Dear Editor:Coenzyme A(CoA)is a primary and predominant acyl group carrier involved in a wide variety of important biochemical *** CoA biosynthetic pathway is composed of five enzymatic steps,of which Pantothenate kin...
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Dear Editor:Coenzyme A(CoA)is a primary and predominant acyl group carrier involved in a wide variety of important biochemical *** CoA biosynthetic pathway is composed of five enzymatic steps,of which Pantothenate kinase(PanK)is a key regulatory *** multiple isoforms of PanK are encoded by four difierent genes[1,2].In our previous studies of SNP markers by genotyping the case-controlled DNAs,we found that one SNP within the hPANK4 gene on chromosome 1 was associated with type 2diabetes[3-5].We subsequently showed that rat PanK4 (rPanK4)was up-regulated when rats were challenged by high concentration ofglucose[6].M2-type pyruvate kinase (Pkm2)was found,both in vitro and in vivo,to be associated with rPanK4[7].
Apoptosis plays a prominent role in ovarian development and function [1-4]. During follicle development, the vast majority of follicles undergo atresia as a consequence of apoptosis of constituent oocyte or follicular...
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Apoptosis plays a prominent role in ovarian development and function [1-4]. During follicle development, the vast majority of follicles undergo atresia as a consequence of apoptosis of constituent oocyte or follicular cells, or both, failing to complete the maturation process. Atresia occurs at all stages of follicular development during the growth and development of follicles. Atresia of the primordial and primary follicles is initiated by oocyte apoptosis, followed by the death of the granulosa cells [1-4]. In comparison, the reduction of the large number of growing follicles to a single ovulatory follicle is achieved primarily by the cell death of granulosa cells [1-4]. Members of the Bcl-2 and caspase families play important roles in the regulation of ovarian cell death, both in follicle development and in response to chemotherapeutic agents [5].
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