results showed that the roots were more suitable for anaerobic digestion and fertilizer utilization, the stems and corncobs were more suitable for combustion utilization, the bracts were more suitable for anaerobic digestion, and the leaves were more suitable for fertilizer utilization and feed utilization. Finally, the feasibility and future development direction of segmented utilization of corn straw were discussed, providing useful information for scientific and efficient utilization of straw resources.
This paper aims to study the multiple low-velocity impact (LVI) response and compression after impact (CAI) performance of composite laminates subjected to different energy impacts. The study includes an analysis of t...
详细信息
This paper aims to study the multiple low-velocity impact (LVI) response and compression after impact (CAI) performance of composite laminates subjected to different energy impacts. The study includes an analysis of the effect of the first impact with different energy on the second impact with the same energy at the same location. The results show that the first impact has a certain enhancement effect on the impact resistance of the laminates when the impact energy is very small. Overall, with the increase of the first impact energy, the impact resistance and the residual compressive strength of the laminate significantly reduce.
Aimsresearch on the appropriate scale structure and spatial layout of ecological, urban, and agricultural spaces and the effective and methodical development and protection of urban space can provide a solid foundatio...
详细信息
Aimsresearch on the appropriate scale structure and spatial layout of ecological, urban, and agricultural spaces and the effective and methodical development and protection of urban space can provide a solid foundation for the sustainable development of the complex socio-economic urban *** on the perspective of a coupled social-ecological system, this paper constructed an assessment model to determine the ecological protection importance anddevelopment suitability of urban space, proposed the ecological-urban-agricultural priority fordensely populated urban areas, and established the appropriate functional layout of urban space using a priority matrix-based mapping *** an empirical case study of Shenzhen, this paperdetermined the optimal scale structure of the types of functional spaces, identified areas of functional conflict, and proposed targeted optimization strategies for functional mismatch areas. The findings show that the appropriate scale ratio of Shenzhen's urban, ecological, and agricultural functions is 5:4:1, which is consistent with the actual structure ratio of Shenzhen's land use *** proposed method can predict the appropriate scale structure of urban space development and ecological protection based on the comprehensive multi-perspective consideration of social and economic factors to provide a scientific reference for effective decision-making on urban space optimization and sustainable development.
High-speedrail wheels are critical components responsible for load-carrying, guiding, and transferring traction and braking forces, impacting the safety, stability, andreliability of trains. Among the mechanical pro...
详细信息
High-speedrail wheels are critical components responsible for load-carrying, guiding, and transferring traction and braking forces, impacting the safety, stability, andreliability of trains. Among the mechanical properties of high-speedrail wheels, tensile properties influence both heat treatment and overall performance evaluation. This study investigated the tensile properties of the rim and spoke of high-speedrail wheels using both conventional and tiny specimens. Additionally, tensile tests were conducted on tiny specimens sampled along the axial and circumferential directions of the wheel rim to assess the distribution of tensile properties. The tensile properties of tiny specimens of the spoke closely aligned with those of conventional specimens. However, the results obtained using tiny and conventional specimens of the wheel rim, although similar, showed greater variability. The tensile properties of the wheel rim exhibited a gradient distribution, with the highest tensile strength near the tread side and the lowest near the spoke side. The plasticity parameters showed minimal variation along both the axial and circumferential directions of the rim. This study provides valuable insights for optimizing the production process of high-speedrail wheels, ultimately enhancing their overall quality. The findings are significant for improving technical support in the manufacturing of high-speedrail wheels.
Conventionally, the designers of electrical machines assume the employment of regular shaped magnets, such as rectangular, sector, or tiled-shapes. The geometry of magnet poles is fixed, and the design purpose is main...
详细信息
Conventionally, the designers of electrical machines assume the employment of regular shaped magnets, such as rectangular, sector, or tiled-shapes. The geometry of magnet poles is fixed, and the design purpose is mainly to optimize the dimensional values. However, these regular shapes employed may not be the best choice, unavoidably limiting the final design result, and compromising the output performance of the electrical machines. An alternative scheme is to conduct topology optimization forrotor poles. By this method, the geometrical shape of magnets along with the iron core is no longer fixed, but automatically obtained through the optimal distribution of materials, such as iron, magnet, and air. It helps to achieve better optimization results with less shape constrains. Therefore, this article proposes a multimaterial topology optimization method based on variable density representation for surface-mounted permanent-magnet synchronous motor to obtain an optimal rotor pole pattern, and thus improve the output performance of electrical machines, especially the torque density, which is crucial in aerospace industry. The computational speed is increased by improving the objective function and the arbitrary volume constraints become clear by combining size and topology optimization. To validate the design method, theoretical, numerical and experimental studies are conducted. First, the operating principle, design variables, constrains, optimization objective, and procedure of the method are introduced in detail. Then, the optimization method is implemented into the rotordesign of one surface-mounted electric machine, and the result is presented anddiscussed. Subsequently, the magnetic flux density and torque output of electric machine with the optimizedrotor poles is compared with conventional design, and it shows that the former can achieve better output performance relatively. Finally, one research prototype of the electrical machine is developed, and experime
γδT cells have emerged as a promising target in tumor therapy,prompting the development of novel strategies to activate these cells directly within the tumor *** this study,we engineered uniformly sized spherical ga...
详细信息
γδT cells have emerged as a promising target in tumor therapy,prompting the development of novel strategies to activate these cells directly within the tumor *** this study,we engineered uniformly sized spherical garlic-derived nanoparticles(GNPs)to stimulate tumor-infiltratingγδT *** intratumoral injection of GNPs,we demonstrated their ability to directly activate γδT cells,leading to potent antitumor *** approach resulted in significant inhibition of various subcutaneous tumors in ***,under computed tomography(CT)guidance,intratumoral injection of GNPs effectively suppressed the growth of orthotopic liver cancer in New Zealand white *** studies revealed that GNPs robustly activated γδT cells,promoting an inflammatory microenvironment within *** approach of using garlic-derived nanoparticles offers the advantages of simplicity in preparation and high yield,presenting a promising avenue for tumor therapy with potential for clinical translation.
In body-centered cubic metals such as molybdenum, screw dislocations critically govern the plastic deformation behavior of alloys. The presence of solute atoms in alloys can effectively alter the formation and movemen...
详细信息
In body-centered cubic metals such as molybdenum, screw dislocations critically govern the plastic deformation behavior of alloys. The presence of solute atoms in alloys can effectively alter the formation and movement of screw dislocations. In this study, we employed first-principles calculations to delve into the electronic origins of these influences. Initially, we constructed single atomic column and triple atomic column models to simulate the formation of screw dislocations with solute atoms. Our investigation revealed that tantalum (Ta) and tungsten (W) increase the formation energy of solute-dislocation interactions, while osmium (Os), iridium (Ir), and platinum (Pt) have the opposite effect. Subsequently, utilizing a screw dislocation dipole model under sheardeformation, we explored the combined effects of solute atoms anddeformation on dislocation core movement. We found that Os, Ir, and Pt, located as the first nearest neighbors of the dislocation core, exhibit an attractive effect on the dislocation core. Solute atoms at specific positions can alter the direction of dislocation slip, inducing cross-slip and enhancing material ductility. In contrast, under the same stress, Ta and W exhibit repulsion towards the dislocation core and cannot change the direction of dislocation slip, only altering the energy barrier fordislocation core movement. This work provides atomic-scale insights into solute-induceddislocation dynamics, offering guidelines for advanced Mo alloy design.
暂无评论