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检索条件"主题词=转录因子/免疫学"
21 条 记 录,以下是1-10 订阅
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The MAZ protein is an autoantigen of Hodgkin's disease and paraneoplastic cerebellar dysfunction
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ANNALS OF NEUROLOGY 2003年 第1期53卷 123-127页
作者: Bataller, L Wade, DF Graus, F Rosenfeld, MR Dalmau, J Univ Arkansas Med Sci Dept Neurol Little Rock AR USA Univ Arkansas Med Sci Dept Microbiol & Immunol Little Rock AR USA Hosp Clin Barcelona Dept Neurol Barcelona Spain Cent Arkansas Vet Hlth Care Syst Little Rock AR USA
Probing a cerebellar expression library with TrAb sera from patients with Hodgkin's disease and paraneoplastic cerebellar degeneration resulted in the isolation of MAZ (myc-associated zinc-finger protein). Eleven ... 详细信息
来源: 评论
Peroxisome proliferator-activated receptor-γ agonists prevent experimental autoimmune encephalomyelitis
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ANNALS OF NEUROLOGY 2002年 第6期51卷 694-702页
作者: Feinstein, DL Galea, E Gavrilyuk, V Brosnan, CF Whitacre, CC Dumitrescu-Ozimek, L Landreth, GE Pershadsingh, HA Weinberg, G Heneka, MT Univ Illinois Dept Anesthesiol Chicago IL 60612 USA Albert Einstein Coll Med Dept Pathol Bronx NY 10467 USA Ohio State Univ Dept Mol Virol Immunol & Med Genet Columbus OH 43210 USA Univ Bonn Dept Neurol D-5300 Bonn Germany Case Western Reserve Univ Dept Neurosci Cleveland OH 44106 USA Case Western Reserve Univ Dept Neurol Cleveland OH 44106 USA Univ Calif Irvine Irvine CA USA Kern Med Ctr Dept Family Med Irvine CA USA
The development of clinical symptoms in multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE) involves T-cell activation and migration into the central nervous system, production of g... 详细信息
来源: 评论
Opposing roles of Elk-1 and its brain-specific isoform, short Elk-1, in nerve growth factor-induced PC12 differentiation
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JOURNAL OF BIOLOGICAL CHEMISTRY 2001年 第7期276卷 5189-5196页
作者: Vanhoutte, P Nissen, JL Brugg, B Della Gaspera, B Besson, MJ Hipskind, RA Caboche, J Univ Paris 06 Inst Neurosci Lab Neurochim Anat CNRSUMR 7624 F-75005 Paris France Univ Paris 06 Inst Neurosci Lab Dev & Vieillissement SNC CNRSUMR 7624 F-75005 Paris France Univ Paris 06 Inst Neurosci Mol Neurogenet Lab CNRSUMR 7624 F-75005 Paris France CNRS IFR 24 UMR 5535 Inst Genet Mol F-34293 Montpellier 5 France
The ternary complex factor Elk-1, a major nuclear target of extracellular signal-regulated kinases, is a strong transactivator of serum-responsive element (SRE) driven gene expression. We report here that mature brain... 详细信息
来源: 评论
Selective elimination of leukemic CD34+ progenitor cells by cytotoxic T lymphocytes specific for WT1
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BLOOD 2000年 第7期95卷 2198-2203页
作者: Gao, LQ Bellantuono, I Elsässer, A Marley, SB Gordon, MY Goldman, JM Stauss, HJ Hammersmith Hosp Imperial Sch Med Dept Immunol London England Hammersmith Hosp Imperial Sch Med Dept Hematol London England
Hematologic malignancies such as acute and chronic myeloid leukemia are characterized by the malignant transformation of immature CD34(+) progenitor cells. Transformation is associated with elevated expression of the ... 详细信息
来源: 评论
HMG-I/Y, a new c-Myc target gene and potential oncogene
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MOLECULAR AND CELLULAR BIOLOGY 2000年 第15期20卷 5490-5502页
作者: Wood, LJ Mukherjee, M Dolde, CE Xu, Y Maher, JF Bunton, TE Williams, JB Resar, LMS Johns Hopkins Univ Sch Med Div Hematol Baltimore MD 21205 USA Johns Hopkins Univ Sch Med Dept Pediat Baltimore MD 21205 USA Johns Hopkins Univ Sch Med Dept Mol Biol & Genet Baltimore MD 21205 USA Johns Hopkins Univ Sch Med Dept Comparat Med Baltimore MD 21205 USA Johns Hopkins Univ Sch Med Dept Oncol Baltimore MD 21205 USA
The HMG-I/Y gene encodes the HMG-I and HMG-Y proteins, which function as architectural chromatin binding proteins important in the transcriptional regulation of several genes. Although increased expression of the HMG-... 详细信息
来源: 评论
Do lampreys have lymphocytes? The Spi evidence
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2000年 第13期97卷 7417-7422页
作者: Shintani, S Terzic, J Sato, A Saraga-Babic, M O'hUigin, C Tichy, H Klein, J Max Planck Inst Biol Immungenet Abt D-7076 Tubingen Germany Univ Split Sch Med Dept Physiol Split Croatia Univ Split Sch Med Dept Histol & Embryol Split Croatia
It is generally accepted that living jawless vertebrates (lampreys and hagfishes) lack the capability of mounting an adaptive immune response. At the same time, however, there are reports describing histological evide... 详细信息
来源: 评论
Human slug is a repressor that localizes to sites of active transcription
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MOLECULAR AND CELLULAR BIOLOGY 2000年 第14期20卷 5087-5095页
作者: Hemavathy, K Guru, SC Harris, J Chen, JD Ip, YT Univ Massachusetts Sch Med Dept Cell Biol Program Mol Med Worcester MA 01605 USA Univ Massachusetts Sch Med Dept Biochem & Mol Biol Worcester MA 01605 USA Univ Massachusetts Sch Med Dept Mol Pharmacol & Toxicol Worcester MA 01605 USA Natl Human Genome Res Inst Genet & Mol Biol Branch NIH Bethesda MD 20892 USA
Snail/Slug family proteins have been identified in diverse species of both vertebrates and invertebrates. The proteins contain four to six zinc fingers and function as DNA-binding transcriptional regulators. Various m... 详细信息
来源: 评论
Signaling via LAT (linker for T-cell activation) and Syk/ZAP70 is required for ERK activation and NFAT transcriptional activation following CD2 stimulation
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BLOOD 2000年 第6期96卷 2181-2190页
作者: Martelli, MP Lin, HM Zhang, WQ Samelson, LE Bierer, BE NHLBI Lab Lymphocyte Biol NIH Bethesda MD 20892 USA NCI Cellular & Mol Biol Lab NIH Bethesda MD 20892 USA
Activation of T cells can be initiated through cell surface molecules in addition to the T-cell receptor-CD3 (TCR-CD3) complex. In human T cells, ligation of the CD2 molecule by mitogenic pairs of anti-CD2 monoclonal ... 详细信息
来源: 评论
Role of Drosophila IKKγ in a Toll-independent antibacterial immune response
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NATURE IMMUNOLOGY 2000年 第4期1卷 342-347页
作者: Rutschmann, S Jung, AC Zhou, R Silverman, N Hoffmann, JA Ferrandon, D CNRS Inst Biol Mol & Cellulaire UPR 9022 F-67084 Strasbourg France Harvard Univ Dept Mol & Cellular Biol Cambridge MA 02138 USA
We have generated, by ethylmethane sulfonate mutagenesis, loss-of-function mutants in the Drosophila homolog of the mammalian I-kappa B kinase (IKK) complex component IKK gamma (also called NEMO). Our data show that D... 详细信息
来源: 评论
XIST RNA associates with specific regions of the inactive X chromatin
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JOURNAL OF BIOLOGICAL CHEMISTRY 2000年 第47期275卷 36491-36494页
作者: Gilbert, SL Pehrson, JR Sharp, PA MIT Ctr Canc Res Dept Biol Cambridge MA 02139 USA Univ Penn Sch Vet Med Dept Biol Anim Philadelphia PA 19104 USA
Microscopy studies have shown that XIST RNA colocalizes with the inactive X chromosome (Xi). However, the molecular basis for this colocalization is unknown, Here we provide two lines of evidence from chromatin immuno... 详细信息
来源: 评论