目的:研究极早产儿和极低出生体重儿动脉导管未闭的危险因素。方法:回顾性收集青岛大学附属烟台毓璜顶医院2019年1月~2022年12月收治的胎龄 Objective: To study the risk factors of patent ductus arteriosus in very preterm and ver...
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目的:研究极早产儿和极低出生体重儿动脉导管未闭的危险因素。方法:回顾性收集青岛大学附属烟台毓璜顶医院2019年1月~2022年12月收治的胎龄 Objective: To study the risk factors of patent ductus arteriosus in very preterm and very low birth weight infants. Methods: A retrospective collection of clinical data was conducted on very preterm infants with gestational age < 32 weeks or very low birth weight infants weighing < 1500 g who were admitted to Yantai Yuhuangding Hospital affiliated with Qingdao University from January 2019 to December 2022. The subjects were divided into two groups based on the ultrasound in the first 5 - 7 days after birth echocardiographic findings: the PDA group (263 cases) and the non-PDA (nPDA) group (262 cases). Univariate and binary logistic regression analyses were used to explore the risk factors of patent ductus arteriosus in very preterm and very low birth weight infants. Results: The results of univariate analyses showed that the occurrence of PDA was associated with premature rupture of membranes, cesarean section, gestational age, birth weight, maternal comorbidities with diabetes mellitus, prenatal use of glucocorticoids and antibiotics, asphyxia, respiratory distress syndrome, respiratory support, endotracheal intubation, caffeine and lung surfactant application, leukocyte counts, 1-minute Apgar score and 5-minute Apgar score (P < 0.05). Binary logistic regression analysis showed that premature rupture of membranes, antepartum use of dexamethasone, and elevated white blood cell counts are independent protective factors for PDA, and tracheal intubation at birth was an independent risk factor (P < 0.05). Conclusion: Identifying the risk factors for arterial ductus arteriosus in very preterm and very low birth weight infants as early as possible can help achieve individualized management of this condition.
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