目的系统评价不同驱动基因突变状态下非小细胞肺癌(NSCLC)相关静脉血栓栓塞症(VTE)发生率,并进一步探讨基因突变状态与VTE发病风险的关系。方法计算机检索PubMed、EMbase、Web of Science、Cochrane Library、中国知网、万方和维普数据...
详细信息
目的系统评价不同驱动基因突变状态下非小细胞肺癌(NSCLC)相关静脉血栓栓塞症(VTE)发生率,并进一步探讨基因突变状态与VTE发病风险的关系。方法计算机检索PubMed、EMbase、Web of Science、Cochrane Library、中国知网、万方和维普数据库,搜索NSCLC相关驱动基因突变状态与VTE发生率关系的相关研究,检索时限为建库至2023年7月3日,采用Stata 14.0软件进行分析。结果共纳入文献32篇,总样本量为18032例。Meta分析结果显示,在携带驱动基因突变的肺癌患者中VTE总发生率为19%[95%CI(15%~23%)];ROS1基因融合状态下VTE并发症发生率最高,为31%[95%CI(22%~39%)];ALK/ROS1基因融合/重排以及PD-L1表达阳性的存在与VTE发生风险增加有关[ALK:OR=2.28,95%CI(1.89~2.76);ROS1:OR=3.18,95%CI(1.89~5.35);PD-L1:OR=1.85,95%CI(1.25~2.72)],而EGFR/KRAS基因突变与VTE发生风险无相关性[EGFR:OR=1.16,95%CI(0.75~1.80);KRAS:OR=1.54,95%CI(0.98~2.43)]。结论不同驱动基因突变状态下NSCLC相关VTE并发症的发生率存在明显差异,ALK/ROS1基因融合/重排以及PD-L1表达阳性的存在与VTE发生风险增加有关,而EGFR/KRAS基因突变与VTE发生风险无明显相关性。
目的:研究极早产儿和极低出生体重儿动脉导管未闭的危险因素。方法:回顾性收集青岛大学附属烟台毓璜顶医院2019年1月~2022年12月收治的胎龄 Objective: To study the risk factors of patent ductus arteriosus in very preterm and ver...
详细信息
目的:研究极早产儿和极低出生体重儿动脉导管未闭的危险因素。方法:回顾性收集青岛大学附属烟台毓璜顶医院2019年1月~2022年12月收治的胎龄 Objective: To study the risk factors of patent ductus arteriosus in very preterm and very low birth weight infants. Methods: A retrospective collection of clinical data was conducted on very preterm infants with gestational age < 32 weeks or very low birth weight infants weighing < 1500 g who were admitted to Yantai Yuhuangding Hospital affiliated with Qingdao University from January 2019 to December 2022. The subjects were divided into two groups based on the ultrasound in the first 5 - 7 days after birth echocardiographic findings: the PDA group (263 cases) and the non-PDA (nPDA) group (262 cases). Univariate and binary logistic regression analyses were used to explore the risk factors of patent ductus arteriosus in very preterm and very low birth weight infants. Results: The results of univariate analyses showed that the occurrence of PDA was associated with premature rupture of membranes, cesarean section, gestational age, birth weight, maternal comorbidities with diabetes mellitus, prenatal use of glucocorticoids and antibiotics, asphyxia, respiratory distress syndrome, respiratory support, endotracheal intubation, caffeine and lung surfactant application, leukocyte counts, 1-minute Apgar score and 5-minute Apgar score (P < 0.05). Binary logistic regression analysis showed that premature rupture of membranes, antepartum use of dexamethasone, and elevated white blood cell counts are independent protective factors for PDA, and tracheal intubation at birth was an independent risk factor (P < 0.05). Conclusion: Identifying the risk factors for arterial ductus arteriosus in very preterm and very low birth weight infants as early as possible can help achieve individualized management of this condition.
暂无评论