Neurodegenerative diseases,including Parkinson＇s disease,Alzheimer＇s disease and Amyotrophic Lateral Sclerosis,are characterized by idiopathic neuron loss in different regions of the central nervous system,which con...
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Neurodegenerative diseases,including Parkinson＇s disease,Alzheimer＇s disease and Amyotrophic Lateral Sclerosis,are characterized by idiopathic neuron loss in different regions of the central nervous system,which contributes to the relevant dysfunctions in the *** application of cell replacement therapy using human embryonic stem（hES） cells,though having attracted much attention,has been hampered by the intrinsic ethical *** has been demonstrated that adult somatic cells can be reprogrammed into the embryonic state,called induced pluripotent stem（iPS） *** is soon realized that iPS cells may be an alternative source for cell replacement therapy,because it raises no ethical problems and using patient-specific iPS cells for autologous transplantation will not lead to immunological ***＇s more,certain types of neurons derived from patient-specific iPS cells may display disease-relevant ***,patientspecific iPS cells can provide a unique opportunity to directly investigate the pathological properties of relevant neural cells in individual patient,and to study the vulnerability of neural cells to pathogenic factors in vitro,which may help reveal the pathogenesis of many neurodegenerative *** this review,the recent development in cellular treatment of neurodegenerative diseases using iPS cells was summarized,and the potential value of iPS cells in the modeling of neurodegenerative disease was discussed.
Objective N-methyl-D-aspartate（NMDA）receptor has been indicated to be involved in the pathogenesis of Alzheimer’s disease（AD）.The NMDA receptor subunit 2b（NR2B）has attracted more attention due to its characteri...
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Objective N-methyl-D-aspartate（NMDA）receptor has been indicated to be involved in the pathogenesis of Alzheimer’s disease（AD）.The NMDA receptor subunit 2b（NR2B）has attracted more attention due to its characteristic distribution and selective reduction in AD *** present study aimed to explore the association between NMDA gene polymorphism and *** A total of 63 AD patients and 68 normal controls in Shanghai city were employed in this *** of C2664T variant（rs1806201）in the exon13 of GRIN2B gene was determined by gene sequencing. Results Among AD patients,15（23.6%）subjects were identified as C/C genotype,and 35（55.6%）were identified as C/T *** left 13（20.6%）subjects were identified as T/T *** normal controls,15（22.1%）subjects were identified as C/C genotype,39（57.4%）as C/T genotype and 14（20.6%）as T/T *** distribution frequency of neither GRIN2B C2664T genotype（P=0.895）nor allele（P=0.790）was significantly different between AD patients and normal controls,even when the subjects were stratified by gender and age of disease onset in AD *** The results suggest that there is no relation between GRIN2B C2664T polymorphism and AD in Chinese Han population of Shanghai City.
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