目的中国是多种常见肝病的高发国家,肝脏疾病的研究对提高防治水平,保障人民健康有着重要的意义。为了全面收集、整理、共享和分析分散于现有数据库和文献资料中的肝脏生理病理学知识,该研究构建了人类肝脏疾病本体HuL DO并展开多方面应用。方法 HuL DO是参考疾病相关的多个权威术语集和肝脏病学专著而构建的,依据该本体中的疾病名称列表,从现有数据库中收集各种肝病的相关数据,以本体结构为数据组织框架构建肝病知识库,以本体为字典挖掘肝病与基因的关系。结果 HuL DO是目前最全面的肝病概念分类系统,以该本体为基础建立了一整套肝病知识的收集、挖掘和展示的工具和策略。结论 HuL DO是全面收集、高效分享和灵活分析各类肝病数据和知识的重要工具。肝病本体的下载地址是ftp://***/***%20Disease%20Ontology/。
Background: During evolution,genomes gradually acquire novel genetic elements,including novel genes that are species/***'s known that some novel genes substantially contribute to the increasing functional and phen...
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Background: During evolution,genomes gradually acquire novel genetic elements,including novel genes that are species/***'s known that some novel genes substantially contribute to the increasing functional and phenotypic ***,there's no genome-wide investigation of their features and regular patterns contributing to organismal ***,we give a comprehensive analysis about the structural and functional features of novel genes and explore their roles in the formation of organismal complexity.
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