The Cajanus cajan *** a natural plant,which contains lots of potential active *** effects of the stilbene extracts from Cajanus cajan L.（sECC） on ovariectomy（OVX）-induced bone loss in rats were *** experimental fe...
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The Cajanus cajan *** a natural plant,which contains lots of potential active *** effects of the stilbene extracts from Cajanus cajan L.（sECC） on ovariectomy（OVX）-induced bone loss in rats were *** experimental female rats were divided into 6 groups,i.e.,sham-operated rats,OVX rats,17β-estradiol（E2）-treated rats,sECC-treated rats with three dosages,50,100,and 200(mg·kg-1),*** weeks after the operation,different dosage of sECC,E2 or deionized water were given to the 6 groups of rats,respectively for another 8 weeks through ***,all rats were *** body weight and uterus wet weight were *** of serum E2,follicle stimulating hormone（FSH）,and luteinizing hormone（LH） were measured by *** morphology was observed by HE *** results showed that there were no changes of the uterine weight and serum E2 concentration in sECC-treated rats compared with OVX ***,the serum FSH and LH concentrations reduced by 11.5% and 15.2%（P<0.05）,*** HE staining,it is found that the 60% of the femur structure had been significantly improved in OVX rats treated with 200 mg·kg-1 of *** trabeculae were thicker and larger than that of OVX *** is clear that sECC improved femoral morphological structure and decreased FSH and LH contents without affecting serum E2 level and uterine weight in OVX *** results suggested that sECC had potential action in treatment of postmenopausal osteoporosis.
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