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Systemic delivery of microRNA for treatment of brain ischemia

Nano Research 2021年第9期14卷 3319-3328页

作者： Chaoyong Liu Jing Wen Dai Li Hongzhao Qi Lina Nih Jialin Zhu Duo Xu Yu Ren Shanshan Zhang Donglin Han Huanhuan Jia Junhu Zhou Meng Qin Jialing Wu Xubo Yuan Ji Liu Jin Zhao Chunsheng Kang Yunfeng Lu Department of Neurosurgery Tianjin Medical University General HospitalTianjin 300052China Key Laboratory of Post-Trauma Neuro-repair and Regeneration in Central Nervous System Ministry of EducationTianjin Key Laboratory of InjuriesVariations and Regeneration of Nervous SystemTianjin Neurological InstituteTianjin 300052China College of Life Science and Technology and Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical TechnologyBeijing 100029China Department of Chemical and Biomolecular Engineering University of CaliforniaLos AngelesLos AngelesCA 90095USA Department of Medicine Tianjin Huanhu HospitalTianjin 300350China Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and EngineeringTianjin UniversityTianjin 300350China Department of Microbiology Immunology and Molecular GeneticsUniversity of CaliforniaLos AngelesLos AngelesCA 90095USA Tianjin Research Center of Basic Medical Science Tianjin Medical UniversityTianjin 300070China Department of Neurology Tianjin Huanhu HospitalTianjin 300350China

Brain ischemia is the second leading cause of death and the third leading cause of disability in the *** delivery of microRNA,a class of molecules that regulate the expression of cellular proteins associated with angiogenesis,cell growth,proliferation and differentiation,holds great promise for the treatment of brain ***,their therapeutic efficacy has been hampered by poor delivery efficiency of *** report herein a platform technology based on microRNA nanocapsules,which enables their effective delivery to the disease sites in the *** by microRNA-21,intravenous injection of the nanocapsules into a rat model of cerebral ischemia could effectively ameliorate the infarct volume,neurological deficit and histopathological severity.

关键词： polymer nanocapsules small RNA delivery microRNA-21 brain ischemia

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A deep learning system for predicting time to progression of diabetic retinopathy

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NATURE MEDICINE 2024年第2期30卷 358-359页

作者： [Anonymous] Shanghai Belt and Road International Joint Laboratory for Intelligent Prevention and Treatment of Metabolic Disorders Department of Computer Science and Engineering School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Department of Endocrinology and Metabolism Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Diabetes Institute Shanghai Clinical Center for Diabetes Shanghai China MOE Key Laboratory of AI School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Shanghai China Department of Ophthalmology Huadong Sanatorium Wuxi China Department of Ophthalmology Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong Hong Kong China Singapore Eye Research Institute Singapore National Eye Centre Singapore Singapore Department of Computer Science and Engineering The Hong Kong University of Science and Technology Hong Kong China Department of Chemical and Biological Engineering The Hong Kong University of Science and Technology Hong Kong China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science Guangzhou China Department of Ophthalmology Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing China Medical Records and Statistics Office Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China Department of Geriatrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China National Engineering Research Center for Big Data Technology and System Services Computing Technology and System Lab Cluster and Grid Computing Lab School of Computer Science and Tech

We developed and validated a deep learning system (termed DeepDR Plus) in a diverse, multiethnic, multi-country dataset to predict personalized risk and time to progression of diabetic retinopathy. We show that DeepDR Plus can be integrated into the clinical workflow to promote individualized intervention strategies for the management of diabetic retinopathy.

关键词： Diabetes complications Machine learning Predictive markers

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Investigation of different membrane porosities on the permeate flux of direct contact membrane distillation 6th

Investigation of different membrane porosities on the permea...

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6th International Conference on Composite materials and Material engineering, ICCMME 2021

作者： Elrasheedy, Asmaa Rabie, Mohammed Elshazly, Ahmed Bassyouni, Mohamed El-Moneim, Ahmed Abd Kady, Marwa El Alexandria21934 Egypt Department of Chemical Engineering Faculty of Engineering Port Said University Port Said42526 Egypt Mechanical Power Engineering Department Mansoura University El-Mansoura35516 Egypt Chemical Engineering Department Faculty of Engineering Alexandria University Alexandria21544 Egypt Materials Science Program Zewail University of Science and Technology City of Science and Technology October Gardens 6th of October Giza12578 Egypt Materials Science and Engineering Department Egypt-Japan University of Science and Technology NewBorg El-Arab Alexandria21934 Egypt Institute of Basic and Applied Sciences Egypt-Japan University of Science and Technology New Borg El-Arab Alexandria21934 Egypt Borg El-Arab City Alexandria21934 Egypt

ISBN: (纸本)9783035718195

In the present study the surface morphology of electrospun fibers at different polystyrene (PS) solution concentration was studied by SEM imaging to determine the best PS solution concentration yielding continuous uniform beadles fibers. Contact angle measurements of the optimum fabricated PS-18 membrane confirmed the super hydrophobic property of the membrane that exhibited a static water contact angle of 145o . Numerical investigation of the performance of PS-18 membrane at different membrane thicknesses and porosities on direct contact membrane distillation showed that increasing the membrane porosity increases the permeate flux considerably. © 2021 Trans Tech Publications Ltd, Switzerland.

关键词： Polystyrenes

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The Main Progress of Perovskite Solar Cells in 2020-2021

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Nano-Micro Letters 2021年第10期13卷 113-130页

作者： Tianhao Wu Zhenzhen Qin Yanbo Wang Yongzhen Wu Wei Chen Shufang Zhang Molang Cai Songyuan Dai Jing Zhang Jian Liu Zhongmin Zhou Xiao Liu Hiroshi Segawa Hairen Tan Qunwei Tang Junfeng Fang Yaowen Li Liming Ding Zhijun Ning Yabing Qi Yiqiang Zhang Liyuan Han State Key Laboratory of Metal Matrix Composites School of Material Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Centre Shanghai Key Laboratory of Functional Materials ChemistryJoint International Research Laboratory of Precision Chemistry and Molecular EngineeringSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyMeilong Road 130Shanghai 200237People’s Republic of China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyLuoyu Road 1037Wuhan 430074People’s Republic of China College of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094People’s Republic of China Beijing Key Laboratory of Novel Thin-Film Solar Cells and State Key Laboratory of Alternate Electrical Power System With Renewable Energy Sources North China Electric Power UniversityBeijing 102206People’s Republic of China Department of Microelectronic Science and Engineering Ningbo UniversityZhejiang 315211People’s Republic of China College of Chemical Engineering Jiangsu Key Lab of Biomass-Based Green Fuels and ChemicalsNanjing Forestry UniversityNanjing 210037People’s Republic of China College of Chemistry and Molecular Engineering Qingdao University of Science and TechnologyQingdao 266042People’s Republic of China Special Division of Environmental and Energy Science Komaba Organization for Educational Excellence(KOMEX)College of Arts and SciencesUniversity of TokyoTokyo 153-8902Japan National Laboratory of Solid State Microstructures Jiangsu Key Laboratory of Artificial Functional MaterialsCollege of Engineering and Applied SciencesNanjing UniversityNanjing 210093People’s Republic of China College of Information Science and Technology Jinan UniversityGuangzhou 510632People’s Republic of China School of Physics and Electronic Science Engineering Research Center of Nan

Perovskite solar cells(PSCs)emerging as a promising photovoltaic technology with high efficiency and low manufacturing cost have attracted the attention from all over the *** the efficiency and stability of PSCs have increased steadily in recent years,and the research on reducing lead leakage and developing eco-friendly lead-free perovskites pushes forward the commercialization of PSCs step by *** review summarizes the main progress of PSCs in 2020 and 2021 from the aspects of efficiency,stability,perovskite-based tandem devices,and lead-free ***,a brief discussion on the development of PSC modules and its challenges toward practical application is provided.

关键词： Perovskite solar cells Stability Solar module Perovskite-based tandem devices Lead-free perovskite

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Size engineering of 2D MOF nanosheets for enhanced photodynamic antimicrobial therapy

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Chinese chemical Letters 2023年第9期34卷 219-224页

作者： Baoli Xue Xiwen Geng Haohao Cui Huiying Chen Zhikang Wu Hong Chen Hai Li Zhan Zhou Meiting Zhao Chaoliang Tan Jingguo Li Henan Provincial People’s Hospital People’s Hospital of Zhengzhou UniversityZhengzhou 450003China College of Chemistry and Chemical Engineering Henan Key Laboratory of Function-Oriented Porous MaterialsLuoyang Normal UniversityLuoyang 471934China Luoyang Key Laboratory of Organic Functional Molecules College of Food and DrugLuoyang Normal UniversityLuoyang 471934China Institute of Advanced Materials(IAM)and Key Laboratory of Flexible Electronics(KLoFE) Nanjing Tech University(NanjingTech)Nanjing 211816China Department of Chemistry Institute of Molecular Aggregation ScienceTianjin Key Laboratory of Molecular Optoelectronic SciencesTianjin UniversityTianjin 300072China Department of Chemistry and Center of Super-Diamond and Advanced Films(COSDAF) City University of Hong KongHong Kong 999077China Shenzhen Research Institute City University of Hong KongShenzhen 518057China Pharmaceutical Sciences Laboratory Abo Akademi UniversityTurku 20520Finland

Although porphyrin-based metal-organic frameworks(MOFs)have been widely explored as photosensitizers for photodynamic therapy,how the size will affect the light-induced catalytic activity for generation of reactive oxygen species(ROS)still remain ***,we first report the size-controlled synthesis of two-dimensional(2D)porphyrin-based PCN-134 MOF nanosheets by a two-step solvothermal method to explore the size effect on its PDT performance,thus yielding enhanced photodynamic antimicrobial *** simply controlling the reaction temperature in the synthesis process,the bulk PCN-134 crystal,large PCN-134(L-PCN-134)nanosheets with a lateral size of 2–3μm and thickness of 33.2–37.5 nm and small PCN-134 nanosheets(S-PCN-134)with a lateral size of 160–180 nm and thickness of 9.1–9.7 nm were successfully ***,the S-PCN-134 nanosheets exhibit much higher photodynamic activity for ROS generation than that of the bulk 3D PCN-134 crystal and L-PCN-134 nanosheets under a660 nm laser irradiation,suggesting that the photodynamic activity of PCN-134 MOF increases when the size ***,the S-PCN-134 nanosheets show much enhanced performance when used as a photosensitizer for photodynamic antimicrobial activity and wound healing.

关键词： 2D nanosheets PCN-134 MOFs Size effect Photodynamic therapy Antibacterial

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Understanding the Electronic Structure and Stability of B_(n)X_(n)^(0/2-)(n=4,6;X=H,F,Cl,Br,I,At,Ts)Clusters

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Chinese Journal of Chemistry 2021年第7期39卷 1811-1818页

作者： Ruo-Ya Wang Jing-Xuan Zhang Xue-Lian Jiang Nana Ma Xuenian Chen Cong-Qiao Xu Jun Li Henan Key Laboratory of Boron Chemistry and Advanced Energy Materials School of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiangHenan453007 China Department of Chemistry Southern University of Science and TechnologyShenzhenGuangdong518055 China Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhouHenan450001 China Department of Chemistry and Key Laboratory of Organic Optoelectronics&Molecular Engineering of Ministry of Education Tsinghua UniversityBeijing100084 China

Main observation and conclusion Borane clusters and their derivatives have attracted extensive attention in inorganic chemistry due to their fascinating multi-center bonding patterns and physicochemical *** we report ... 详细信息

关键词： Boron Multi-center bonding Electronic structure chemical bonding Aromaticity

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molecular engineering of Dispersed Tin Phthalocyanine on Carbon Nanotubes for Selective Co2 Reduction to Formate

SSRN

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SSRN 2023年

作者： Chen, Baotong Zou, Haiyuan Gong, Lei Zhang, Hao Li, Ning Pan, Houhe Wang, Kang Yang, Tao Liu, Yunpeng Duan, Lele Liu, Jiemin Jiang, Jianzhuang Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory for Science Application of Functional Molecular and Crystalline Materials Department of Chemistry and Chemical Engineering School of Chemistry and Biological Engineering University of Science and Technology Beijing Beijing100083 China Institute of High Energy Physics Chinese Academy of Sciences Beijing100049 China China Innovation Research Institute for Carbon Neutrality University of Science and Technology Beijing Beijing100083 China

The synthesis of formic acid/formate from CO2 electrolysis is appealing for the sustainable production of fuels, which however requires highly active and selective electrocatalysts. Herein, supporting a series of phthalocyanine tin (IV) complexes on multi-walled carbon nanotubes (CNTs) generated three composite catalysts, namely SnPc@CNTs, SnPc-8F@CNTs, and SnPc-8OCH3@CNTs. Electrochemical tests indicate the high activity of these three catalysts in particular SnPc-8F@CNTs towards CO2-to-formate conversion with a maximal Faraday efficiency (FE) of 91.3% at -1.2 V versus RHE and excellent stability in flow cell, comparable to thus far state-of-the-art catalysts towards CO2-to-formate conversion. Remarkably, when used as the cathode catalyst in membrane electrode assembly, SnPc-8F@CNTs stably delivers a current density of 100 mA cm-2 with a FEformate of 85% at -2.6 V for 200 h. A series of in situ spectroscopy tests and theoretical calculations demonstrate the significant effect of the electron-withdrawing F atoms on improving the catalytic activity of SnPc-8F@CNTs. © 2023, The Authors. All rights reserved.

关键词： Carbon dioxide

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Valley-polarized Exitonic Mott Insulator in WS2/WSe2 Moiré Superlattice

arXiv

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arXiv 2023年

作者： Lian, Zhen Meng, Yuze Ma, Lei Maity, Indrajit Yan, Li Wu, Qiran Huang, Xiong Chen, Dongxue Chen, Xiaotong Chen, Xinyue Blei, Mark Taniguchi, Takashi Watanabe, Kenji Tongay, Sefaattin Lischner, Johannes Cui, Yong-Tao Shi, Su-Fei Department of Chemical and Biological Engineering Rensselaer Polytechnic Institute TroyNY12180 United States Departments of Materials The Thomas Young Centre for Theory and Simulation of Materials Imperial College London United Kingdom Department of Physics and Astronomy University of California RiversideCA92521 United States Department of Materials Science and Engineering University of California RiversideCA92521 United States Materials Science and Engineering Program School for Engineering of Matter Transport and Energy Arizona State University TempeAZ85287 United States International Center for Materials Nanoarchitectonics National Institute for Materials Science 1-1 Namiki Tsukuba305-0044 Japan Research Center for Functional Materials National Institute for Materials Science 1-1 Namiki Tsukuba305-0044 Japan Department of Electrical Computer & Systems Engineering Rensselaer Polytechnic Institute TroyNY12180 United States

Strongly enhanced electron-electron interaction in semiconducting moiré superlattices formed by transition metal dichalcogenides (TMDCs) heterobilayers has led to a plethora of intriguing fermionic correlated states1–7. Meanwhile, interlayer excitons in a type-II aligned TMDC heterobilayer moiré superlattice, with electrons and holes separated in different layers8,9, inherit this enhanced interaction and strongly interact with each other, promising for realizing tunable correlated bosonic quasiparticles10,11 with valley degree of freedom. We employ photoluminescence spectroscopy to investigate the strong repulsion between interlayer excitons and correlated electrons in a WS2/WSe2 moiré superlattice and combine with theoretical calculations to reveal the spatial extent of interlayer excitons and the band hierarchy of correlated states. We further find that an excitonic Mott insulator state emerges when one interlayer exciton occupies one moiré cell, evidenced by emerging photoluminescence peaks under increased optical excitation power. Double occupancy of excitons in one unit cell requires overcoming the energy cost of exciton-exciton repulsion of about 30-40 meV, depending on the stacking configuration of the WS2/WSe2 heterobilayer. Further, the valley polarization of the excitonic Mott insulator state is enhanced by nearly one order of magnitude. Our study demonstrates the WS2/WSe2 moiré superlattice as a promising platform for engineering and exploring new correlated states of fermion, bosons, and a mixture of both12 © 2023, CC BY.

关键词： Excitons

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Revisiting the Temperature Dependence of Protein Diffusion inside Bacteria: Validity of the Stokes-Einstein Equation

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Physical Review Letters 2022年第1期129卷 018101-018101页

作者： Asmaa A. Sadoon William F. Oliver Yong Wang Department of Physics University of Arkansas Fayetteville Arkansas 72701 USA Materials Science and Engineering Program University of Arkansas Fayetteville Arkansas 72701 USA Department of Physics University of Thi-Qar Nassiriya 64001 Iraq Cell and Molecular Biology Program University of Arkansas Fayetteville Arkansas 72701 USA

Although the transport and mixing of proteins and other molecules inside bacteria rely on the diffusion of molecules, many aspects of the molecular diffusion in bacterial cytoplasm remain unclear or controversial, including how the diffusion-temperature relation follows the Stokes-Einstein equation. In this study, we applied single-particle tracking photoactivated localization microscopy to investigate the diffusion of histonelike nucleoid structuring (HNS) proteins and free dyes in bacterial cytoplasm at different temperatures. Although the diffusion of HNS proteins in both live and dead bacteria increased at higher temperatures and appeared to follow the Arrhenius equation, the diffusion of free dyes decreased at higher temperatures, questioning the previously proposed theories based on superthermal fluctuations. To understand the measured diffusion-temperature relations, we developed an alternative model, in which the bacterial cytoplasm is considered as a polymeric network or mesh. In our model, the Stokes-Einstein equation remains valid, while the polymeric network contributes a significant term to the viscosity experienced by the molecules diffusing in bacterial cytoplasm. Our model was successful in predicting the diffusion-temperature relations for both HNS proteins and free dyes in bacteria. In addition, we systematically examined the predicted diffusion-temperature relations with different parameters in the model, and predicted the possible existence of phase transitions.

关键词： Anomalous diffusion Diffusion Intracellular transport Network diffusion Proteins

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Isolated Pt atoms tethered to N-doped MoSx as highly efficient and sustainable hydrogen evolution reaction electrocatalyst

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Applied Surface science 2023年 614卷

作者： Lee, Ting-Wei Lo, Ying-Chen Wu, Chia-Hua Ho, Cheng-Yuan Alamani, Bryan G. Chen, Jeng-Lung Chen, Chiaying Department of Environmental Engineering National Chung Hsing University Taichung City402 Taiwan Department of Materials Science and Engineering National Yang Ming Chiao Tung University Hsinchu300 Taiwan Department of Chemical Engineering College of Engineering University of the Philippines Diliman Quezon City1101 Philippines Environmental Engineering Program College of Engineering University of the Philippines Diliman Quezon City1101 Philippines National Synchrotron Radiation Research Center Hsinchu30076 Taiwan

In this work, synergistic NH4+ intercalation and nitrogen-containing molecule doping realize a crystalline-to-amorphous (i.e., MoSx) structure transition with enhanced HER reactivity and superior stability obtained via structural distortion and abundant active sites. The applied N dopants partially replace the bridging S22− and form Mo-N bonds, where the alkyl N-dopant tetramethylammonium chloride (TEA) achieves the most effective doping. The HER activity increases with an increasing number of bridging S22− and MoⅤ species, both of which contribute to advance electrocatalytic performance. Furthermore, N-doped MoSx is identified as an exceptional stabilizing platform to anchor single Pt atoms (PtSA) through Pt-S bonding, rendering MoSx/TEA/PtSA a highly promising electrocatalyst. MoSx/TEA/PtSA achieved comparable performance to that of the benchmark Pt/C catalyst (i.e., a cathodic current density of 10 mA·cm−2 at overpotential of 97 mV) with much lower loading of Pt (0.67 wt%). Theoretical calculations based on density functional theory indicate that Pt atoms and Pt-adjacent sulfur atoms act as active sites. The superior interfacial electron transfer and thus HER performance of MoSx/TEA/PtSA arises from (1) boosted electronic metal-support interaction through Pt-S bonds and (2) enhanced H adsorption ability of Pt-adjacent sulfur atoms due to Pt coordination. © 2022 Elsevier B.V.

关键词： Doping (additives)

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