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检索条件"主题词=Bnip3"
514 条 记 录,以下是51-60 订阅
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FOXO3a protects glioma cells against temozolomide-induced DNA double strand breaks via promotion of bnip3-mediated mitophagy
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中国药理学报(英文版) 2021年 第8期42卷 1324-1337页
作者: Chuan He Shan Lu Xuan-zhong Wang Chong-cheng Wang Lei Wang Shi-peng Liang Tian-fei Luo Zhen-chuan Wang Mei-hua Piao Guang-fan Chi Peng-fei Ge Department of Neurosurgery First Hospital of Jilin UniversityChangchun 130021China Research Center of Neuroscience First Hospital of Jilin UniversityChangchun 130021China Research Center of Neuroscience First Hospital of Jilin UniversityChangchun 130021China Department of Neurology First Hospital of Jilin UniversityChangchun 130021China Department of Anesthesiology First hospital of Jilin UniversityChangchun 130021China Key Laboratory of Pathobiology Ministry of EducationJilin UniversityChangchun 130021China
FOXO3a(forkhead box transcription factor 3a)is involved in regulating multiple biological processes in cancer ***3(Bcl-2/adenovirus E1B 19-kDa-interacting protein 3)is a receptor accounting for priming damaged mitocho... 详细信息
来源: 评论
Angelica polysaccharide moderates hypoxia-evoked apoptosis and autophagy in rat neural stem cells by downregulation of bnip3 (Publication with Expression of Concern)
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ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY 2019年 第1期47卷 2492-2499页
作者: Xue, Yongzhen Li, Dongmei Zhang, Yige Gao, Hang Li, Hui East Med Dist Linyi Peoples Hosp Dept Childrens Healthcare Linyi Shandong Peoples R China Shandong Prov Coal Linyi Hot Springs Sanat Hosp Dept Internal Med Linyi Shandong Peoples R China Qingdao Univ Dept Med Classe Six Clin Five Year Syst Qingdao Shandong Peoples R China Jining Med Univ Basic Med Coll Class Eight Clin Med Jining Peoples R China Linyi Womens & Childrens Hosp Dept Childrens Rehabil 1 Qinghe South Rd Linyi 276000 Shandong Peoples R China
Neonatal hypoxia-ischemia is a troublesome disease. Angelica polysaccharide (AP) is proved to have antioxidant effects. Our study was performed to confirm the effects of AP in hypoxia-exposed neural stem cells (NSCs).... 详细信息
来源: 评论
Upregulation of long noncoding RNA RP4 exacerbates hypoxia injury in cardiomyocytes through regulating miR-939/bnip3/Wnt/β-catenin pathway (Publication with Expression of Concern. See vol. 50, pg. 221, 2022)
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ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY 2019年 第1期47卷 3013-3020页
作者: Rong, Jingfeng Xu, Jijie Liu, Qian Wu, Yaoyao Guo, Honglin Mu, Ting Zhou, Hua Chi, Hao Zhengzhou Univ Luoyang Cent Hosp Dept Med Cardiovasc Luoyang Henan Peoples R China Shanghai Univ Tradit Chinese Med Shuguang Hosp Inst Cardiovasc Res Shanghai Peoples R China Shanghai Univ Tradit Chinese Med Shuguang Hosp Dept Cardiovasc Shanghai Peoples R China Shanghai Univ Tradit Chinese Med Shuguang Hosp Dept Cardiothorac Surg 528 Zhangheng Rd Shanghai 201499 Peoples R China
This research planned to dig the impacts and potential principles of long noncoding RNA RP4 onH9c2 cell injury induced by hypoxia. The H9c2 cardiac muscle cells were cultured under 3% O-2 concentration to induce hypox... 详细信息
来源: 评论
Synchronised phosphorylation of bnip3, Bcl-2 and Bcl-xL in response to microtubule-active drugs is JNK-independent and requires a mitotic kinase
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BIOCHEMICAL PHARMACOLOGY 2010年 第11期79卷 1562-1572页
作者: Mellor, Howard R. Rouschop, Kasper M. Wigfield, Simon M. Wouters, Bradly G. Harris, Adrian L. Univ Oxford Growth Factor Grp CR UK Mol Oncol Labs John Radcliffe HospWeatherall Inst Mol Med Oxford OX3 9DS England Maastricht Univ Dept Radiat Oncol Maastro Lab GROW Res Inst Maastricht Netherlands Univ Toronto Ontario Canc Inst Univ Hlth Network Dept Radiat Oncol & Med Biophys Toronto ON Canada
bnip3 is a hypoxia-inducible BH3-only member of the Bcl-2 family of proteins that regulate apoptosis and autophagy. However the role of bnip3 in the hypoxia response has proved difficult to define and remains controve... 详细信息
来源: 评论
In vitro study of normoxic epidermal growth factor receptor-induced hypoxia-inducible factor-1-alpha, vascular endothelial growth factor, and bnip3 expression in head and neck squamous cell carcinoma cell lines: Implications for anti-epidermal growth factor receptor therapy
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HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 2015年 第8期37卷 1150-1162页
作者: Secades, Pablo de Santa-Maria, Ines Saenz Merlo, Anna Suarez, Carlos Chiara, Maria-Dolores Univ Oviedo Serv Otorrinolaringol Hosp Univ Cent Asturias Inst Univ Oncol Principado Asturias Oviedo Spain
BackgroundWe previously showed that activation of epidermal growth factor receptor (EGFR) induces hypoxia inducible factor-1 (HIF-1) in head and neck squamous cell carcinoma (HNSCC) cells. In this study, we have furth... 详细信息
来源: 评论
Role of bnip3 and NIX in cell death, autophagy, and mitophagy
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CELL DEATH AND DIFFERENTIATION 2009年 第7期16卷 939-946页
作者: Zhang, J. Ney, P. A. St Jude Childrens Hosp Dept Biochem Memphis TN 38117 USA Univ Tennessee Hlth Sci Ctr Integrated Program Biomed Sci Memphis TN 38126 USA
bnip3 and NIX are proteins related to the BH3-only family, which induce both cell death and autophagy. Consistent with their ability to induce cell death, bnip3 and NIX are implicated in the pathogenesis of cancer and... 详细信息
来源: 评论
The mitophagy receptor bnip3 is critical for the regulation of metabolic homeostasis and mitochondrial function in the nucleus pulposus cells of the intervertebral disc
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AUTOPHAGY 2023年 第6期19卷 1821-1843页
作者: Madhu, Vedavathi Hernandez-Meadows, Miriam Boneski, Paige K. Qiu, Yunping Guntur, Anyonya R. Kurland, Irwin J. Barve, Ruteja A. Risbud, Makarand V. Thomas Jefferson Univ Sidney Kimmel Med Coll Dept Orthopaed Surg Philadelphia PA USA Mayo Clin Dept Neurosci Jacksonville FL USA Albert Einstein Coll Med Einstein Mt Sinai Diabet Res Ctr ES DRC Bronx NY USA Maine Med Ctr Res Inst Ctr Mol Med Scarborough ME USA Washington Univ Genome Technol Access Ctr Sch Med Dept GenetMcDonnell Genome Inst St Louis MO USA Thomas Jefferson Univ Dept Orthopaed Surg 1025 Walnut StSuite 511 Coll Bldg Philadelphia PA 19107 USA
The contribution of mitochondria to the metabolic function of hypoxic NP cells has been overlooked. We have shown that NP cells contain networked mitochondria and that mitochondrial translocation of bnip3 mediates hyp... 详细信息
来源: 评论
A20 ameliorates disc degeneration by suppressing mTOR/bnip3 axis-mediated mitophagy
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GENES & GENOMICS 2023年 第5期45卷 657-671页
作者: Peng, Xin Zhang, Cong Gao, Jia-Wei Wang, Feng Bao, Jun-Ping Zhou, Zhi-Min Sun, Rui Ji, Hang-Yu Vlf, Cabral Wu, Xiao-Tao Med Sch Southeast Univ Nanjing Peoples R China Southeast Univ Zhongda Hosp Dept Orthoped Nanjing Peoples R China
Background The pathological mechanism of intervertebral disc degeneration (IDD) is an unanswered question that we are committed to exploring. A20 is an anti-inflammatory protein of nucleus pulposus (NP) cells and play... 详细信息
来源: 评论
Resistance to Hypoxia-Induced, bnip3-Mediated Cell Death Contributes to an Increase in a CD133-Positive Cell Population in Human Glioblastomas In Vitro
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JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 2012年 第12期71卷 1086-1099页
作者: Kahlert, Ulf Dietrich Maciaczyk, Donata Dai, Fangping Claus, Rainer Firat, Elke Doostkam, Soroush Bogiel, Tomasz Carro, Maria Stella Doebroessy, Mate Herold-Mende, Christel Niedermann, Gabriele Prinz, Marco Nikkhah, Guido Maciaczyk, Jaroslaw Univ Freiburg Med Ctr Dept Gen Neurosurg D-79106 Freiburg Germany Univ Freiburg Med Ctr Div Stereotact Neurosurg D-79106 Freiburg Germany Univ Heidelberg Med Ctr Dept Neurosurg Div Neurosurg Res Heidelberg Germany Univ Freiburg Fac Biol D-79106 Freiburg Germany Univ Freiburg Med Ctr Dept Neuropathol D-79106 Freiburg Germany Univ Freiburg BIOSS Ctr Biol Signaling Studies D-79106 Freiburg Germany 10th Mil Clin Hosp Dept Pathomorphol Clin Genet Lab Bydgoszcz Poland Univ Med Ctr Freiburg Dept Med 1 Div Hematol Oncol Freiburg Germany
In addition to intrinsic regulatory mechanisms, brain tumor stemlike cells (BTSCs), a small subpopulation of malignant glial tumor-derived cells, are influenced by environmental factors. Previous reports showed that l... 详细信息
来源: 评论
Yessotoxin induces ER-stress followed by autophagic cell death in glioma cells mediated by mTOR and bnip3
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CELLULAR SIGNALLING 2014年 第2期26卷 419-432页
作者: Rubiolo, J. A. Lopez-Alonso, H. Martinez, P. Milian, A. Cagide, E. Vieytes, M. R. Vega, F. V. Botana, L. M. USC Fac Vet Dept Farmacol Lugo 27002 Spain Univ Santiago Compostela Fac Vet Dept Genet Lugo 27002 Spain Lab CIFGA SA Lugo 27002 Spain Univ Santiago de Compostela Fac Vet Dept Fisiol Lugo 27002 Spain
Yessotoxin at nanomolar concentrations can induce programmed cell death in different model systems. Paraptosis-like cell death induced by YTX in BC3H1 cells, which are insensitive to several caspase inhibitors, has al... 详细信息
来源: 评论