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检索条件"主题词=冠状动脉血栓形成/血液"
12 条 记 录,以下是1-10 订阅
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Antithrombotic efficacy of thrombin inhibitor L-374,087: Intravenous activity in a primate model of venous thrombus extension and oral activity in a canine model of primary venous and coronary artery thrombosis
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JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 1999年 第1期289卷 503-510页
作者: Cook, JJ Gardell, SJ Holahan, MA Sitko, GR Stump, GL Wallace, AA Gilberto, DB Hare, TR Krueger, JA Dyer, DL Sanderson, PEJ Vacca, JP Shafer, JA Lynch, JJ Merck Res Labs Dept Pharmacol W Point PA 19486 USA Merck Res Labs Dept Biol Chem W Point PA 19486 USA Merck Res Labs Dept Lab Anim Resources W Point PA 19486 USA Merck Res Labs Dept Med Chem W Point PA 19486 USA
The small molecule direct thrombin inhibitor L-374,087 was characterized across species in an in vitro activated partial thromboplastin clotting time (aPTT) assay and in vivo in rhesus monkey and dog thrombosis models... 详细信息
来源: 评论
Antithrombin activity during the period of percutaneous coronary revascularization - Relation to heparin use, thrombotic complications and restenosis
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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 1999年 第5期33卷 1248-1256页
作者: Matthai, WH Kurnik, PB Groh, WC Untereker, WJ Siegel, JE Univ Penn Sch Med Dept Med Philadelphia PA 19104 USA Univ Med & Dent New Jersey Robert Wood Johnson Med Sch Dept Med Camden NJ 08103 USA Univ Med & Dent New Jersey Robert Wood Johnson Med Sch Dept Med New Brunswick NJ 08903 USA
OBJECTIVES This study evaluated changes in antithrombin (AT) activity around the time of percutaneous transluminal coronary revascularization (PTCR) with unfractionated heparin anticoagulation and the effects these ch... 详细信息
来源: 评论
PlA polymorphism of glycoprotein IIIa and risk of adverse events after coronary stent placement
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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 2000年 第1期36卷 84-89页
作者: Kastrati, A Koch, W Gawaz, M Mehilli, J Böttiger, C Schömig, K von Beckerath, N Schömig, A Deutsch Herzzentrum Munich D-80636 Munich Germany Tech Univ Munich Med Klin Rechts Isar 1 D-8000 Munich Germany
OBJECTIVE We designed this prospective study to test the hypothesis that platelet antigen (P1(A)) polymorphism of glycoprotein (GP) IIIa is associated with an increased risk for adverse events after coronary stent pla... 详细信息
来源: 评论
Prognostic significance of elevated hemostatic markers in patients with acute myocardial infarction
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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 1999年 第6期33卷 1543-1548页
作者: Li, YH Teng, JK Tsai, WC Tsai, LM Lin, LJ Guo, HR Chen, JH Natl Cheng Kung Univ Hosp Dept Internal Med Div Cardiol Tainan 70428 Taiwan
OBJECTIVES The purpose of this study was to determine whether the elevated levels of hemostatic markers in the early phase of myocardial infarction may serve as risk factors for subsequent cardiac mortality. BACKGROUN... 详细信息
来源: 评论
Pravastatin therapy in hyperlipidemia: Effects on thrombus formation and the systemic hemostatic profile
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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 1999年 第5期33卷 1294-1304页
作者: Dangas, G Badimon, JJ Smith, DA Unger, AH Levine, D Shao, JH Meraj, P Fier, C Fallon, JT Ambrose, JA Mt Sinai Sch Med Dept Med New York NY 10029 USA Mt Sinai Sch Med Dept Pathol New York NY 10029 USA Cornell Univ Coll Med Rogosin Inst New York NY USA
OBJECTIVES The study sought to determine the effects of lipid-lowering with pravastatin on the systemic fibrinolytic profile and on thrombus formation under dynamic flow conditions. BACKGROUND Lowering cholesterol (C)... 详细信息
来源: 评论
Increased platelet reactivity in patients given Orbofiban after an acute coronary syndrome:: An OPUS-TIMI 16 substudy
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AMERICAN JOURNAL OF CARDIOLOGY 2000年 第4期85卷 491-493页
作者: Holmes, MB Sobel, BE Cannon, CP Schneider, DJ Univ Vermont Coll Med Cardiol Unit Dept Med Burlington VT 05401 USA Brigham & Womens Hosp Cambridge MA USA Harvard Univ Sch Med Cambridge MA 02138 USA
Platelet reactivity is increased in patients with acute coronary syndromes, accounting in part for the propensity to progressive or recurrent thrombosis.1,2 Accordingly, platelet surface glycoprotein IIb-IIIa (GP IIb-... 详细信息
来源: 评论
Evidence that high-density lipoprotein cholesterol is an independent predictor of acute platelet-dependent thrombus formation
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AMERICAN JOURNAL OF CARDIOLOGY 1999年 第9期84卷 1011-1017页
作者: Naqvi, TZ Shah, PK Ivey, PA Molloy, MD Thomas, AM Panicker, S Ahmed, A Cercek, B Kaul, S Cedars Sinai Med Ctr Div Cardiol Burns & Allen Res Inst Dept Med Los Angeles CA 90048 USA Cedars Sinai Med Ctr Vasc Physiol & Thrombosis Res Lab Atherosclerosis Res Ctr Los Angeles CA 90048 USA Univ Calif Los Angeles Sch Med Los Angeles CA 90024 USA Specialty Labs Inc Santa Monica CA USA
Plasma total and low-density lipoprotein (LDL) cholesterol are established risk factors for atherosclerotic vascular disease and may also contribute to a prothrombotic risk via enhanced platelet reactivity, This study... 详细信息
来源: 评论
Low intracellular magnesium levels promote platelet-dependent thrombosis in patients with coronary artery disease
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AMERICAN HEART JOURNAL 2000年 第2期140卷 212-218页
作者: Shechter, M Merz, CNB Rude, RK Labrador, MJP Meisel, SR Shah, PK Kaul, S Cedars Sinai Med Ctr Dept Med Div CardiolAtherosclerosis Res Ctr Cedars Sinai Burns & Allen Res Inst Los Angeles CA 90048 USA Cedars Sinai Med Ctr Dept Med Div CardiolPrevent & Rehabil Cardiac Ctr Cedars Sinai Burns & Allen Res Inst Los Angeles CA 90048 USA Univ Calif Los Angeles Sch Med Los Angeles CA USA Univ So Calif Orthoped Hosp Dept Endocrinol Los Angeles CA USA Univ So Calif Sch Med Los Angeles CA USA
Background Although reduced intracellular levels of magnesium have been described in patients with acute myocardial infarction, its significance as a regulator of thrombosis remains unknown. Methods and Results To det... 详细信息
来源: 评论
Lipoprotein(a) and coronary thrombosis and restenosis after stent placement
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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 1999年 第4期33卷 1005-1012页
作者: Wehinger, A Kastrati, A Elezi, S Baum, H Braun, S Neumann, FJ Schömig, A Deutsch Herzzentrum D-80636 Munich Germany Tech Univ Munich Klinikum Rechts Isar Med Klin 1 Munich Germany Tech Univ Munich Inst Klin Chem & Pathochem Munich Germany
OBJECTIVES The objective of this prospective study was to evaluate the relation between high lipoprotein(a) levels and thrombotic and restenotic events after coronary stent implantation. BACKGROUND Lipoprotein(a) may ... 详细信息
来源: 评论
Early risk stratification of unstable angina non-Q myocardial infarction: biochemical markers of coronary thrombosis
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INTERNATIONAL JOURNAL OF CARDIOLOGY 1999年 第sup1期68卷 S55-S61页
作者: Galvani, M Ferrini, D Ottani, F Eisenberg, PR Fondaz Cardiol Sacco Cardiovasc Res Unit Forli Italy GB Morgagni L Pierantoni Hosp Div Cardiol Forli Italy Civile Hosp Div Cardiol Bentivoglio Italy Washington Univ Div Cardiovasc St Louis MO USA
Coronary thrombosis is an important determinant of prognosis in patients with acute coronary syndromes (ACS), However, the identification of patients at high-risk for progression of coronary thrombosis is difficult pa... 详细信息
来源: 评论