Hirsute women pose a diagnostic dilemma when urinary 17-ketosteroid and serum testosterone levels are normal. To locate the site of androgen excess in 19 hirsute women, blood samples were collected from the left ovari...
详细信息
Hirsute women pose a diagnostic dilemma when urinary 17-ketosteroid and serum testosterone levels are normal. To locate the site of androgen excess in 19 hirsute women, blood samples were collected from the left ovarian and adrenal veins via a catheter inserted into the right femoral vein. Laparoscopy and bilateral ovarian biopsies were also performed in 18 of the 19 patients studied. Nine women had elevated 17-ketosteroid (five patients) and/or antecubital serum testosterone (five patients) levels. Fourteen woman had elevated testosterone concentrations distributed as follows: ovarian vein (six), adrenal vein (one), adrenal and ovarian veins (seven). Androstenedione was elevated in the ovarian vein (seven) and both adrenal and ovarian veins (11) in 18 patients. Laparoscopic examination revealed that less than 50 per cent of the enlarged ovaries could be detected by pelvic examination. Histologic studies suggested that these patients comprised two groups: a group (six patients) who appeared to ovulate and a group (12 patients) who lacked evidence of ovulation.
Testosterone-estradiol-binding-globulin (TEBG) is a major determinant of androgen disposition and action. TEBG levels, but not free testosterone levels, correlate with the metabolic clearance rate (MCR) of testosteron...
详细信息
The effectiveness of two oral contraceptives in suppressing plasma androstenedione (A), testosterone (T), LH, and FSH and in stimulating testosterone-estradiol-binding globulin TeBG) was evaluated in 39 hirsute women....
详细信息
暂无评论