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Osteogenesis of MC3T3 Preosteoblasts on 3D Bioactive Peptide Modified Nano-Macroporous Bioactive Glass Scaffolds

Journal of Biomaterials and Nanobiotechnology 2015年第3期6卷 146-159页

作者： Colin Przybylowski Mohamed Ammar Courtney LeBlon Sabrina S. Jedlicka Integrated Degree in Engineering Arts & Sciences (IDEAS) Program Lehigh University Bethlehem PA USA Bioengineering Program Lehigh University Bethlehem PA USA Department of Materials Science & Engineering Lehigh University Bethlehem PA USA Department of Mechanical Engineering & Mechanics Lehigh University Bethlehem PA USA Center for Advanced Materials & Nanotechnology Lehigh University Bethlehem PA USA

Biointerface design that targets osteogenesis is a growing area of research with significant implications in biomedicine. Materials known to either support or stimulate osteogenesis are composed of a biomimetic ceramic material, such as bioactive glass. Bioactive glass is osteoproductive, and the potential for osteoproductivity can be enhanced by the addition of proteins or other additives designed to alter functionality. In addition, soluble growth factors are often added to osteogenic culture on bioactive glasses, further intensifying the effects of the material. In this paper, synthetic peptide combinations, covalently bound to a three-dimensional bioactive glass network, are used to mimic the effects of the whole fibronectin and bone morphogenetic proteins (BMP) 2 and 9. Peptide-silanes possessing critical binding sequences from each of these proteins are synthesized and used to decorate the surface of three-dimensional (3D) nano-macroporous bioactive glass. MC3T3 preosteoblast cells are then assessed for differentiation on the materials in the absence of soluble differentiation cues. MC3T3 preosteoblasts undergo enhanced differentiation on the peptide-silane samples over the standard nano-macroporous bioactive glass, and the differentiation capacity of the cells exposes only to peptide-silane surfaces approaches that of cells grown in chemical differentiation induction media.

关键词： Bioactive Glass Bioactive Peptide MC3T3 Osteogenesis

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Lipid-dependent conformational dynamics underlie the unctional versatility of T-cell receptor

Lipid-dependent conformational dynamics underlie the unction...

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中国生物化学与分子生物学会2016年全国学术会议

作者：李华郭兴东闫成松施小山黄敏黄文茂王英芳炜铃蔡明军李伦乙吴微白轶冰张弛刘志军王鑫艳张晓辉唐淳王宏达刘万里欧阳波黄超兰周界文曹毅许琛琦上海生命科学研究院生化与细胞生物学研究所国家蛋白质中心分子生物学重点实验室南京大学物理学院长春应用化学研究所 Bioengineering Program & Department of Mechanical Engineering and Mechanics Lehigh University 清华大学 Department of Biological Chemistry and Molecular Pharmacology Harvard Medical School 上海科技大学

T细胞受体(T-cell receptor,TCR)是T细胞发挥识别"自我"和"非我"功能的主要受体,其可以和抗原呈递细胞(APC)表面特定的peptide-MHC复合物(p MHC)结合来特异性识别抗原。TCR与p MHC结合这一物理信号信号会跨过细胞... 详细信息

T细胞受体(T-cell receptor,TCR)是T细胞发挥识别"自我"和"非我"功能的主要受体,其可以和抗原呈递细胞(APC)表面特定的peptide-MHC复合物(p MHC)结合来特异性识别抗原。TCR与p MHC结合这一物理信号信号会跨过细胞膜传递到胞内,引起TCR复合物胞内段免疫酪氨酸基序(immunoreceptortyrosine-based activation motifs,ITAMs)中酪氨酸的磷酸化,从而引起下游信号的产生。TCR可以结合不同强度的抗原而引起不同的抗原特异性的

关键词： TCR CD3ε lipid-dependent conformational dynamics versatilesignaling

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Self-Tracking Energy Transfer for Neural Stimulation in Untethered Mice

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Physical Review Applied 2015年第2期4卷 024001-024001页

作者： John S. Ho Yuji Tanabe Shrivats Mohan Iyer Amelia J. Christensen Logan Grosenick Karl Deisseroth Scott L. Delp Ada S. Y. Poon Department of Electrical Engineering Stanford University Stanford California 94305 USA Department of Bioengineering Stanford University Stanford California 94305 USA Neurosciences Program Stanford University Stanford California 94305 USA Department of Psychiatry and Behavioral Sciences Stanford University Stanford California 94305 USA Howard Hughes Medical Institute Stanford University Stanford California 94305 USA CNC Program Stanford University Stanford California 94305 USA Department of Mechanical Engineering Stanford University Stanford California 94305 USA

Optical or electrical stimulation of neural circuits in mice during natural behavior is an important paradigm for studying brain function. Conventional systems for optogenetics and electrical microstimulation require tethers or large head-mounted devices that disrupt animal behavior. We report a method for wireless powering of small-scale implanted devices based on the strong localization of energy that occurs during resonant interaction between a radio-frequency cavity and intrinsic modes in mice. The system features self-tracking over a wide (16-cm diameter) operational area, and is used to demonstrate wireless activation of cortical neurons with miniaturized stimulators (10 mm3, 20 mg) fully implanted under the skin.

关键词： Brain Neuronal network activity Neuronal imaging

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Tissue engineering: Nano-Enabled Approaches for Stem Cell-Based Cardiac Tissue engineering(Adv. Healthcare Mater. 13/2016).

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Advanced healthcare materials 2016年第13期5卷

作者： Mahshid Kharaziha Adnan Memic Mohsen Akbari David A Brafman Mehdi Nikkhah Biomaterials Research Group Department of Materials Engineering Isfahan University of Technology Isfahan *** Iran. Center of Nanotechnology King Abdulaziz University Jeddah 21589 Saudi Arabia. Department of Mechanical Engineering University of Victoria Victoria BC Canada. School of Biological and Health Systems Engineering (SBHSE) Harington Bioengineering Program Arizona State University Tempe Arizona 85287 USA.

On page 1533 M. Nikkhah and co-workers review tissue engineering strategies in the treatment of cardiac diseases with emphasis on the use of nanoenabled approaches (e.g. nanoparticles, nanotopographies) in combination... 详细信息

关键词： biomaterials cardiac tissue engineering nanofeatured surfaces nanomaterials stem cells

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Design and Synthesis of Nanoparticle Contrast Agents for Spectral (color) X-Ray Imaging

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MRS Online Proceedings Library (OPL) 2015年第1期1719卷 mrsf14-1719-c05-08-mrsf14-1719-c05-08页

作者： Prakash D. Nallathamby Tracie L. Mcginnity Lisa E. Cole Margaret E. Best Tracy Vargo-Gogola Ryan K. Roeder Department of Aerospace & Mechanical Engineering University of Notre Dame Mishawaka IN United States. Bioengineering Graduate Program University of Notre Dame Notre Dame IN United States. Harper Cancer Research Institute University of Notre Dame Notre Dame IN United States. Department of Biochemistry and Molecular Biology Indiana University Medical School South Bend IN United States.

Computed tomography (CT) is an important tool in clinical diagnostic imaging enabling three-dimensional anatomic imaging at high spatial resolution with short scan times. However, X-ray attenuation differences in physiological fluids and soft tissues are relatively small, requiring the use of contrast agents to achieve sufficient imaging contrast. Recent advances in energy-sensitive X-ray detectors have made spectral (color) CT commercially feasible by unmixing the energy-dependent attenuation profile of different materials and will potentially enable molecular imaging in CT. In order to leverage these capabilities for diagnostic imaging, we are developing a spectral library of nanoparticle contrast agents with K-shell absorption edges spaced at least 10 keV apart. The objective of this study was to demonstrate the ability of spectral CT to simultaneously detect up to three different contrast agents and unmixed their signals to create color images. Gadolinium oxide (Gd), hafnium oxide (Hf) and gold (Au) were chosen due to exhibiting K-edges spaced 10-20 keV apart. Core-shell nanoparticles of each composition were synthesized by various methods to have a core diameter of 15-20 nm and were coated with a silica shell at least 2-4 nm in thickness to create a common platform for surface functionalization. The contrast agents were imaged in a soft tissue equivalent phantom using source-side method for spectral CT imaging. The source-side approach utilized monochromatic synchrotron radiation at the Argonne National Laboratory which, while not clinically applicable, served as a gold standard due to providing the highest spectral resolution. The nanoparticles designed for this study have broad applications in biomedical imaging due to their modular assembly, potential for enabling multi-modal detection, and surface functionalization with biomolecules (e.g., antibodies, peptides or enzymes) for active targeting.

关键词： x-ray tomography nanoscale optical

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Cell Spread and Alignment on a Microwavy Surface

Cell Spread and Alignment on a Microwavy Surface

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8th IUPAP International Conference on Biological Physics(第八届IUPAP国际生物物理大会)

作者： Yaling Liu Jia Hu Ezgi Yalcintas Arkady Voloshin Bioengineering Program Lehigh UniversityBethlehemPAUSA Department of Mechanical Engineering and MechanicsLehigh UniversityBethlehemPAUSA Department of Mechanical Engineering and Mechanics Lehigh UniversityBethlehemPAUSA

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Improving liver fibrosis diagnosis based on forward and backward second harmonic generation signals

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Applied Physics Letters 2015年第8期106卷

作者： Peng, Qiwen Zhuo, Shuangmu So, Peter T. C. Yu, Hanry Biosystems and Micromechanics IRG Singapore-MIT Alliance for Research and Technology 1 CREATE Way #04-13/14 Enterprise Wing Singapore138602 Singapore Institute of Laser and Optoelectronics Technology Fujian Normal University Fuzhou350007 China Computation and System Biology Program Singapore-MIT Alliance 4 Engineering Drive 3 E4-04-10 117576 Singapore Institute of Bioengineering and Nanotechnology A STAR The Nanos 31 Biopolis Way #04-01 Singapore138669 Singapore Department of Mechanical Engineering Massachusetts Institute of Technology CambridgeMA02139 United States Department of Biological Engineering Massachusetts Institute of Technology CambridgeMA02139 United States Department of Physiology Yong Loo Lin School of Medicine National University of Singapore Singapore117597 Singapore Mechanobiology Institute National University of Singapore Singapore117411 Singapore

The correlation of forward second harmonic generation (SHG) signal and backward SHG signal in different liver fibrosis stages was investigated. We found that three features, including the collagen percentage for forward SHG, the collagen percentage for backward SHG, and the average intensity ratio of two kinds of SHG signals, can quantitatively stage liver fibrosis in thioacetamide-induced rat model. We demonstrated that the combination of all three features by using a support vector machine classification algorithm can provide a more accurate prediction than each feature alone in fibrosis diagnosis. © 2015 AIP Publishing LLC.

关键词： Harmonic generation

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Enhanced assessment of limb neuro-mechanics via a haptic display

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Robotics and Biomimetics 2014年第1期1卷 1-10页

作者： Melendez-Calderon, Alejandro Piovesan, Davide Patton, James L Mussa-Ivaldi, Ferdinando A Department of Physical Medicine and Rehabilitation Northwestern University Chicago USA Sensory Motor Performance Program Rehabilitation Institute of Chicago Chicago USA Biomedical Program Department of Mechanical Engineering Gannon University Erie USA Department of Bioengineering University of Illinois at Chicago Chicago USA Department of Biomedical Engineering Northwestern University Evanston USA Department of Mechanical Engineering Northwestern University Evanston USA Department of Physiology Northwestern University Chicago USA

Current state-of-the-art quantitative assessments of abnormal neuro-mechanics (e.g., spasticity, rigidity, dystonia) require sophisticated measurement systems that, together with the lengthiness of the data acquisition, make these approaches impractical for the clinical setting. Our long-term goal is to create a tool that enhances the capability of therapists to diagnose abnormal neuro-mechanics without the need of lengthy procedures and sophisticated equipment. Towards this direction, we present a haptic display of abnormal limb neuro-mechanics. This haptic display can be used as a training device for clinicians to understand the causality of the haptic sensation associated with neurological impairments and abnormal biomechanics during manipulation of a patients' limb. Other uses include the testing of operational research algorithms to maximize the exchange of haptic information, reproducing conditions of human-human interaction, and a test bed for developing novel assessment techniques and targeted interventions. Experimental results support the hypothesis that the best assessment of abnormalities can be obtained via specific manipulation strategies.

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Quantitative assessment of a therapeutic exercise in mitigating micrographia associated with Parkinson's disease

Quantitative assessment of a therapeutic exercise in mitigat...

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Health Innovations and POCT

作者： Naiqian Zhi Beverly Kris Jaeger Andrew Gouldstone Samuel Frank Rifat Sipahi Department of Mechanical and Industrial Engineering Northeastern University Boston MA Bioengineering Program College of Engineering Northeastern University Boston MA Department of Neurology Boston University Medical Center Boston MA

Parkinson's disease (PD) is the second most common neurodegenerative disorder. The debilitating nature of this medical condition can negatively impact use of the upper limb for tasks such as handwriting, which affects daily lives of many PD patients. A two-week self-administrated handwriting therapeutic exercise protocol, Amplified Air Writing (AAW), has been conducted by six PD subjects who have demonstrated micrographia symptoms, to investigate its influence on their writing samples. To study handwriting changes, several computerized metrics developed by our group to quantify micrographia were implemented. Metric results demonstrate significant temporary improvement for post-AAW handwriting performance; cursive samples especially show clear benefits for the subjects. Therefore, this self-administrated AAW exercise has potential to impart benefits on a larger PD population in their handwriting.

关键词： Measurement Ink Writing Parkinson's disease Protocols Nervous system

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Modular Peptide-Based Hybrid Nanoprobes for Bio-Imaging and Bio-Sensing

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MRS Online Proceedings Library (OPL) 2014年第1期1621卷 155-161页

作者： Banu Taktak Karaca James Meyer Sarah VanOosten Mark Richter Candan Tamerler Bioengineering Research Center (BERC) & Bioengineering Program University of Kansas Lawrence KS 66045 USA Department of Molecular Biology and Genetics Istanbul Technical University Istanbul 34469 Turkey Department of Molecular Biosciences University of Kansas Lawrence KS 66045 USA Department of Mechanical Engineering University of Kansas Lawrence KS 66045 USA

The self-organization of functional proteins directly onto solid materials is attractive to a wide range of biomaterials and systems that need to accommodate a biological recognition element. In such systems, inorganic binding peptides may be an essential component due to their high affinity and selective binding features onto different types of solid surfaces. This study demonstrates a peptide-enabled self-assembly technique for designing well-defined protein arrays over a metal surface. To illustrate this concept, we designed a fusion protein that simultaneously displays a red fluorescence protein (DsRed-monomer), which is highly selective for copper ions, and a gold binding peptide AuBP. The peptide tag, AuBP, self-directs the organization of DsRed-monomer protein onto a gold surface and forms arrays built upon an efficient control of the organic/inorganic interface at the molecular level. The peptide-assisted design offers a modular approach for fabrication of fluorescent-based protein arrays with copper ion sensing ability.

关键词： adsorption biological biomimetic (assembly)

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