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A description of human t-lymphotropic virus type I-related chronic interstitial keratitis in 20 patients

AMERICAN JOURNAL OF OPHtHALMOLOGY 2001年第3期131卷 305-308页

作者： Merle, H Cabre, P Merle, S Gerard, M Smadja, D CHU Ft de France Hop Pierre Zobda Quitman Serv Ophtalmol BP 632 Fort De France 97261 Martinique France CHU Ft de France Serv Ophtalmol Fort De France 97261 Martinique France CHU Ft de France Serv Neurol Fort De France 97261 Martinique France Entree Hop Clarac Observ Reg Sante Martinique Fort De France Martinique France

OBJECtIVE: this study aimed to describe a syndrome that the authors call human t-lymphotropic virus type I-related chronic interstitial keratitis. MEtHODS: A consecutive series of 194 human t-lymphotropic virus type I-infected patients (divided into 119 patients with human t-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis and 75 asymptomatic human t-lymphotropic virus type I carriers) was systematically examined. RESULtS: twenty patients (10.3%) had bilateral anterior stromal lesions made up of approximately 10 elevated, rounded or cloudy whitish opacities that were more or less confluent. the opacities were characteristically situated at the periphery of the anterior stroma, and the visual axis remained unaffected, the interstitial keratitis was chronic and unresponsive to topical administration of corticosteroids. It was mainly observed in patients affected by human t-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis among whom there were 18 cases (15.1%), as opposed to two cases (2.7%) in asymptomatic carriers. CONCLUSION: A new cause of interstitial keratitis is reported. Human t-lymphotropic virus type I infection may have a much broader spectrum of ocular manifestations than previously described. As with the other manifestations of human t-lymphotropic virus type I infection, corneal lesions could be linked to a lymphoplasmocytic infiltration of the stroma leading to corneal opacities. (Am J Ophthalmol 2001;131:305-308. (C) 2001 by Elsevier Science Inc, All rights reserved.).

关键词：慢性病角膜混浊/流行病学角膜混浊/病理学角膜混浊/病毒学角膜基质/病理学角膜基质/病毒学眼感染病毒性/流行病学眼感染病毒性/病理学眼感染病毒性/病毒学 HtLV-Ⅰ抗体/分析人类嗜t淋巴细胞病毒1型/分离和提纯角膜炎/流行病学角膜炎/病理学角膜炎/病毒学马提尼克/流行病学轻截瘫热带痉挛性/流行病学轻截瘫热带痉挛性/病理学轻截瘫热带痉挛性/病毒学前瞻性研究综合征视敏度成年人老年人老年人 80以上女(雌)性人类男(雄)性中年人

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New corneal findings in human t-cell lymphotropic virus type 1 infection

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AMERICAN JOURNAL OF OPHtHALMOLOGY 2001年第6期132卷 950-950页

作者： Branco, BC Chamon, W Belfort, R Carneiro, NF Brites, C São Paulo Brazil Brahia Brazil

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Conjunctival t-cell lymphoma caused by human t-cell lymphotrophic virus infection

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AMERICAN JOURNAL OF OPHtHALMOLOGY 2001年第3期131卷 381-383页

作者： Buggage, RR Smith, JA Shen, DF Chan, CC NEI Immunol Lab NIH Bethesda MD 20892 USA

PURPOSE: to examine the cause of adult t-cell leukemia/ lymphoma. MEtHODS: We examined a conjunctival biopsy from a 29-year-old Jamaican man who developed bilateral conjunctival masses. Adult t-cell leukemia/lymphoma was diagnosed using routine histology, immunohistochemistry, electron microscopy, microdissection, and the polymerase chain reaction. RESULtS: Histopathologic examination revealed a conjunctival lymphoma. Clonality of the t-cell receptor gamma gene and human t-cell lymphotrophic virus gag gene were detected in the malignant cells. the demonstration of the human t-cell lymphotrophic virus gene and the rearrangement of the t-cell receptor gene in this neoplasm provide proof that human t-cell lymphotrophic virus is the cause of this conjunctival t-cell lymphoma, CONCLUSION: Human t-cell lymphotrophic virus is the cause of adult t-cell leukemia/lymphoma, an aggressive malignancy of CD4+ lymphocytes. (Am J Ophthalmol 2001;131:381-383, (C) 2001 by Elsevier Science Inc. All rights reserved.).

关键词：活组织检查 CD4阳性t淋巴细胞/病毒学结膜肿瘤/诊断结膜肿瘤/病毒学 DNA 肿瘤/分析基因重排 t淋巴细胞/遗传学基因 gag/遗传学人类嗜t淋巴细胞病毒1型/遗传学人类嗜t淋巴细胞病毒1型/分离和提纯聚合酶链反应受体抗原 t细胞 γ-δ/遗传学成年人人类男(雄)性

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New corneal findings in human t-cell lymphotrophic virus type 1 infection

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AMERICAN JOURNAL OF OPHtHALMOLOGY 2001年第3期131卷 309-313页

作者： Buggage, RR Levy-Clarke, GA Smith, JA NEI Immunol Lab NIH Bethesda MD 20892 USA

PURPOSE: Human t-cell lymphotrophic virus type 1 is a RNA retrovirus that primarily affects CD4+ t-cells. Human t-cell lymphotrophic virus type 1 infection is the established cause of adult t-cell leukemia/lymphoma, an aggressive malignancy of CD4+ t-cells, and two non-neoplastic conditions: human t-cell lymphotrophic virus type 1-associated myelopathy/tropical spastic paraparesis and human t-cell lymphotrophic virus type 1 uveitis. Other reported ophthalmic manifestations of human t-cell lymphotrophic virus type I infection include lymphomatous and leukemic infiltrates in the eye and ocular adnexa in patients with adult t-cell leukemia/lymphoma, retinal pigmentary degeneration, and neuro-ophthalmic disorders in patients with human t-cell lymphotrophic virus type 1-associated myelopathy/tropical spastic paraparesis and keratoconjunctivitis sicca, episcleritis, and sclerouveitis in asymptomatic human t-cell lymphotrophic virus type I carriers. this report describes the ocular findings in three Jamaican patients with human t-cell lymphotrophic virus type 1 infection and adult t-cell leukemia/lymphoma. MEtHODS: the clinical records of three patients with human t-cell lymphotrophic virus type 1 infection and adult t-cell leukemia/lymphoma examined at the National Eye Institute were reviewed. Each patient had one or more complete ophthalmic evaluations. RESULtS: All three patients had corneal abnormalities, including corneal haze and central opacities with thinning;bilateral immunoprotein keratopathy;and peripheral corneal thinning, scarring, and neovascularization. All three patients had elevated serum immunoglobulin levels. CONCLUSIONS: We believe that the novel corneal findings in these patients are most likely a consequence of the hypergammaglobulinemia induced by the human t-cell lymphotrophic virus type 1 infection or the t-cell malignancy. (Am J Ophthalmol 2001;131:309-313. (C) 2001 by Elsevier Science Inc. All rights reserved.).

关键词：角膜疾病/诊断角膜疾病/人种学角膜疾病/病毒学眼感染病毒性/诊断眼感染病毒性/人种学眼感染病毒性/病毒学 HtLV-Ⅰ抗体/分析人类嗜t淋巴细胞病毒1型/免疫学人类嗜t淋巴细胞病毒1型/分离和提纯高丙种球蛋白血症/免疫学高丙种球蛋白血症/病毒学免疫球蛋白G/免疫学牙买加/流行病学轻截瘫热带痉挛性/诊断轻截瘫热带痉挛性/人种学轻截瘫热带痉挛性/病毒学视敏度成年人女(雌)性人类男(雄)性中年人

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HLA alleles determine human t-lymphotropic virus-I (HtLV-I) proviral load and the risk of HtLV-I-associated myelopathy

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PROCEEDINGS OF tHE NAtIONAL ACADEMY OF SCIENCES OF tHE UNItED StAtES OF AMERICA 1999年第7期96卷 3848-3853页

作者： Jeffery, KJM Usuku, K Hall, SE Matsumoto, W taylor, GP Procter, J Bunce, M Ogg, GS Welsh, KI Weber, JN Lloyd, AL Nowak, MA Nagai, M Kodama, D Izumo, S Osame, M Bangham, CRM Univ London Imperial Coll Sci Technol & Med Sch Med Dept Immunol London W2 1PG England Univ London Imperial Coll Sci Technol & Med Sch Med Dept Genitourinary Med & Communicable dis London W2 1PG England Kagoshima Univ Fac Med Dept Med Informat Kagoshima 8908520 Japan Kagoshima Univ Fac Med Dept Internal Med 3 Kagoshima 8908520 Japan Kagoshima Univ Fac Med Ctr Chron Viral Dis Div Mol Pathol Kagoshima 8908520 Japan Churchill Hosp Nuffield Dept Surg Oxford Transplant Ctr Oxford OX3 7LJ England John Radcliffe Hosp Inst Mol Med Oxford OX3 9DU England Univ Oxford Dept Zool Oxford OX1 3PS England

the risk of disease associated with persistent virus infections such as HIV-I, hepatitis B and C, and human t-lymphotropic virus-I (HtLV-I) is strongly determined by the virus load. However, it is not known whether a persistent class I HLA-restricted antiviral cytotoxic t lymphocyte (CtL) response reduces viral load and is therefore beneficial or causes tissue damage and contributes to disease pathogenesis. HtLV-I-associated myelopathy (HAM/tSP) patients have a high virus load compared with asymptomatic HtLV-I carriers, We hypothesized that HLA alleles control HtLV-I provirus load and thus influence susceptibility to HAM/tSP. Here we show that, after infection with HtLV-I, the class I allele HLA-A*02 halves the odds of HAM/tSP (P < 0.0001), preventing 28% of potential cases of HAM/tSP. Furthermore, HLA-A*02(+) healthy HtLV-I carriers have a proviral load one-third that (P = 0.014) of HLA-A*02(-) HtLV-I carriers, An association of HLA-DRB1*0101 with disease susceptibility also was identified, which doubled the odds of HAM/tSP in the absence of the protective effect of HLA-A*02. these data have implications for other persistent virus infections in which virus load is associated with prognosis and imply that an efficient antiviral CtL response ran reduce virus load and so prevent disease in persistent virus infections.

关键词：等位基因基因 MHCⅠ类基因 MHCⅡ类疾病遗传易感性/免疫学 HLA-A抗原/遗传学 HLA-B抗原/遗传学 HLA-DR抗原/遗传学 HLA-DRB1链 HtLV-Ⅰ感染/血液 HtLV-Ⅰ感染/遗传学 HtLV-Ⅰ感染/免疫学组织相容性试验人类嗜t淋巴细胞病毒1型/免疫学人类嗜t淋巴细胞病毒1型/分离和提纯轻截瘫热带痉挛性/血液轻截瘫热带痉挛性/遗传学轻截瘫热带痉挛性/免疫学危险因素病毒载量人类

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two types of HtLV-1 particles are released from Mt-2 cells

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VIROLOGY 1999年第2期255卷 279-284页

作者： Morozov, VA Weiss, RA Inst Canc Res Chester Beatty Labs London SW3 6JB England Russian Acad Med Sci Canc Res Ctr Inst Carcinogenesis Moscow 115478 Russia

the Mt-2 cell line transformed by human t-cell leukemia virus type 1 (HtLV-1) contains one complete provirus and seven defective proviruses. Four defective genomes have an identical structure (LtR-MA-delta CA-pX-LtR) with an open reading frame that spans from MA to pX, giving rise to a 3.4-kb (24S) RNA transcript encoding a chimeric Gag-pX protein, p28. Mt-2 cells release two distinct types of virions. the major "classic" type of particle has a buoyant density of 1.155-1.16 g/cm(3) and contains the standard HtLV-I structural proteins and reverse transcriptase (Rt). In addition, about 5% of particles are "light" approximately 1.12 g/cm(3), and contain p28, Rt activity, and the 3.4-kb RNA transcript. Rt-PCR and in vitro translation indicate that some of the classic HtLV-I particles package 3.4-kb RNA as well as full-length 8.5-kb RNA. In addition to matrix features, the p28 protein has a motif resembling a zinc finger at the C-terminal, pX0 region, which may play a role in the assembly of the defective light virions. (C) 1999 Academic Press.

关键词：细胞系转化离心法梯密度化学分馏法基因产物 gag/分离和提纯人类嗜t淋巴细胞病毒1型/遗传学人类嗜t淋巴细胞病毒1型/分离和提纯人类嗜t淋巴细胞病毒1型/代谢 RNA指导的DNA聚合酶/代谢逆转录病毒科蛋白质类致癌/分离和提纯病毒粒子/分离和提纯人类

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