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检索条件"主题词=non-coding DNA"
119 条 记 录,以下是61-70 订阅
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Fishing for Function in the Human Gene Pool
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TRENDS IN GENETICS 2016年 第7期32卷 392-394页
作者: Barozzi, Iros Visel, Axel Dickel, Diane E. Lawrence Berkeley Natl Lab Berkeley CA 94720 USA US DOE Joint Genome Inst Walnut Creek CA 94598 USA Univ Calif Sch Nat Sci Merced CA USA
Identification and characterization of causal non-coding variants in human genomes is challenging and requires substantial experimental resources. A new study by Tehranchi et al. describes a cost-effective approach fo... 详细信息
来源: 评论
Regulated Formation of lncRNA-dna Hybrids Enables Faster Transcriptional Induction and Environmental Adaptation (vol 61, pg 393, 2016)
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MOLECULAR CELL 2016年 第1期62卷 148-148页
作者: Cloutier, Sara C. Wang, Siwen Ma, Wai Kit Al Husini, Nadra Dhoondia, Zuzer Ansari, Athar Pascuzzi, Pete E. Tran, Elizabeth J.
来源: 评论
Plastid Genotyping Reveals the Uniformity of Cytoplasmic Male Sterile-T Maize Cytoplasms
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PLANT PHYSIOLOGY 2015年 第3期169卷 2129-2137页
作者: Bosacchi, Massimo Gurdon, Csanad Maliga, Pal Rutgers State Univ Waksman Inst Microbiol Piscataway NJ 08854 USA
Cytoplasmic male-sterile (CMS) lines in maize (Zea mays) have been classified by their response to specific restorer genes into three categories: cms-C, cms-S, and cms-T. A mitochondrial genome representing each of th... 详细信息
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Genome-wide ultraconserved elements exhibit higher phylogenetic informativeness than traditional gene markers in percomorph fishes
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MOLECULAR PHYLOGENETICS AND EVOLUTION 2015年 92卷 140-146页
作者: Gilbert, Princess S. Chang, Jonathan Pan, Calvin Sobel, Eric M. Sinsheimer, Janet S. Faircloth, Brant C. Alfaro, Michael E. Univ Calif Los Angeles Dept Ecol & Evolutionary Biol Los Angeles CA 90095 USA Univ Calif Los Angeles Dept Med Los Angeles CA 90095 USA Univ Calif Los Angeles Dept Biomath Los Angeles CA 90095 USA Univ Calif Los Angeles Dept Human Genet Los Angeles CA 90095 USA Univ Calif Los Angeles Dept Biostat Los Angeles CA 90095 USA Louisiana State Univ Dept Biol Sci Baton Rouge LA 70803 USA Louisiana State Univ Museum Nat Sci Baton Rouge LA 70803 USA
Ultraconserved elements (UCEs) have become popular markers in phylogenomic studies because of their cost effectiveness and their potential to resolve problematic phylogenetic relationships. Although UCE datasets typic... 详细信息
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A dna shape-based regulatory score improves position-weight matrix-based recognition of transcription factor binding sites
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BIOINFORMATICS 2015年 第21期31卷 3445-3450页
作者: Yang, Jichen Ramsey, Stephen A. Oregon State Univ Dept Biomed Sci Corvallis OR 97331 USA Oregon State Univ Sch Elect Engn & Comp Sci Corvallis OR 97331 USA
Motivation: The position-weight matrix (PWM) is a useful representation of a transcription factor binding site (TFBS) sequence pattern because the PWM can be estimated from a small number of representative TFBS sequen... 详细信息
来源: 评论
In silico identification and characterisation of 17 polymorphic anonymous non-coding sequence markers (ANMs) for red grouse (Lagopus lagopus scotica)
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CONSERVATION GENETICS RESOURCES 2015年 第2期7卷 319-323页
作者: Wenzel, Marius A. Piertney, Stuart B. Univ Aberdeen Inst Biol & Environm Sci Aberdeen AB24 2TZ Scotland
Anonymous non-coding sequence markers (ANMs) are powerful neutral genetic markers with great utility in phylogeography, population genetics and population genomics. Developing ANMs has previously relied on sequencing ... 详细信息
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motifbreakR: an R/Bioconductor package for predicting variant effects at transcription factor binding sites
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BIOINFORMATICS 2015年 第23期31卷 3847-3849页
作者: Coetzee, Simon G. Coetzee, Gerhard A. Hazelett, Dennis J. Cedars Sinai Med Ctr Bioinformat & Computat Biol Res Ctr Los Angeles CA 90048 USA USC Norris Comprehens Canc Ctr Dept Urol & Prevent Med Los Angeles CA USA
The Summary: Functional annotation represents a key step toward the understanding and interpretation of germline and somatic variation as revealed by genome-wide association studies (GWAS) and The Cancer Genome Atlas ... 详细信息
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Rare pseudoautosomal copy-number variations involving SHOX and/or its flanking regions in individuals with and without short stature
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JOURNAL OF HUMAN GENETICS 2015年 第9期60卷 553-556页
作者: Fukami, Maki Naiki, Yasuhiro Muroya, Koji Hamajima, Takashi Soneda, Shun Horikawa, Reiko Jinno, Tomoko Katsumi, Momori Nakamura, Akie Asakura, Yumi Adachi, Masanori Ogata, Tsutomu Kanzaki, Susumu Natl Res Inst Child Hlth & Dev Dept Mol Endocrinol Tokyo 1578535 Japan Natl Ctr Child Hlth & Dev Div Endocrinol & Metab Tokyo Japan Kanagawa Childrens Med Ctr Dept Endocrinol & Metab Yokohama Kanagawa Japan Aichi Childrens Hlth & Med Ctr Div Endocrinol & Metab Obu Japan St Marianna Univ Sch Med Dept Pediat Kawasaki Kanagawa Japan Hokkaido Univ Sch Med Dept Pediat Sapporo Hokkaido 060 Japan Hamamatsu Univ Sch Med Dept Pediat Hamamatsu Shizuoka 4313192 Japan Tottori Univ Fac Med Div Pediat & Perinatol Tottori 680 Japan
Pseudoautosomal region 1 (PAR1) contains SHOX, in addition to seven highly conserved non-coding dna elements (CNEs) with cis-regulatory activity. Microdeletions involving SHOX exons 1-6a and/or the CNEs result in idio... 详细信息
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Running spell-check to identify regulatory variants
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NATURE GENETICS 2015年 第8期47卷 853-855页
作者: Kircher, Martin Shendure, Jay Univ Washington Dept Genome Sci Seattle WA 98195 USA
A major challenge in human genetics is pinpointing which non-coding genetic variants affect gene expression and disease risk. A new study in this issue describes a broadly applicable approach for this task that explic... 详细信息
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Integrating regulatory and methylome data for the discovery of clear cell Renal Cell Carcinoma (ccRCC) variants
Integrating regulatory and methylome data for the discovery ...
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作者: Calvert-Joshua, Tracey University of the Western Cape
学位级别:master
Kidney cancers, of which clear cell renal cell carcinoma comprises an estimated 70%, have been placed amongst the top ten most common cancers in both males and females. With a mortality rate that exceeds 40%, kidney c... 详细信息
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