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Advancing the potential of nanoparticles for cancer detection and precision therapeutics

Medical Oncology 2025年第7期42卷 1-32页

作者： Kiani, Muhammad Naeem Khaliq, Hamza Abubakar, Muhammad Rafique, Merium Jalilov, Fazliddin Ashraf, Ghulam Abbas Ayari-Akkari, Amel Akremi, Ali Guangdong Key Laboratory of Biomedical Measurements and Ultrasound Imaging School of Biomedical Engineering Medical School Shenzhen University Shenzhen China College of Environment Hohai University Nanjing 210098 China Academy of Medical Engineering and Translational Medicine Medical College Tianjin University Tianjin China Department of Chemistry University of Azad Jammu and Kashmir Pakistan Alfraganus University Yukori Karakamish Street 2a Tashkent 100190 Uzbekistan Low Dimensional Materials Research Center Khazar University Baku Azerbaijan Biology Department College of Science King Khalid University P.O. Box 960 Abha Saudi Arabia Department of Chemistry Faculty of Science Northern Border University Arar Saudi Arabia

Cancer poses a significant challenge with high death rate marked by heterogeneity, complexity, and resistance to available treatments, hence requiring creative approaches to improve early detection and precision medicines. Nanoparticles (NPs) exhibit distinctive physicochemical characteristics, including a high surface area-to-volume ratio, adjustable size and shape, and multifunctionality. This review paper critically explored the recent advancements in various NPs, such as graphene-based materials (to overcome cancer resistance and for diagnostic and therapeutics applications), metal organic frameworks (precised and targeted release of drug, e.g., glutathione-sensitive disulfide bonds for intracellular delivery), carbon dots, rhodamine 6G, polymer-based nanoformulation (CAP/ZnO NPs for lung cancer therapy), gold NPs (as radiosensitizing action), nanocarrier systems (including epigenetic control systems), aptamers, mesoporous polydopamine-based nanodrug, polymeric NPs, pH-responsive polymeric nanostructures (particularly in acidic tumor environment), multifunctional NPs, and carbon coated ferrite nanodots for targeted delivery to cancer cells. We, particularly, investigated their dual abilities in precise drug delivery of several payloads, like small molecules, proteins, and nucleic acids, in addition to their capabilities for real-time monitoring of therapeutic response in malignant cells. Moreover, this review underscores how the integration of Artificial Intelligence and machine learning algorithms with such NPs-based architectures is improving diagnostic precision and facilitating personalized cancer therapy approaches, navigating obstacles, including bioavailability and multidrug resistance. By evaluating critical recent breakthroughs about the role of nanotechnology in precision cancer therapy, this review paper highlights the pioneering capabilities of such intelligent nanomedicines in impacting cancer development, consequently advancing patient outcomes. ©

关键词： AI/ML Cancer theranostics Diagnosis Nanomedicines Nanotechnology Personalized treatment Tumor microenvironment

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Analgesic nanomedicines for the treatment of chronic pain

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BMEMat(biomedical engineering materials) 2024年第1期2卷 76-87页

作者： Hao Liu Hongjun Zhuang Ya Wang Yuen Yee Cheng Feixiang Chen Jian Chen Xinglei Song Run Zhang Yanyan Liu Wenbo Bu State Key Laboratory of Molecular Engineering of Polymers Department of Materials ScienceFudan UniversityShanghaiChina Department of Rehabilitation Zhongshan HospitalFudan UniversityShanghaiChina Central Laboratory The First Affiliated Hospital of Xiamen UniversityXiamenChina Institute for Biomedical Materials&Devices(IBMD) Faculty of ScienceThe University of Technology SydneySydneyNew South WalesAustralia Department of Anatomy and Physiology Shanghai Jiao Tong University School of MedicineShanghaiChina Australian Institute for Bioengineering and Nanotechnology The University of QueenslandBrisbaneQueenslandAustralia

Chronic pain is a major cause of suffering that often accompanies diseases and therapies,affecting approximately 20%of individuals at some point in their ***,current treatment modalities,such as anesthetic and antipyretic analgesics,have limitations in terms of efficacy and side *** technology offers a promising avenue to overcome these challenges and introduce new therapeutic *** article reviews the recent research on nanomedicine analgesics,integrating analyses of neuroplasticity changes in neurons and pathways related to the transition from acute to chronic ***,it explores potential future strategies using nanomaterials,aiming to provide a roadmap for new analgesic development and improved clinical pain *** leveraging nanotechnology,these approaches hold the potential to revolutionize pain treatment by delivering targeted and effective relief while minimizing side effects.

关键词： analgesics chronic pain local anesthetics nanomedicine neuroplasticity

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Metal-Doped NASICON/Polymer Composite Solid Electrolyte for Lithium Titania Anode in Lithium-Ion Batteries

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Polymers 2024年第9期16卷 1251页

作者： Hsieh, Chien-Te Cho, Tzu-Shaing Chang, Jeng-Kuei Patra, Jagabandhu Department of Chemical Engineering and Materials Science Yuan Ze University Taoyuan32003 Taiwan Department of Mechanical Aerospace and Biomedical Engineering University of Tennessee KnoxvilleTN37996 United States Research Center National Cheng Kung University 1 University Road Tainan70101 Taiwan Department of Materials Science and Engineering National Yang Ming Chiao Tung University Hsinchu30010 Taiwan Department of Chemical Engineering Chung Yuan Christian University Taoyuan32023 Taiwan

This study reports five types of metal-doped (Co, Cu, Sn, V, and Zr) NASICON-type Li1.3Al0.3Ti1.7(PO4)3 (LATP)/polymer composite solid electrolytes (CSEs) enabling Li4Ti5O12 (LTO) anodes to have high rate capability and excellent cycling performance. The high Li+-conductivity LATP samples are successfully synthesized through a modified sol–gel method followed by thermal calcination. We find that the cation dopants clearly influence the substitution of Al for Ti, with the type of dopant serving as a crucial factor in determining the ionic conductivity and interfacial resistance of the solid electrolyte. The CSE containing poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP), lithium bis(trifluoromethanesulfonyl)imide (LiTFSI), and Sn-LATP shows an ionic conductivity of 1.88 × 10−4 S cm−1 at ambient temperature. The optimum conductivity can be attributed to alterations in the lattice parameters and Li+ transport pathways owing to Sn doping. The solid-state cell equipped with the LTO-supported CSE containing Sn-LATP fillers demonstrates both excellent high rate capability at 5 C (with a capacity retention of 86% compared to the value measured at 0.2 C) and superior cycling stability, maintaining high Coulombic efficiency (>99.0%) over 510 cycles. These findings indicate that the proposed CSE is highly promising for use in solid-state lithium batteries with desirable charge–discharge properties and high durability. © 2024 by the authors.

关键词： Ionic conductivity

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Symmetrical dual D-shape fiber for waveguide coupled surface plasmon resonance sensing

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Optik 2023年第1期287卷

作者： Wang, Jianxin Liu, Wei Yang, Lin Lv, Jingwei Yin, Qianqian Liu, Qiang Lv, Yan Chu, Paul K. Liu, Chao School of Physics and Electronic Engineering Northeast Petroleum University Daqing163318 China Department of Physics Department of Materials Science and Engineering and Department of Biomedical Engineering City University of Hong Kong Tat Chee Avenue Hong Kong Kowloon China

A waveguide-coupled surface plasmon resonance (WCSPR) sensor consisting of two D-shape single-mode fibers is designed and analyzed by the finite element method (FEM). The optical field of the surface plasmon polaritons (SPPs) mode is confined in the dielectric cavity between the dual metallic thin films. Therefore, the effective refractive index of the SPP mode depends largely on the refractive index of the analyte and an anomalous dispersion relationship is observed between the SPP mode and x-polarized core-guide mode of the dual D-shape fiber. The excitation mechanism of surface plasmon resonance (SPR) in the coupling region is attributed to phase matching of the two modes. Further analysis shows that the narrow bandwidth peak in the loss spectrum of the core mode is determined by the sensor dimensions contributed jointly by the thicknesses of the silver film, dielectric layer, and titanium dioxide film. Compared to the single-fiber structure, the optimized dual D-shape WCSPR sensor achieves a maximum wavelength sensitivity of 52,200 nm/RIU with a full-width at half-minimum (FWHM) of 9.47 nm and a figure of merit (FOM) of 346.6 RIU−1 in the analyte refractive index range of 1.32–1.42. © 2023 Elsevier GmbH

关键词： Refractive index

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Electron Ptychography for Investigating Magnetic Textures in Micro- and Nano- Scale Magnets via Lorentz Transmission Electron Microscopy

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Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2023年第1期29卷 1847-1848页

作者： Trujillo, Kayna L Mendoza Divan, Ralu N S Li, Yue Jiang, Yi McCray, Arthur R C Petford-Long, Amanda K. Phatak, Charudatta Department of Materials Science and Engineering Northwestern University Evanston IL United States Materials Science Division Argonne National Laboratory Lemont IL United States Center for Nanoscale Materials Argonne National Laboratory Lemont IL United States Advanced Photon Source Argonne National Laboratory Lemont IL United States Applied Physics Program Northwestern University Evanston IL United States

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Microstructural and Interfacial Characteristics of Supersonic/Kinetically Reclaimed 2024al-T3 Substrate Using Cold Sprayed 2024al Deposit

SSRN

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SSRN 2024年

作者： Zhong, Yuan Zhang, Yingpeng Liu, Zhihao Ramachandran, Chidambaram Seshadri Cha, Limei Wang, Qun College of Materials Science and Engineering Hunan University Hunan Changsha410082 China The Material Science and Engineering Program Guangdong Technion Israel Institute of Technology Shantou515063 China Department of Materials Science and Engineering The State University of New York Stony BrookNY11794 2275 United States

This work systematically investigated the microstructure and interfacial characteristics of cold sprayed (CS) 2024Al coating on 2024Al-T3 substrate. Within the internal structure of the layer, recrystallization processes induced by intense stress were seen, resulting in the formation of nanograins with sizes ranging from 30-100 nm, as well as ultrafine grains with sizes ranging from 100-300 nm. Different bonding modes of splat/splat, including mechanical bonding, mechanical interlocking, and metallurgical bonding, have been found at the interface between splat/substrate. There were no apparent pores and gaps between the particles in the mechanical bonding area and between the coating and the substrate. In regions of metallurgical bonding, adiabatic shear instability promoted the occurrence of continuous dynamic recrystallization (CDRX) on the one hand, leading to viscous flow of local materials, which damaged the original splat/substrate bonding surface and generating new bonding surfaces, on the other hand, promoted atomic diffusion between the coating and the substrate, allowing a close lattice match formed at the splat/substrate interface. Therefore, the CS 2024Al coating exhibited excellent comprehensive properties with a porosity level of 0.31±0.09%, a hardness of 143.4 HV0.025, and an adhesion/cohesion strength exceeding 55.5 MPa. These properties were derived from the strong bonding among splats and between the splats and the substrate. © 2024, The Authors. All rights reserved.

关键词： Shear flow

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Acoustofluidic separation enables early diagnosis of traumatic brain injury based on circulating exosomes

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Microsystems & Nanoengineering 2021年第2期7卷 59-69页

作者： Zeyu Wang Haichen Wang Ryan Becker Joseph Rufo Shujie Yang Brian E.Mace Mengxi Wu Jun Zou Daniel T.Laskowitz Tony Jun Huang Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNC27708USA Department of Neurology Duke UniversityDurhamNC27708USA Department of Biomedical Engineering Duke UniversityDurhamNC27708USA Department of Geriatrics Duke UniversityDurhamNC27708USA Department of Electrical&Computer Engineering Texas A&M UniversityCollege StationTX77840USA

Traumatic brain injury(TBI)is a global cause of morbidity and *** management and risk stratification of patients with TBI is made difficult by the relative insensitivity of screening radiographic studies as well as by the absence of a widely available,noninvasive diagnostic *** particular,a blood-based biomarker assay could provide a quick and minimally invasive process to stratify risk and guide early management strategies in patients with mild TBI(mTBI).Analysis of circulating exosomes allows the potential for rapid and specific identification of tissue *** applying acoustofluidic exosome separation—which uses a combination of microfluidics and acoustics to separate bioparticles based on differences in size and acoustic properties—we successfully isolated exosomes from plasma samples obtained from mice after *** isolation eliminated interference from other blood components,making it possible to detect exosomal biomarkers for TBI via flow *** cytometry analysis indicated that exosomal biomarkers for TBI increase in the first 24 h following head trauma,indicating the potential of using circulating exosomes for the rapid diagnosis of *** levels of TBI biomarkers were only detected in the samples separated via acoustofluidics;no changes were observed in the analysis of the raw plasma *** finding demonstrated the necessity of sample purification prior to exosomal biomarker *** acoustofluidic exosome separation can easily be integrated with downstream analysis methods,it shows great potential for improving early diagnosis and treatment decisions associated with TBI.

关键词： diagnosis separation injury

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Antagonizing exosomal miR-18a-5p derived from prostate cancer cells ameliorates metastasis-induced osteoblastic lesions by targeting Hist1h2bc and activating Wnt/β-catenin pathway

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Genes & Diseases 2023年第4期10卷 1626-1640页

作者： Fanchun Zeng Chunrong Zhao Rujie Wang Lingyan Ren Hao Qiu Zhi Zou Haibin Ding Zhongyi Sun Jianmei Li Shiwu Dong Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular ImplantsCollege of BioengineeringChongqing UniversityChongqing 400030China Department of Biomedical Materials Science Army Medical UniversityChongqing 400038China Department of Orthopedics Xinqiao HospitalArmy Medical UniversityChongqing 400038China Antenatal Diagnosis Centre Guizhou Provincial People’s HospitalGuiyangGuizhou 550003China Department of Urology Shenzhen University General HospitalShenzhen UniversityShenzhenGuangdong 518055China

More than 50%of prostate cancer(PCa)patients have bone metastasis with osteo-blastic ***-18a-5p is associated with the development and metastasis of PCa,but it remains unclear whether it is involved in osteoblastic *** first found that miR-18a-5p was highly expressed in the bone microenvironment of patients with PCa bone *** address how miR-18a-5p affects PCa osteoblastic lesions,antagonizing miR-18a-5p in PCa cells or pre-osteoblasts inhibited osteoblast differentiation in ***,injection of PCa cells with miR-18a-5p inhibition improved bone biomechanical properties and bone mineral mass in ***,miR-18a-5p was transferred to osteoblasts by exosomes derived from PCa cells and targeted the Hist1h2bc gene,resulting in Ctnnb1 up-regulation in the Wnt/β-catenin signaling ***,antagomir-18a-5p significantly improved bone biomechanical properties and alleviated sclerotic lesions from osteoblastic me-tastases in BALB/c nude *** data suggest that inhibition of exosome-delivered miR-18a-5p ameliorates PCa-induced osteoblastic lesions.

关键词： Bone metastasis MiR-18a-5p Osteoblastic lesions Prostate cancer Wnt/β-catenin pathway

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Formation of a ZnO nanorods-patterned coating with strong bactericidal capability and quantitative evaluation of the contribution of nanorods-derived puncture and ROS-derived killing

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Bioactive materials 2022年第5期7卷 181-191页

作者： Jing Ye Bo Li Mei Li Yufeng Zheng Shuilin Wu Yong Han State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an710049China Department of Orthopedics Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou510080China Center for Biomedical Materials and Tissue Engineering Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing100871China School of Materials Science&Engineering The Key Laboratory of Advanced Ceramics and Machining Technology By the Ministry of Education of ChinaTianjin UniversityTianjin300072China

To endow Ti-based orthopedic implants with strong bactericidal activity,a ZnO nanorods-patterned coating(namely ZNR)was fabricated on Ti utilizing a catalyst-and template-free method of micro-arc oxidation(MAO)and hydrothermal treatment(HT).The coating comprises an outer layer of ZnO nanorods and a partially crystallized inner layer with nanocrystalline TiO_(2) and Zn_(2)TiO_(4) embedded amorphous matrix containing Ti,O and *** HT,Zn^(2+)ions contained in amorphous matrix of the as-MAOed layer migrate to surface and react with OH􀀀in hydrothermal solution to form ZnO nuclei growing in length at expense of the migrated Zn^(2+).ZNR exhibits intense bactericidal activity against the adhered and planktonic *** in vitro and in *** crucial contributors to kill the adhered bacteria are ZnO nanorods derived mechano-penetration and released reactive oxygen species(ROS).Within 30 min of *** incubation,ROS is the predominant bactericidal contributor with quantitative contribution value of ~20%,which transforms into mechano-penetration with prolonging time to reach quantitative contribution value of ~96% at 24 *** addition,the bactericidal contributor against the planktonic bacteria of ZNR is relied on the released Zn^(2+).This work discloses an in-depth bactericidal mechanism of ZnO nanorods.

关键词： Anti-bacteria ZnO nanorods Hydrothermal treatment Formation mechanism Bactericidal contributors quantitation

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Biopolymer-based Sustainable Membrane for Skin Regeneration

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materials Circular Economy 2024年第1期6卷 1-7页

作者： Paramasivan, Mareeswari S, Shuvetha Priya K, Niranjan Balaji R, Varshini B, Yugesh Prasanna Gonmei, Monica Chingchuilin M K, Padmanabhan Mahajan, Roop L. P, Chithra Lekha Healthcare Technologies Division Virginia Tech India Research and Education Forum Indian Institute of Technology Madras Research Park Chennai India Department of Biomedical Engineering SRM Institute of Science and Technology Ramapuram Chennai India Dr MGR Educational and Research Institute (Deemed to Be University) Chennai India Department of Mechanical Engineering Department of Materials Science and Engineering Virginia Tech Blacksburg USA

The primary objective of this study is to develop a membrane designed to expedite the healing process of burns and wounds. In our approach, we use Bacterial nanocellulose (BNC) cultivated from a kombucha tea culture, along with gelatin to create a sustainable wound-healing membrane. From the FTIR, the functional groups of both the BNC and gelatine in the membrane were apparent. The hydrophilic nature of the membrane indicated by its contact angle of 78.4 ± 3.4° promotes skin regeneration, by facilitating cell spreading, attachment, and tissue growth. Studies on the antibacterial activity of the generated membrane have shown that it successfully inhibits the growth of bacterial species such as Staphylococcus aureus and E. coli. The BNCG membrane demonstrates over 90% biocompatibility in MTT assay results validating its safe use in skin regeneration post third-degree burns. The formulated BNCG membrane shows a 95% closure rate in the L929 cell line, outperforming the control.

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