采用硅胶、ODS、Toyopearl HW-40(s)、制备型HPLC等多种色谱技术和波谱学方法,结合物理化学性质,从五倍子的95%乙醇提取物中分离并鉴定了7个化合物,分别为benzoic acid,3,4-dihydroxy-5-[(3,4,5-trihydroxybenzoyl)oxy]-,5-ethoxycarbonyl-2,3-dihydroxyphenyl ester(1)、trigallic acid(2)、1,2,3,4,6-penta-O-galloyl-β-D-glucose(3)、莽草酸(4)、没食子酸(5)、没食子酸甲酯(6)、没食子酸乙酯(7)。其中,化合物1为新化合物,化合物2为首次从该属植物中分离得到。对五倍子中分离得到的单体化合物进行了体外抗HSV-1、RSV A strain、RSV Long strain病毒活性测试,化合物3表现出显著的抗病毒活性,其IC50分别为13.3,3.3和3.3 mmol/L。
The Securinega alkaloids are a group of compounds isolated from the plants of Securinega,Phyllanthus and Flueggea genera belonging to the Euphorbiaceae *** of these compounds exhibit a wide range of biological activit...
详细信息
The Securinega alkaloids are a group of compounds isolated from the plants of Securinega,Phyllanthus and Flueggea genera belonging to the Euphorbiaceae *** of these compounds exhibit a wide range of biological activities,such as GAB A receptor antagonist,antimalarial and antibacterial *** to the special structural features of Securinega alkaloids, the synthesis strategies for their different structural skeletons are challenging for organic and medicinal *** the review, we will provide an overview of the total synthesis of several Securinega alkaloids and their biological activities.
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