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Ultra-high throughput enrichment of viable circulating tumor cells 15

15th International Conference on Biomedical engineering, ICBME 2013

作者： Khoo, B.L. Warkiani, M.E. Guan, Guofeng Tan, Daniel Shao-Weng Lim, Alvin S. T. Lim, Wan-Teck Yap, Yoon Sim Lee, Soo Chin Soo, Ross A Han, Jongyoon Lim, Chwee Teck Centre Singapore Mechanobiology Institute National University of Singapore Singapore Department of Bioengineering National University of Singapore Singapore Department of Medical Oncology National Cancer Centre Singapore Singapore Cancer Therapeutics Research Laboratory National Cancer Centre Singapore Singapore Clearbridge BioMedics Pte Ltd Singapore Department of Pathology Singapore General Hospital Singapore Department of Hematology-Oncology National University Hospital Singapore Department of Electrical Engineering and Computer Science Department of Biological Engineering Massachusetts Institute of Technology CambridgeMA United States

ISBN: (纸本)9783319029122

Detection, enumeration and characterization of rare circulating tumor cells (CTCs) from the peripheral blood of cancer patients potentially provide critical insights into tumor biology and is promising for cancer diagnosis and prognosis. Here, we present a novel multiplexed spiral microfluidic device for ultra-high throughput, label-free enrichment of CTCs from clinically relevant blood volumes. The fast processing time of the technique (7.5 mL blood in © Springer International Publishing Switzerland 2014.

关键词： Genome

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Highly efficient (11.1%) small molecule multi-junction organic photovoltaic cells

Highly efficient (11.1%) small molecule multi-junction organ...

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2014 IEEE 40th Photovoltaic Specialist Conference (PVSC)

作者： Xiaozhou Che Xin Xiao Stephen R. Forrest Applied Physics Program University of Michigan Ann Arbor MI USA Department of Electrical Engineering and Computer Science University of Michigan Ann Arbor MI USA

We present multi-junction small molecule organic photovoltaic (OPV) cells with efficiencies over 11%. The devices consist of two or three, vacuum thermally evaporated planar-mixed heterojunction sub-cells with minimal absorption overlap between the cells. By introducing a transparent interconnecting layer, a dual element (tandem) cell achieves a power conversion efficiency of 10.0 ± 0.5%. We further improve the cell performance by adding an additional (3 rd ) sub-cell that absorbs at the second order optical interference maximum within the stack. The triple-junction cell significantly improves the quantum efficiency at shorter wavelengths, achieving a power conversion efficiency of 11.1 ± 0.5%, which to our knowledge, is the highest reported for a multi-junction OPV cell in the scientific literature.

关键词： Absorption Photovoltaic cells Interference Adaptive optics Cathodes Current measurement Optical filters

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Low noise single photon counting chip with energy window for hybrid pixel detector with precise offset and gain correction

Low noise single photon counting chip with energy window for...

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IEEE Nuclear science Symposium

作者： P. Maj P. Grybos P. Kmon R. Szczygiel Department of Measurements and Electronics at the Faculty of Electrical Engineering Automatics Computer Sciences and Bioengineering at the AGH University of Science and Technology al. A. Mickiewicza 30 30-059 Krak??w Poland

ISBN: (纸本)9781479960989

We report on the design of an integrated circuit operating in a single photon counting mode for readout of hybrid pixel detectors. The prototype IC was designed and fabricated in CMOS 130 nm technology and consists of 23552 square shaped pixels of 75 μm pitch. Each pixels consists of charge sensitive amplifier, shaper, two discriminators and two 14-bit counters. Additionally each pixel contains also novel key blocks for offset and gain trimming. The prototype IC works with two energy thresholds in the readout mode separate from exposure. In a continuous mode (with a zero dead time) the IC operates with single threshold. The readout pixel has an equivalent noise charge of 89 e- rms and dissipates only 25 μW. Tests prove exceptional uniformity of IC: an offset spread below 12e- rms and a gain spread of only 3%.

关键词： pixel Integrated circuits readout offsets photon counting gain calibration equivalent noise keystone detector low noise

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Intrinsic Dimensionality of Extracellular Action Potentials

Intrinsic Dimensionality of Extracellular Action Potentials

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Annual International Conference of the IEEE engineering in Medicine and Biology Society

作者： Kathryn Scannell Agnieszka F. Szymanska Zoran Nenadic Graduate Program in Mathematical University of California Irvine (UCI) Irvine CA USA Department of Biomedical Engineering UCI Irvine CA USA Department of Electrical Engineering and Computer Science UCI Irvine CA USA

Linear approaches to low-dimensional feature extraction may not be appropriate when statistical data are generated by a nonlinear interaction of parameters. Equally inadequate are linear methods for determining the dimension of the feature space. This article estimates the intrinsic dimension of extracellular action potentials (EAPs), which can be viewed as the minimum number of nonlinearly interacting parameters sufficient to describe the data. When combined with nonlinear feature extraction methods, this information may lead to a more faithful, low-dimensional EAP representation. These points are demonstrated using EAPs recorded experimentally by a multi-sensor electrode.

关键词： Feature extraction Extracellular Principal component analysis Noise Electrodes Wavelet analysis Standards

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Integrated 4H-silicon carbide diode bridge rectifier for high temperature (773 K) environment

Integrated 4H-silicon carbide diode bridge rectifier for hig...

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European Conference on Solid-State Device Research (ESSDERC)

作者： Shiqian Shao Wei-Cheng Lien Ayden Maralani Albert P. Pisano Department of Mechanical Engineering University of California at Berkeley USA Applied Science and Technology Program University of California at Berkeley USA Department of Electrical Engineering and Computer Science University of California at Berkeley USA Jacobs School of Engineering University of California at San Diego USA

In this paper, we demonstrate the stable operation of integrated 4H-silicon carbide (SiC) diode bridge rectifier circuits at high temperature up to 773 K for the first time. The turn-on voltages of the fabricated 4H-SiC pn diode are 2.6 V and 1.4 V at room temperature and 773 K, respectively, with a low shifting rate of 2.2 mV/K. The integration of the 4H-SiC diode bridge rectifier circuit was achieved with contact and interconnect metallization technique for high temperature. The demonstration of the extremely high temperature operation of the integrated 4H-SiC diode bridge rectifier circuits brings promising applications in harsh environment electronics and sensing.

关键词： Bridge circuits Rectifiers Silicon carbide Temperature sensors Plasma temperature Temperature measurement Fabrication

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A web-based, hospital-wide health care-associated bloodstream infection surveillance and classification system: Development and evaluation

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JMIR Medical Informatics 2015年第3期3卷 e31页

作者： Tseng, Yi-Ju Wu, Jung-Hsuan Lin, Hui-Chi Chen, Ming-Yuan Ping, Xiao-Ou Sun, Chun-Chuan Shang, Rung-Ji Sheng, Wang-Huei Chen, Yee-Chun Lai, Feipei Chang, Shan-Chwen Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei Taiwan Computational Health Informatics Program Boston Children's Hospital Boston MA United States Department of Electrical Engineering National Taiwan University Taipei Taiwan Center for Infection Control National Taiwan University Hospital Taipei Taiwan National Taiwan University Hospital Information Systems Office Taipei Taiwan Department of Computer Science and Information Engineering National Taiwan University Taipei Taiwan Department of Internal Medicine National Taiwan University Hospital and College of Medicine Taipei Taiwan National Health Research Institutes National Institute of Infectious Diseases and Vaccinology Miaoli Taiwan

Background: Surveillance of health care-associated infections is an essential component of infection prevention programs, but conventional systems are labor intensive and performance dependent. Objective: To develop an automatic surveillance and classification system for health care-associated bloodstream infection (HABSI), and to evaluate its performance by comparing it with a conventional infection control personnel (ICP)-based surveillance system. Methods: We developed a Web-based system that was integrated into the medical information system of a 2200-bed teaching hospital in Taiwan. The system automatically detects and classifies HABSIs. Results: In this study, the number of computer-detected HABSIs correlated closely with the number of HABSIs detected by ICP by department (n=20;r=.999 P<.001) and by time (n=14;r=.941;P<.001). Compared with reference standards, this system performed excellently with regard to sensitivity (98.16%), specificity (99.96%), positive predictive value (95.81%), and negative predictive value (99.98%). The system enabled decreasing the delay in confirmation of HABSI cases, on average, by 29 days. Conclusions: This system provides reliable and objective HABSI data for quality indicators, improving the delay caused by a conventional surveillance system. © 2020 JMIR Publications Inc. All rights reserved.

关键词： Health care-associated infection Infection control Information systems Surveillance Web-based services

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High Quality Wafer-scale CVD Graphene on Molybdenum Thin Film for Sensing Application

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Procedia engineering 2014年 87卷 1501-1504页

作者： Yelena Grachova Sten Vollebregt Andrea Leonardo Lacaita Pasqualina M. Sarro Delft Unviersity of Technology Faculty of Electrical Engineering Mathematics and Computer Science Department of Microelectronics Delft Institute of Microsystems and Nanoelectronics(Dimes) Feldmannweg 17 2628 CT Delft The Netherlands Politecnico di Milano Faculty of Electrical Engineering The Departmen of Electronics Information and Bioengineering Piazza Leonardo da Vinci 32 20133 Milan Italy

The superb physical properties of graphene make it a material with great potential for sensing applications, including chemical sensors, Hall sensors and pressure sensors. However, its availability on large area substrates and the development of a scalable manufacturing process need to be addressed. In this work we propose wafer-scale, chemical vapour deposition (CVD) of graphene on sputtered thin-films of molybdenum, as alternative to the more commonly used CVD graphene processes based on copper films. The high melting point of Mo, its low thermal expansion, along with its smooth surface, create potentially favourable conditions to produce large area, wrinkle free, high quality graphene. Furthermore, the advantage of Mo, being commonly used in IC and sensor manufacturing environment, makes it an attractive choice for large volume production of sensing devices.

关键词： Graphene copper molybdenum thin-films chemical vapour deposition Raman spectroscopy atomic force microscopy

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Transgenetic Algorithms for the Multi-objective Quadratic Assignment Problem

Transgenetic Algorithms for the Multi-objective Quadratic As...

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Brazilian Conference on Intelligent Systems (BRACIS)

作者： Carolina Paula de Almeida Richard Aderbal Gonçalves Elizabeth Ferreira Goldbarg Marco Cesar Goldbarg Myriam Regattieri Delgado Computer Science Department-UNICENTRO Guarapuava PR Brazil Federal University of Rio Grande do Norte Natal RN Brazil Graduate Program in Electrical and Computer Engineering Federal University of Parana Curitiba PR Brazil

The multi-objective Quadratic Assignment Problem (mQAP) is a hard optimization problem with many real-world applications, such as in hospital layouts. The main purposes of this paper are: (1) the investigation of hybrid algorithms combining Transgenetic Algorithms and Evolutionary Multi-objective Optimization (EMO) frameworks to deal with mQAP and (2) to compare the ability of EMO algorithms based on Pareto dominance with those based on decomposition to deal with the mQAP. Transgenetic Algorithms (TAs) are evolutionary algorithms based on cooperation as the main evolutionary strategy. Two hybrid algorithms are proposed to deal with the mQAP: NSTA (TA + NSGA-II) and MOTA/D (TA + MOEA/D). To analyze the performance of the proposed algorithms, non-parametric statistical tests and multi-objective quality indicators are used. The proposed algorithms are compared with NSGA-II and MOEA/D in 126 instances of the mQAP. The results demonstrate the superiority of decomposition and transgenetic based algorithms, particularly in MOTA/D.

关键词： Biological cells Vectors Sociology Statistics Sorting Optimization Algorithm design and analysis

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Symmetry-protected mode coupling near normal incidence for narrow-band transmission filtering in a dielectric grating

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Physical Review B 2014年第16期89卷 165111-165111页

作者： J. M. Foley S. M. Young J. D. Phillips Applied Physics Program University of Michigan Ann Arbor Michigan 48109 USA Electrical Engineering and Computer Science Department University of Michigan Ann Arbor Michigan 48109 USA Physics Department University of Michigan Ann Arbor Michigan 48109 USA

A narrow-band transmission filter is demonstrated near normal incidence that operates through relaxation of supported-mode selection rules and is explained in the context of group theory. We calculated the transverse magnetic and transverse electric dispersion relations of a dielectric grating in the subwavelength and near-wavelength region using finite element modal analysis and determine the modes' corresponding irreducible representations. Coupling to select transverse magnetic modes at normal incidence is optimized to yield broadband high reflectance that acts as the background for the transmission filter. While some modes couple at normal incidence, others are shown to remain inaccessible due to symmetry mismatch. Away from normal incidence, the reduced symmetry relaxes the selection rules, enabling weak coupling between the incident field and these symmetry-protected modes. This weak coupling produces narrow transmission bands within the opaque background. Furthermore, by choosing the plane of incidence to include or exclude the grating periodicity, we show that orthogonal mode sets can independently be selected to couple to the incident light, yielding separate transmission bands. This spectral filtering is experimentally demonstrated with a suspended silicon grating in the infrared spectrum (7–14μm), which agrees well with simulated transmittance spectra and modal analysis.

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Transient Electronics: Materials and Wireless Microfluidic Systems for Electronics Capable of Chemical Dissolution on Demand (Adv. Funct. Mater. 9/2015)

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Advanced Functional Materials 2015年第9期25卷

作者： Chi Hwan Lee Jae‐Woong Jeong Yuhao Liu Yihui Zhang Yan Shi Seung‐Kyun Kang Jeonghyun Kim Jae Soon Kim Na Yeon Lee Bong Hoon Kim Kyung‐In Jang Lan Yin Min Ku Kim Anthony Banks Ungyu Paik Yonggang Huang John A. Rogers Department of Materials Science and Engineering Beckman Institute for Advanced Science and Technologyand Frederick Seitz Materials Research Laboratory University of Illinois at Urbana‐Champaign Urbana IL 61801 USA Department of Electrical Computer and Energy Engineering University of Colorado Boulder CO 80309 USA Department of Civil and Environmental Engineering and Mechanical Engineering Northwestern University Evanston IL 60208 USA Center for Mechanics and Materials Tsinghua University Beijing 100084 China State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and Astronautics Nanjing 210016 China Department of Materials Science and Engineering Department of Energy Engineering Hanyang University Seoul 133‐791 Republic of Korea Department of Chemistry University of Illinois at Urbana‐Champaign Urbana IL 61801 USA Department of Bioengineering University of Illinois at Urbana‐Champaign Urbana IL 61801 USA Department of Electrical and Computer Engineering University of Illinois at Urbana‐Champaign Urbana IL 61801 USA

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