咨询与建议

限定检索结果

文献类型

  • 113 篇 期刊文献
  • 4 篇 学位论文
  • 2 篇 会议

馆藏范围

  • 119 篇 电子文献
  • 0 种 纸本馆藏

日期分布

学科分类号

  • 97 篇 理学
    • 88 篇 生物学
    • 10 篇 统计学(可授理学、...
    • 4 篇 化学
    • 2 篇 生态学
    • 1 篇 数学
    • 1 篇 物理学
  • 48 篇 农学
    • 19 篇 作物学
  • 36 篇 工学
    • 23 篇 生物工程
    • 11 篇 计算机科学与技术...
    • 2 篇 化学工程与技术
    • 2 篇 食品科学与工程(可...
  • 28 篇 医学
    • 17 篇 基础医学(可授医学...
    • 14 篇 临床医学
    • 4 篇 药学(可授医学、理...
    • 2 篇 公共卫生与预防医...
    • 1 篇 中西医结合
  • 3 篇 管理学
    • 3 篇 管理科学与工程(可...
  • 1 篇 法学
    • 1 篇 社会学
  • 1 篇 教育学
    • 1 篇 教育学

主题

  • 119 篇 non-coding dna
  • 11 篇 gene expression
  • 9 篇 transcription fa...
  • 8 篇 genomes
  • 8 篇 genomics
  • 7 篇 human genome
  • 6 篇 non-coding rna
  • 5 篇 evolution
  • 5 篇 research
  • 5 篇 microrna
  • 5 篇 genetic regulati...
  • 5 篇 crisprs (genetic...
  • 5 篇 chromatin
  • 4 篇 dna repeats
  • 4 篇 molecular evolut...
  • 4 篇 comparative geno...
  • 4 篇 gene regulation
  • 4 篇 mutation (biolog...
  • 3 篇 single nucleotid...
  • 3 篇 cancer

机构

  • 3 篇 univ politecn ca...
  • 2 篇 harvard med sch ...
  • 2 篇 queen mary unive...
  • 2 篇 univ florida dep...
  • 2 篇 longyan univ col...
  • 2 篇 univ penn childr...
  • 1 篇 univ strasbourg ...
  • 1 篇 univ bonn nees i...
  • 1 篇 univ arizona ua ...
  • 1 篇 wayne state univ...
  • 1 篇 genome biology d...
  • 1 篇 indian inst sci ...
  • 1 篇 univ toronto mcl...
  • 1 篇 field museum nat...
  • 1 篇 swiss inst bioin...
  • 1 篇 howard florey in...
  • 1 篇 univ belgrade fa...
  • 1 篇 sci life lab upp...
  • 1 篇 univ haifa 199 a...
  • 1 篇 univ cambridge c...

作者

  • 5 篇 qiu guo-hua
  • 3 篇 zheng xintian
  • 3 篇 huang cuiqin
  • 3 篇 subirana juan a.
  • 3 篇 fu mingjun
  • 2 篇 coetzee gerhard ...
  • 2 篇 kimball rebecca ...
  • 2 篇 han kin-lan
  • 2 篇 braun michael j.
  • 2 篇 raoult didier
  • 2 篇 hazelett dennis ...
  • 2 篇 braun edward l.
  • 2 篇 yang xiaoyan
  • 2 篇 sinsheimer janet...
  • 2 篇 messeguer xavier
  • 2 篇 alfaro michael e...
  • 2 篇 gilbert princess...
  • 1 篇 rodio donatella ...
  • 1 篇 ko yunhee
  • 1 篇 shin susie

语言

  • 115 篇 英文
  • 4 篇 其他
检索条件"主题词=non-coding DNA"
119 条 记 录,以下是61-70 订阅
排序:
A meta-analysis of the genomic and transcriptomic composition of complex life
收藏 引用
CELL CYCLE 2013年 第13期12卷 2061-2072页
作者: Liu, Ganqiang Mattick, John S. Taft, Ryan J. Univ Queensland Inst Mol Biosci Brisbane Qld Australia St Vincents Hosp Garvan Inst Med Res Darlinghurst NSW 2010 Australia
It is now clear that animal genomes are predominantly non-protein-coding, and that these sequences encode a wide array of RNA transcripts and other regulatory elements that are fundamental to the development of comple... 详细信息
来源: 评论
Patterns of variation in cis-regulatory regions: examining evidence of purifying selection
收藏 引用
BMC GENOMICS 2018年 第1期19卷 1-14页
作者: Naidoo, Thijessen Sjodin, Per Schlebusch, Carina Jakobsson, Mattias Uppsala Univ Dept Organismal Biol Uppsala Sweden Sci Life Lab Uppsala Sweden
Background: With only 2 % of the human genome consisting of protein coding genes, functionality across the rest of the genome has been the subject of much debate. This has gained further impetus in recent years due to... 详细信息
来源: 评论
Evolutionary Constraint in Flanking Regions of Avian Genes
收藏 引用
MOLECULAR BIOLOGY AND EVOLUTION 2011年 第9期28卷 2481-2489页
作者: Kunstner, Axel Nabholz, Benoit Ellegren, Hans Uppsala Univ Dept Evolutionary Biol Evolutionary Biol Ctr Uppsala Sweden
An important comprehension from comparative genomic analysis is that sequence conservation beyond neutral expectations is frequently found outside protein-coding regions, indicating important functional roles of nonco... 详细信息
来源: 评论
Systematic mapping of functional enhancer-promoter connections with CRISPR interference
收藏 引用
SCIENCE 2016年 第6313期354卷 769-773页
作者: Fulco, Charles P. Munschauer, Mathias Anyoha, Rockwell Munson, Glen Grossman, Sharon R. Perez, Elizabeth M. Kane, Michael Cleary, Brian Lander, Eric S. Engreitz, Jesse M. Broad Inst MIT & Harvard Cambridge MA 02142 USA Harvard Med Sch Dept Syst Biol Boston MA 02115 USA MIT Div Hlth Sci & Technol Cambridge MA 02139 USA MIT Dept Biol 77 Massachusetts Ave Cambridge MA 02139 USA MIT Computat & Syst Biol Program 77 Massachusetts Ave Cambridge MA 02139 USA
Gene expression in mammals is regulated by noncoding elements that can affect physiology and disease, yet the functions and target genes of most noncoding elements remain unknown. We present a high-throughput approach... 详细信息
来源: 评论
Beyond the exome: the role of non-coding somatic mutations in cancer
收藏 引用
ANNALS OF ONCOLOGY 2016年 第2期27卷 240-248页
作者: Piraino, S. W. Furney, S. J. Univ Coll Dublin Sch Med Conway Inst Biomol & Biomed Res Dublin 4 Ireland
The comprehensive identification of mutations contributing to the development of cancer is a priority of large cancer sequencing projects. To date, most studies have scrutinized mutations in coding regions of the geno... 详细信息
来源: 评论
Evidence for a slightly deleterious effect of intron polymorphisms at the EF1α gene in the deep-sea hydrothermal vent bivalve Bathymodiolus
收藏 引用
GENE 2007年 第1-2期406卷 99-107页
作者: Faure, B. Bierne, N. Tanguy, A. Bonhomme, F. Jollivet, D. UPMC CNRS Biol Stn UMR 7144 F-29682 Roscoff France Univ Montpellier 2 CNRS UM2 Inst Sci EvolutUMR5554 Dept Integrat Biol F-34095 Montpellier France
A multilocus analysis was initiated in order to infer the general effect of demography and the indirect effect of positive selection on some chromosome segments in Bathymodiolus. Mussels of the genus Bathymodiolus inh... 详细信息
来源: 评论
motifbreakR: an R/Bioconductor package for predicting variant effects at transcription factor binding sites
收藏 引用
BIOINFORMATICS 2015年 第23期31卷 3847-3849页
作者: Coetzee, Simon G. Coetzee, Gerhard A. Hazelett, Dennis J. Cedars Sinai Med Ctr Bioinformat & Computat Biol Res Ctr Los Angeles CA 90048 USA USC Norris Comprehens Canc Ctr Dept Urol & Prevent Med Los Angeles CA USA
The Summary: Functional annotation represents a key step toward the understanding and interpretation of germline and somatic variation as revealed by genome-wide association studies (GWAS) and The Cancer Genome Atlas ... 详细信息
来源: 评论
Similarity in oligonucleotide usage in introns and intergenic regions contributes to long-range correlation in the Caenorhabditis elegans genome
收藏 引用
GENE 1999年 第1期232卷 87-95页
作者: Frontali, C Pizzi, E Ist Super Sanita Cell Biol Lab I-00161 Rome Italy
A method is presented which allows detection of a sequence correlation effect not related to patchiness in base composition or to preferences in codon usage. Recurrence plots providing local views of oligonucleotide r... 详细信息
来源: 评论
Evolutionary coupling between the deleteriousness of gene mutations and the amount of non-coding sequences
收藏 引用
JOURNAL OF THEORETICAL BIOLOGY 2007年 第4期244卷 621-630页
作者: Knibbe, Carole Mazet, Olivier Chaudier, Fabien Fayard, Jean-Michel Beslon, Guillaume Inst Natl Sci Appl Dept Comp Sci F-69621 Villeurbanne France Inst Natl Sci Appl INRA UMR 203 Lab Biol Fonct Insectes & Interact F-69621 Villeurbanne France Inst Natl Sci Appl Camille Jordan Inst Math F-69621 Villeurbanne France Inst Natl Sci Appl Dept Biosci F-69621 Villeurbanne France
The phenotypic effects of random mutations depend on both the architecture of the genome and the gene-trait relationships. Both levels thus play a key role in the mutational variability of the phenotype, and hence in ... 详细信息
来源: 评论
LncRNA/dna binding analysis reveals losses and gains and lineage specificity of genomic imprinting in mammals
收藏 引用
BIOINFORMATICS 2017年 第10期33卷 1431-1436页
作者: Liu, Haihua Shang, Xiaoxiao Zhu, Hao Southern Med Univ Sch Basic Med Sci Bioinformat Sect Guangzhou 510515 Guangdong Peoples R China
Motivation: Genomic imprinting is regulated by lncRNAs and is important for embryogenesis, physiology and behaviour in mammals. Aberrant imprinting causes diseases and disorders. Experimental studies have examined gen... 详细信息
来源: 评论