Breast cancer is a common malignant *** is essential to develop suitable animal models for discovering novel preventive and therapeutic *** shrews（Tupaia belangeri chinensis） have a closer evolutionary relationship ...
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Breast cancer is a common malignant *** is essential to develop suitable animal models for discovering novel preventive and therapeutic *** shrews（Tupaia belangeri chinensis） have a closer evolutionary relationship with humans than do rodents,which have been widely used in laboratory *** breast tumors were identified in tree shrews in 1960s;however,no detailed studies about tree shrew breast tumors have been conducted to ***,we characterized a spontaneous breast tumor from tree shrews by Haematoxylin Eosin（HE） *** tumor was identified as a papillary *** staining（IHC） for progesterone receptor（PR）,Ki-67 and cleaved caspase-3 showed that tumor cells were positive for PR,highly proliferative,and less apoptotic compared to normal breast epithelial ***,the spontaneous tumor of tree shrew is very close to human papillary tumors in terms of morphology and pathology and we concluded that tree shrew may be a suitable animal model for breast cancer research.
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