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In situ forming oxygen/ROS-responsive niche-like hydrogel enabling gelation-triggered chemotherapy and inhibition of metastasis

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Bioactive materials 2023年第3期21卷 86-96页

作者： Shi-Xiong Chen Ji Zhang Fengfeng Xue Wei Liu Yichen Kuang Bingxin Gu Shaoli Song Hangrong Chen State Key Laboratory of High Performance Ceramics and Superfine Microstructures Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050PR China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049PR China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesSub-lane Xiangshan Road 1Hangzhou310024PR China Department of Nuclear Medicine Fudan University Shanghai Cancer CenterShanghai200032PR China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai200032PR China Center for Biomedical Imaging Fudan UniversityShanghai200032PR China Shanghai Engineering Research Center of Molecular Imaging Probes Shanghai200032PR China

Though the development of the diverse hypoxia-activated prodrugs(HAPs)has made great progresses in the last several decades,current cancer therapy based on HAPs still suffers many obstacles,e.g.,poor therapeutic outcome owing to hard deep reaching to hypoxic region,and the occurrence of metastasis due to *** by engineered niches,a novel functional chitosan polymer(CS-FTP)is synthesized for construction of a hydrogel-based bio-niche(CS-FTP-gel)in aiming at remodeling tumor hypoxic *** CS-FTP polymers are crosslinked to form a niche-like hydrogel via enzyme-mediated oxygen-consumable dimerization after injected into tumor,in which a HAP(i.e.,AQ4N)could be physically encapsulated,resulting in enhanced tumor hypoxia to facilitate AQ4N-AQ4 toxic transformation for maximizing efficacy of ***,Pazopanib(PAZ)conjugated onto the CS backbone via ROS-sensitive linker undergoes a stimuli-responsive release behavior to promote antiangiogenesis for tumor starvation,eventually contributing to the inhibition of lung metastasis and synergistic action with AQ4N-based chemotherapy for an orthotopic 4T1 breast tumor *** study provides a promising strategy for hypoxia-based chemotherapy and demonstrates an encouraging clinical potential for multifunctional hydrogel applicable for antitumor treatment.

关键词： Hypoxia-activated prodrugs Bio-niches Hypoxia-inducible hydrogels Antimetastases

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FRESH-Printing of a Multi-actuator Biodegradable Robot Arm for Articulation and Grasping 12th

FRESH-Printing of a Multi-actuator Biodegradable Robot Arm f...

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Proceedings of the 12th International Conference on Biomimetic and Biohybrid Systems, Living Machines 2023

作者： Williamson, Avery S. Sun, Wenhuan Sukhnandan, Ravesh Coffin, Brian Majidi, Carmel Feinberg, Adam Yao, Lining Webster-Wood, Victoria A. Department of Mechanical Engineering Carnegie Mellon University PittsburghPA15218 United States Department of Biomedical Engineering Carnegie Mellon University PittsburghPA15218 United States Department of Materials Science and Engineering Carnegie Mellon University PittsburghPA15218 United States Human-Computer Interaction Institute School of Computer Science Carnegie Mellon University PittsburghPA15218 United States McGowan Institute for Regenerative Medicine Carnegie Mellon University PittsburghPA15218 United States

ISBN: (纸本)9783031388569

The recent popularity of soft robots for marine applications has established a need for the reliable fabrication of actuators that enable locomotion, articulation, and grasping in aquatic environments. These actuators should also reduce the negative impact on sensitive ecosystems by using biodegradable materials such as organic hydrogels. Freeform Reversible Embedding of Suspended Hydrogels (FRESH) printing can be used for additive manufacturing of small-scale biologically derived, marine-sourced hydraulic actuators by printing thin-wall structures out of sustainably sourced calcium-alginate hydrogels. However, controlling larger alginate robots with complex geometries and multiple actuation mechanisms remains challenging due to the reduced strength of such soft structures. For tethered hydrogel hydraulic robots, a direct interface with fluid lines is necessary for actuation, but the drag forces associated with tethered lines can quickly overcome the actuation force of distal and extremity structures. To overcome this challenge, in this study, we identify printing parameters and interface geometries to allow the working fluid to be channeled to distal components of FRESH-printed alginate robots and demonstrate a proof-of-concept biodegradable robotic arm for small object manipulation and grasping in marine environments. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2023.

关键词： Biodegradability

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Dynamic Semantic-Based Spatial Graph Convolution Network for Skeleton-Based Human Action Recognition 38

Dynamic Semantic-Based Spatial Graph Convolution Network for...

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38th AAAI Conference on Artificial Intelligence, AAAI 2024

作者： Xie, Jianyang Meng, Yanda Zhao, Yitian Nguyen, Anh Yang, Xiaoyun Zheng, Yalin CDT in Distributed Algorithms School of EEECS University of Liverpool United Kingdom Department of Eye and Vision Sciences University of Liverpool Liverpool United Kingdom Department of Computer Sciences University of Liverpool Liverpool United Kingdom Cixi Institute of Biomedical Engineering Ningbo Institute of Materials Technology and Engineering CAS Cixi China Remark AI UK Limited London United Kingdom Liverpool Centre for Cardiovascular Science Liverpool United Kingdom

ISBN: (纸本)1577358872

Graph convolutional networks (GCNs) have attracted great attention and achieved remarkable performance in skeleton-based action recognition. However, most of the previous works are designed to refine skeleton topology without considering the types of different joints and edges, making them infeasible to represent the semantic information. In this paper, we proposed a dynamic semantic-based graph convolution network (DS-GCN) for skeleton-based human action recognition, where the joints and edge types were encoded in the skeleton topology in an implicit way. Specifically, two semantic modules, the joints type-aware adaptive topology and the edge type-aware adaptive topology, were proposed. Combining proposed semantics modules with temporal convolution, a powerful framework named DS-GCN was developed for skeleton-based action recognition. Extensive experiments in two datasets, NTU-RGB+D and Kinetics-400 show that the proposed semantic modules were generalized enough to be utilized in various backbones for boosting recognition accuracy. Meanwhile, the proposed DS-GCN notably outperformed state-of-the-art methods. The code is released here https://***/davelailai/DS-GCN. Copyright © 2024, Association for the Advancement of Artificial Intelligence (***). All rights reserved.

关键词： Convolution

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Annular Dark Field Imaging with Variable Angle for Improving STEM Tomography of Biological Samples

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Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2023年第1期29卷 945-947页

作者： Li, Wing Shun Roth, Eric Bleher, Reiner Backman, Vadim Dravid, Vinayak P. Applied Physics Program Northwestern University Evanston IL United States Department of Materials Sciences and Engineering Northwestern University Evanston IL United States Northwestern University Atomic and Nanoscale Characterization Experimental (NUANCE) Center Northwestern University Evanston IL United States Department of Biomedical Engineering Northwestern University Evanston IL United States International Institute of Nanotechnology Northwestern University Evanston IL United States

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Immunomodulatory poly(L-lactic acid)nanofibrous membranes promote diabetic wound healing by inhibiting inflammation,oxidation and bacterial infection

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Burns & Trauma 2024年第1期12卷 510-535页

作者： Yan Wu Jin Zhang Anqi Lin Tinglin Zhang Yong Liu Chunlei Zhang Yongkui Yin Ran Guo Jie Gao Yulin Li Yanhui Chu Heilongjiang Key Laboratory of Tissue Damage and Repair Mudanjiang Medical University3 Tongxiang StreetAimin DistrictMudanjiang 157011China Clinical Laboratory Zhejiang Medical&Health Group Quzhou Hospital62 Wenchang RoadKecheng DistrictQuzhou 324004China The Key Laboratory for Ultrafine Materials of Ministry of Education State Key Laboratory of Bioreactor EngineeringEngineering Research Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and Technology130 Meilong RoadLingyun StreetXuhui DistrictShanghai 200237China Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical University168 Changhai RoadYangpu DistrictShanghai 200433China Scientific Research Sharing Platform Mudanjiang Medical University3 Tongxiang StreetAimin DistrictMudanjiang 157011China Department of Physiology Mudanjiang Medical University3 Tongxiang StreetAimin DistrictMudanjiang 157011China

Background:Given the significant impact on human health,it is imperative to develop novel treatment approaches for diabetic wounds,which are prevalent and serious complications of *** diabetic wound microenvironment has a high level of reactive oxygen species(ROS)and an imbalance between proinflammatory and anti-inflammatory cells/factors,which hamper the healing of chronic *** study aimed to develop poly(L-lactic acid)(PLLA)nanofibrous membranes incorporating curcumin and silver nanoparticles(AgNPs),defined as PLLA/C/Ag,for diabetic wound ***:PLLA/C/Ag were fabricated via an air-jet spinning *** membranes underwent preparation and characterization through various techniques including Fourier-transform infrared spectroscopy,measurement of water contact angle,X-ray photoelectron spectroscopy,X-ray diffraction,scanning electron microscopy,assessment of in vitro release of curcumin and Ag+,testing of mechanical strength,flexibility,water absorption and *** addition,the antioxidant,antibacterial and anti-inflammatory properties of the membranes were evaluated in vitro,and the ability of the membranes to heal wounds was tested in vivo using diabetic ***:Loose hydrophilic nanofibrous membranes with uniform fibre sizes were prepared through air-jet *** membranes enabled the efficient and sustained release of *** importantly,antibacterial AgNPs were successfully reduced in situ from AgNO_(3).The incorporation of AgNPs endowed the membrane with superior antibacterial activity,and the bioactivities of curcumin and the AgNPs gave the membrane efficient ROS scavenging and immunomodulatory effects,which protected cells from oxidative damage and reduced *** results from animal studies indicated that the PLLA/C/Ag membranes had the most efficient wound healing properties,which were achieved by stimulating angiogenesis and collagen deposition and inhibiting ***:In

关键词： Nanofibrous membrane Poly(L-lactic acid) Curcumin Silver nanoparticles Autophagy Wound healing Diabetic wound Inflammation Oxidation Infection Bacterial

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Adult dental epithelial stem cell-derived organoids deposit hydroxylapatite biomineral

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International Journal of Oral science 2023年第4期15卷 676-690页

作者： Hyun-Yi Kim Victoria Cooley Eun-Jung Kim Shujin Li Jong-Min Lee Dina Sheyfer Wenjun Liu Ophir D.Klein Derk Joester Han-Sung Jung NGeneS Inc. Ansan-siGyeonggi-doKorea Department of Materials Science and Engineering Northwestern UniversityEvanstonILUSA X-ray Science Division Advanced Photon SourceArgonne National LaboratoryLemontILUSA Division in Anatomy and Developmental Biology Department of Oral BiologyOral Science Research CenterBK21 FOUR ProjectYonsei University College of DentistrySeoulKorea Department of Orofacial Sciences and Program in Craniofacial Biology University of CaliforniaSan FranciscoCAUSA Department of Pediatrics Cedars-Sinai Guerin Children’sLos AngelesCAUSA

Ameloblasts are specialized cells derived from the dental epithelium that produce enamel,a hierarchically structured tissue comprised of highly elongated hydroxylapatite(OHAp)*** unique function of the epithelial cells synthesizing crystallites and assembling them in a mechanically robust structure is not fully elucidated yet,partly due to limitations with in vitro experimental ***,we demonstrate the ability to generate mineralizing dental epithelial organoids(DEOs)from adult dental epithelial stem cells(aDESCs)isolated from mouse incisor *** expressed ameloblast markers,could be maintained for more than five months(11 passages)in vitro in media containing modulators of Wnt,Egf,Bmp,Fgf and Notch signaling pathways,and were amenable to *** transplanted underneath murine kidney capsules,organoids produced OHAp crystallites similar in composition,size,and shape to mineralized dental tissues,including some enamel-like elongated *** are thus a powerful in vitro model to study mineralization process by dental epithelium,which can pave the way to understanding amelogenesis and developing regenerative therapy of enamel.

关键词： epithelium maintained specialized

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Experimental and theoretical study of the phase transition between perovskite polytypes of BaPtO3 under high pressure and temperature

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Physical Review B 2024年第9期110卷 094108页

作者： Hongze Li Yanyao Zhang Nisha Geng Jiaming He Stella Chariton Vitali Prakapenka Carlos Alberto López José Antonio Alonso Eva Zurek Jung-Fu Lin Jianshi Zhou Materials Science and Engineering Program Walker Department of Mechanical Engineering Department of Earth and Planetary Sciences Jackson School of Geosciences Department of Chemistry Center for Advanced Radiation Sources The INTEQUI (UNSL-CONICET) and Facultad de Química Bioquímica y Farmacia CSIC Cantoblanco 28049 Madrid Spain

APtO3 (A = Ca, Sr, Ba) is a unique family in the complex transition metal oxides with the AMO3 formula. Most 3d and 4dAMO3 compounds adopt the perovskite structure when synthesized at ambient or high pressure; however, APtO3 perovskites have not been reported, even if their geometric tolerance factor, t, falls in the range suitable for the perovskite structure. Herein, we studied the crystal structures of BaPtO3 by performing the in situ x-ray diffraction over a broad range in the pressure (P)–temperature (T) phase diagram. The perovskite BaPtO3 can be stabilized at P>35 GPa and T>1100 K. A variety of crystal structures, including the perovskite structure and its hexagonal polytypes, observed in the P–T phase diagram of BaPtO3 match the structure predictions from the first-principles calculations reasonably well.

关键词： High-pressure studies Structural phase transition Perovskites Density functional calculations Pressure techniques X-ray diffraction

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Micro-Nanostructured Polymeric Scaffolds for Bone Tissue engineering

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International Journal of High Speed Electronics and Systems 2024年第2-3期33卷

作者： Abdulmalik, Sama Wijekoon, Suranji Danazumi, Khadija Basiru Srinivasan, Sai Sadhananth Vobbineni, Laxmi Obopilwe, Elifho Kumbar, Sangamesh G. Department of Biomedical Engineering University of Connecticut StorrsCT06269 United States Department of Orthopedic Surgery University of Connecticut Health Center FarmingtonCT06030 United States Department of Materials Science and Engineering University of Connecticut StorrsCT06269 United States

While bone tissue allograft and autograft are commonly used in bone healing, their application is limited by factors such as availability, donor site morbidity, and immune response to the grafted tissue. Tissue-engineered implants, such as acellular or cellular polymeric structures, offer a promising alternative, and are a current trend in tissue engineering. Leveraging recent advancements in bone tissue engineering (BTE), we utilize 3D printing to develop biodegradable scaffolds that combine mechanical strength and bioactivity to facilitate bone repair and regeneration. This study focuses on the design and fabrication of mechanically competent 3D printed poly (L-lactic acid) (PLLA) micro-structured scaffolds. These scaffolds are enhanced with collagen type I nanofibrils to create bioactive scaffolds that promote tissue regeneration. The performance of these mechanically competent, micro-nanostructured polymeric matrices, in combination with bone marrow stromal cells (BMSCs), is evaluated in PLLA and PLLA-collagen scaffolds. The resulting micro-nanostructured PLLA-Collagen scaffolds mimic trabecular bone architecture, mechanical strength, and the extracellular matrix environment found in native bone tissue. The composite PLLA-collagen scaffolds exhibit mechanical properties in the mid-range of human trabecular bone. Both PLLA and PLLA-Collagen scaffolds support human BMSCs adhesion, proliferation, and osteogenic differentiation. A significantly higher number of implanted host cells are distributed in the PLLA-Collagen scaffolds with greater bone density, more uniform cell distribution, and attachment compared to the PLLA microstructure. Additionally, the biomimetic collagen nanostructure potently induces osteogenic transcription evidenced by increased alkaline phosphatase activity and upregulation of bone markers such as sialoprotein and collagen type I, ultimately guiding stem cell-mediated formation of a mature, mineralized bone matrix throughout the interconnecte

关键词： Stem cells

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pH-Sensitive nanocarrier assisted delivery of adenosine to treat osteoporotic bone loss

pH-Sensitive nanocarrier assisted delivery of adenosine to t...

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作者： Newman, Hunter Hoque, Jiaul Shih, Yu-Ru V. Marushack, Gabrielle Ko, Unghyeon Gonzales, Gavin Varghese, Shyni Department of Mechanical Engineering and Materials Science Duke University DurhamNC27710 United States Department of Orthopaedic Surgery Duke University School of Medicine DurhamNC27710 United States Department of Biomedical Engineering Duke University DurhamNC27710 United States

Bone tissue undergoes continuous remodeling via osteoclast-mediated bone resorption and osteoblast-mediated bone formation. An imbalance in this process with enhanced osteoclastic activity can lead to excessive bone resorption, resulting in bone thinning. Once activated, osteoclasts bind to the bone surface and acidify the local niche. This acidic environment could serve as a potential trigger for the delivery of therapeutic agents into the osteoporotic bone tissue. To this end, we developed a pH-responsive nanocarrier-based drug delivery system that binds to the bone tissue and delivers an osteoanabolic molecule, adenosine. Adenosine is incorporated into a hyaluronic acid (HA)-based nanocarrier through a pH-sensitive ketal group. The HA-nanocarrier is further functionalized with alendronate moieties to improve binding to the bone tissues. Systemic administration of the nanocarrier containing adenosine attenuated bone loss in ovariectomized mice and showed comparable bone qualities to that of healthy mice. Delivery of osteoanabolic small molecules that can contribute to bone formation and inhibit excessive osteoclast activity by leveraging the tissue-specific milieu could serve as viable therapeutics for osteoporosis. © 2022 The Royal Society of Chemistry.

关键词： Molecules

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Synergistic antibacterial activity of physical-chemical multi-mechanism by TiO2 nanorod arrays for safe biofilm eradication on implant

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Bioactive materials 2021年第1期6卷 12-25页

作者： Xiangyu Zhang Guannan Zhang Maozhou Chai Xiaohong Yao Weiyi Chen Paul KChu Laboratory of Biomaterial Surfaces&Interfaces Institute of New Carbon MaterialsTaiyuan University of TechnologyTaiyuan030024China College of Biomedical Engineering Taiyuan University of TechnologyTaiyuan030024China Second Hospital of Shanxi Medical University Taiyuan030024China Department of Physics Department of Materials Science and EngineeringDepartment of Biomedical EngineeringCity University of Hong KongTat Chee AvenueKowloonHong KongChina

Treatment of implant-associated infection is becoming more challenging,especially when bacterial biofilms form on the surface of the *** multi-mechanism antibacterial methods to combat bacterial biofilm infections by the synergistic effects are superior to those based on single modality due to avoiding the adverse effects arising from the *** this work,TiO2 nanorod arrays in combination with irradiation with 808 nearinfrared(NIR)light are proven to eradicate single specie biofilms by combining photothermal therapy,photodynamic therapy,and physical killing of *** TiO2 nanorod arrays possess efficient photothermal conversion ability and produce a small amount of reactive oxygen species(ROS).Physiologically,the combined actions of hyperthermia,ROS,and puncturing by nanorods give rise to excellent antibacterial properties on titanium requiring irradiation for only 15 min as demonstrated by our experiments conducted in vitro and in *** importantly,bone biofilm infection is successfully treated efficiently by the synergistic antibacterial effects and at the same time,the TiO2 nanorod arrays improve the new bone formation around *** this protocol,besides the biocompatible TiO2 nanorod arrays,an extra photosensitizer is not needed and no other ions would be *** findings reveal a rapid bacteria-killing method based on the multiple synergetic antibacterial modalities with high biosafety that can be implemented in vivo and obviate the need for a second *** concept and antibacterial system described here have large clinical potential in orthopedic and dental applications.

关键词： Titanium implants TiO2 nanorod Anti-biofilm Physical insertion Light-triggered therapy

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