检索结果-内蒙古大学图书馆

Decoding the non-coding: Tools and Databases Unveiling the Hidden World of "Junk" rnas for Innovative Therapeutic Exploration

引用

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE 2024年第7期7卷 1901-1915页

作者： Chaudhary, Uma Banerjee, Satarupa Vellore Inst Technol VIT Sch Biosci & Technol Dept Biotechnol Vellore 632014 Tamil Nadu India

non-coding rnas are pivotal regulators of gene and protein expression, exerting crucial influences on diverse biological processes. Their dysregulation is frequently implicated in the onset and progression of diseases, notably cancer. A profound comprehension of the intricate mechanisms governing ncrnas is imperative for devising innovative therapeutic interventions against these debilitating conditions. Significantly, nearly 80% of our genome comprises ncrnas, underscoring their centrality in cellular processes. The elucidation of ncrna functions is pivotal for grasping the complexities of gene regulation and its implications for human health. Modern genome sequencing techniques yield vast datasets, stored in specialized databases. To harness this wealth of information and to understand the crosstalk of non-coding rnas, knowledge of available databases is required, and many new sophisticated computational tools have emerged. These tools play a pivotal role in the identification, prediction, and annotation of ncrnas, thereby facilitating their experimental validation. This Review succinctly outlines the current understanding of ncrnas, emphasizing their involvement in disease development. It also highlights the databases and tools instrumental in classifying, annotating, and evaluating ncrnas. By extracting meaningful biological insights from seemingly "junk" data, these tools empower scientists to unravel the intricate roles of ncrnas in shaping human health.

关键词： non-coding rna Microrna Long non-coding rna Circularrna Cancer Database

来源：评论

学校读者我要写书评

暂无评论

Long non-coding rnas in cancer / 1

Long non-coding RNAs in cancer /

引用

丛书名： Methods in Molecular Biology, 2348

2021年

作者： Alfons Navarro (editor)

ISBN: (纸本)9781071615805

This volume presents techniques needed for the study of long non-coding rnas (lncrnas) in cancer from their identification to functional characterization. Chapters guide readers through identification of lncrna expression signatures in cancer tissue or liquid biopsies by rnaseq, single Cell rnaseq, Phospho rnaseq or Nanopore Sequencing techniques; validation of lncrna signatures by Real time PCR, digital PCR or in situ hybridization; and functional analysis by sirna or CRISPR based methods for lncrna silencing or overexpression. Lipid based nanoparticles for delivery of sirnas in vivo, lncrna-protein interactions, viral lncrnas and circrnas are also treated in this volume. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Long non-coding rnas in Cancer aims to provide a collection of laboratory protocols, bioinformatic pipelines, and review chapters to further research in this vital field. .

关键词： Cancer non-coding rna

来源：评论

学校读者我要写书评

暂无评论

The copious capabilities of non-coding rnas in cancer regulation, diagnosis and treatment

引用

CANCER TREATMENT AND RESEARCH COMMUNICATIONS 2023年 37卷 100768-100768页

作者： McCabe, Aideen Zaheed, Oza Derlipanska, Magdalina Merrin, George Dean, Kellie Univ Coll Cork Sch Biochem & Cell Biol Coll Sci Engn & Food Sci Cork Ireland SFI Ctr Res Training Genom Data Sci Dublin Ireland

Globally, cancer is one of the leading causes of mortality, accounting for 10 million deaths per year. non-coding rnas (ncrnas) play integral and diverse roles in cancer, possessing the ability to both promote oncogenesis and impede tumor formation. This review discusses the various roles of micrornas, transfer rna-derived small rnas, long non-coding rnas and lncrna-derived microproteins in cancer progression and prevention. We highlight the diagnostic and therapeutic potential of these ncrnas, with a particular focus on detection in liquid biopsies and targeting of ncrnas with small inhibitory molecules. Ultimately, the biological functions of cancer- associated ncrnas, as well as the development of ncrna-based technologies, are compelling areas for further research, holding the possibility of revolutionizing cancer treatment and diagnosis.

关键词： non-coding rna Microprotein Cancer Liquid biopsy Therapeutics

来源：评论

学校读者我要写书评

暂无评论

Immuno'logical (the scientific updates you wouldn't dare to read anywhere else): X chromosome, Xist, and female autoimmunity

引用

Revue de Medecine Interne 2025年第6期46卷 348-351页

作者： Lacombe, Valentin Service de Médecine interne et polyvalente centre hospitalier du Haut-Anjou 1 quai du Dr Lefèvre Château-Gontier 53200 France MitoLab unité MITOVASC UMR CNRS 6015 Inserm U1083 SFR ICAT université d'Angers Angers 49000 France

This first article in the Immuno'logical series explores the role of the X chromosome and the non-coding rna Xist in the female predisposition to autoimmune diseases, by breaking down three fundamental research studies to make them more digestible for non-experts. Xist is a non-coding rna that inactivates one of the two X chromosomes in every female cell by wrapping around it. Here, we dive into how Xist is involved in the production of anti-RNP antibodies in lupus, how the TLR7 gene can be a rebel and escape Xist's control, and how a lack of affinity between Xist and its X chromosome can contribute to other autoimmune diseases. Let's be serious without taking ourselves too seriously, and uncover the fascinating world of Xist in autoimmunity! © 2025 Société Nationale Française de Médecine Interne (SNFMI)

关键词： Autoimmunity non-coding rna Toll-like receptor 7 X chromosome Xist

来源：评论

学校读者我要写书评

暂无评论

Whole transcriptome analyses and comparison reveal the metabolic differences between oxidative and glycolytic skeletal muscles of yak

引用

MEAT SCIENCE 2022年 194卷 108948页

作者： Wu, Xiaoyun Zhou, Xuelan Chu, Min Guo, Xian Pei, Jie Xiong, Lin Ma, Xiaoming Bao, Pengjia Liang, Chunnian Yan, Ping Chinese Acad Agr Sci Key Lab Yak Breeding Engn Key Lab Anim Genet & Breeding Tibetan Plateau Minist Agr & Rural AffairsLanzhou Inst Husb Pharm Lanzhou 730050 Peoples R China Chinese Acad Agr Sci Lanzhou Inst Husb & Pharmaceut Sci Lanzhou 730050 Peoples R China

Mammalian skeletal muscle is composed of various muscle fibers that exhibit different physiological and metabolic features. Muscle fiber type composition has significant influences on the meat quality of livestock. In this study, we comprehensively analyzed the whole transcriptome profiles of the oxidative muscle biceps femoris (BF) and the glycolytic muscle obliquus externus abdominis (OEA) of yak. A total of 1436 mrnas, 1172 lncrnas, and 218 circrnas were differentially expressed in the oxidative muscles compared with the glycolytic muscles. KEGG annotation showed that differentially expressed mrnas regulated by lncrna and circrna were mainly involved in PPAR signaling pathway, citrate cycle (TCA cycle), and PI3K-Akt signaling pathway, which reflect the different metabolic properties between oxidative and glycolytic muscles. In addition, regulatory networks associated with muscle fiber type conversion and mitochondria energy metabolism in muscles were constructed. Our study provides new evidence for a better understanding of the molecular mechanisms underlying skeletal muscle fiber determination and meat quality traits of yak.

关键词： Yak Oxidative muscle Glycolytic muscle non-coding rna Whole transcriptome sequencing

来源：评论

学校读者我要写书评

暂无评论

Interaction of noncoding rnas with hippo signaling pathway in cancer cells and cancer stem cells

引用

non-coding rna RESEARCH 2024年第4期9卷 1292-1307页

作者： Abedimanesh, Saba Safaralizadeh, Reza Jahanafrooz, Zohreh Najafi, Souzan Amini, Mohammad Nazarloo, Shabnam Soltani Mahdavi, Seyedeh Zahra Bahojb Baradaran, Behzad Jebelli, Asiyeh Mokhtarzadeh, Amir Ali Univ Tabriz Fac Nat Sci Dept Anim Biol Tabriz Iran Univ Maragheh Fac Sci Dept Biol Maragheh Iran Tabriz Univ Med Sci Immunol Res Ctr Tabriz Iran Azarbaijan Shahid Madani Univ Fac Basic Sci Dept Biol Tabriz Iran Higher Educ Inst Rab Rashid Fac Basic Sci Dept Biol Sci Tabriz Iran Tabriz Univ Med Sci Clin Res Dev Unit Tabriz Valiasr Hosp Tabriz Iran

The Hippo signaling pathway has a regulatory function in the organogenesis process and cellular homeostasis, switching the cascade reactions of crucial kinases acts to turn off/on the Hippo pathway, altering the downstream gene expression and thereby regulating proliferation, apoptosis, or stemness. Disruption of this pathway can lead to the occurrence of various disorders and different types of cancer. Recent findings highlight the importance of ncrnas, such as microrna, circular rna, and lncrnas, in modulating the Hippo pathway. Defects in ncrnas can disrupt Hippo pathway balance, increasing tumor cells, tumorigenesis, and chemotherapeutic resistance. This review summarizes ncrnas' inhibitory or stimulatory role in - Hippo pathway regulation in cancer and stem cells. Identifying the relation between ncrnas and the components of this pathway could pave the way for developing new biomarkers in the treatment and diagnosis of cancers.

关键词： non-coding rna Hippo pathway Cancer cell Cancer stem cell

来源：评论

学校读者我要写书评

暂无评论

non-coding rnas in celiac disease

引用

Clinica chimica acta;international journal of clinical chemistry 2025年 576卷 120417页

作者： Asma Vafadar Elham Shirazi-Tehrani Parisa Vosough Shayan Khalili Alashti Hossein Kargar Jahromi Kamran Bagheri Lankarani Amir Savardashtaki Sajad Ehtiati Student Research Committee Shiraz University of Medical Sciences Shiraz Iran Department of Medical Biotechnology School of Advanced Medical Sciences and Technologies Shiraz University of Medical Sciences Shiraz Iran. Department of Biomedicine Faculty of Veterinary Medicine University of Montreal Saint-Hyacinthe QC J2S 2M2 Canada. Department of Medical Biotechnology School of Advanced Medical Sciences and Technologies Shiraz University of Medical Sciences Shiraz Iran Epilepsy Research Center Shiraz University of Medical Sciences Shiraz Iran. Research Center for Noncommunicable Diseases Jahrom University of Medical Sciences Jahrom Iran. Health Policy Research Center Institute of Health Shiraz University of Medical Sciences Shiraz Iran. Electronic address: Laknkaran@sums.ac.ir. Epilepsy Research Center Shiraz University of Medical Sciences Shiraz Iran Infertility Research Center Shiraz University of Medical Sciences Shiraz Iran. Electronic address: dashtaki63@***. Student Research Committee Department of Clinical Biochemistry School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran. Electronic address: sajadehtiaty@***.

Celiac disease (CeD) is a prevalent gluten-induced autoimmune condition that affects approximately 1%-2% of the global population. Recent research has emphasized the pivotal role of non-coding rnas (ncrnas) in regulating inflammatory responses and modulating autoimmune processes. This diverse group contains micrornas (mirnas), long non-coding rnas (lncrnas), and circular rnas (circrnas),and serves as critical regulators in various physiological and disease-related pathways.A group of validated non-coding rnas have emerged as promising biomarkers forthe diagnosis and treatment *** review aims to elucidate the pathogenesis of CeD and investigate the potential of mirnas, lncrnas, and circrnas as diagnostic biomarkers for this condition. By doing so, we hope to offer valuable insights into the underlying mechanisms of CeD and demonstrate the utility of ncrnas as diagnostic and therapeutic tools in managing this autoimmune disorder.

关键词： Celiac disease Epigenetics non-coding rna circrna lncrna mirna ncrna

来源：评论

学校读者我要写书评

暂无评论

Emerging roles of long non-coding rnas in the p53 network

引用

rna BIOLOGY 2020年第11期17卷 1648-1656页

作者： Jain, Abhinav K. Univ Texas MD Anderson Canc Ctr Dept Epigenet & Mol Carcinogenesis Univ Texas MD Anderson UT Hlth Grad Sch Biomed Sc Ctr Canc Epigenet Houston TX 77030 USA

Transcription factor p53 is activated in response to numerous stress stimuli in order to promote repair and survival or death of abnormal cells. For decades, regulatory mechanisms and downstream targets that execute the many biological functions of tumour suppressor p53 largely focused on the products of protein-coding genes. Recently, an entirely new class of molecules, termed long non-coding rnas (lncrnas), were discovered as key regulatory players in shaping p53 activity and biological outcomes. Many p53-regulated lncrnas are now reported to either directly or indirectly intervene in p53-regulatory networks, generally in fine-tuning p53's tumour surveillance programme. Recent studies reveal that signals that converge upon p53 to regulate its activity, and molecules that implement downstream p53-response include both proteins and lncrnas. In this review, we discuss the non-proteomic component of p53-regulatory networks, focusing on lncrnas regulated by p53 and/or that regulate p53 activity, and their impact on biological outcomes.

关键词： P53 tumour suppressor long non-coding rna Lncrna cancer non-coding rna ncrna transcription factor

来源：评论

学校读者我要写书评

暂无评论

Role of non-coding rnas as novel biomarkers for detection of colorectal cancer progression through interaction with the cell signaling pathways

引用

GENE 2020年 753卷 144796页

作者： Esmaeili, Mohadeseh Keshani, Maryam Vakilian, Mehrdad Esmaeili, Maryam Peymani, Maryam Seyed Forootan, Farzad Chau, Tieu Lan Ismail Goktuna, Serkan Zaker, Sayed Rasoul Nasr Esfahani, Mohammad Hossein Ghaedi, Kamran ACECR Inst Higher Educ Dept Modern Biol Isfahan Branch Esfahan Iran Islamic Azad Univ Fac Basic Sci Dept Biol Shahrekord Branch POB *** Shahrekord Iran Univ Isfahan Fac Biol Sci & Technol Dept Cell & Mol Biol & Microbiol Esfahan Iran ACECR Royan Inst Biotechnol Dept Cellular Biotechnol Cell Sci Res Ctr POB 816513-1378 Esfahan Iran Legal Med Org Legal Med Res Ctr Tehran Iran Univ Seville Andalusian Ctr Mol Biol & Regenerat Med CABIMER Dept Cell Regenerat & Adv Therapies Univ Pablo OlavideCSIC Seville Spain Univ Malaga Fac Sci Dept Cellular Biol Genet & Physiol Malaga Spain Bilkent Univ Fac Sci Dept Mol Biol & Genet Ankara Turkey Bilkent Univ Natl Nanotechnol Res Inst UNAM Ankara Turkey Univ Isfahan Fac Biol Sci & Technol Dept Plant & Anim Biol Esfahan Iran

Colorectal cancer (CRC) is one of the most common types of cancer which affects the colon and the rectum. Approximately one third of annual CRC mortality occurs due to the late detection of this type of cancer. Therefore, there is an urgent need for more powerful diagnostic and prognostic tools for identification and treatment of colorectal tumorigenesis. non-coding rnas (ncrnas) have been implicated in the pathology of CRC and also linked to metastasis, proliferation, differentiation, migration, angiogenesis and apoptosis in numerous cancers. Recently, attention has turned towards ncrnas as specific targets for diagnosis, prognosis and treatment of various types of cancers, including CRC. In this review, we have tried to outline the roles of ncrnas, and their involvement in signaling pathways responsible for the progression of CRC.

关键词： Circular rna Colorectal cancer Long non-coding rna mirna non-coding rna

来源：评论

学校读者我要写书评

暂无评论

Micrornas and long non-coding rnas as novel regulators of ribosome biogenesis

引用

BIOCHEMICAL SOCIETY TRANSACTIONS 2020年第2期48卷 595-612页

作者： McCool, Mason A. Bryant, Carson J. Baserga, Susan J. Yale Univ Dept Mol Biophys & Biochem New Haven CT 06520 USA Yale Univ Dept Genet New Haven CT 06520 USA Yale Univ Dept Therapeut Radiol New Haven CT 06520 USA

Ribosome biogenesis is the fine-tuned, essential process that generates mature ribosomal subunits and ultimately enables all protein synthesis within a cell. Novel regulators of ribosome biogenesis continue to be discovered in higher eukaryotes. While many known regulatory factors are proteins or small nucleolar ribonucleoproteins, micrornas (mirnas), and long non-coding rnas (lncrnas) are emerging as a novel modulatory layer controlling ribosome production. Here, we summarize work uncovering non-coding rnas (ncrnas) as novel regulators of ribosome biogenesis and highlight their links to diseases of defective ribosome biogenesis. It is still unclear how many mirnas or lncrnas are involved in phenotypic or pathological disease outcomes caused by impaired ribosome production, as in the ribosomopathies, or by increased ribosome production, as in cancer. In time, we hypothesize that many more ncrna regulators of ribosome biogenesis will be discovered, which will be followed by an effort to establish connections between disease pathologies and the molecular mechanisms of this additional layer of ribosome biogenesis control.

关键词： cancer gene regulation non-coding rna nucleolus ribosomopathies

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：