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Efficacy and safety of lamivudine in renal transplant patients with chronic hepatitis B

TRANSPLANTATION PROCEEDINGS 2000年第2期32卷 384-385页

作者： Antoine, C Landau, A Menoyo, V Duong, JP Duboust, A Glotz, D Hop Broussais Serv Nephrol INSERM U430AURA Bessin F-75014 Paris France Hop Broussais Serv Gastroenterol INSERM U430AURA Bessin F-75014 Paris France Hop Broussais Serv Anatomopathol INSERM U430AURA Bessin F-75014 Paris France

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Severe exacerbation of asthma:: A new side effect of interferon-α in patients with asthma and chronic hepatitis C

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MAYO CLINIC PROCEEDINGS 1999年第4期74卷 367-370页

作者： Bini, EJ Weinshel, EH Dept Vet Affairs Med Ctr Div Gastroenterol 111D New York NY 10010 USA NYU Med Ctr Bellevue Hosp Div Gastroenterol New York NY 10016 USA

Interferon-alpha is used by physicians to treat numerous common medical disorders;however, therapy is often limited by side effects, Pulmonary complications, such as interstitial pneumonitis and bronchiolitis obliterans organizing pneumonia, have been described in patients receiving interferon-alpha therapy. Exacerbation of asthma induced by subcutaneous administration of interferon-alpha has not been previously reported, We describe two patients with mild asthma in whom treatment with interferon-alpha for chronic hepatitis C resulted in exacerbation of the underlying asthma, The severe asthmatic symptoms resolved promptly after use of interferon-alpha was discontinued and corticosteroid therapy was initiated, Repeated treatment with interferon-alpha several months later resulted in a rapid, more severe exacerbation of asthma in both patients. Patients undergoing therapy with interferon-alpha, especially those with chronic asthma, should be monitored closely for pulmonary symptoms, If these symptoms develop, patients should be instructed to discontinue use of interferon-alpha and seek medical attention immediately.

关键词：急性病抗病毒药/副作用抗病毒药/治疗应用哮喘/化学诱导哮喘/并发症丙型肝炎慢性/并发症丙型肝炎慢性/药物疗法干扰素α/副作用干扰素α/治疗应用复发成年人人类男(雄)性中年人

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Normal erythropoietin response in chronic hepatitis C patients with ribavirin-induced anaemia

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ANTIVIRAL THERAPY 2003年第1期8卷 57-63页

作者： Mangoni, ED Marrone, A Saviano, D Del Vecchio, C Utili, R Ruggiero, G Univ Naples 2 Cattedra & Div Med Interna Epatol Naples Italy Studio Diagnost Nucl Naples Italy Univ Sannio Dipartimento Ingn Benevento Italy

Background: Ribavirin administration for chronic hepatitis C is associated with the development of haemolytic anaemia, which affects treatment efficacy and tolerability. In a pilot study, the exogenous administration of erythropoietin has been shown to be beneficial, reducing the rate of ribavirin dose reduction. How ribavirin administration affects normal erythropoietin production has not been determined. Aim: To investigate the endogenous erythropoietin response in hepatitis C patients with ribavirin-induced anaemia. Methods: Serum erythropoietin was measured before and during interferon-ribavirin treatment in 18 HCV-positive subjects. Mathematical analysis and modelling were applied to compare the degree of erythropoietin increase in HCV-positive and in otherwise healthy anaemic patients, and estimate the endogenous excess erythropoietin production in response to ribavirin-induced anaemia. Results: Erythropoietin concentration increased significantly in response to anaemia caused by ribavirin. The physiological erythropoietin response to the ribavirin-induced anaemia was as adequate in HCV-positive subjects as it is in anaemic subjects without liver disease. The recommended exogenous erythropoietin dose appears three-times greater than the endogenous erythropoietin boost. Conclusion: Chronic liver damage by HCV does not affect the physiological erythropoietin response to ribavirin-induced anaemia. While the rationale for erythropoietin treatment of ribavirin-induced anaemia is not straightforward, the currently recommended dosing regimen should be reassessed.

关键词：贫血溶血性/化学诱导抗病毒药/副作用抗病毒药/治疗应用药物疗法联合红细胞生成素/血液丙型肝炎慢性/药物疗法丙型肝炎慢性/代谢干扰素α/治疗应用模型生物学重组蛋白质类利巴韦林/副作用利巴韦林/治疗应用成年人老年人女(雌)性人类男(雄)性中年人

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Interferons, serotonin and neurotoxicity

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PSYCHOLOGICAL MEDICINE 2000年第2期30卷 259-268页

作者： Menkes, DB MacDonald, JA Dunedin Publ Hosp Dunedin New Zealand Univ Otago Dunedin Sch Med Dunedin New Zealand

Background. Interferons are a class of cytokines profoundly affecting immune function. Several interferons are now synthesized and used clinically, notably for viral diseases and cancer. In addition to their desired immune effects, interferons cause a number of toxicities, including prominent effects on the nervous system. Methods. This literature review focused on the incidence of depression associated with interferon treatment. Possible neurochemical mechanisms and remedial strategies were also considered. Results. Interferon treatment, particularly with the alpha subtype, is unquestionably linked with depression, but the strength of association is uncertain because of erratic ascertainment and pretreatment co-morbidity. A likely pathogenic mechanism has been described, involving interferon suppression of serotonin synthesis. Controlled treatment trials of interferon-induced depression are not yet available. Conclusions. Neurotoxicity substantially limits the use of interferons. At least some of the risk of depression appears to derive from their anti-serotonergic effects, consistent with the large body of evidence pointing to a general link between serotonin and affective illness. Vigilant detection and aggressive treatment of depression is necessary to optimize interferon treatment of many patients.

关键词：抗肿瘤药/副作用抗肿瘤药/治疗应用抗病毒药/副作用抗病毒药/治疗应用脑/药物作用脑/病理生理学抑郁症/化学诱导抑郁症/病理生理学干扰素类/副作用干扰素类/治疗应用产品监测售后危险因素血清素/生理学人类

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不同CD4^＋细胞水平HIV感染者抗病毒治疗的疗效及药物不良反应分析

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中国医师杂志 2015年第1期17卷 52-54,57页

作者：丁佩佩何纲陈晓华甄沛林吴兴柳李志杰黄劲华江门市中心医院感染科广东省江门529030 新会区人民医院感染科台山市人民医院感染科

目的探讨不同CD4^＋细胞水平HIV感染者抗病毒治疗的疗效及药物不良反应。方法回顾性分析广东省江门地区接受TDF（替诺福韦酯）＋3TC（拉米夫定）＋EFV（依非韦伦）方案抗HIV治疗患者的资料，根据患者CD4^＋细胞水平不同分为A组（350／tx... 详细信息

目的探讨不同CD4^＋细胞水平HIV感染者抗病毒治疗的疗效及药物不良反应。方法回顾性分析广东省江门地区接受TDF（替诺福韦酯）＋3TC（拉米夫定）＋EFV（依非韦伦）方案抗HIV治疗患者的资料，根据患者CD4^＋细胞水平不同分为A组（350／txl≤CD4^＋〈500／μl），B组（200／μl≤CD4‘〈350／μl），C组（CD4^＋〈200／μ1），对比各组患者的治疗效果及药物不良反应。结果共收集临床病例132份。其中A组32例，B组42例，C组58例。三组患者在性别构成、年龄以及传播途径上差异无统计学意义（P〉0．05）。A／B／C三组患者CD4^＋细胞水平均较治疗前明显升高（P〈0．05），但治疗后6个月上升数值（75．6±52．1；80．5±58．7；97．5±78．7）及治疗后12个月上升数值（71．4±58．9；110．8±71．6；113．7±88．3）三组间比较差异无统计学意义（P〉0．05）。临床不良反应发生率3个月内C组（32／58）〉B组（14／42）〉A组（4／32），3～12个月时C组（22／58）〉B组（8／42）〉A组（1／32），三组间差异有统计学意义（P〈0．05）。结论抗病毒治疗在各个时期启动均有效果，早期启动抗病毒治疗有利于减少药物的不良反应发生率。

关键词： CD4淋巴细胞计数 HIV感染/药物疗法抗病毒药/副作用回顾性研究

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Capillaritis associated with interferon-alfa treatment of chronic hepatitis C infection

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JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY 2000年第5期43卷 937-938页

作者： Gupta, G Holmes, SC Spence, E Mills, PR Univ Glasgow Western Infirm Dept Dermatol Glasgow G11 6NT Lanark Scotland Univ Glasgow Western Infirm Dept Gastroenterol Glasgow G11 6NT Lanark Scotland

We report the case of a 36-year-old man who was referred with an asymptomatic eruption that started on both lower legs. This started shortly after being commenced on interferon-alfa for chronic hepatitis secondary to hepatitis C. Clinically, the eruption was consistent with a capillaritis (pigmented purpuric dermatosis). Histology confirmed this to be lymphocytic vasculitis. Lymphocytic vasculitis is frequently identified in the salivary glands of patients who are hepatitis C positive. Although leukocytoclastic vasculitis confined to the skin is frequently reported with hepatitis C, lymphocytic vasculitis is rarely reported. We consider that the lymphocytic vasculitis in our patient occurred as a result of interferon-alfa treatment because of the strong temporal relationship between the onset of the skin eruption and drug therapy.

关键词：抗病毒药/副作用抗病毒药/治疗应用丙型肝炎慢性/药物疗法组织细胞/病理学干扰素α/副作用干扰素α/治疗应用淋巴细胞/病理学皮肤/病理学皮肤疾病血管性/化学诱导皮肤疾病血管性/病理学血管炎/化学诱导血管炎/病理学成年人人类男(雄)性

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Treatment of severe recurrent hepatitis C after liver transplantation with ribavirin plus interferon alpha

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TRANSPLANTATION PROCEEDINGS 1999年第1-2期31卷 494-495页

作者： Fischer, L Sterneck, M Valentin-Gamazo, C Feucht, HH Malagó, M Broelsch, CE Univ Hamburg Hosp Eppendorf Dept Med Microbiol Hamburg Germany Univ Hamburg Hosp Eppendorf Chirurg Klin Dept Surg D-20246 Hamburg Germany

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药物性急性肾衰竭5例分析

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中国误诊学杂志 2008年第27期8卷 6777-6778页

作者：杜飞张克非袁立英汪晓媛遵义医学院第三附属医院肾内科贵州遵义563002

现将我科2008—02/2008—04收治的药物所致急性肾衰竭(ARF)5例分析如下。1临床资料1.1一般资料本组中应用阿昔洛韦2例,男1例,女1例,年龄28－34岁,平均31岁;用药前疾病:2例均为带状疱疹;静滴剂量0.75－1.25g/次,1次/d,持续2－6d。应用庆... 详细信息

现将我科2008—02/2008—04收治的药物所致急性肾衰竭(ARF)5例分析如下。1临床资料1.1一般资料本组中应用阿昔洛韦2例,男1例,女1例,年龄28－34岁,平均31岁;用药前疾病:2例均为带状疱疹;静滴剂量0.75－1.25g/次,1次/d,持续2－6d。应用庆大霉素1例,男,62岁,用药前疾病感染性腹泻,静滴剂量32万U/次,2次/d,持续3d。[第一段]

关键词：肾功能衰竭,急性/化学诱导抗病毒药/副作用病例报告[文献类型] 人类

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Interferon and plasma lipids

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MEDICINA CLINICA 2000年第2期114卷 74-76页

作者： García-Escaño, MD Andrade, RJ González-Santos, P Fac Med Unidad Hepatol Dept Med Malaga 29071 Spain

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甘利欣注射液引起发热九例

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中国医院药学杂志 1996年第11期16卷 525页

作者：吕忠民浙江东阳东阳市人民医院 322100

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